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Topic Review
Ras-Associated Protein 1 in Cancer
Metastasis is known as the most life-threatening event in cancer patients. In principle, the immune system can prevent tumor development. However, dysfunctional T cells may fail to eliminate the tumor cells effectively and provide additional survival advantages for tumor proliferation and metastasis. Constitutive activation of Ras-associated protein1 (Rap1) has not only led to T cell anergy, but also inhibited autophagy and supported cancer progression through various oncogenic events. Inhibition of Rap1 activity with its negative regulator, Rap1GAP, impairs tumor progression. However, active Rap1 reduces tumor invasion in some cancers, indicating that the pleiotropic effects of Rap1 signaling in cancers could be cancer-specific. All in all, targeting Rap1 signaling and its regulators could potentially control carcinogenesis, metastasis, chemoresistance and immune evasion. Rap1GAP could be a promising therapeutic target in combating cancer. 
  • 1.3K
  • 23 Sep 2020
Topic Review
L-Aspartate
L-aspartate (Asp) serves as a central building block, in addition to being a constituent of proteins, for many metabolic processes in most organisms, such as biosynthesis of other amino acids, nucleotides, nicotinamide adenine dinucleotide (NAD), the tricarboxylic acid (TCA) cycle and glycolysis pathway intermediates, and hormones, which are vital for growth and defense.
  • 1.3K
  • 16 Apr 2021
Topic Review
Postharvest Ultraviolet Radiation in Fruit and Vegetables
Ultraviolet (UV) radiation comprises the region of the electromagnetic spectrum (EM) between visible light and X-rays (100–400 nm). It was discovered in 1801 by Johann Wilhelm Ritter, who observed that radiation outside the violet end of the visible solar spectrum could decompose silver chloride. Seven decades later, it was discovered that UV light could prevent microbial growth.
  • 1.3K
  • 24 Apr 2022
Topic Review
Postbiotics
Postbiotics include any substance released by or produced through the metabolic activity of the microorganism, which exerts a beneficial effect on the host, directly or indirectly. As postbiotics do not contain live microorganisms, the risks associated with their intake are minimized. Postbiotics play a vital role in the maturation of the immune system, affect barrier tightness and the intestinal ecosystem, and indirectly shape the structure of the microbiota. Postbiotics display pleiotropic effects, including their immunomodulatory, anti-inflammatory, antioxidant, and anti-cancer properties. As such, postbiotics may be useful in treating or preventing many disease entities, including those for which effective causal therapy has not yet been found.
  • 1.3K
  • 05 Nov 2020
Topic Review
Perfume and Flavor Engineering
The Perfumery Ternary Diagram enables us to determine the dominant odor for each perfume composition.
  • 1.3K
  • 29 Jun 2021
Topic Review
Plant Secondary Metabolite in stress
Plant secondary metabolites (SMs) play important roles in plant survival and in creating ecological connections between other species. The accumulation of SMs are highly dependent on environmental factors such as light, temperature, soil water, soil fertility, and salinity. For most plants, a change in an individual environmental factor can alter the content of secondary metabolites even if other factors remain constant. In this review, we focus on how individual environmental factors affect the accumulation of secondary metabolites in plants during both biotic and abiotic stress conditions. Furthermore, we discuss the application of abiotic and biotic elicitors in culture systems as well as their stimulating effects on the accumulation of secondary metabolites. Genes responsible for secondary metabolite biosynthesis in various plant species during stress conditions are regulated by transcriptional factors such as WRKY, MYB, AP2/ERF, bZIP, bHLH, and NAC, which are also discussed here.
  • 1.3K
  • 28 May 2021
Topic Review
Selfish Brain Theory
The “Selfish Brain” theory describes the characteristic of the human brain to cover its own, comparably high energy requirements with the utmost of priorities when regulating energy fluxes in the organism. The brain behaves selfishly in this respect. The "Selfish brain" theory amongst other things provides a possible explanation for the origin of obesity, the severe and pathological form of overweight. The Luebeck obesity and diabetes specialist Achim Peters developed the fundamentals of this theory between 1998 and 2004. The interdisciplinary “Selfish Brain: brain glucose and metabolic syndrome” research group headed by Peters and supported by the German Research Foundation (DFG) at the University of Luebeck has in the meantime been able to reinforce the basics of the theory through experimental research.
  • 1.3K
  • 04 Nov 2022
Topic Review
Quadruplex Structures: Cancer Therapeutic Targets
Non-canonical, four-stranded nucleic acids secondary structures are present within regulatory regions in the human genome and transcriptome. To date, these quadruplex structures include both DNA and RNA G-quadruplexes, formed in guanine-rich sequences, and i-Motifs, found in cytosine-rich sequences, as their counterparts. Quadruplexes have been extensively associated with cancer, playing an important role in telomere maintenance and control of genetic expression of several oncogenes and tumor suppressors. Therefore, quadruplex structures are considered attractive molecular targets for cancer therapeutics with novel mechanisms of action.
  • 1.3K
  • 11 Dec 2020
Topic Review
Vitamin D Scarcity in Arctic and  Tropical Peoples
Vitamin D metabolism differs among human populations because the species has adapted to different natural and cultural environments. Two environments are particularly difficult for the production of vitamin D by the skin: the Arctic, where the skin receives little solar UVB over the year; and the Tropics, where the skin is highly melanized and blocks UVB. In both cases, natural selection has favored the survival of those individuals who use vitamin D more efficiently or have some kind of workaround that ensures sufficient uptake of calcium and other essential minerals from food passing through the intestines. Vitamin D scarcity has either cultural or genetic solutions. Cultural solutions include consumption of meat in a raw or boiled state and extended breastfeeding of children. Genetic solutions include higher uptake of calcium from the intestines, higher rate of conversion of vitamin D to its most active form, stronger binding of vitamin D to carrier proteins in the bloodstream, and greater use of alternative metabolic pathways for calcium uptake. Because their bodies use vitamin D more sparingly, indigenous Arctic and Tropical peoples can be misdiagnosed with vitamin D deficiency and wrongly prescribed dietary supplements that may push their vitamin D level over the threshold of toxicity.
  • 1.3K
  • 20 Oct 2022
Topic Review
Chemical Control Techniques for Vegetables
Diseases and pests are important factors in vegetable cultivation; they not only affect the growth and appearance of vegetables but also affect the yield and quality. The disease and pest control of vegetables is dominated by chemical sprays, for now. As a result, the excessive use of pesticides has been a crucial factor of pesticides’ non-point source pollution, and it is also the main cause of excessive pesticide residues in vegetables. 
  • 1.3K
  • 23 Feb 2022
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