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Topic Review
Donor-Derived Cell-Free DNA in Kidney Transplantation
Donor derived cell-free DNA has been identified as a measurable lab test that may be able to adequately diagnose rejection at early stages, precluding the need for invasive procedures like biopsy.
  • 1.4K
  • 27 Oct 2022
Topic Review
Google Friend Connect
Google Friend Connect was a free social networking site from 2008 to 2012. Similar in practice to Facebook Platform and MySpaceID, it took a decentralised approach, allowing users to build a profile to share and update information (through messaging, photographs and video content) via third-party sites. These sites acted as a host for profile sharing and social exchanges. Google Friend Connect used open standards such as OpenID, oAuth and OpenSocial and with the intent of freeing users from having to register for additional accounts or usernames. Once authenticated they could use their existing profile and access a social graph when posting messages. It has been said that "social network APIs (how different services on the web talk to each other) such as the[MySpace API, Facebook Connect and Google Friend Connect take the online social graph beyond social networking sites to external web sites and applications". This social graph feature allowed a user to post a message on a third-party site, but allowed viewing access only to other authorised "friends" contained within the user's chosen social graph. Friend Connect was removed for all non-Blogger sites by March 1, 2012, and for Blogger sites on January 11, 2016.
  • 1.4K
  • 24 Nov 2022
Topic Review
ACT-R
ACT-R (pronounced /ˌækt ˈɑr/; short for "Adaptive Control of Thought—Rational") is a cognitive architecture mainly developed by John Robert Anderson and Christian Lebiere at Carnegie Mellon University. Like any cognitive architecture, ACT-R aims to define the basic and irreducible cognitive and perceptual operations that enable the human mind. In theory, each task that humans can perform should consist of a series of these discrete operations. Most of the ACT-R's basic assumptions are also inspired by the progress of cognitive neuroscience, and ACT-R can be seen and described as a way of specifying how the brain itself is organized in a way that enables individual processing modules to produce cognition.
  • 1.4K
  • 05 Dec 2022
Topic Review
Peptide Drug Conjugates in Cancer Therapy
Drug conjugates have become a significant focus of research in the field of targeted medicine for cancer treatments. Peptide-drug conjugates (PDCs), a subset of drug conjugates, are composed of carrier peptides ranging from 5 to 30 amino acid residues, toxic payloads, and linkers that connect the payload to the peptide. PDCs are further broken down into cell-penetrating peptides (CPPs) and cell-targeting peptides (CTPs), each having their own differences in the delivery of cytotoxic payloads. Generally, PDCs as compared to other drug conjugates—like antibody-drug conjugates (ADCs)—have advantages in tumor penetration, ease of synthesis and cost, and reduced off-target effects. Further, as compared to traditional cancer treatments (e.g., chemotherapy and radiation), PDCs have higher specificity for the target cancer with generally less toxic side effects in smaller doses. 
  • 1.4K
  • 19 Jan 2023
Topic Review
Molecular Mechanisms in Autoimmune Thyroid Disease
The most common cause of acquired thyroid dysfunction is autoimmune thyroid disease, which is an organ-specific autoimmune disease with two presentation phenotypes: hyperthyroidism (Graves-Basedow disease) and hypothyroidism (Hashimoto’s thyroiditis). Hashimoto’s thyroiditis is distinguished by the presence of autoantibodies against thyroid peroxidase and thyroglobulin. Meanwhile, autoantibodies against the thyroid-stimulating hormone (TSH) receptor have been found in Graves-Basedow disease. Numerous susceptibility genes, as well as epigenetic and environmental factors, contribute to the pathogenesis of both diseases. 
  • 1.4K
  • 24 Mar 2023
Topic Review
Polyploid Giant Cancer Cells and Tumor Survival
Precision and organization govern the cell cycle, ensuring normal proliferation. However, some cells may undergo abnormal cell divisions (neosis) or variations of mitotic cycles (endopolyploidy). Consequently, the formation of polyploid giant cancer cells (PGCCs), critical for tumor survival, resistance, and immortalization, can occur. Newly formed cells end up accessing numerous multicellular and unicellular programs that enable metastasis, drug resistance, tumor recurrence, and self-renewal or diverse clone formation. An integrative literature review was carried out, searching articles in several sites, including: PUBMED, NCBI-PMC, and Google Academic, published in English, indexed in referenced databases and without a publication time filter, but prioritizing articles from the last 3 years, to answer the following questions: (i) “What is the current knowledge about polyploidy in tumors?”; (ii) “What are the applications of computational studies for the understanding of cancer polyploidy?”; and (iii) “How do PGCCs contribute to tumorigenesis?”
  • 1.4K
  • 18 Apr 2023
Topic Review
Use of Plant Extracts as Sustainable Corrosion Inhibitors
Corrosion inhibitors have traditionally been utilised to protect copper alloy sculptures from corrosion despite the recognised environmental and human health risks. Knowing the associated toxicity, ongoing extensive research seeks alternative substances for corrosion reduction, giving rise to the emergence of green inhibitors. In this pursuit, plant extract inhibitors have gained attention, particularly in the heritage field. 
  • 1.4K
  • 28 Feb 2024
Topic Review
Cancer-Associated Gangliosides as Tumor Markers
Aberrant expression of glycosphingolipids is a hallmark of cancer cells and is associated with their malignant properties. Disialylated gangliosides GD2 and GD3 are considered as markers of tumors from neuroectoderm origin, whereas fucosyl-GM1 is expressed in very few normal tissues but overexpressed in a variety of cancers, especially in small cell lung carcinoma. These gangliosides are absent in most normal adult tissues, making them targets of interest in immuno-oncology. Passive and active immunotherapy strategies have been developed and have shown promising results in clinical trials.
  • 1.4K
  • 22 Jun 2021
Topic Review
Selenium Nanoparticles in the Plant Production
Selenium (Se) is a common trace metalloid found in the Earth’s crust. In 1817, chemist Jacob Berzelius isolated it for the first time, and since then, it has been known for its properties. Recent research has shown that treatment with Se at low concentrations has a beneficial influence on plant development and yield. Se may work as an essential factor by interfering with a several of physiological processes. It is a remarkable antioxidant and pro-oxidant agent of plants that helps to cope with a variety of abiotic stresses, such as salinity, drought, intense temperature fluctuations, toxic metals/metalloids, and other environmental pollutants and toxins.
  • 1.4K
  • 17 Nov 2021
Topic Review
The Dual Nature of Amaranth
The beneficial health-promoting properties of plants have been known to mankind for generations. Preparations from them are used to create recipes for dietary supplements, functional food, and medicinal products. Recently, amaranth has become an area of increasing scientific and industrial interest. This is due to its valuable biological properties, rich phytochemical composition, and wide pharmacological activity. Amaranth is a pseudo-cereal crop with a dual character, combining the features of food and health-promoting product. 
  • 1.4K
  • 24 Mar 2022
Topic Review
Pathophysiolocigal and Molecular Mechanisms in Vascular Aging
Vascular aging, characterized by structural and functional alterations of the vascular wall, is a hallmark of aging and is tightly related to the development of cardiovascular mortality and age-associated vascular pathologies. 
  • 1.4K
  • 29 Aug 2022
Topic Review
Event
In philosophy, events are objects in time or instantiations of properties in objects. On some views, only changes in the form of acquiring or losing a property can constitute events, like the lawn's becoming dry. According to others, there are also events that involve nothing but the retaining of a property, e.g. the lawn's staying wet. Events are usually defined as particulars that, unlike universals, cannot repeat at different times. Processes are complex events constituted by a sequence of events. But even simple events can be conceived as complex entities involving an object, a time and the property exemplified by the object at this time. Traditionally, metaphysicians tended to emphasize static being over dynamic events. This tendency has been opposed by so-called process philosophy or process ontology, which ascribes ontological primacy to events and processes.
  • 1.4K
  • 24 Oct 2022
Topic Review
Metal–Support Interaction Effect
Metal–support interaction (MSI) is considered a key effect of electronic and geometric structures of catalysts on tuning catalytic performance. The oxygen evolution reaction (OER) is a crucial process during energy conversion and storage. MSI describes the influence of the interaction of metals and their compounds on carriers on the catalytic reaction process, especially OER mechanism.
  • 1.4K
  • 16 Mar 2023
Topic Review
Effects of Cinnamon in Dentistry
Dental medicine is one of the fields of medicine where the most common pathologies are of bacterial and fungal origins. This review is mainly focused on the antimicrobial effects of cinnamon essential oil (EO), cinnamon extracts, and pure compounds against different oral pathogens and the oral biofilm and the possible effects on soft mouth tissue. Basic information is provided about cinnamon, as is a review of its antimicrobial properties against the most common microorganisms causing dental caries, endodontic and periodontal lesions, and candidiasis. Cinnamon EO, cinnamon extracts, and pure compounds show significant antimicrobial activities against oral pathogens and could be beneficial in caries and periodontal disease prevention, endodontics, and candidiasis treatment
  • 1.4K
  • 20 Oct 2020
Topic Review
Antioxidant Nutraceuticals against Neurodegenerative Disease
This entry discusses on selected nutraceuticals and their plausible antioxidant effects on Alzheimer and Parkinson disease. Nutraceuticals such as resveratrol, curcumin and vitamin E alleviate oxidative stress by scavenging free radicals, metal chelators, and enhance antioxidant enzymes. Additionally they regulate intracellular signaling such as inflammatory, survival and apoptotic pathways. 
  • 1.4K
  • 28 Sep 2021
Topic Review
Hovenia dulcis Thumberg
Hovenia dulcis Thunberg is an herbal plant, belonging to the Rhamnaceae family, widespread in west Asia, USA, Australia and New Zealand, but still almost unknown in Western countries. H. dulcis has been described to possess several pharmacological properties, such as antidiabetic, anticancer, antioxidant, anti-inflammatory and hepatoprotective, especially in the hangover treatment, validating its use as an herbal remedy in the Chinese Traditional Medicine. These biological properties are related to a variety of secondary metabolites synthesized by the different plant parts. Root, bark and leaves are rich of dammarane-type triterpene saponins; dihydrokaempferol, quercetin, 3,3′,5′,5,7-pentahydroflavone and dihydromyricetin are flavonoids isolated from the seeds; fruits contain mainly dihydroflavonols, such as dihydromyricetin (or ampelopsin) and hovenodulinol, and flavonols such as myricetin and gallocatechin; alkaloids were found in root, barks (frangulanin) and seeds (perlolyrin), and organic acids (vanillic and ferulic) in hot water extract from seeds. Finally, peduncles have plenty of polysaccharides which justify the use as a food supplement.
  • 1.4K
  • 02 Mar 2021
Topic Review
Novel Selective RET Inhibitors
RET-selective tyrosine kinase inhibitors (TKIs) pralsetinib and selpercatinib, are effective against the RET V804L/M gatekeeper mutants. However, adaptive mutations that cause resistance at the solvent front RET G810 residue have been found, pointing to the need for the development of the next-generation of RET-specific TKIs. 
  • 1.4K
  • 29 Apr 2021
Topic Review
Polyphenols and Ischemic Stroke
Stroke is now the second leading cause of death worldwide, and is defined as an impairment in blood supply to the brain, and is linked to different cardiovascular dysfunctions. Two main types of stroke exist: ischemic stroke (due to clot-mediated blood vessel occlusion), which accounts for about 85% of all stroke cases, and hemorrhagic stroke (caused by blood vessel rupture), which accounts for 15% of total cases. Following the stroke, while the core region undergoes sudden death, the surrounding injured regions (called penumbra) may be able to recover their functions.
  • 1.4K
  • 23 Jun 2021
Topic Review
Direct Ultrafast Laser Processing
Direct ultrafast laser processing is nowadays considered the most flexible technique allowing to generate complex 3D optical functions in bulk glasses. The fact that the built-in optical element is embedded in the material brings several advantages in terms of prototype stability and lifetime, but equally in terms of complexity and number of possible applications, due to the 3D design. The generated optical functions, and in particular the single mode character of the light guiding element alongside the accessibility toward different spectral windows, depend on the refractive index contrast that can be achieved within the material transparency window and on the characteristic dimensions of the optical modification. In particular, the accessibility to the infrared and mid-infrared spectral domains, and to the relevant applications in sensing and imaging, requires increasing the cross-section of the guiding element in order to obtain the desired normalized frequency. Moreover, efficient signal extraction from the transported light requires nanometer size void-like index structures. All this demands a thorough knowledge and an optimal control of the material response within the interaction with the ultrafast laser pulse.
  • 1.4K
  • 25 Jun 2021
Topic Review
Bioactive Properties in Brown Algae
Brown algae are a source of interesting natural bioactive compounds that could be employed in the development of new industrial applications. However, the bioactive compound content in algal extracts is highly dependent on the extraction method applied. Our research was focused on the effect of five different extracting solvents: EtOH, AcO, EtAc, Chl, and Hex, on the extraction yield, polyphenolic content, and antioxidant and antimicrobial activities of nine brown algae from the NW coastal region of the Iberian Peninsula. As expected, all parameters were significantly affected by the species and the nature of the extracting solvent. In fact, the highest extraction yield was achieved when ethanol was used as solvent. Nevertheless, regarding TPC, DPPH-RSA, and FRAP values, EtAc and AcO were reported to be the most effective solvents, depending on the algae assessed, which suggests a differential composition of brown macroalgae in terms of phenolic compounds with antioxidant activity. Concerning the extracts, the highest TPC and FRAP values were found for Ascophyllum nodosum using EtAc as solvent, showing a possible correlation between polyphenol production and antioxidant activity in terms of reducing power, while the highest DPPH-RSA values were achieved by Bifurcaria bifurcata extracted with hexane, thus suggesting the hydrophobic nature of the antioxidant produced by this species.
  • 1.4K
  • 26 Aug 2021
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