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Topic Review
Pancreatic Cancer Treatment by Nab-Paclitaxel with Gemcitabine Combination
Pancreatic cancer has one of the highest mortality rates among cancers, and a combination of nab-paclitaxel with gemcitabine remains the cornerstone of first-line therapy. Nab-paclitaxel with gemcitabine in combination with other therapeutic agents can be new treatment strategies in pancreatic cancer. Seven therapeutic agents (ibrutinib, necuparanib, tarextumab, apatorsen, cisplatin, enzalutamide, and momelotinib) are found. 
  • 622
  • 01 Mar 2022
Topic Review
Fabrication of Receptors, Devices for Quantification of Fluoride
Fluoride (F¯) is the most electronegative and lightest member of the halogen group of elements. The contamination of groundwater with inorganic fluoride is due to the withering of underground rocks and also due to increased globalization. According World Health Organisation (WHO) High fluoride concentration in groundwater beyond the permissible limit of 1.5 mg/L is a major threat to human and animal health. 
  • 622
  • 21 Oct 2022
Topic Review
Technical Features of Polysaccharide-Based Hydrogels in Drug Delivery
Hydrogels are a form of highly hydrophilic biomaterials with three-dimensional architecture that can retain a significant amount of water and swell without disintegrating. Hydrogels can be either synthetic, natural, or hybrid forms. Natural polymer hydrogels are those derived from naturally sourced polymers, including polysaccharides, polynucleotides, and proteins. Neutral, cationic, and anionic categories describe the chemical properties of natural sources of polymers. These polymers are easily accessible, ubiquitous, affordable, non-toxic, renewable, and have other appealing biological features.
  • 622
  • 22 Dec 2022
Topic Review
Piezoelectric-Triboelectric Effects Coupled Nanogenerators
Piezoelectric and triboelectric nanogenerators have been widely studied for their advantages of easy design/manufacturing, small size, and flexibility. Nanogenerators that are developed based on the coupled piezoelectric and triboelectric effects (PTCNG) can make full use of the mechanical energies and achieve both higher output and sensing performance.
  • 621
  • 08 Feb 2023
Topic Review
Nano-Sized Titania Particles as Additives in Automotive Lubricants
This study focuses on the wear effects of nano-sized titania as a potential engine lubricant additive. Titanium dioxide nanoparticles have promising wear-reducing properties and significant tribological potential. Titania nanoparticles were homogenized in Group III automotive oil at five different concentrations (0.1; 0.2...0.5 wt%). The nanodoped oil samples were tested on a linear oscillating tribometer with oil circulation. Based on the tribological results, titania nanoparticles increased friction by 20–32% but can reduce the wear area by up to 32%. According to the confocal microscopic examination, wear volume can be reduced by up to 57% with titania nanoparticles. Titania nanoparticles improved the repeatability of tribological measurements. A scanning electron microscopy examination of the wear track revealed that the characteristic wear of the tribological system was abrasive, but a significant amount of adhesive wear was also observed. Energy dispersive X-ray spectroscopy analysis found that the nanoparticles fill the deeper trenches of the wear. The worn surface uniformly contains TiO2 particles and the quantified normalized titanium concentration was between 0.56 and 0.62%.
  • 622
  • 16 Oct 2023
Topic Review
Chrysoeriol7 against Brown Planthopper in Rice
Brown planthopper (BPH, Nilaparvata lugens Stal.) is the most damaging rice pest affecting stable rice yields worldwide. Currently, methods for controlling BPH include breeding a BPH‐resistant cultivar and using synthetic pesticides. Nevertheless, the continuous cultivation of resistant cultivars allows for the emergence of various resistant races, and the use of synthetic pesticides can induce environmental pollution as well as the emergence of unpredictable new pest species. As plants cannot migrate to other locations on their own to combat various stresses, the production of secondary metabolites allows plants to protect themselves from stress and tolerate their reproduction. Pesticides using natural products are currently being developed to prevent environmental pollution and ecosystem disturbance caused by synthetic pesticides. In this study, after BPH infection in rice, chrysoeriol7 (C7), a secondary metabolite that induces resistance against BPH, was assessed. After C7 treatment and BPH infection, relative expression levels of the flavonoid‐related genes were elevated, suggesting that in plants subjected to BPH, compounds related to flavonoids, among the secondary metabolites, play an important role in inducing resistance. The plant‐derived natural compound chrysoeriol7 can potentially thus be used to develop environmentally friendly pesticides. The suggested control of BPH can be effectively used to alleviate concerns regarding environmental pollution and to construct a relatively safe rice breeding environment.
  • 621
  • 21 Mar 2022
Topic Review
Milk Whey Hydrolysates as High Value-Added Natural Polymers
There are two types of milk whey obtained from cheese manufacture: sweet and acid. It retains around 55% of the nutrients of the milk. Milk whey is considered as a waste, creating a critical pollution problem, because 9 L of whey are produced from every 10 L of milk. Some treatments such as hydrolysis by chemical, fermentation process, enzymatic action, and green technologies (ultrasound and thermal treatment) are successful in obtaining peptides from protein whey. Milk whey peptides possess excellent functional properties such as antihypertensive, antiviral, anticancer, immunity, and antioxidant, with benefits in the cardiovascular, digestive, endocrine, immune, and nervous system.
  • 621
  • 27 Apr 2022
Topic Review
Analytical Techniques for Detection of Quantum Dots
Since the discovery of Quantum Dots (QDs) by Alexey I. Ekimov in 1981, the interest of researchers in that particular type of nanomaterials (NMs) with unique optical and electrical properties has been increasing year by year. Thus, since 2009, the number of scientific articles published on this topic has not been less than a thousand a year. The increasing use of QDs due to their biomedical, pharmaceutical, biological, photovoltaics or computing applications, as well as many other high-tech uses such as for displays and solid-state lighting (SSL), has given rise to a considerable number of studies about its potential toxicity. However, there are a really low number of reported studies on the detection and quantification of QDs, and these include ICP–MS and electrochemical analysis, which are the most common quantification techniques employed for this purpose. Keeping in mind both human health and environmental risks of QDs as well as the scarcity of analytical techniques and methodological approaches for their detection, the adaptation of existing techniques and methods used with other NMs appears necessary. 
  • 621
  • 27 Jul 2022
Topic Review
Progress of Natural Product Databases
Natural products (NPs) are a rich source of structurally novel molecules, and the chemical space they encompass is far from being fully explored. NPs have represented a significant source of bioactive molecules and have served as a source of inspiration for developing many drugs on the market. Computer-aided drug design (CADD) has contributed to drug discovery research, mitigating costs and time. In this sense, compound databases represent a fundamental element of CADD. 
  • 621
  • 08 Oct 2022
Topic Review
Mesoporous Silica-Based Hybrid Materials
Hybrid organic-inorganic catalysts have been extensively investigated by several research groups in the last decades, as they allow combining the structural robust-ness of inorganic solids with the versatility of organic chemistry. Within the field of hybrid catalysts, synthetic strategies based on silica are among the most exploitable, due to the convenience of sol-gel chemistry, to the array of silylderivative precursors that can be synthesized and to the number of post-synthetic functionalization strategies available, amongst others. Exemplificative studies involving mono- and multi-functional silica-based hybrid catalysts featuring different types of active sites (acid, base, redox) have been studied. Materials obtained through different approaches are described and their properties, as well as their catalytic performances, are compared in the literature.
  • 620
  • 25 Feb 2021
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