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Topic Review
A New Parcel Delivery System
This entry proposes a novel parcel delivery system which consists of a drone and public transportation vehicles such as trains, trams, etc. This system involves two delivery schemes: drone-direct scheme referring to delivering to a customer by a drone directly and drone–vehicle collaborating scheme referring to delivering a customer based on the collaboration of a drone and public transportation vehicles. The fundamental characteristics including the delivery time, energy consumption and battery recharging are modelled, based on which a time-dependent scheduling problem for a single drone is formulated. It is shown to be NP-complete and a dynamic programming-based exact algorithm is presented. Since its computational complexity is exponential with respect to the number of customers, a sub-optimal algorithm is further developed. This algorithm accounts the time for delivery and recharging, and it first schedules the customer which leads to the earliest return.
  • 804
  • 01 Nov 2020
Topic Review
A New Perspective on Perceived Overqualification
A new perspective on perceived overqualification:This article contains five variables, perceived overqualification, innovative behavior, felt trust, ability face pressure and length of service. Perceived overqualifications refer to the level of knowledge, skills, experience, and ability that an individual possesses that exceeds the requirements of the current job, which is a situation of underemployment. Employee innovative behavior refers to the new ideas, new products, new services, or new methods that employees generate in their work that are meaningful to the enterprise. Felt trust refers to the perception of one party’s willingness to take risks for the actions of another party. Ability face pressure, also known as “perceived face threat based on ability,” is a result of the perceived possibility and potential risk of losing face due to the individual’s desire for others to recognize their own abilities, achievements, and status. Length of service is the length of time an employee has worked since entering an organization, where the length of service can have an important impact on employees’ perceptions, self-evaluations, attitudes, and even behaviors. In studying the relationship between perceived overqualification and innovation behavior, this entry introduces new perspectives and variables, felt trust, ability face pressure, and length of service to conduct research, and has made some findings, as detailed in the entry.
  • 697
  • 08 Apr 2022
Topic Review
A New Product Development Model for SMEs
The success of new product development (NPD) is of vital importance for the growth and prosperity of manufacturing companies. Complex product demands are increasing and companies must be able to produce the right products at the right time and at an affordable price; otherwise, they can quickly lose their competitive advantage. Especially vulnerable are small and medium-sized enterprises (SMEs) that can find it difficult to compete with larger companies on a global market and are also more prone to suffer from potential losses related to unsuccessful NPD, as they have a smaller set of both financial and non-financial resources. In order to survive in today’s highly competitive global market, small and medium-sized enterprises (SMEs) have had to transition from sequential to concurrent product development, which significantly shortens development cycles, reduces costs, and ensures high product quality. 
  • 1.4K
  • 28 Mar 2022
Topic Review
A New Role of Acute Phase Proteins
The prevailing general view of acute-phase proteins (APPs) is that they are produced by the liver in response to the stress of the body as part of a systemic acute-phase response. A coordinated, local production of these proteins upon cell stress by the stressed cells has been demonstrated. The local, stress-induced APP production has been demonstrated in different tissues (kidney, breast cancer) and with different stressors (hypoxia, fibrosis and electromagnetic heat). Thus, this local acute-phase response (APR) seems to be a universal mechanism. APP production is an ancient defense mechanism observed in nematodes and fruit flies as well. Local APP production at the tissue level is also supported by sporadic literature data for single proteins.
  • 336
  • 01 Apr 2022
Topic Review
A Novel Composited Electromagnetic Linear Actuator
Electromagnetic linear actuators, as key executive components, have a vital impact on the performance of fully flexible variable valve trains. The research results show that the maximum starting force of the composited electromagnetic linear actuator (CELA) with the end-passive self-holding ability is 574.92 N while the holding force can approach 229.25 N. Moreover, the CELA is proven to have excellent dynamic characteristics and control precision under different motion modes and to have an improved adaptability to the complex working conditions of internal combustion engines.
  • 849
  • 11 Jan 2022
Topic Review
A Novel Innate Immune Regulatory Player: LncRNAs
Long non-coding RNAs (lncRNAs) represent crucial transcriptional and post-transcriptional gene regulators during antimicrobial responses in the host innate immune system. Studies have shown that lncRNAs are expressed in a highly tissue- and cell-specific- manner and are involved in the differentiation and function of innate immune cells, as well as inflammatory and antiviral processes, through versatile molecular mechanisms. These lncRNAs function via the interactions with DNA, RNA, or protein in either cis or trans pattern, relying on their specific sequences or their transcriptions and processing. The dysregulation of lncRNA function is associated with various human non-infectious diseases, such as inflammatory bowel disease, cardiovascular diseases, and diabetes mellitus. Here, we provide an overview of the regulation and mechanisms of lncRNA function in the development and differentiation of innate immune cells, and during the activation or repression of innate immune responses. These elucidations might be beneficial for the development of therapeutic strategies targeting inflammatory and innate immune-mediated diseases.
  • 815
  • 09 Oct 2021
Topic Review
A Novel, Pan-PDE Inhibitor From the Group of 7,8-Disubstituted Purine-2,6-Dione Derivatives
Phosphodiesterases (PDEs) inhibitors are currently a widespread and extensively studied group of anti-inflammatory and anti-fibrotic compounds which may find use in the treatment of numerous lung diseases, including asthma and chronic obstructive pulmonary disease. Several PDE inhibitors are currently in clinical development, and some of them, e.g. roflumilast, are already recommended for clinical use. Due to numerous reports indicating that elevated intracellular adenosine 3’,5’-cyclic monophosphate (cAMP) levels may contribute to alleviation of inflammation and airway fibrosis, new and effective PDE inhibitors are constantly being sought. Recently, a group of 7,8-disubstituted purine-2,6-dione derivatives, representing novel and prominent pan-PDE inhibitors has been synthesized. Some of them were reported to modulate transient receptor potential ankyrin 1 (TRPA1) ion channels as well. Compound 145 (4-(8-butoxy-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(5-(tert-butyl)-2-hydroxyphenyl)butanamide) – a pan-PDE inhibitor and a weak TRPA1 modulator inhibited fibroblast to myofibroblasts transition (FMT) as well as MRC-5 human lung fibroblasts proliferation, migration, and contraction. The effect of this compound appeared to depend mainly on its strong PDE inhibitory properties, and not on its effects on TRPA1 modulation. The strong anti-remodelling effects of 145 required activation of the cAMP/protein kinase A/CREB pathway leading to inhibition of transforming growth factor type β1 (TGF-β1) and Smad-dependent signalling in MRC-5 cells.
  • 661
  • 09 Sep 2021
Topic Review
A Paraoxonase for All Seasons
Paraoxonases (PON) are a multigene family consisting of three enzymes, PON1, PON2, and PON3, located on human chromosome 7 (7q21.3–22.1). All three PONs have been shown to act as antioxidants and consequently have anti-inflammatory effects in various disease states such as atherosclerosis and cardiovascular diseases.
  • 613
  • 12 Apr 2022
Topic Review
A Patch-Based CNN Built on the VGG-16 Architecture
Facial recognition is a prevalent method for biometric authentication that is utilized in a variety of software applications. This technique is susceptible to spoofing attacks, in which an imposter gains access to a system by presenting the image of a legitimate user to the sensor, hence increasing the risks to social security. Consequently, facial liveness detection has become an essential step in the authentication process prior to granting access to users. A patch-based convolutional neural network (CNN) with a deep component for facial liveness detection for security enhancement was developed, which was based on the VGG-16 architecture.
  • 645
  • 13 Sep 2022
Topic Review
A Pathophysiological Intersection of Diabetes and Alzheimer’s Disease
Diabetes is among the most prevalent diseases of the modern world and is strongly linked to an increased risk of numerous neurodegenerative disorders, although the exact pathophysiological mechanisms are not clear yet. Insulin resistance is a serious pathological condition, connecting type 2 diabetes, metabolic syndrome, and obesity. Insulin resistance has been proven to be connected also to cognitive decline and dementias, including the most prevalent form, Alzheimer’s disease. The relationship between diabetes and Alzheimer’s disease regarding pathophysiology is so significant that it has been proposed that some presentations of the condition could be termed type 3 diabetes.
  • 292
  • 18 Oct 2022
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