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Topic Review
Bioelectricity in Living Organisms
Biomolecular recognition is approached within the establishment of coherent synchronizations among signaling players, whose physical nature can be equated to oscillators tending to the coherent synchronization of their vibrational modes. Cytoskeletal elements are now emerging as senders and receivers of physical signals, “shaping” biological identity from the cellular to the tissue/organ levels.
  • 1.1K
  • 06 Apr 2022
Topic Review
Fluorescence Microscopy to Aanalyze Lignin
Lignin is one of the most studied and analyzed materials due to its importance in cell structure and in lignocellulosic biomass. Because lignin exhibits autofluorescence, fluorescence microscopy methods have been developed that allow it to be analyzed and characterized directly in plant tissue and in samples of lignocellulose fibers. Compared to destructive and costly analytical techniques, fluorescence microscopy presents suitable alternatives for the analysis of lignin autofluorescence. The existing qualitative methods are Epifluorescence and Confocal Laser Scanning Microscopy; however, other semi-qualitative methods have been developed that allow fluorescence measurements and to quantify the differences in the structural composition of lignin. The methods are fluorescence lifetime spectroscopy, two-photon microscopy, Föster resonance energy transfer, fluorescence recovery after photobleaching, total internal reflection fluorescence, and stimulated emission depletion. With these methods, it is possible to analyze the transport and polymerization of lignin monomers, distribution of lignin of the syringyl or guaiacyl type in the tissues of various plant species, and changes in the degradation of wood by pulping and biopulping treatments as well as identify the purity of cellulose nanofibers through lignocellulosic biomass.
  • 1.1K
  • 21 Mar 2022
Topic Review
CIPA
Congenital insensitivity to pain with anhidrosis (CIPA) has two characteristic features: the inability to feel pain and temperature, and decreased or absent sweating (anhidrosis). This condition is also known as hereditary sensory and autonomic neuropathy type IV. The signs and symptoms of CIPA appear early, usually at birth or during infancy, but with careful medical attention, affected individuals can live into adulthood.
  • 1.1K
  • 04 Jan 2021
Topic Review
Mitochondrial VDAC1 as Therapeutic Target of Inflammation-Related Diseases
The multifunctional protein, voltage-dependent anion channel 1 (VDAC1), is located on the mitochondrial outer membrane. It is a pivotal protein that maintains mitochondrial function to power cellular bioactivities via energy generation. VDAC1 is involved in regulating energy production, mitochondrial oxidase stress, Ca2+ transportation, substance metabolism, apoptosis, mitochondrial autophagy (mitophagy), and many other functions. VDAC1 malfunction is associated with mitochondrial disorders that affect inflammatory responses, resulting in an up-regulation of the body’s defensive response to stress stimulation. Overresponses to inflammation may cause chronic diseases. Mitochondrial DNA (mtDNA) acts as a danger signal that can further trigger native immune system activities after its secretion. VDAC1 mediates the release of mtDNA into the cytoplasm to enhance cytokine levels by activating immune responses. VDAC1 regulates mitochondrial Ca2+ transportation, lipid metabolism and mitophagy, which are involved in inflammation-related disease pathogenesis. 
  • 1.1K
  • 26 Oct 2022
Topic Review
Glucose 6-P Dehydrogenase in Skeletal Muscle during Exercise
Hypomorphic Glucose 6-P dehydrogenase (G6PD) catalyzes the rate-limiting step in the pentose phosphate pathway (PPP), which provides the precursors of nucleotide synthesis for DNA replication as well as reduced nicotinamide adenine dinucleotide phosphate (NADPH). NADPH is involved in the detoxification of cellular reactive oxygen species (ROS) and de novo lipid synthesis. An association between increased PPP activity and the stimulation of cell growth has been reported in different tissues including the skeletal muscle, liver, and kidney. PPP activity is increased in skeletal muscle during embryogenesis, denervation, ischemia, mechanical overload, the injection of myonecrotic agents, and physical exercise. In fact, the highest relative increase in the activity of skeletal muscle enzymes after one bout of exhaustive exercise is that of G6PD, suggesting that the activation of the PPP occurs in skeletal muscle to provide substrates for muscle repair. The age-associated loss in muscle mass and strength leads to a decrease in G6PD activity and protein content in skeletal muscle. G6PD overexpression in Drosophila Melanogaster and mice protects against metabolic stress, oxidative damage, and age-associated functional decline, and results in an extended median lifespan. 
  • 1.1K
  • 02 Nov 2022
Biography
Sarah Teichmann
Sarah Amalia Teichmann (born 1975)[1] FMedSci[2] is Head of Cellular Genetics at the Wellcome Sanger Institute[3] and a visiting research group leader at the European Bioinformatics Institute (EMBL-EBI).[4][5] She is also a Director of Research (equivalent to Professor)[6] in the Cavendish Laboratory,[7] at the University of Cambridge and a Senior Research Fellow at Churchill College, Cambridge.
  • 1.1K
  • 24 Nov 2022
Topic Review
Whole Genome Amplification in Preimplantation Genetic Testing
Successful whole genome amplification (WGA) is a cornerstone of contemporary preimplantation genetic testing (PGT). Choosing the most suitable WGA technique for PGT can be particularly challenging.
  • 1.1K
  • 27 Jul 2022
Topic Review
Vascular Plant
Vascular plants (from la vasculum 'duct'), also called tracheophytes (/trəˈkiː.əˌfaɪts/) or collectively Tracheophyta (from grc τραχεῖα ἀρτηρία) 'windpipe', and φυτά , form a large group of land plants (c. 300,000 accepted known species) that have lignified tissues (the xylem) for conducting water and minerals throughout the plant. They also have a specialized non-lignified tissue (the phloem) to conduct products of photosynthesis. Vascular plants include the clubmosses, horsetails, ferns, gymnosperms (including conifers) and angiosperms (flowering plants). Scientific names for the group include Tracheophyta,:251 Tracheobionta and Equisetopsida sensu lato. Some early land plants (the rhyniophytes) had less developed vascular tissue; the term eutracheophyte has been used for all other vascular plants, including all living ones. Historically, vascular plants were known as "higher plants," as it was believed that they were further evolved than other plants due to being more complex organisms. However, this is an antiquated remnant of the obsolete scala naturae, and the term is generally considered to be unscientific.
  • 1.1K
  • 29 Sep 2022
Topic Review
Mechanisms of Phase Variation
Bacteria live in environments that are in constant flux, and therefore have developed numerous methods to adapt to their ever-changing surroundings. One of these methods of adaptation is called Phase Variation (PV) which is a mechanism of -high-frequency reversible gene expression switching that enables bacteria to generate heterogeneity to successfully compete in uncertain conditions. This entry details the mechanisms of PV and takes a look at them in the context of examples from different bacterial species, with a focus on S. aureus. 
  • 1.1K
  • 02 Mar 2021
Topic Review
Poultry Production in Developing Countries under COVID-19 Crisis
Poultry farming is a significant source of revenue generation for small farmers in developing countries. It plays a vital role in fulfilling the daily protein requirements of humans through meat and eggs consumption. The recently emerged pandemic Coronavirus Disease-19 (COVID-19) impacts the poultry production sector. Although the whole world is affected, these impacts may be more severe in developing countries due to their dependency on exporting necessary supplies such as feed, vaccines, drugs, and utensils. 
  • 1.1K
  • 18 Mar 2022
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