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Topic Review
Rubi idaei fructus as a Source of Antioxidants
Given the increased incidence of lifestyle diseases, scientists are searching for natural bioactive compounds with a broad spectrum of activity but no side effects to be used in the production of pharmaceutical and cosmetic formulations. Rubi idaei fructus is a promising source of antioxidants that can serve as substitutes for synthetic agents in prophylaxis and adjuvant therapies.
  • 176
  • 26 Jan 2024
Topic Review
miRNA in the Pathogenesis of Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is the most common endocrine-metabolic disease in females of reproductive age, affecting 4–20% of pre-menopausal women worldwide. MicroRNAs (miRNAs) are endogenous, single-stranded, non-coding, regulatory ribonucleic acid molecules found in eukaryotic cells. Abnormal miRNA expression has been associated with several diseases and could possibly explain their underlying pathophysiology. MiRNAs have been extensively studied for their potential diagnostic, prognostic, and therapeutic uses in many diseases, such as type 2 diabetes, obesity, cardiovascular disease, PCOS, and endometriosis.
  • 178
  • 26 Jan 2024
Topic Review
Food Security and Intercropping Systems
Various environmental, food security and population health problems have been correlated with the use of intensive agriculture production systems around the world. This type of system leads to the loss of biodiversity and natural habitats, high usage rates of agrochemicals and natural resources, and affects soil composition, human health, and nutritional plant quality in rural areas. Agroecological intercropping systems that respect agrobiodiversity, on the other hand, can significantly benefit ecosystems, human health, and food security by modifying the nutritional profile and content of some health-promoting bioactive compounds in the species cultivated in this system.
  • 680
  • 26 Jan 2024
Topic Review
Enigmatic Role of GIGANTEA in Plant Biology
GIGANTEA (GI) is a conserved nuclear protein crucial for orchestrating the clock-associated feedback loop in the circadian system by integrating light input, modulating gating mechanisms, and regulating circadian clock resetting. It serves as a core component which transmits blue light signals for circadian rhythm resetting and overseeing floral initiation. Beyond circadian functions, GI influences various aspects of plant development (chlorophyll accumulation, hypocotyl elongation, stomatal opening, and anthocyanin metabolism). GI has also been implicated to play a pivotal role in response to stresses such as freezing, thermomorphogenic stresses, salinity, drought, and osmotic stresses. Positioned at the hub of complex genetic networks, GI interacts with hormonal signaling pathways like abscisic acid (ABA), gibberellin (GA), salicylic acid (SA), and brassinosteroids (BRs) at multiple regulatory levels. This intricate interplay enables GI to balance stress responses, promoting growth and flowering, and optimize plant productivity.
  • 105
  • 26 Jan 2024
Topic Review
Photodynamic Therapy: Principles and Reaction Mechanisms
Photodynamic therapy (PDT) is a two-stage treatment that implies the use of light energy, oxygen, and light-activated compounds (photosensitizers) to elicit cancerous and precancerous cell death after light activation (phototoxicity). The biophysical, bioengineering aspects and its combinations with other strategies are highlighted herein, both conceptually and as they are currently applied clinically. Advancements of PDT with the use of nanotechnology are further explored, including quantum dots as innovative photosensitizers or energy donors as well as the combination of PDT with radiotherapy and immunotherapy as future promising cancer treatments. Finally, the potential significance of organoids as physiologically relevant models for PDT has been emphasized.
  • 218
  • 26 Jan 2024
Topic Review
Organoids and iPSC-Based Models
Organoids are self-organized, three-dimensional structures derived from stem cells that can mimic the structure and physiology of human organs. Patient-specific induced pluripotent stem cells (iPSCs) and 3D organoid model systems allow cells to be analyzed in a controlled environment to simulate the characteristics of a given disease by modeling the underlying pathophysiology. 
  • 145
  • 26 Jan 2024
Topic Review
Enteric Glial Cells and Their Involvement in PD
The brain–gut axis has been identified as an important contributor to the physiopathology of Parkinson’s disease (PD).  In this pathology, inflammation is thought to be driven by the damage caused by aggregation of α-synuclein in the brain. Activation and reactive gliosis are associated to the neurodegeneration produced by Parkinson’s disease in the enteric nervous system.
  • 94
  • 26 Jan 2024
Topic Review
Tissue Nanotransfection Chips for In Vivo Tissue Reprogramming
Tissue nanotransfection (TNT), a cutting-edge technique of in vivo gene therapy, has gained substantial attention in various applications ranging from in vivo tissue reprogramming in regenerative medicine, and wound healing to cancer treatment. This technique harnesses the advancements in the semiconductor processes, facilitating the integration of conventional transdermal gene delivery methods—nanoelectroporation and microneedle technologies. TNT silicon chips have demonstrated considerable promise in reprogramming fibroblast cells of skin in vivo into vascular or neural cells in preclinical studies to assist in the recovery of injured limbs and damaged brain tissue.
  • 152
  • 25 Jan 2024
Topic Review
Cancer Cells and Induced Pluripotent Stem Cells
Cancer cells, especially cancer stem cells (CSCs), share many molecular features with induced pluripotent stem cells (iPSCs) that enable the derivation of induced pluripotent cancer cells by reprogramming malignant cells. Conversely, normal iPSCs can be converted into cancer stem-like cells with the help of tumor microenvironment components and genetic manipulation. These CSC models can be utilized in oncogenic initiation and progression studies, understanding drug resistance, and developing novel therapeutic strategies.
  • 93
  • 25 Jan 2024
Topic Review
Neurobiology of Pathogen Avoidance and Mate Choice
The risk of parasitic infection has a major influence on animal behaviour. Organisms must adjust their behaviour to avoid various modes of parasitic infection and pathogen acquisition. Social species are at an increased risk of parasitic transmission as they spend more time in the proximity of others that may carry parasites. The detection of parasitic risk is also critical in mate assessment and choice. Perceptual systems and behavioural responses have evolved to detect individuals who are parasitized and pose the risk of parasitic transmission. This includes the integration of inputs from various sensory modalities (e.g., olfaction), brain regions and networks, and neuromodulatory systems. Understanding the neurobiological systems involved in detecting the parasite infection risk and the expression of disgust will allow us to better understand the evolution and regulation of pathogen avoidance and mate choice.
  • 125
  • 25 Jan 2024
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