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HNPP

This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/hereditary-neuropathy-with-liability-to-pressure-palsies

Hereditary neuropathy with liability to pressure palsies is a disorder that affects peripheral nerves. These nerves connect the brain and spinal cord to muscles and sensory cells that detect touch, pain, and temperature. In people with this disorder, the peripheral nerves are unusually sensitive to pressure, such as the pressure that occurs when carrying heavy grocery bags, leaning on an elbow, or sitting without changing position, particularly with crossed legs. These activities would not normally cause sensation problems in people without the disorder.

genetic conditions

1. Introduction

Hereditary neuropathy with liability to pressure palsies is characterized by recurrent episodes of numbness, tingling, and loss of muscle function (palsy) in the region associated with the affected nerve, usually an arm, hand, leg, or foot. An episode can last from several minutes to several months, but recovery is usually complete. Repeated incidents, however, can cause permanent muscle weakness or loss of sensation. This disorder is also associated with pain in the limbs, especially the hands.

A pressure palsy episode results from pressure on a single nerve, and any peripheral nerve can be affected. Although episodes often recur, they can affect different nerves. The most common problem sites involve nerves in the wrists, elbows, and knees. The fingers, shoulders, hands, feet, and scalp can also be affected. Many people with this disorder experience carpal tunnel syndrome, which occurs when a nerve in the wrist (the median nerve) is involved. Carpal tunnel syndrome is characterized by numbness, tingling, and weakness in the hand and fingers. An episode in the hand may affect fine motor activities such as writing, opening jars, and fastening buttons. An episode of nerve compression in the knee can lead to a condition called foot drop, which makes walking, climbing stairs, or driving difficult or impossible.

The symptoms of hereditary neuropathy with liability to pressure palsies usually begin during adolescence or early adulthood but may develop anytime from childhood to late adulthood. Symptoms vary in severity; many people never realize they have the disorder, while some people experience prolonged disability. Hereditary neuropathy with liability to pressure palsies does not affect life expectancy.

2. Frequency

Hereditary neuropathy with liability to pressure palsies is estimated to occur in 2 to 5 per 100,000 individuals.

3. Causes

Hereditary neuropathy with liability to pressure palsies is most commonly caused by the deletion of one copy of the PMP22 gene. This loss reduces the amount of PMP22 protein produced. Other PMP22 gene mutations that lead to a reduction of PMP22 protein can also cause the condition.

The PMP22 protein is a component of myelin, a protective substance that covers nerves and promotes the efficient transmission of nerve impulses. Studies suggest that the PMP22 protein is particularly important in protecting nerves from physical pressure, helping them restore their structure after compression. Compression can interrupt nerve signaling, leading to the sensation commonly referred to as a limb "falling asleep." The ability of nerves to recover from normal, day-to-day pressure, for example when sitting for long periods, keeps the limbs from constantly losing sensation.

The consequences of PMP22 gene mutations are not clearly understood. A shortage of PMP22 protein appears to make nerves less able to recover from compression, which impairs the transmission of nerve impulses, causing the signs and symptoms of hereditary neuropathy with liability to pressure palsies.

4. Inheritance

This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder.

5. Other Names for This Condition

compression neuropathy
entrapment neuropathy
familial pressure sensitive neuropathy
hereditary motor and sensory neuropathy
hereditary pressure sensitive neuropathy
inherited tendency to pressure palsies
tomaculous neuropathy
Hereditary neuropathy with liability to pressure palsies

References

Bai Y, Zhang X, Katona I, Saporta MA, Shy ME, O'Malley HA, Isom LL, Suter U,Li J. Conduction block in PMP22 deficiency. J Neurosci. 2010 Jan 13;30(2):600-8. doi: 10.1523/JNEUROSCI.4264-09.2010.
Chance PF. Genetic evaluation of inherited motor/sensory neuropathy. SupplClin Neurophysiol. 2004;57:228-42. Review.
Chance PF. Inherited focal, episodic neuropathies: hereditary neuropathy with liability to pressure palsies and hereditary neuralgic amyotrophy. NeuromolecularMed. 2006;8(1-2):159-74. Review.
Chrestian N. Hereditary Neuropathy with Liability to Pressure Palsies. 1998Sep 28 [updated 2020 Aug 27]. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE,Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2020. Available fromhttp://www.ncbi.nlm.nih.gov/books/NBK1392/
Guo J, Wang L, Zhang Y, Wu J, Arpag S, Hu B, Imhof BA, Tian X, Carter BD,Suter U, Li J. Abnormal junctions and permeability of myelin in PMP22-deficientnerves. Ann Neurol. 2014 Feb;75(2):255-65. doi: 10.1002/ana.24086.
Li J, Krajewski K, Lewis RA, Shy ME. Loss-of-function phenotype of hereditary neuropathy with liability to pressure palsies. Muscle Nerve. 2004Feb;29(2):205-10.
Potulska-Chromik A, Sinkiewicz-Darol E, Ryniewicz B, Lipowska M, Kabzińska D, Kochański A, Kostera-Pruszczyk A. Clinical, electrophysiological, and molecularfindings in early onset hereditary neuropathy with liability to pressure palsy.Muscle Nerve. 2014 Dec;50(6):914-8. doi: 10.1002/mus.24250.
Rosso G, Liashkovich I, Gess B, Young P, Kun A, Shahin V. Unravelling crucial biomechanical resilience of myelinated peripheral nerve fibres provided by theSchwann cell basal lamina and PMP22. Sci Rep. 2014 Dec 2;4:7286. doi:10.1038/srep07286.
van de Wetering RA, Gabreëls-Festen AA, Timmerman V, Padberg GM, Gabreëls FJ, Mariman EC. Hereditary neuropathy with liability to pressure palsies with a smalldeletion interrupting the PMP22 gene. Neuromuscul Disord. 2002 Oct;12(7-8):651-5.
Yilmaz U, Bird TT, Carter GT, Wang LH, Weiss MD. Pain in hereditary neuropathywith liability to pressure palsy: an association with fibromyalgia syndrome?Muscle Nerve. 2015 Mar;51(3):385-90. doi: 10.1002/mus.24331.

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Subjects: Genetics & Heredity

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Peter Tang

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Entry Collection: MedlinePlus

Update Date: 04 Jan 2021

Table of Contents

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1. Introduction

2. Frequency

3. Causes

4. Inheritance

5. Other Names for This Condition

References

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1. Introduction

2. Frequency

3. Causes

3.1. The gene associated with Hereditary neuropathy with liability to pressure palsies

4. Inheritance

5. Other Names for This Condition

References