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Topic Review
Contacts at the Nanoscale
Contact scaling is a major challenge in nano complementary metal–oxide–semiconductor (CMOS) technology, as the surface roughness, contact size, film thicknesses, and undoped substrate become more problematic as the technology shrinks to the nanometer range. These factors increase the contact resistance and the nonlinearity of the current–voltage characteristics, which could limit the benefits of the further downsizing of CMOS devices. 
  • 161
  • 06 Mar 2024
Topic Review
Robotic Applications in Maintenance, Repair, and Overhaul Hangar
The aerospace industry has continually evolved to guarantee the safety and reliability of aircraft to make air travel one of the safest and most reliable means of transportation. Mobile robots encompass comprehensive system structures that work together through perception, detection, motion planning, and control. The subject of autonomous robot navigation entails mapping, localisation, obstacle detection, avoidance, and achieving an optimal path from a starting point to a predefined target location efficiently.
  • 129
  • 06 Mar 2024
Topic Review
Dexterity of Anthropomorphic Soft Hand
Humans possess dexterous hands that surpass those of other animals, enabling them to perform intricate, complex movements. Soft hands, known for their inherent flexibility, aim to replicate the functionality of human hands. By mimicking the shape, structure, and functionality of human hands, soft hands can partially replicate human-like movements, offering adaptability and operability during grasping tasks. 
  • 108
  • 06 Mar 2024
Topic Review
Marine-Derived Bisindoles for Potent Selective Cancer Drug Discovery
Indole is a multifunctional active pharmacophore and a heterocyclic compound widely present in natural and synthetic compounds with biological activity. Indole alkaloids from natural sources display diverse mechanisms and structures and exert anticancer potential through various antiproliferation mechanisms. Thus, indole alkaloids play a significant role in the discovery of new anticancer drugs. Scientists have subsequently isolated various new bisindole alkaloids from marine organisms, especially deep-water sponges. They are usually extracted with organic solvents (e.g., methanol, ethyl acetate). And the extracts were concentrated and partitioned between organic and aqueous phases. The organic phase is separated with chromatography separation technology, including silica gel column chromatography, high-performance liquid chromatography, etc. Most marine-derived bisindoles exist in solid form, which makes it convenient for us to determine their absolute configuration by single crystal. A number of marine-derived bisindoles exhibit strong and varied biological activities. Due to their unique biological activities and chemical structures, they have become a research focal point in pharmaceutical chemistry as lead compounds for new drug development. It is noteworthy that many drugs based on marine-derived bisindoles have been approved or are currently in clinical research, such as midostaurin, lestaurtinib, and enzastaurin. These drug molecules have shown potent selective anti-tumor effects.
  • 213
  • 06 Mar 2024
Topic Review
Cultural Values as Catalysts of Technological Innovation
Innovation is a key element for companies that aim to achieve and sustain a competitive advantage. A great number of academics and practitioners have focused on the role of cultural values to provide further incentives to firms to invest more in innovation that will give them a market edge. 
  • 107
  • 06 Mar 2024
Topic Review
Polymer Single-Crystal Functionalization Applications
Polymer physics has evolved significantly over the past century, transitioning from the early recognition of the chain structure of polymers to a mature field integrating principles from statistical mechanics, thermodynamics, and condensed matter physics. As an important part of polymer physics, polymer single crystals are crucial for understanding molecular structures and behaviors, enhancing material properties, and enabling precise functionalization. They offer insights into polymer crystallization kinetics, serve as templates for nanofabrication, and have applications in electronics, sensors, and biomedical fields.
  • 225
  • 06 Mar 2024
Topic Review Peer Reviewed
Antitumor Strategies Targeting Peptidergic Systems
Peptidergic systems show promise as targets for fighting tumors. While some peptides encourage the growth and spread of tumor cells and angiogenic mechanisms, others display antitumor properties. As such, peptide ligands and receptor antagonists could be used as antitumor agents alone or in conjunction with chemotherapy or radiotherapy. Peptide receptor antagonists can counteract the oncogenic effects of specific peptides by inducing apoptosis in various types of tumor cells, hindering cancer cell migration and inhibiting angiogenesis. Peptides and peptide receptor antagonists are not currently used in clinical practice as antitumor agents. Still, aprepitant, a neurokinin 1 receptor antagonist, is a promising candidate due to its ability to promote apoptosis in many cancer cells. However, to utilize aprepitant as an anticancer agent, the dosage must be increased and administered for a more extended period. Moving beyond current protocols for aprepitant’s use as an antiemetic is essential. Additionally, a common anticancer strategy with aprepitant is possible regardless of cancer cell type. Finally, combining aprepitant with chemotherapy or radiotherapy is encouraged.
  • 287
  • 06 Mar 2024
Topic Review
Neural Circuitry Plasticity in SDH during Pain Pathogenesis
Pathological pain emerges from nociceptive system dysfunction, resulting in heightened pain circuit activity. Various forms of circuitry plasticity, such as central sensitization, synaptic plasticity, homeostatic plasticity, and excitation/inhibition balance, contribute to the malfunction of neural circuits during pain pathogenesis. A new form of plasticity in the spinal dorsal horn (SDH), named neural circuit polarization (NCP), was discovered in pain models induced by HIV-1 gp120 and chronic morphine administration. NCP manifests as an increase in excitatory postsynaptic currents (EPSCs) in excitatory neurons and a decrease in EPSCs in inhibitory neurons, presumably facilitating hyperactivation of pain circuits. The expression of NCP is associated with astrogliosis. Ablation of reactive astrocytes or suppression of astrogliosis blocks NCP and, concomitantly, the development of gp120- or morphine-induced pain.
  • 209
  • 06 Mar 2024
Topic Review
Liquid Biopsy in Type 2 Diabetes
As the burden of type 2 diabetes (T2D) continues to escalate globally, there is a growing need for novel, less-invasive biomarkers capable of early diabetes detection and monitoring of disease progression. Liquid biopsy, recognized for its minimally invasive nature, is increasingly being applied beyond oncology, and nevertheless shows its potential when the collection of the tissue biopsy is not possible. This diagnostic approach involves utilizing liquid biopsy markers such as cell-free nucleic acids, extracellular vesicles, and diverse metabolites for the molecular diagnosis of T2D and its related complications.
  • 102
  • 06 Mar 2024
Topic Review
Control Technology of Offshore Wind Power Systems
As global energy crises and climate change intensify, offshore wind energy, as a renewable energy source, is given more attention globally. The wind power generation system is fundamental in harnessing offshore wind energy, where the control and design significantly influence the power production performance and the production cost.
  • 210
  • 06 Mar 2024
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