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Topic Review
Heterocyclic Anticancer Compounds
Heterocyclic organic compounds are designated as integral components on a wide array of structures with both pharmacological and biological importance. They constitute a large cohort of structures with immense importance in the life sciences. 
  • 1.6K
  • 29 Mar 2022
Topic Review
Heteroatom-Doped Metal-Free Carbon Nanomaterials
In comparison to the undoped carbon nanomaterials, heteroatoms such as nitrogen-, sulphur-, boron-, phosphorous-, etc., incorporated nanomaterials have become well-accepted as potential electrocatalysts in water splitting, supercapacitors and dye-sensitized solar cells. 
  • 547
  • 08 Feb 2022
Topic Review
Heteroaromatic Diazirines in Material and Medicinal Chemistry
In materials (polymer) science and medicinal chemistry, heteroaromatic derivatives play the role of the central skeleton in development of novel devices and discovery of new drugs. On the other hand, (3-trifluoromethyl)phenyldiazirine (TPD) is a crucial chemical method for understanding biological processes such as ligand–receptor, nucleic acid–protein, lipid–protein, and protein–protein interactions. In particular, use of TPD has increased in materials science to create novel electric and polymer devices with comparative ease and reduced costs. Therefore, a combination of heteroaromatics and (3-trifluoromethyl)diazirine is a promising option for creating better materials and elucidating the unknown mechanisms of action of bioactive heteroaromatic compounds.
  • 570
  • 15 Feb 2023
Topic Review
Heteroaromatic N-Oxides in Asymmetric Catalysis
Chiral heteroaromatic N-oxides can work as powerful electron-pair donors, providing suitable electronic environments in the transition state formed within the reaction. The nucleophilicity of the oxygen atom in N-oxides, coupled with a high affinity of silicon to oxygen, represent ideal properties for the development of synthetic methodology based on nucleophilic activation of organosilicon reagents.
  • 604
  • 28 Apr 2022
Topic Review
Herbicide Resistance Risk and Novel Potential Herbicide Targets
To date, effectively controlling resistant weeds has been a great challenge in modern agricultural production. Developing new modes of action of herbicides would be an efficient, convenient, and . In particular, new modes of herbicide action do not appear to have evolutionary resistance or cross-resistance with existing herbicides. However, a few successful herbicides with new modes of action (MoAs) have been marketed in the past 20 years. Researchers summarized the positive herbicide targets for the herbicides that have been discovered in recent years, such as Solanyl Diphosphate Synthase (SPS), Fatty Acid Thioesterase (FAT), Plastid Peptide Deformylase (PDEF), and Dihydroxy-Acid Dehydratase (DHAD). Some commercial herbicide varieties have been obtained based on novel herbicide targets, such as Homogentisate Solanesyltransferase (HST) and Dihydroorotate Dehydrogenase (DHODH). This provides a new reference and idea for herbicide molecular design in the future. 
  • 504
  • 21 Nov 2022
Topic Review
HER2-Positive Breast Cancer Targeted Therapies
Breast cancer represents the most common cancer type and one of the major leading causes of death in the female worldwide population. Overexpression of human epidermal growth factor (HER2), a transmembrane glycoprotein related to the epidermal growth factor receptor, results in a biologically and clinically aggressive breast cancer subtype. It is also the primary driver for tumor detection and progression and, in addition to being an important prognostic factor in women diagnosed with breast cancer, HER2 is a widely known therapeutic target for drug development. In breast cancer, the overexpression of the HER2 receptor makes it a reliable biomarker and a successful therapeutic target. Several strategies have been developed to target HER2, using various targeting molecules including monoclonal antibodies and tyrosine kinase inhibitors, antibody–drug conjugates, small molecules, and peptides.
  • 397
  • 12 Sep 2023
Topic Review
Heparin–Protamine Particles for Biomedical Application
Heparin and protamine are a clinically relevant pair of biomolecules. Heparin is a mixture of linear anionic polysaccharides with many sulfate groups. In cardiac and vascular surgery, the use of the anticoagulant is followed by the administration of protamine, a small arginine-rich cationic protein, to neutralize the heparin. The fact that pharmaceutical grade heparin and protamine are commercially available and clinically used in cardiac and vascular surgery makes these biomolecules attractive as building blocks for in vivo applications.
  • 457
  • 16 Mar 2022
Topic Review
Helichrysum Genus in Management of Diabetes Mellitus
Diabetes mellitus (DM) is a very prevalent disease affecting both developed and developing countries. Concerted efforts by the International Diabetes Federation (IDF) and the American Diabetes Association (ADA) to reduce the spike in global diabetes cases and mortality have witnessed different advocacies over the past years. The IDF report shows that 463 million (9.3%) adults worldwide are suffering from diabetes, and this number is projected to increase by 51% in 2030 (578 million) and 2045 (700 million). The prevalence of diabetes varies according to geographical region, with more than 80% of diabetic patients living in low-to-middle-income countries, which poses additional challenges with ineffective treatment. Despite the success recorded from these synthetic drugs, the traditional method of treatment using medicinal plants is increasingly accepted by the locals due to its low cost and the perceived no side effects. Helichrysum species are used in folk medicine and are documented for the treatment of DM in different regions of the world. 
  • 574
  • 10 Jun 2022
Topic Review
Heavy Metal Adsorption Using Magnetic Nanoparticles
Research on contamination of groundwater and drinking water is of major importance. Due to the rapid and significant progress in the last decade in nanotechnology and its potential applications to water purification, such as adsorption of heavy metal ion from contaminated water, a wide number of articles have been published. An evaluating frame of the main findings of recent research on heavy metal removal using magnetic nanoparticles, with emphasis on water quality and method applicability, is presented. A large number of articles have been studied with a focus on the synthesis and characterization procedures for bare and modified magnetic nanoparticles as well as on their adsorption capacity and the corresponding desorption process of the methods are presented.
  • 579
  • 21 Dec 2021
Topic Review
Heating's Influence Trans Fatty Acid in Oils
Consumption of trans fatty acids (TFA) is associated with adverse health outcomes and places a considerable burden on morbidity and mortality globally. TFA may be generated by common cooking practices and hence contribute to daily dietary intake. Heating edible oils to common cooking temperatures (≤200 °C) has minimal effect on TFA generation whereas heating to higher temperatures can increase TFA level. 
  • 1.1K
  • 24 May 2022
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