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Land Use Efficiency and Value Capture
This article aims to relate intrinsic aspects of urban planning that are becoming increasingly important both within the international scientific debate and within urban planning tools. These aspects are land consumption and land value capture. Their centrality is given by the growing importance that in recent years have assumed the aspects related to the sustainable development of settlements. This article aims to summarize the main theories regarding the relationship between the efficiency of land use and the policies of capturing public value. The reference scenario is dictated by sustainable development policies that, if contextualized in the sphere of urban development, imply a rational use of resources to ensure the formation of resilient, safe, and inclusive settlements. This aspect introduces the existing link between urban form and sustainability. It is therefore understood how the achievement of the targets set at the international level are implemented in local urban policies. For this reason, many scholars have argued that the challenge of adapting to new pressures, such as climate change, necessarily means creating efficient urban settlements. The question becomes: which land use can be considered more efficient than the others? This article intends to answer this question by investigating the main theories that have tried to define the mechanisms and methods of comparison of different urban development scenarios. The article goes on to reconstruct the steps that have helped to evaluate urban development according to purely fiscal aspects up to the introduction of qualitative aspects related to public value. To do so, it analyzes the terms and tools related to the concepts of public value and the capture of public value and attempts to synthesize the main theories and research in the sector.
  • 1.4K
  • 08 Dec 2022
Biography
John S. Foster Jr.
John Stuart Foster Jr. (born September 18, 1922) is an American physicist, best known as the fourth director of Lawrence Livermore National Laboratory and as Director, Defense Research and Engineering under four Secretaries of Defense and two Presidents. Foster was born September 18, 1922 in New Haven, Connecticut. He received his Bachelor of Science degree in 1948 from McGill University, whe
  • 1.4K
  • 12 Dec 2022
Topic Review
Placenta Extract on Liver
The placenta contains multiple biologically active substances, which exert antioxidation, anti-inflammatory, immunomodulatory, and delayed aging effects. Its extract can improve hepatic morphology and function: on the one hand, it can reduce liver interstitial collagen deposition, lipogenesis, and inflammatory cell infiltration and improve fibrosis; on the other hand, it can prevent hepatocellular degeneration by scavenging reactive oxygen species (ROS) and inhibiting inflammatory cytokine production, further improve hepatocyte apoptosis and necrosis, and promote hepatocyte regeneration, making it a promising liver-protective agent.
  • 1.4K
  • 15 Dec 2022
Topic Review
Role of Pyroptosis in Intervertebral Disc Degeneration
Intervertebral disc degeneration (IDD), a progressive and multifactorial pathological process, is predominantly associated with low back pain and permanent disability. Pyroptosis is a type of lytic programmed cell death triggered by the activation of inflammasomes and caspases. Unlike apoptosis, pyroptosis is characterized by the rupture of the plasma membrane and the release of inflammatory mediators, accelerating the destruction of the extracellular matrix (ECM). Recent studies have shown that pyrin domain-containing 3 (NLRP3) inflammasome-mediated pyroptosis in nucleus pulposus (NP) cells is activated in the progression of IDD. Furthermore, targeting pyroptosis in IDD demonstrates the excellent capacity of ECM remodeling and its anti-inflammatory properties, suggesting that pyroptosis is involved in the IDD process. Here, the molecular mechanism of pyroptosis and the pathogenesis of IDD are briefly summarized. Researchers also focus on the role of pyroptosis in the pathological progress of IDD and its targeted therapeutic application.
  • 1.4K
  • 20 Dec 2022
Topic Review
Challenges According to the ‘7Vs’ of Big Data
Big Data has challenges that sometimes are the same as its own characteristics. These characteristics are known as the Vs. The researchers describe ‘7Vs’ that they have found and are the most used and more related to general data used in Big Data, including an explanation and challenges that exist according to them. Some of them have different subtypes according to the differences detected in the literature and working with them. Some authors create a different V for similar purposes, and here, the researcher gather them into one due to the similarities.
  • 1.4K
  • 12 Apr 2023
Topic Review
Polyphenol
The use of naturally derived drugs in anti-cancer therapies has grown exponentially in recent years. Among natural compounds, polyphenols have shown potential therapeutic applications in treatment due to their protective functions in plants, their use as food additives, and their excellent antioxidant properties, resulting in beneficial effects on human health. Building more efficient cancer therapies with fewer side effects on human health can be achieved by combining natural compounds with conventional drugs, which are typically more aggressive than natural chemicals with polyphenols.
  • 1.4K
  • 19 Jun 2023
Topic Review
Basic Differences between Cell Cycle and Endocycle
The standard cell cycle is divided into two periods: (1) the interphase, with the phases G1, S, and G2 and (2) cell division, either mitosis or meiosis. Initially, each new cell is in the G1 (Gap 1) phase. Then, the content of genetic material in the cell nucleus amounts to 2C, i.e., it reaches the basic value in vegetative cells.
  • 1.4K
  • 10 Aug 2023
Topic Review
Chinese Baijiu and Whisky
Baijiu is a traditional spirit with high reputation in the Chinese community, and whisky, on the other hand, is a renowned spirit in Western culture, with both contributing a major proportion to the consumption and revenue in the global spirit market. Interestingly, starting with similar raw materials, such as grains, diverse production methods lead to different organoleptic profiles. In addition, such enormous attention they attract renders them as a crucial part in food and the related industry. Therefore, great efforts are made in improving product quality and optimizing production processes, such as flavor enhancement, facility development, and deep utilization of byproducts. Given the huge impacts and great involvements of these spirits in the general food industry, research focusing on either spirit is of referential significance for other relevant fields.
  • 1.4K
  • 23 Aug 2023
Topic Review
Drug-Induced Acute Pancreatitis in Adults
Acute pancreatitis (AP) is an acute inflammation of the pancreas caused by the activation of digestive enzymes in the pancreatic tissue. The main causes of AP are cholelithiasis and alcohol abuse; less commonly, it can be caused by drugs, with a prevalence of up to 5%. Causal associations between drugs and pancreatitis are largely based on case reports or case series with limited evidence.
  • 1.4K
  • 09 Jan 2024
Topic Review
Retrieval-Augmented Generation with Large Language Models in Nephrology
The integration of large language models (LLMs) into healthcare, particularly in nephrology, represents a significant advancement in applying advanced technology to patient care, medical research, and education. These advanced models have progressed from simple text processors to tools capable of deep language understanding, offering innovative ways to handle health-related data, thus improving medical practice efficiency and effectiveness. A significant challenge in medical applications of LLMs is their imperfect accuracy and/or tendency to produce hallucinations—outputs that are factually incorrect or irrelevant. This issue is particularly critical in healthcare, where precision is essential, as inaccuracies can undermine the reliability of these models in crucial decision-making processes. To overcome these challenges, various strategies have been developed. One such strategy is prompt engineering, like the chain-of-thought approach, which directs LLMs towards more accurate responses by breaking down the problem into intermediate steps or reasoning sequences. Another one is the retrieval-augmented generation (RAG) strategy, which helps address hallucinations by integrating external data, enhancing output accuracy and relevance. Hence, RAG is favored for tasks requiring up-to-date, comprehensive information, such as in clinical decision making or educational applications. 
  • 1.4K
  • 18 Mar 2024
Topic Review
Beehive Products as Antibacterial Agents
Apitherapy is a branch of unconventional medicine that relies on the usage of bee products which consist of honey, pollen, propolis, royal jelly and bee venom (BV). Besides having high nutritional importance and health benefits, honey showed antifungal, antiviral, antiseptic, anticancer, anti-diabetic, anti-inflammatory and cardio protective activities. As for the BV, despite its possible adverse effects like the allergic reactions that might occur after the bee sting, one cannot disregard its various therapeutic effects. BV exerts anticancer, antiviral, antifungal and antibacterial effects, it is also used for the treatment of many neurodegenerative diseases. Regarding propolis, it has the capacity to fight against cancer and many microorganisms. Moreover, pollen possesses antioxidant, anticoagulant and anti-inflammatory properties. Also, royal jelly exhibits several interesting biological activities including antioxidant, anti-aging, antitumor anti-inflammatory, antimicrobial, and neurotrophic activities. Hence, this review aims to highlight one of the most important and commonly shared biological activity of all of the above-mentioned beehive products, which is the antibacterial activity.
  • 1.4K
  • 12 Jul 2021
Topic Review
Holographic Optical Tweezers for Biomedical Applications
Holographic optical tweezers (HOT) is a programmable technique used for manipulation of microsized samples. In combination with computer-generation holography (CGH), a spatial light modulator reshapes the light distribution within the focal area of the optical tweezers. HOT can be used to realize real-time multiple-point manipulation in fluid, and this is useful in biological research.
  • 1.4K
  • 27 Oct 2022
Topic Review
Agricultural Water
Monitoring the microbial quality of water used in agriculture is important to reduce the likelihood of produce contamination and possible future foodborne outbreaks. The U.S. Food and Drug Administration has established the Produce Safety Rule as part of the Food Safety Modernization Act to improve the safety of produce that is normally consumed raw during growing, harvesting, packing and holding activities. In order to comply with the rule, growers need to follow some standards for the microbial quality of water that is used on the produce field, however, more information on the water microbial profile is necessary in order to improve the accuracy of the testing.
  • 1.4K
  • 11 Jan 2022
Topic Review
Human Coronavirus (HCoV)
Coronaviruses (CoVs) were identified in the 1930s as zoonotic spherical pathogens causing mostly respiratory or enteric diseases. Coronaviruses vary in size and are enveloped with club-shaped spikes on their surface. A helically symmetrical nucleocapsid comprising positive-sense single-stranded RNA is one of the largest virus genomes, ranging from 26 to 32 kilobases in length. Although CoVs are distributed mainly among mammals and birds, since 1960 seven species of human coronaviruses (HCoVs) have been described and some HCoVs infections (SARS-CoV, MERS-CoV and SARS-CoV-2) have resulted in lethal epidemics. The global range and high fatality rate of the newest HCoV pandemic has made SARS-CoV-2 the focus of the scientific world.
  • 1.4K
  • 17 Dec 2020
Topic Review
Statin Treatment in the Elderly
Ample evidence supports the use of statin therapy for secondary prevention in patients with a history of atherosclerotic cardiovascular disease (ASCVD), but evidence is wanting in the case of primary prevention, low-risk individuals, and elderly adults 65+. The efficacy of statins can be contrasted for distinct subsets of patients based on age, diabetes, ASCVD, and coronary artery calcium (CAC) status. Most cardiovascular risk calculators heavily weight age and overestimate one’s absolute risk of ASCVD, particularly in very old adults. Improvements in risk assessment will enable the identification of specific patient populations that benefit most from statin treatment. Derisking is particularly important for adults over 75, in whom treatment benefits are reduced and adverse musculoskeletal effects are amplified. The CAC score stratifies the benefit effect size obtainable with statins, and CAC > 100 can be regarded as a significant patient benefit group. Robust biomarkers, improved risk estimator tools, and personalized, evidence-based approaches are needed to optimally reduce cardiovascular events and mortality rates through administration of cholesterol-lowering medications.
  • 1.4K
  • 26 Nov 2020
Topic Review
Fermentative Foods
Fermented foods identify cultures and civilizations. History, climate and the particulars of local production of raw materials have urged humanity to exploit various pathways of fermentation to produce a wide variety of traditional edible products which represent adaptations to specific conditions.
  • 1.4K
  • 28 Sep 2021
Topic Review
Macrophages in Cancer
Macrophages in cancer represent a major part of the immune cells within the TME and they are more frequently associated with a bad prognosis.
  • 1.4K
  • 21 Feb 2021
Topic Review
Myeloid-Derived Suppressor Cells in HGG
The immune microenvironment of high-grade gliomas (HGG) is a complex and heterogeneous system, consisting of diverse cell types such as microglia, bone marrow-derived macrophages (BMDMs), myeloid-derived suppressor cells (MDSCs), dendritic cells, natural killer (NK) cells, and T-cells. Of these, MDSCs are one of the major tumor-infiltrating immune cells and are correlated not only with overall worse prognosis but also poor clinical outcomes. Upon entry from the bone marrow into the peripheral blood, spleen, as well as in tumor microenvironment (TME) in HGG patients, MDSCs deploy an array of mechanisms to perform their immune and non-immune suppressive functions. 
  • 1.4K
  • 15 Jun 2021
Topic Review
IPSC Preparation and Epigenetic Memory
The derivation of induced pluripotent stem cells (iPSCs) from somatic human cells by Takahashi and Yamanaka in 2007 represented a turning point for the field. For the first time, they provided isogenic pluripotent cells with the potential for personalized cell replacement therapies; no ethical issues would be created by using the somatic cells. This opportunity marks a decisive step compared to the generation of human embryonic stem cells (ESCs) arranged by Thomson et al. in 1998. The production of induced pluripotent stem cells (iPSCs) represent a breakthrough in regenerative medicine, providing new opportunities for understanding basic molecular mechanisms of human development and molecular aspects of degenerative diseases.
  • 1.4K
  • 22 Jun 2021
Topic Review
Pancreatic ductal adenocarcinoma (PDAC)
Pancreatic ductal adenocarcinoma (PDAC) is currently the third leading cause of cancer-related mortality. About 90% of PDAC cases are diagnosed in patients older than 55 years, and with increased longevity in the general population PDAC burden is expected to rise. Still, the survival is abysmal, with a 5-year survival rate of 8.2%.
  • 1.4K
  • 02 Aug 2021
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