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Topic Review
Urgent Threat of Infections by Antimicrobial Resistant Bacteria
Infectious disease outbreaks have caused thousands of deaths and hospitalizations, along with severe negative global economic impacts. Among these, infections caused by antimicrobial-resistant microorganisms are a major growing concern. The misuse and overuse of antimicrobials have resulted in the emergence of antimicrobial resistance (AMR) worldwide. Carbapenem-resistant Enterobacterales (CRE) are among the bacteria that need urgent attention globally. The emergence and spread of carbapenem-resistant bacteria are mainly due to the rapid dissemination of genes that encode carbapenemases through horizontal gene transfer (HGT). The rapid dissemination enables the development of host colonization and infection cases in humans who do not use the antibiotic (carbapenem) or those who are hospitalized but interacting with environments and hosts colonized with carbapenemase-producing (CP) bacteria. There are continuing efforts to characterize and differentiate carbapenem-resistant bacteria from susceptible bacteria to allow for the appropriate diagnosis, treatment, prevention, and control of infections.
  • 271
  • 04 Jul 2023
Topic Review
The Ketogenic Diet and Cardiovascular Diseases
The ketogenic diet has been shown to have a multifaceted effect on the prevention and treatment of cardiovascular diseases (CVD). Among other aspects, it has a beneficial effect on the blood lipid profile, even compared to other diets. It shows strong anti-inflammatory and cardioprotective potential, which is due, among other factors, to the anti-inflammatory properties of the state of ketosis, the elimination of simple sugars, the restriction of total carbohydrates and the supply of omega-3 fatty acids. In addition, ketone bodies provide “rescue fuel” for the diseased heart by affecting its metabolism. They also have a beneficial effect on the function of the vascular endothelium, including improving its function and inhibiting premature ageing. The ketogenic diet has a beneficial effect on blood pressure and other CVD risk factors through, among other aspects, weight loss. The evidence cited is often superior to that for standard diets, making it likely that the ketogenic diet shows advantages over other dietary models in the prevention and treatment of cardiovascular diseases.
  • 271
  • 07 Sep 2023
Topic Review
Transmastoid Superior Semicircular Canal Plugging for SSCD
The transmastoid plugging of a superior semicircular canal is considered a safe and effective technique for the management of superior semicircular canal dehiscence (SSCD). 
  • 271
  • 20 Oct 2023
Topic Review
Virtual Reality and Its Influence on Brain Health
Dynamic technological development and its enormous impact on modern societies are posing new challenges for 21st-century neuroscience. A special place is occupied by technologies based on virtual reality (VR). VR tools have already played a significant role in both basic and clinical neuroscience due to their high accuracy, sensitivity and specificity and, above all, high ecological value. Being in a digital world affects the functioning of the body as a whole and its individual systems. The data obtained so far, both from experimental and modeling studies, as well as (clinical) observations, indicate their great and promising potential, but apart from the benefits, there are also losses and negative consequences for users.
  • 270
  • 01 Feb 2024
Topic Review
Symptom Burden in Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD), the sixth leading cause of death in the United States in 2022 and the third leading cause of death in England and Wales in 2022, is associated with high symptom burden, particularly dyspnoea. Frailty is a complex clinical syndrome associated with an increased vulnerability to adverse health outcomes.
  • 270
  • 27 Feb 2024
Topic Review
Psychometric Properties of Suboptimal Health Status Instruments
Suboptimal health status (SHS) measurement has now been recognized as an essential construct in predictive, preventive, and personalized medicine. Currently, there are limited tools, and an ongoing debate about appropriate tools.
  • 268
  • 27 Feb 2023
Topic Review
Children with Attention Deficit Hyperactivity Disorder
Children with attention deficit hyperactivity disorder are characterized by inattention, hyperactivity, impulsivity, difficulty in controlling behavior, or such comprehensive symptoms, while children with ASD have apparent deficits in social communication skills and repetitive stereotyped behavior patterns. Despite significant differences in the core symptoms between children with ADHD and ASD, clinical studies have supported the similarity of the behavioral disorders, and the findings suggest that the two types of children not only have highly shared heritability, but also represent the performance of the same endophenotype and can be classified into the same diagnostic entity.
  • 267
  • 03 Apr 2023
Topic Review
Objectivizing Measures of Post-Stroke Hand Rehabilitation through Multi-Disciplinary Scales
There is a wide variety of tools and measures for rehabilitation outcomes in post-stroke patients with impairments in the upper limb and hand, such as paralysis, paresis, flaccidity, and spasticity. However, there is a lack of general recommendations for selecting the most appropriate scales, tests, and instruments to objectively evaluate therapy outcomes. Reviews on upper limb and hand measurements reveal that clinicians’ choices of tools and methods are highly varied. Some clinicians and medical teams continue to employ non-standard and unverified metrics in their research and measurements.
  • 267
  • 09 Jan 2024
Topic Review
Green Dental Environmentalism
In every workplace, human sustainability is closely connected to the quality of establishments, the accessibility of green and blue spaces, and safety In dentistry, as in other fields, the physical setting is linked to an employee’s ability to physically engage with the workplace. A healthy dental workplace atmosphere positively influences individual employees’ behavior, enthusiasm, creativity, motivation, and efficiency, and, on the other hand, their desire to quit.
  • 266
  • 27 Jun 2023
Topic Review
Use of 3D Reconstruction in Laparoscopic Microwave Ablation
Laparoscopic ablation of hepatic tumors is a demanding procedure. In the preoperative period, 3D reconstruction of radiological imaging associated with virtual reality permits to evaluate of exactly the position of the lesions. During the operation, augmented reality and intraoperative ultrasound examination are useful tools to perform a safe ablation of the lesion. ICG fluorescence imaging can be used to identify new subglissonian nodules, to guide with more precision microwave antenna e to verify the effect of associated procedures as well as the intra-hepatic vascular occlusion.
  • 266
  • 13 Apr 2023
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