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Topic Review
Last Four Decades' Viral Pandemics
The last four decades have witnessed some of the deadliest viral pandemics with far-reaching consequences. These include the Human Immunodeficiency Virus (HIV) (1981), Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) (2002), Influenza A virus subtype H1N1 (A/H1N1) (2009), Middle East Respiratory Syndrome Coronavirus (MERS-CoV) (2012), Ebola virus (2013) and the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) (2019-present). Age- and gender-based characterizations suggest that SARS-CoV-2 resembles SARS-CoV and MERS-CoV with regard to higher fatality rates in males, and in the older population with comorbidities. The invasion-mechanism of SARS-CoV-2 and SARS-CoV, involves binding of its spike protein with angiotensin-converting enzyme 2 (ACE2) receptors; MERS-CoV utilizes dipeptidyl peptidase 4 (DPP4), whereas H1N1 influenza is equipped with hemagglutinin protein.
  • 1.4K
  • 08 Jan 2021
Topic Review
Treatment Strategies for Glioblastoma Multiforme
Immunotherapies represent a promising strategy for glioblastoma multiforme (GBM) treatment. Different immunotherapies include the use of checkpoint inhibitors, adoptive cell therapies such as chimeric antigen receptor (CAR) T cells, and vaccines such as dendritic cell vaccines. Antibodies have also been used as toxin or radioactive particle delivery vehicles to eliminate target cells in the treatment of GBM. Oncolytic viral therapy and other immunogenic cell death-inducing treatments bridge the antitumor strategy with immunization and installation of immune control over the disease. These strategies should be included in the standard treatment protocol for GBM. Some immunotherapies are individualized in terms of the medicinal product, the immune target, and the immune tumor–host contact. Current individualized immunotherapy strategies focus on combinations of approaches. Standardization appears to be impossible in the face of complex controlled trial designs.
  • 1.4K
  • 24 Jan 2021
Topic Review
Eukaryotic Cell
Eukaryotic cells, are complex cells that evolved through endosymbiosis when one cell (typically bacterial, forming mitochondria and plastids) is incorporated by a host cell. It might well be that other cellular organelles are also of endosymbiotic nature. 
  • 1.4K
  • 18 Mar 2021
Topic Review
Static Osteogenesis versus Dynamic Osteogenesis
Static (SO) and dynamic (DO) osteogenesis are two very different types of osteogenesis, which are thus named because the former is characterized by pluristratified cords of unexpectedly stationary osteoblasts which differentiate at a fairly constant distance from the blood capillaries and transform into osteocytes without moving from the onset site, while the latter is distinguished by the well-known typical monostratified laminae of movable osteoblasts, which secrete bone moving towards the vessels.
  • 1.4K
  • 25 Mar 2021
Topic Review
Massive MIMO Techniques for 5G
The general concept of massive MIMO is defined as a physical-layer technology which equips each BS with a huge number of active antennas that can be used to spatially multiplex many UEs so that it is possible to communicate with them on the same time-frequency resource. The spectral efficiency per cell can be improved by orders-of magnitude over classical cellular networks by coping with the signal attenuation and interference through spatial signal processing with techniques such as receive combining and transmit precoding. To resume, massive MIMO is an upgraded version of the Space-Division Multiple Access (SDMA), pushing the spatial multiplexing to an extreme level.
  • 1.4K
  • 12 Aug 2021
Topic Review
Nodal Proteins
Nodal proteins show a different affinity to TGF-β receptors; it was demonstrated that the presence of binding proteins that act as partners enhances the signal cascade, improving the interactions between Nodal and its receptors. It was established that a fundamental obligatory co-receptor for the TGF-β family member Nodal is the cell surface glycosylphosphatidylinositol (GPI)-linked glycoprotein Cripto-1 (CR-1). Co-immunoprecipitation experiments show the interaction between Nodal and CR-1, supporting the idea that CR-1 acts as an obliged coreceptor for Nodal that potentiates its signal cascade.
  • 1.4K
  • 07 Sep 2021
Topic Review
Magnetic Material Nanoparticles
Magnetic material nanoparticles (MNPs) have been widely used in the detection and treatment of bacterial infections as detection agents and therapeutics. Infections caused by pathogenic bacteria, especially multidrug-resistant bacteria, have become a serious worldwide public health problem. Early diagnosis and treatment can effectively prevent the adverse effects of such infections. Therefore, there is an urgent need to develop effective methods for the early detection, prevention, and treatment of diseases that are caused by bacterial infections.
  • 1.4K
  • 23 May 2024
Topic Review
Dynamic Cancer Cell Heterogeneity
Though heterogeneity of cancers is recognized and has been much discussed in recent years, the concept often remains overlooked in different routine examinations. Indeed, in clinical or biological articles, reviews, and textbooks, cancers and cancer cells are generally presented as evolving distinct entities rather than as an independent heterogeneous cooperative cell population with its self-oriented biology. There are, therefore, conceptual gaps which can mislead the interpretations/diagnostic and therapeutic approaches.
  • 1.4K
  • 07 Feb 2022
Topic Review
Human Heart Organoid Development
The emergence of human-induced Pluripotent Stem Cells (hiPSCs) has dramatically improved the understanding of human developmental processes under normal and diseased conditions. The hiPSCs have been differentiated into various tissue-specific cells in vitro, and the advancement in three-dimensional (3D) culture has provided a possibility to generate those cells in an in vivo-like environment. Tissues with 3D structures can be generated using different approaches such as self-assembled organoids and tissue-engineering methods, such as bioprinting. Researchers are interested in studying the self-assembled organoids differentiated from hiPSCs, as they have the potential to recapitulate the in vivo developmental process and be used to model human development and congenital defects. Organoids of tissues such as those of the intestine and brain were developed many years ago, but heart organoids were not reported until recently.
  • 1.4K
  • 10 May 2022
Topic Review
Business Recommender Systems
Besides the typical applications of recommender systems in B2C scenarios such as movie or shopping platforms, there is a rising interest in transforming the human-driven advice provided, e.g., in consultancy via the use of recommender systems. There are two main classes of recommender systems: information-filtering-based and knowledge-based systems. The former category selects items from a large collection of items based on user preferences and is further classified as collaborative-filtering recommenders and content-based filtering recommenders. The knowledge-based recommenders make recommendations by applying constraints or similarities based on domain or contextual knowledge. Common applications are in B2C scenarios such as e-commerce, tourism, news, movie, music, etc.
  • 1.4K
  • 10 Jun 2022
Topic Review
Housing Sustainability
Housing plays an essential role in sustainable governance due to its socio-economic and environmental connection. In terms of housing sustainability, the housing market is influenced by how sustainability is defined, driving factors, policy objectives, and the way demand and supply are managed in response to housing market activities.
  • 1.4K
  • 08 Jul 2022
Topic Review
Global Utilizations of Cement Kiln Dust
A large quantity of cement kiln dust is produced daily, associated with ordinary Portland cement production worldwide. Most of these quantities are disposed of in landfills to meet the environmental requirement. Meanwhile, only a small proportion can be recycled in cement manufacturing. Recently, utilizing cement kiln dust (CKD) in many commercial applications has significantly increased due to the potential benefits of adding CKD, in different percentages, to the engineering properties of the prepared product. Moreover, utilizing CKD as a partial replacement for cement in industrial applications reduces the overconsumption of natural resources used for cement manufacturing and promotes sustainability.
  • 1.4K
  • 15 Aug 2022
Topic Review
NDIS Participants with Psychosocial Disabilities and Life-Limiting Diagnoses
Australia’s National Disability Insurance Scheme (NDIS) is a key reform providing support to the disability population nationally. No peer-reviewed or grey literature was retrieved on the phenomena. Therefore, three lines of enquiry were developed: experiences of NDIS participants living with psychosocial disabilities; the death, dying, and palliative care supports and experiences of NDIS participants of any disability type; and the experiences for people living with severe and persistent mental illness (SPMI) and life-limiting diagnoses. 
  • 1.4K
  • 09 Sep 2022
Topic Review
Castanea mollissima
Chestnut (Castanea spp., Fagaceae family) is an economically important tree in the wood processing industry that occurs in Asia, Europe, Africa, and the Americas. There are four most important and cultivated chestnut varieties: C. molissima (Chinese chestnut) and C. crenata (Japanese chestnut) are distributed in Asia; C. sativa is distributed in continental Europe (European chestnut); and Castanea dentata is distributed in North America (American chestnut). Chestnuts are a source of nuts and industrial raw materials, including wood, that can be used as firewood, as well as to build timber and barrels for winemaking. Extracts from chestnut shells (e.g., tannins, polyphenols, and polysaccharides), female flower, and spring buds have been applied in the medical, pharmaceutical, and healthcare fields. Discarded chestnut shells, inner shells, burs, and leaves have been re-utilized as biomass and catalyst material. The important economic and environmental roles of chestnut underlie its high value to ecosystems and agroforestry systems.
  • 1.4K
  • 16 Sep 2022
Topic Review
Myocardial Injury Related to SARS-CoV-2 Pneumonia
The diagnosis of SARS-CoV-2 pneumonia is expected to worsen, and mortality will be higher when combined with myocardial injury (MI). The combination of novel coronavirus infections in patients with MI can cause confusion in diagnosis and assessment, with each condition exacerbating the other, and increasing the complexity and difficulty of treatment.
  • 1.4K
  • 08 Oct 2022
Topic Review
Head Direction Cells
Head direction cells are type of neuron involved in spatial processing. Head direction (HD) cells are neurons found in a number of brain regions that increase their firing rates above baseline levels only when the animal's head points in a specific direction. They have been reported in rats, monkeys, mice, chinchillas and bats, but are thought to be common to all mammals, perhaps all vertebrates and perhaps even some invertebrates, and to underlie the "sense of direction". When the animal's head is facing in the cell's "preferred firing direction" these neurons fire at a steady rate (i.e., they do not show adaptation), but firing decreases back to baseline rates as the animal's head turns away from the preferred direction (usually about 45° away from this direction). HD cells are found in many brain areas, including the cortical regions of postsubiculum (also known as the dorsal presubiculum), retrosplenial cortex, and entorhinal cortex, and subcortical regions including the thalamus (the anterior dorsal and the lateral dorsal thalamic nuclei), lateral mammillary nucleus, dorsal tegmental nucleus and striatum. It is thought that the cortical head direction cells process information about the environment, while the subcortical ones process information about angular head movements. A striking characteristic of HD cells is that in most brain regions they maintain the same relative preferred firing directions, even if the animal is moved to a different room, or if landmarks are moved. This has suggested that the cells interact so as to maintain a unitary stable heading signal (see "Theoretical models"). Recently, however, a subpopulation of HD neurons has been found in the dysgranular part of retrosplenial cortex that can operate independently of the rest of the network, and which seems more responsive to environmental cues. The system is related to the place cell system, located in the hippocampus, which is mostly orientation-invariant and location-specific, whereas HD cells are mostly orientation-specific and location-invariant. However, HD cells do not require a functional hippocampus to express their head direction specificity. They depend on the vestibular system, and the firing is independent of the position of the animal's body relative to its head. Some HD cells exhibit anticipatory behaviour: the best match between HD activity and the animal's actual head direction has been found to be up to 95 ms in future. That is, activity of head direction cells predicts, 95 ms in advance, what the animal's head direction will be. This possibly reflects inputs from the motor system ("motor efference copy") preparing the network for an impending head turn. HD cells continue to fire in an organized manner during sleep, as if animals were awake. However, instead of always pointing toward the same direction—the animals are asleep and thus immobile—the neuronal "compass needle" moves constantly. In particular, during rapid eye movement sleep, a brain state rich in dreaming activity in humans and whose electrical activity is virtually indistinguishable from the waking brain, this directional signal moves as if the animal is awake: that is, HD neurons are sequentially activated, and the individual neurons representing a common direction during wake are still active, or silent, at the same time.
  • 1.4K
  • 16 Nov 2022
Topic Review
Structure and Properties of Glucansucrase
Glucansucrase (GS) belongs to the GH70 family, which not only can synthesize exopolysaccharides (EPSs) with different physicochemical properties through glucosyl transglycosylation (by hydrolyzing sucrose) but can also produce oligosaccharides. 
  • 1.4K
  • 25 Nov 2022
Biography
Florian Goebel
Karl Florian Goebel (18 October 1972 — 10 September 2008) was a Germany astrophysicist attached to the Max Planck Institute for Physics in Munich. He had also been a member of DESY, a German-based research center that develops and runs several particle accelerators and detectors, most notably the ZEUS project. At the time of his death he was managing the MAGIC-II telescope project. His death
  • 1.4K
  • 27 Dec 2022
Topic Review
Dictyostelium as a Drug Resource
The cellular slime mold Dictyostelium discoideum is an excellent model organism for the study of cell and developmental biology because of its simple life cycle and ease of use. Recent findings suggest that Dictyostelium and possibly other genera of cellular slime molds, are potential sources of novel lead compounds for pharmacological and medical research.
  • 1.4K
  • 02 Oct 2021
Topic Review
NNetEn Entropy
NNetEn is the first entropy measure that is based on artificial intelligence methods. The method modifies the structure of the LogNNet classification model so that the classification accuracy of the MNIST-10 digits dataset indicates the degree of complexity of a given time series. The calculation results of the proposed model are similar to those of existing methods, while the model structure is completely different and provides considerable advantages.
  • 1.4K
  • 19 Jun 2023
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