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Topic Review
Neuromodulation of Eating Disorders
Eating disorders are a group of psychiatric conditions that involve pathological relationships between patients and food. The most prolific of these disorders are anorexia nervosa, bulimia nervosa, and binge eating disorder. 
  • 139
  • 05 Mar 2024
Topic Review
Conformational Dynamics of Lipoxygenases
Lipoxygenases (LOXs) are a family of enzymes that includes different fatty acid oxygenases with a common tridimensional structure. The main functions of LOXs are the production of signaling compounds and the structural modifications of biological membranes.
  • 95
  • 05 Mar 2024
Topic Review
Antioxidant Bioactive Molecules against Ischemic Stroke
Stroke is a major contributor to global mortality and disability. While reperfusion is essential for preventing neuronal death in the penumbra, it also triggers cerebral ischemia-reperfusion injury, a paradoxical injury primarily caused by oxidative stress, inflammation, and blood–brain barrier disruption. An oxidative burst inflicts marked cellular damage, ranging from alterations in mitochondrial function to lipid peroxidation and the activation of intricate signalling pathways that can even lead to cell death.
  • 119
  • 05 Mar 2024
Topic Review
AI Applications in Pancreatic Ductal Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) stands out as the predominant malignant neoplasm affecting the pancreas, characterized by a poor prognosis, in most cases patients being diagnosed in a nonresectable stage. Image-based artificial intelligence (AI) models implemented in tumor detection, segmentation, and classification could improve diagnosis with better treatment options and increased survival. 
  • 180
  • 05 Mar 2024
Topic Review
Correlation of NETs to Atherosclerosis and Implication
Neutrophil extracellular traps (NETs) have attracted much attention recently, beyond elemental host immunity, due to their fundamental implication in a variety of pathologic conditions and widespread impactful diseases. Atherosclerotic cardiovascular disease (ASCVD) is one of them, and a major cause of mortality and disability worldwide. Consequently, years of basic and clinical research were dedicated to shedding light on every possible pathophysiologic mechanism that could be used as an effective prevention and treatment tool to ameliorate its burden. This led to the development of complex and prevention protocols and regimens that are now widely used, with lipid-lowering treatment being the current cornerstone; however, this is not adequate to alleviate the residual cardiovascular risk, which remains prominent. 
  • 114
  • 05 Mar 2024
Topic Review
A Regulatory Perspective on Biosimilar Medicines
By definition, biosimilar medicinal products are biological medicinal products that are similar to other biological medicinal products that are already on the market—the reference medicinal products.
  • 293
  • 05 Mar 2024
Topic Review
Merging Ontologies and Data from Electronic Health Records
The Electronic Health Record (EHR) is a system for collecting and storing patient medical records as data that can be mechanically accessed, hence facilitating and assisting the medical decision-making process. EHRs exist in several formats, and each format lists thousands of keywords to classify patients data. The keywords are specific and are medical jargon; hence, data classification is very accurate. As the keywords constituting the formats of medical records express concepts by means of specific jargon without definitions or references, their proper use is left to clinicians and could be affected by their background, hence the interpretation of data could become slow or less accurate than that desired.
  • 154
  • 05 Mar 2024
Topic Review
Digital Inclusivity
In the fast-paced digital economy, stakeholders across regions, industries and organisational typologies are recognising the growing significance of adopting customer-centric digital strategies. Inexorably, this necessitates the comprehension of consumer behaviours across a diverse customer spectrum, including individuals with disabilities (PwD).
  • 251
  • 05 Mar 2024
Topic Review
Cardiomyocytes Contractile Activity on Poly(vinyl-alcohol)/Bioglass Electrospun Scaffolds
Tissue scaffolds are generally used as three-dimensional structural supports destined to mimic the morphological structure and function in regeneration processes. Still, beyond this, they are expected to perform the physiological functions for which each tissue or organ is intended. In the case of cardiac tissue, it brings oxygen through the blood to each part of the body through the contraction of the cardiac muscle cells (cardiomyocytes). This contraction is neurologically stimulated through a voltage and calcium-dependent process denominated excitation-contraction coupling, which is mediated by several factors. In this sense, the composition of the scaffold becomes relevant.
  • 143
  • 05 Mar 2024
Topic Review
miR-Based Treatments for Acute Respiratory Distress Syndrome
Acute Respiratory Distress Syndrome (ARDS) is characterized by lung inflammation and increased membrane permeability, which represents the leading cause of mortality in ICUs. Mechanical ventilation strategies are at the forefront of supportive approaches for ARDS. Recently, an increasing understanding of RNA biology, function, and regulation, as well as the success of RNA vaccines, has spurred enthusiasm for the emergence of novel RNA-based therapeutics. The most common types of RNA seen in development are silencing (si)RNAs, antisense oligonucleotide therapy (ASO), and messenger (m)RNAs that collectively account for 80% of the RNA therapeutics pipeline. These three RNA platforms are the most mature, with approved products and demonstrated commercial success. 
  • 188
  • 05 Mar 2024
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