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Topic Review
Protein Caging Tools for Protein Photoactivation
In biosciences and biotechnologies, it is recently critical to promote research regarding the regulation of the dynamic functions of proteins of interest. Light-induced control of protein activity is a strong tool for a wide variety of applications because light can be spatiotemporally irradiated in high resolutions. Therefore, synthetic, semi-synthetic, and genetic engineering techniques for photoactivation of proteins have been actively developed. As a solution for overcoming barriers in conventional ones, researchers' recent approaches in which proteins were chemically modified with biotinylated caging reagents are introduced to photo-activate a variety of proteins without genetic engineering and elaborate optimization.
  • 1.4K
  • 21 Apr 2022
Topic Review
Individualized Risk Assessment in Cardiovascular Disease
Cardiovascular disease is a major global cause of death, with an estimated 17.9 million cardiovascular disease-related deaths in 2019, representing nearly one third of global deaths. Atherosclerosis, which can begin in childhood, is a multifactorial, chronic condition that contributes to cardiovascular disease. Characterized by lipid deposition in the blood vessel intima, atherosclerosis is associated with inflammation and calcification and can cause vessel stenosis with thrombotic occlusion and/or embolism. A more precise and sophisticated tool that can reliably predict the thrombosis and bleeding risks at an individual level is required in order for clinicians to confidently recommend early interventions with a favorable risk–benefit profile. Critical to the development of this tool is the assessment and understanding of Virchow’s triad and its complex interactions between hypercoagulability, endothelial dysfunction and vessel flow, a fundamental concept to the development of thrombosis. 
  • 1.4K
  • 19 Jul 2022
Topic Review
New Trends in Aquaculture Feed Production
Fish plays a crucial role in global human nutrition as a source of essential nutrients. Marine-derived ingredients (fishmeal and fish oil) are of critical importance in fish feed production. Fishmeal primarily provides protein for fish growth but is also a valuable source of micro-nutrients such as vitamins, minerals, and lipids. In addition, fishmeal contributes to improved feed digestibility and palatability, particularly in weaning diets for many species. 
  • 1.4K
  • 05 Sep 2022
Topic Review
RETRIEVE
RETRIEVE is a database management system (DBMS) offered on Tymshare's systems starting in August 1971. It was written in Tymshare's own SUPER FORTRAN on the SDS 940. It offered basic single-file, non-relational database functionality using an interactive programming language. It is one of the earliest examples of software as a service (SaaS). RETRIEVE was highly influential and spawned a number of relatively direct clones. Wang Laboratories's RECALL on the Wang 2200 minicomputer was almost identical to RETRIEVE, to the point the differences were detailed in a single page. JPL made a version known as JPLDIS for the UNIVAC 1108 in 1973 that was also very similar. Wayne Ratliff, a contractor at JPL for many years, was inspired by JPLDIS to port it to the IMSAI 8080 to manage his football pool, later releasing it commercially as Vulcan for CP/M in 1979. Ashton-Tate licensed Vulcan and re-released it as dBASE II in 1980, which sparked the microcomputer database market. Most of RETRIEVE's original syntax remains unchanged in dBASE and the many xBASE clones that survive into the 21st century.
  • 1.4K
  • 10 Oct 2022
Topic Review
Progesterone on Plant Growth and Development
Progesterone is a steroid hormone that is synthesized in the ovaries, placenta, and adrenal glands. The regulation of progesterone on plant growth is concentration-dependent. For example, low progesterone concentrations (0.01–1 μM) stimulate hypocotyl elongation, while high concentrations (100 μM) inhibit hypocotyl growth in Arabidopsis.
  • 1.4K
  • 14 Oct 2022
Topic Review
2015 Cash for Vote Scam
The 2015 cash-for-votes scam was a political scandal, the second scandal of its kind since the 2008 cash-for-votes scandal. The 2015 political scandal started off when the Telugu Desam Party Leaders of Telangana state were caught in a video footage, aired in the media, offering bribes to a nominated MLA for his vote in the 2015 elections of the Telangana Legislative Council. The Telugu Desam MLA Revanth Reddy was arrested by the Telangana Police when he was offering Rs. 50 lakhs to the nominated MLA Elvis Stephenson. Reddy was then presented before the court of justice and sent to jail. Similarly, the phone conversation, which was quoted as the voice of N. Chandrababu Naidu, the Andhra Pradesh Chief Minister, with the same nominated MLA was aired in the news media. The Telugu Desam party alleged that the scandal, was a political vendetta, doctored by the Telangana State Government under the direction of K. Chandrashekhar Rao, the Chief Minister of Telangana, alongside the YSR Congress Party. In a further development, The High Court of Judicature at Hyderabad for the States of Andhra Pradesh, and Telangana, granted bail to Revanth Reddy and two other co-accused due to lack of substantial evidence.
  • 1.4K
  • 18 Oct 2022
Topic Review
Nutrition in Chronic Pain Management
A poor nutritional status such as malnutrition, unhealthy dietary behaviors, and a suboptimal dietary intake can play a significant role in the occurrence, development, and prognosis of chronic pain. The relationship between nutrition and chronic pain is complex and may involve many underlying mechanisms such as oxidative stress, inflammation, and glucose metabolism. As such, pain management requires a comprehensive and interdisciplinary approach that includes nutrition. Nutrition is the top modifiable lifestyle factor for chronic non-communicable diseases including chronic pain.
  • 1.4K
  • 26 Oct 2022
Topic Review
Role of Iron Deficiency in Heart Failure
The association of chronic heart failure (CHF) and iron deficiency (ID) with or without anemia is frequently encountered in current medical practice and has a negative prognostic impact, worsening patients’ exercise capacity and increasing hospitalization costs. Moreover, anemia is common in patients with chronic kidney disease (CKD) and CHF, an association known as cardio-renal anemia syndrome (CRAS) possessing a significantly increased risk of death.
  • 1.4K
  • 17 Feb 2023
Topic Review
Campus Energy Management
Energy is very important in daily life. The smart power system provides an energy management system using various techniques. Among other load types, campus microgrids are very important, and they consume large amounts of energy. Energy management systems in campus prosumer microgrids have been addressed in different works.
  • 1.4K
  • 27 Feb 2023
Topic Review Peer Reviewed
Tokenization in the Theory of Knowledge
Tokenization is a procedure for recovering the elements of interest in a sequence of data. This term is commonly used to describe an initial step in the processing of programming languages, and also for the preparation of input data in the case of artificial neural networks; however, it is a generalizable concept that applies to reducing a complex form to its basic elements, whether in the context of computer science or in natural processes. In this entry, the general concept of a token and its attributes are defined, along with its role in different contexts, such as deep learning methods. Included here are suggestions for further theoretical and empirical analysis of tokenization, particularly regarding its use in deep learning, as it is a rate-limiting step and a possible bottleneck when the results do not meet expectations.
  • 1.4K
  • 11 Apr 2023
Topic Review Video Peer Reviewed
Depression in Elderly People
Depression is not a sign of weakness, nor a lack of will or laziness. It is not a simple “being sad” or bored, but rather a pathology that needs intervention, treatment, and monitoring by professionals with expertise in mental health. It is a disorder that impacts the lives of people who do not receive timely help affecting not only the individual himself in his feelings, thoughts, and behaviors but also harming his relationships and daily life and is prevalent among elderly people. Depression manifests through multiple symptoms, is caused by numerous factors, and is preventable with specific practices. It is described as the “most frequent mental health problem worldwide,” has a higher prevalence in women, is different from mourning and sadness, and needs to be addressed to avoid extreme situations, such as suicide.
  • 1.4K
  • 31 May 2023
Topic Review
Melatonin in the Epithelial-to-Mesenchymal Transition in Cancer
The epithelial-to-mesenchymal transition (EMT) is a process taking place during carcinogenesis. The phenotypic changes include the acquisition of new properties such as increased motility and polarity, leading to invasiveness and the formation of metastasis and chemo- and radioresistance. During the process, epithelial markers are lost whilst mesenchymal markers are overexpressed. EMT-related transcription factors are induced and multiple signaling pathways are activated. Several microRNAs are altered during the transition. Many of these molecules are regulated by melatonin, the pineal hormone, thus behaving as an inhibitor of the EMT in cancer progression. 
  • 1.4K
  • 12 Mar 2024
Topic Review
ERK/MAPK Pathway in Gastric Cancer
Gastric Cancer (GC) is turning out today to be one of the most important welfare issues for both Asian and European countries. Indeed, while the vast majority of the disease burden is located in China and in Pacific and East Asia, GC in European countries still account for about 100.000 deaths per year. With this review article, we aimed to focus the attention on one of the most complex cellular pathways involved in GC proliferation, invasion, migration and metastasis: the MAP Kinases. Such large kinases family is to date constantly studied, since their discovery more than 30 years ago, due to the important role that it plays in the regulation of physiological and pathological processes. Interactions with other cellular proteins as well as miRNAs and lncRNAs may modulate their expression influencing the cellular biological features. Here, we summarize the most important and recent studies involving MAPK in GC. At the same time, we need to underlie that, differently from cancers arising from other tissues, where MAPK pathways seems to be a gold target for anticancer therapies, GC seems to be unique in any aspect. Our aim is to review the current knowledge in MAPK pathways alterations leading to GC, including H. pylori MAPK-triggering to derail from gastric normal epithelium to GC and to encourage researches involved in MAPK signal transduction, that seems to definitely sustain GC development.
  • 1.4K
  • 28 Oct 2020
Topic Review
Cardiac Development
Cardiac development is a complex developmental process that is initiated soon after gastrulation, as two sets of precardiac mesodermal precursors are symmetrically located and subsequently fused at the embryonic midline forming the cardiac straight tube. Thereafter, the cardiac straight tube invariably bends to the right, configuring the first sign of morphological left–right asymmetry and soon thereafter the atrial and ventricular chambers are formed, expanded and progressively septated. As a consequence of all these morphogenetic processes, the fetal heart acquired a four-chambered structure having distinct inlet and outlet connections and a specialized conduction system capable of directing the electrical impulse within the fully formed heart.
  • 1.4K
  • 26 Feb 2021
Topic Review
Hematological Analysis in Fish Toxicology
Hematological analysis is commonly used to assess the physiological state of fish. It includes red blood cell parameters, white blood cell parameters, and the number of thrombocytes per blood volume unit. Hematological analysis is one of the basic tools (often accompanied by biochemical and histopathological analyses) to assess the influence of organic and inorganic substances on fish. It is, therefore, applicable in both ecotoxicology and pharmacotoxicology. 
  • 1.4K
  • 30 Aug 2023
Topic Review
Morphological and Dynamic Changes in Mitochondria
Mitochondria are highly dynamic organelles with the ability to continuously cleavage and fuse, regulating dynamic homeostatic processes in response to the needs of organism growth and the changes in external environmental conditions.
  • 1.4K
  • 06 Jan 2023
Topic Review
Fluoro-Modified Surface
The original fluoro-modified polyurethane encapsulated process was designed to rapidly fabricate low flow-resistance surfaces on the zinc substrate. For the further enhancement of the drag-reduction effect, chemical etching was introduced during the fabrication process, and its surface morphology, wettability, and flow-resistance properties in a microchannel were also studied in this paper. It is indicated that the zinc substrate with micro-nano scale roughness obtained by Cu2+ assisted nitric acid etching was super hydrophilic. However, after the etched zinc substrate encapsulated with fluoro-polyurethane, the superhydrophobic wettability can be obtained. As this newly fabricated surface being applied into the microchannel, it was found that with the increase of Reynolds number, the drag reduction rate of the superhydrophobic surface remained basically unchanged at 4.0 % compared with the original zinc substrate. Furthermore, the prepared superhydrophobic surfaces exhibited outstanding reliability in most liquids, and such chemical-etching methodology were capable to be commercialized in the piping as well as the coating industry.
  • 1.4K
  • 30 Oct 2020
Topic Review
Sperm Cryopreservation Protocol
The storage of frozen sperm samples from birds in Germoplasm Banks could be a way out for the conservation of thousands of threatened species. The cryopreserved samples could be later used in reintroduction projects. This technology also allows for the selection of individuals of genetic interest and the exchange of samples between distant locations. Although the sperm cryopreservation is greatly developed in domestic species, in birds it is still in its infancy. The objective of this study was optimize the cryopreservation protocol in a bird of prey, peregrine falcon (Falco peregrinus) which could be used as a model for other threats. Thus, the freezing/thawing protocol and the type and concentration of cryoprotectant were evaluated.
  • 1.4K
  • 30 Oct 2020
Topic Review
Water Footprint of Food Production
Blue water footprint - the volume of fresh surface and groundwater that has been evaporated or incorporated into a product. Green water footprint - the rainwater that is stored in the root zone of the soil and evapotranspired or incorporated into the product. Unsustainable blue water footprint - when it exceeds the available renewable blue water, thereby violating the environmental flow standard and depleting groundwater Water footprint - an indicator of the direct and indirect water use to produce the goods and services we use.
  • 1.4K
  • 26 Oct 2020
Topic Review
HNPP
Hereditary neuropathy with liability to pressure palsies is a disorder that affects peripheral nerves. These nerves connect the brain and spinal cord to muscles and sensory cells that detect touch, pain, and temperature. In people with this disorder, the peripheral nerves are unusually sensitive to pressure, such as the pressure that occurs when carrying heavy grocery bags, leaning on an elbow, or sitting without changing position, particularly with crossed legs. These activities would not normally cause sensation problems in people without the disorder.
  • 1.4K
  • 04 Jan 2021
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