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Topic Review
Integrins
Integrins belong to a group of cell adhesion molecules (CAMs) which is a large group of membrane-bound proteins. They are involved both in cell attachment to the extracellular matrix (ECM) and in signal transduction from the ECM to the cells. They also take part in numerous biological activities, namely extravasation, cell-to-cell adhesion, cell migration, and function as receptors for certain viruses, including adenovirus, echovirus, hantavirus, foot-and-mouth disease, polio virus and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). CAMs also include selectins, cadherins, immunoglobulin superfamily and other molecules, including CD44. Cell adhesion molecules are classified using the CD nomenclature (from 1 to 130). Integrins receive and transmit biochemical and mechanical signals through the cell membrane in both directions. Signals which develop inside the cell lead to conformational changes of the molecule and transmission of integrin into a state which enables ligand binding. The name “integrins” has been coined to denote the function they have maintaining a multicellular organism as a whole. They significantly affect the integrity of the cytoskeleton–ECM connections.
  • 1.4K
  • 04 Aug 2021
Topic Review
Microneedles in Drug Delivery
In recent years, an innovative transdermal delivery technology has attracted great interest for its ability to distribute therapeutics and cosmeceuticals for several applications, including vaccines, drugs, and biomolecules for skin-related problems. The advantages of microneedle patch technology have been extensively evaluated in the latest literature; hence, the academic publications in this area are rising exponentially. 
  • 1.4K
  • 29 Mar 2022
Topic Review
HAR in Smart Homes
Human Activity Recognition (HAR) consists in monitoring and analyzing the behavior of one or more persons in order to deduce their activity. In a smart home context, the HAR consists in monitoring daily activities of the residents, based on a network of IoT devices. Owing to this monitoring, a smart home can offer personalized home assistance services to improve quality of life, autonomy and health of their residents, especially for elderly and dependent people.
  • 1.4K
  • 19 Nov 2021
Topic Review
Nanoporous Graphene Membranes for Organic Solvent Nanofiltration
The organic solvent nanofiltration (OSN) technique has attracted significant attention in separation processes in the chemical and pharmaceutical industries because it can serve as an integrated system, has high energy efficiency at mild operating conditions. Nanoporous graphene has been used for OSN membrane fabrication and ultrafast solvent permeance with precise molecular separation has been demonstrated.
  • 1.4K
  • 16 Nov 2021
Topic Review
The Development of Renewable Energy in China
Renewable energy is now the world’s most reliable and sustainable solution to environmental pollution, the energy crisis, and social sustainability. In order to regulate renewable energies and ensure the sustainable development of renewable energy in China, a regulatory framework is imperative. In 2020, China’s electricity generation and consumption increased by 0.9 and 1.3 percent annually, respectively, producing capacity of power plants increased by 5.6 GW, coal consumption of power supply decreased by 4.3 g/kWh, power generation projects investment increased by 51.6 billion RMB, power grid projects investment decreased by 1.8 billion RMB, and newly installed generation capacity increased by 769 GW year on year (YOY). During the first three quarters of 2021, the generation, consumption and coal consumption of electricity increased respectively by 10.7 and 12.9%, the generating capacity of power plants increased by 9.4 GW, the average coal consumption of power supply decreased by 0.9 g/kWh, power generation projects investment increased by 1.8 billion RMB, while power grid projects investment decreased by 0.3 billion RMB and new generation capacity added around 20.16 GW compared to the same period last year. Furthermore, domestic power consumption grew by 6.0% and 7%, respectively, in 2020–2021. 
  • 1.4K
  • 25 Mar 2022
Topic Review
Genetic Engineering Technology
Genetic engineering refers to the specific molecular biological modification of DNA sequences. With the rapid development of genetic engineering methods, especially the breakthroughs in guiding endonuclease technology, gene remodeling of crops has become simpler, more precise, and efficient. Genetic engineering techniques can be used to develop crops with superior traits such as high trace elements and high plant nutrients, providing an important tool to meet the needs of nearly 7.6 billion people in the world for crop yield and quality and to achieve sustainable development.
  • 1.4K
  • 13 Apr 2022
Topic Review
Phage-Bacteria Interactions
With the increasing global threat of antibiotic resistance, there is an urgent need to develop new effective therapies to tackle antibiotic-resistant bacterial infections. Bacteriophage therapy is considered as a possible alternative over antibiotics to treat antibiotic-resistant bacteria. Bacteria can evolve resistance towards bacteriophages through antiphage defense mechanisms, which is a major limitation of phage therapy. The antiphage mechanisms target the phage life cycle, including adsorption, the injection of DNA, synthesis, the assembly of phage particles, and the release of progeny virions.
  • 1.4K
  • 21 Jul 2022
Topic Review
Famous Photographical Manipulations
Photographical Manipulation is the alteration of a photograph. The U.S. National Press Photographers Association (NPPA) Digital Manipulation Code of Ethics states: “As journalists we believe the guiding principle of our profession is accuracy; therefore, we believe it is wrong to alter the content of a photograph in any way that deceives the public. As photojournalists, we have the responsibility to document society and to preserve its images as a matter of historical record. It is clear that the emerging electronic technologies provide new challenges to the integrity of photographic images... in light of this, we the National Press Photographers Association, reaffirm the basis of our ethics: Accurate representation is the benchmark of our profession. We believe photojournalistic guidelines for fair and accurate reporting should be the criteria for judging what may be done electronically to a photograph. Altering the editorial content... is a breach of the ethical standards recognized by the NPPA.”
  • 1.4K
  • 17 Oct 2022
Topic Review
Morpha
In biology, polymorphism is the occurrence of two or more clearly different morphs or forms, also referred to as alternative phenotypes, in the population of a species. To be classified as such, morphs must occupy the same habitat at the same time and belong to a panmictic population (one with random mating). Put simply, polymorphism is when there are two or more possibilities of a trait on a gene. For example, there is more than one possible trait in terms of a jaguar's skin colouring; they can be light morph or dark morph. Due to having more than one possible variation for this gene, it is termed 'polymorphism'. However, if the jaguar has only one possible trait for that gene, it would be termed "monomorphic". For example, if there was only one possible skin colour that a jaguar could have, it would be termed monomorphic. The term polyphenism can be used to clarify that the different forms arise from the same genotype. Genetic polymorphism is a term used somewhat differently by geneticists and molecular biologists to describe certain mutations in the genotype, such as single nucleotide polymorphisms that may not always correspond to a phenotype, but always corresponds to a branch in the genetic tree. See below. Polymorphism is common in nature; it is related to biodiversity, genetic variation, and adaptation. Polymorphism usually functions to retain a variety of forms in a population living in a varied environment.:126 The most common example is sexual dimorphism, which occurs in many organisms. Other examples are mimetic forms of butterflies (see mimicry), and human hemoglobin and blood types. According to the theory of evolution, polymorphism results from evolutionary processes, as does any aspect of a species. It is heritable and is modified by natural selection. In polyphenism, an individual's genetic makeup allows for different morphs, and the switch mechanism that determines which morph is shown is environmental. In genetic polymorphism, the genetic makeup determines the morph. The term polymorphism also refers to the occurrence of structurally and functionally more than two different types of individuals, called zooids, within the same organism. It is a characteristic feature of cnidarians. For example, Obelia has feeding individuals, the gastrozooids; the individuals capable of asexual reproduction only, the gonozooids, blastostyles; and free-living or sexually reproducing individuals, the medusae. Balanced polymorphism refers to the maintenance of different phenotypes in population.
  • 1.4K
  • 11 Nov 2022
Biography
J. W. Dunne
John William Dunne FRAeS (2 December 1875 – 24 August 1949) was a British soldier, aeronautical engineer and philosopher. As a young man he fought in the Second Boer War, before becoming a pioneering aeroplane designer in the early years of the 20th century. Dunne worked on automatically stable aircraft, many of which were of tailless swept wing design, to achieve the first certified stable ai
  • 1.4K
  • 15 Nov 2022
Topic Review
Heterogeneous Relation
In mathematics, a heterogeneous relation is a binary relation, a subset of a Cartesian product A × B, where A and B are distinct sets. The prefix hetero is from the Greek ἕτερος (heteros, "other, another, different"). A heterogeneous relation has been called a rectangular relation, suggesting that it does not have the square-symmetry of a homogeneous relation on a set where A = B. Commenting on the development of binary relations beyond homogeneous relations, researchers wrote, "...a variant of the theory has evolved that treats relations from the very beginning as heterogeneous or rectangular, i.e. as relations where the normal case is that they are relations between different sets." Developments in algebraic logic have facilitated usage of binary relations. The calculus of relations includes the algebra of sets, extended by composition of relations and the use of converse relations. The inclusion R ⊆ S, meaning that aRb implies aSb, sets the scene in a lattice of relations. But since [math]\displaystyle{ P \subseteq Q \equiv (P \cap \bar{Q} = \varnothing ) \equiv (P \cap Q = P), }[/math] the inclusion symbol is superfluous. Nevertheless, composition of relations and manipulation of the operators according to Schröder rules, provides a calculus to work in the power set of A × B. In contrast to homogeneous relations, the composition of relations operation is only a partial function. The necessity of matching range to domain of composed relations has led to the suggestion that the study of heterogeneous relations is a chapter of category theory as in the category of sets, except that the morphisms of this category are relations. The objects of the category Rel are sets, and the relation-morphisms compose as required in a category.
  • 1.4K
  • 21 Nov 2022
Topic Review
Slurry Shield Tunneling
The penetration characteristics of the slurry and the support pressure transfer mechanisms are critical to the tunnel face stability control during a mechanized excavation. The reasonableness of the numerical model is verified by comparing the variation patterns of the soil permeability coefficients monitored in the numerical tests with the results of existing laboratory tests. The mesoscopic transport characteristics of the slurry particles in the sand soil pores are considered based on numerical tests, while the slurry support effects corresponding to different penetration types are evaluated.
  • 1.4K
  • 18 Jan 2023
Topic Review
Energy Situation in Informal Settlements
Informal Settlements (ISs) are a widespread phenomenon in cities in the global south. In Sub-Saharan Africa (SSA), about 56% of the urban population lives in ISs. More than half of the urban population of Sub-Saharan Africa lives in informal housing conditions. While urban areas are, in general, characterized by a high electrification rate, residents of informal settlements are still affected by energy poverty, the use of traditional energy sources and unreliable electricity supply. 
  • 1.4K
  • 04 Jul 2023
Topic Review
Orthotropic Steel–UHPC Composite Deck
Although orthotropic steel decks (OSDs) have been widely used in the construction of long-span bridges, there are frequently reported fatigue cracks after years of operation, and the bridge deck overlay also presents severe damage due to OSD crack-induced stiffness reduction. Ultra-high performance concrete (UHPC), recognized as the most innovative cementitious composites and the next generation of high-performance materials, shows high strength, ductility, toughness, and good performance on durability. After its first application to the OSD bridge in the early 2000s, the orthotropic steel–UHPC composite deck has been comprehensively studied worldwide.
  • 1.4K
  • 14 Aug 2023
Topic Review
African Clawless Otter
The African Clawless Otter (Aonyx capensis) is a fascinating semi-aquatic mammal native to sub-Saharan Africa. Renowned for its sleek, streamlined body and lack of visible claws on its forelimbs, this otter species is well-adapted to its aquatic lifestyle in freshwater habitats, including rivers, lakes, and wetlands. With a diet consisting primarily of fish, crustaceans, and amphibians, the African Clawless Otter plays a vital role in maintaining the health and balance of aquatic ecosystems across its range.
  • 1.4K
  • 08 Feb 2024
Topic Review
Flat-headed Cat
The Flat-headed Cat (Prionailurus planiceps) is a small and elusive felid species native to the wetlands of Southeast Asia, particularly found in countries like Malaysia, Indonesia, and Thailand. Its unique name is derived from its distinctive flattened head shape, which aids in navigating through dense vegetation and hunting aquatic prey. Despite its secretive nature, the Flat-headed Cat is classified as endangered due to habitat loss, pollution, and hunting, highlighting the urgent need for conservation efforts to protect this rare and elusive feline species.
  • 1.4K
  • 08 Mar 2024
Topic Review
Sequrity aspects in Smart Meters
Smart meters are of the basic elements in the so-called Smart Grid. These devices, connected to the Internet, keep bidirectional communication with other devices in the Smart Grid structure to allow remote readings and maintenance. As any other device connected to a network, smart meters become vulnerable to attacks with different purposes, like stealing data or altering readings. Nowadays, it is becoming more and more popular to buy and plug-and-play smart meters, additionally to those installed by the energy providers, to directly monitor the energy consumption at home. This option inherently entails security risks that are under the responsibility of householders. In this paper, we focus on an open solution based on Smartpi 2.0 devices with two purposes. On the one hand, we propose a network configuration and different data flows to exchange data (energy readings) in the home. These flows are designed to support collaborative among the devices in order to prevent external attacks and attempts of corrupting the data. On the other hand, we check the vulnerability by performing two kind of attacks (denial of service and stealing and changing data by using a malware).
  • 1.4K
  • 27 Oct 2020
Topic Review
Arenaviridae Nucleoprotein
Arenaviridae is a family of viruses harbouring important emerging pathogens belonging to the Bunyavirales order. Like in other segmented negative strand RNA viruses, the nucleoprotein (NP) is a major actor of the viral life cycle being both (i) the necessary co-factor of the polymerase present in the L protein, and (ii) the last line of defence of the viral genome (vRNA) by physically hiding its presence in the cytoplasm. The NP is also one of the major players interfering with the immune system. Several structural studies of NP have shown that it features two domains: a globular RNA binding domain (NP-core) in its N-terminal and an exonuclease domain (ExoN) in its C-terminal. Further studies have observed that significant conformational changes are necessary for RNA encapsidation. We here present the architecture and latest structural data available on Arenaviridae NP.  
  • 1.4K
  • 27 Jul 2020
Topic Review
Looking for Metropolitan ecological area
       Compact housing structures located in city centers are considered to be the most energy and environmentally effective, mainly due to the access to services, transport networks and municipal infrastructures. There is the question how to look for metropolitan ecologacl areas and why so many of the acknowledged ecological housing complexes are located on the outskirts of cities or suburbs and . Numerous cities decide to introduce strategies either to densify city centers, hoping to improve energy efficiency. The Tricity Metropolitan Area is a special case undergoing dynamic transformation, and its development overlaps with the processes of both planned densification of the center as well as uncontrolled suburbanization.  The goal  was to find the correlation between optimal location of an eco-district from the functional center of the Tricity Metropolitan Area, allowing for the most favorable energy and environmental parameters related both to the architectural and urban scale. The research was conducted in four different scenarios, concerning present and future development. In these scenarios, specific locations were examined, and the following were compared: total energy consumption, ecological footprint and CO2 lifecycle emissions. This study showed the possibility for suburban housing complexes with appropriate parameters in an edge city model to have the same or better results than complexes situated closer to the functional center of the city. This is mainly due to the building’s energy efficiency, sustainable mobility, municipal infrastructure and relevant service access. The research proves the importance of implementing sustainable energy-saving and environmentally oriented activities at both an architectural and urban scale planning process.
  • 1.4K
  • 29 Oct 2020
Topic Review
Breast Cancer
Breast cancer is a disease in which certain cells in the breast become abnormal and multiply uncontrollably to form a tumor.
  • 1.4K
  • 31 Dec 2020
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