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Tang, P. CIPA. Encyclopedia. Available online: https://encyclopedia.pub/entry/6034 (accessed on 20 September 2026).
Tang P. CIPA. Encyclopedia. Available at: https://encyclopedia.pub/entry/6034. Accessed September 20, 2026.
Tang, Peter. "CIPA" Encyclopedia, https://encyclopedia.pub/entry/6034 (accessed September 20, 2026).
Tang, P. (2021, January 04). CIPA. In Encyclopedia. https://encyclopedia.pub/entry/6034
Tang, Peter. "CIPA." Encyclopedia. Web. 04 January, 2021.
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Congenital insensitivity to pain with anhidrosis (CIPA) has two characteristic features: the inability to feel pain and temperature, and decreased or absent sweating (anhidrosis). This condition is also known as hereditary sensory and autonomic neuropathy type IV. The signs and symptoms of CIPA appear early, usually at birth or during infancy, but with careful medical attention, affected individuals can live into adulthood.
genetic conditions
References
- Indo Y, Tsuruta M, Hayashida Y, Karim MA, Ohta K, Kawano T, Mitsubuchi H,Tonoki H, Awaya Y, Matsuda I. Mutations in the TRKA/NGF receptor gene in patientswith congenital insensitivity to pain with anhidrosis. Nat Genet. 1996Aug;13(4):485-8.
- Indo Y. Molecular basis of congenital insensitivity to pain with anhidrosis(CIPA): mutations and polymorphisms in TRKA (NTRK1) gene encoding the receptortyrosine kinase for nerve growth factor. Hum Mutat. 2001 Dec;18(6):462-71.Review.
- Kaplan DR, Miller FD. Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol. 2000 Jun;10(3):381-91. Review.
- Miranda C, Di Virgilio M, Selleri S, Zanotti G, Pagliardini S, Pierotti MA,Greco A. Novel pathogenic mechanisms of congenital insensitivity to pain withanhidrosis genetic disorder unveiled by functional analysis of neurotrophictyrosine receptor kinase type 1/nerve growth factor receptor mutations. J BiolChem. 2002 Feb 22;277(8):6455-62.
- Verhoeven K, Timmerman V, Mauko B, Pieber TR, De Jonghe P, Auer-Grumbach M.Recent advances in hereditary sensory and autonomic neuropathies. Curr OpinNeurol. 2006 Oct;19(5):474-80. Review.
- Verpoorten N, De Jonghe P, Timmerman V. Disease mechanisms in hereditarysensory and autonomic neuropathies. Neurobiol Dis. 2006 Feb;21(2):247-55.
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