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Topic Review
Healthy Residential Buildings
Healthy residential buildings represent the future of construction concerned with the environment, which is increasingly emphasized. This is directly related to the research and development of environmentally friendly building materials, which on the one hand meet the specific requirements of the builder, and on the other hand do not harm the environment. It has possibility of achieving increased variability in healthy residential buildings via the customization of recycled polyvinyl butyral using smart technologies for sustainable design. 
  • 1.5K
  • 09 Sep 2021
Topic Review
Stress-Induced Epstein-Barr Virus Reactivation
Epstein-Barr virus (EBV) is typically found in a latent, asymptomatic state in immunocompetent individuals. Perturbations of the host immune system can stimulate viral reactivation. Furthermore, there are a myriad of EBV-associated illnesses including various cancers, post-transplant lymphoproliferative disease, and autoimmune conditions. A thorough understanding of this virus, and the interplay between stress and the immune system, is essential to establish effective treatment.
  • 1.5K
  • 07 Oct 2021
Topic Review
Spirochetes as Causative Agents of Alzheimer’s Disease
Spirochetes are bacteria that can also form biofilms, and there is increasing evidence regarding infections with specific species. Borrelia burgdorferi, and several species of treponemes are some of the most studied spirochetes regarding Alzheimer’s Disease. Spirochetes were visualized in the neurofibrillary tangles and senile plaques in the brains of individuals with AD, and peptidoglycan was also located near Aβ deposits.
  • 1.5K
  • 06 Jan 2022
Topic Review
White Fat Browning Associate with Obesity
Obesity is negatively associated with the increase in social productivity and endangers people’s health. It is caused by the excessive energy consumption as well as the collection and an excessive level of triglycerides and lipids, which are stored in adipocytes.  Studying the signal transduction pathways of the white fat browning might provide novel ideas for the treatment of obesity and alleviation of obesity-related glucose and lipid metabolism disorders.
  • 1.5K
  • 26 Jul 2022
Topic Review
Tryptophan Dysmetabolism and Quinolinic Acid in Neurodegenerative Diseases
Evidence suggests that neuroinflammation is involved in both depression and neurodegenerative diseases. The kynurenine pathway, generating metabolites which may play a role in pathogenesis, is one of several competing pathways of tryptophan metabolism. A disturbed tryptophan metabolism with increased activity of the kynurenine pathway and production of quinolinic acid may result in deficiencies in tryptophan and derived neurotransmitters. Quinolinic acid is an N-methyl-D-aspartate receptor agonist, and raised levels in CSF, together with increased levels of inflammatory cytokines, have been reported in mood disorders. Increased quinolinic acid has also been observed in neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, and HIV-related cognitive decline. 
  • 1.5K
  • 29 Jul 2022
Topic Review
Floating Photovoltaics
Floating photovoltaics (FPV) addresses this issue by installing solar photovoltaics (PV) on bodies of water. Globally, installed FPV is increasing and becoming a viable option for many countries. 
  • 1.5K
  • 18 Aug 2022
Topic Review
Cosmetic Container
A cosmetic container is a fully enclosed object used to contain, store, and transport cosmetics. Cosmetics or cosmetic products are substances intended to enhance or preserve the human body's physical appearance or scent. Cosmetic containers are a deeper topic of cosmetic packaging, relating to ISO 22715. According to ISO, cosmetic containers are primary packaging. The container houses the actual product, while the outermost package is considered secondary packaging. These containers play important roles in both marketing and protecting the product.
  • 1.5K
  • 17 Oct 2022
Topic Review
Corynebacterium Pseudotuberculosis
Corynebacterium pseudotuberculosis is a Gram-positive bacterium known globally to infect ruminants, horses, and rarely people. This bacterium is a facultative anaerobic organism that is catalase positive and capable of beta-hemolysis. In small ruminants, C. pseudotuberculosis causes a disease called caseous lymphadenitis characterized by pyogranulomatous abscess formation. In general, this bacterium causes lesions of the skin, lymph nodes, and internal organs. A disease known as ulcerative lymphagenitis can also result from infection with C. pseudotuberculosis in the distal limbs of horses. This bacterium uses the virulence factors phospholipase D and mycolic acid to damage eukaryotic cell walls and resist phagocytic lysosomal degradation, respectively. Infection with this bacterium is often confirmed by bacterial culture of the purulent exudate. Once the diagnosis has been made, treatment of the infection can begin, but this is difficult due to the nature of the organism and the lesions it forms. Specifically, C. pseudotuberculosis is intrinsically resistant to streptomycin, with varying resistance to penicillin and neomycin depending on the strain. It has been shown to be susceptible to ampicillin, gentamicin, tetracycline, lincomycin, and chloramphenicol. Vaccines have also been produced to develop acquired immunity to this infection.
  • 1.5K
  • 19 Oct 2022
Topic Review
Progressive Utilization Theory
Progressive Utilization Theory (PROUT) is a socioeconomic and political theory created by the Indian philosopher and spiritual leader Prabhat Ranjan Sarkar. Sarkar conceived of PROUT in 1959. Supporters of PROUT (Proutists) claim that the theory exposes and overcomes the limitations of both capitalism and communism. It aims to be economically progressive and improve social development. The theory is in line with Sarkar's Neohumanist values which aim to provide "proper care" to every being on the planet, including humans, animals and plants.
  • 1.5K
  • 20 Nov 2022
Topic Review
George C. Marshall Institute
The George C. Marshall Institute (GMI) was a nonprofit conservative think tank in the United States. It was established in 1984 with a focus on science and public policy issues and was initially active mostly in the area of defense policy. Since the late 1980s, the Institute put forward environmental skepticism views, and in particular has promoted fringe views regarding the scientific consensus on climate change. The think tank received extensive financial support from oil companies. It closed in 2015, morphing somewhat into the CO2 Coalition.
  • 1.5K
  • 01 Dec 2022
Topic Review
Folic Acid Antimetabolites
Antimetabolites of folic acid represent a large group of drugs and drug candidates, including those for cancer chemotherapy. Antimetabolites, which are antagonists of natural metabolites, belong to a group of highly efficient anticancer drugs. Based on the chemical structure, these groups can be divided into several sub-groups, such as non-natural amino-acids or peptides, including phospha-analogues, analogues of purine and pyrimidine bases, such as competitors in the synthesis of the nucleic acids, as well as vitamin actions including folic acid, hormones, coenzymes, and other substrates responsible for the normal functioning of cells and tissues of the human body.
  • 1.5K
  • 29 Dec 2022
Topic Review
Phycobilisomes and Phycobiliproteins
Eukaryotic photosynthesis arose in the course of evolution as a result of the incorporation of an unstored cyanobacterium and its transformation into chloroplasts by an ancestral heterotrophic eukaryotic cell. The pigment apparatus of earlier evolved  Archaeplastida algae and other later algal phyla turned out to be arranged in the same way having pigment-protein complexes of photosystem I (PS I), photosystem II (PS II) and antenna complex. PS I and PS II are characterized by uniform structures, while the light-harvesting antennae have undergone a number  of changes.
  • 1.5K
  • 14 Feb 2023
Topic Review
Resilient UAV Swarms
UAVs have rapidly become prevalent in applications related to surveillance, military operations, and disaster relief. Their low cost, operational flexibility, and unmanned capabilities make them ideal for accomplishing tasks in areas deemed dangerous for humans to enter. They can also accomplish previous high-cost and labor-intensive tasks, such as land surveying, in a faster and cheaper manner. Researchers studying UAV applications have realized that a swarm of UAVs working collaboratively on tasks can achieve better results. The dynamic work environment of UAVs makes controlling the vehicles a challenge. 
  • 1.5K
  • 04 May 2023
Topic Review
Venom Components of Imported Fire Ant Venom
In the United States, imported fire ants are often referred to as red imported fire ants, Solenopsis invicta Buren, black imported fire ants, S. richteri Forel, and their hybrid (S. invicta × S. richteri). Due to their aggressive stings and toxic venom, imported fire ants pose a significant threat to public health, agriculture, and ecosystem health.
  • 1.5K
  • 11 Aug 2023
Topic Review
Green Innovation as A Conceptual Framework
The growing emergence of environmental problems has meant that sustainability and related concepts such as green innovation have acquired special importance. This has resulted in a significant body of literature addressing these concepts. 
  • 1.5K
  • 01 Sep 2023
Topic Review
Bacteria on 2-keto-L-gulonic Acid Production
Vitamin C, a water-soluble vitamin with strong reducing power, cannot be synthesized by the human body and participates in a variety of important biochemical reactions. Vitamin C is widely used in the pharmaceutical, food, health care, beverage, cosmetics, and feed industries, with a huge market demand. The classical two-step fermentation method is the mainstream technology for vitamin C production. D-sorbitol is transformed into L-sorbose by Gluconobacter oxydans in the first step of fermentation; then, L-sorbose is transformed into 2-keto-L-gulonic acid (2-KGA) by a coculture system composed of Ketogulonicigenium vulgare and associated bacteria; and finally, 2-KGA is transformed into vitamin C through chemical transformation.
  • 1.5K
  • 06 Dec 2023
Topic Review
Antimicrobial Peptides and Antibiotics
Antimicrobial peptides constitute one of the most promising alternatives to antibiotics since they could be used to treat bacterial infections, especially those caused by multidrug-resistant pathogens. Many antimicrobial peptides, with various activity spectra and mechanisms of actions, have been described. 
  • 1.5K
  • 23 Sep 2021
Topic Review
The Microbiota–Gut–Brain Axis
The commensal gut microbiome is an important regulator of the gut–brain axis and plays a critical role in brain physiology. Engaging microbiome-generated metabolites such as short-chain fatty acids, the immune system, the enteric nervous system, the endocrine system (including the HPA axis), tryptophan metabolism or the vagus nerve plays a crucial role in communication between the gut microbes and the brain. Humans are exposed to a wide range of pollutants in everyday life that impact our intestinal microbiota and manipulate the bidirectional communication between the gut and the brain, resulting in predisposition to psychiatric or neurological disorders.
  • 1.5K
  • 28 Jul 2022
Topic Review
Mannose Ligands for Mannose Receptor Targeting
The mannose receptor (MR, CD 206) is an endocytic receptor primarily expressed by macrophages and dendritic cells, which plays a critical role in both endocytosis and antigen processing and presentation. MR carbohydrate recognition domains (CRDs) exhibit a high binding affinity for branched and linear oligosaccharides. Furthermore, multivalent mannose presentation on the various templates like peptides, proteins, polymers, micelles, and dendrimers was proven to be a valuable approach for the selective and efficient delivery of various therapeutically active agents to MR. 
  • 1.5K
  • 20 Feb 2024
Topic Review
Protofibrils in Alzheimer’s Disease
Worldwide, Alzheimer's disease (AD) is the most common age-related neurodegenerative disease and is characterized by unique pathological hallmarks in the brain, including plaques composed of amyloid β-protein (Aβ) and neurofibrillary tangles of tau protein. Genetic studies, biochemical data, and animal models have suggested that Aβ is responsible for the pathogenesis of AD (i.e., the amyloid hypothesis). Indeed, Aβ molecules tend to aggregate, forming oligomers, protofibrils, and mature fibrils. However, while these Aβ species form amyloid plaques of the type implicated in AD neurodegeneration, recent clinical trials designed to reduce the production of Aβ and/or the plaque burden have not demonstrated clinical efficacy. In addition, recent studies using synthetic Aβ peptides, cell culture models, Arctic transgenic mice, and human samples of AD brain tissues have suggested that the pre-fibrillar forms of Aβ, particularly Aβ protofibrils, may be the most critical species, compared with extracellular fibrillar forms. We recently reported that protofibrils of Aβ1-42 disturbed membrane integrity by inducing reactive oxygen species generation and lipid peroxidation, resulting in decreased membrane fluidity, intracellular calcium dysregulation, depolarization, and synaptic toxicity. Therefore, the therapeutic reduction of protofibrils may prevent the progression of AD by ameliorating neuronal damage and cognitive dysfunction through multiple mechanisms.
  • 1.5K
  • 21 Apr 2021
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