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Topic Review
Marine Collagen in Pharmacological, Biomedical, and Regenerative Medicine
Several bioactive compounds of marine origin are being studied, and among these, marine collagen represents one of the most attractive bio-resources, given its use in various disciplines, such as clinical applications, cosmetics, the food sector, and many other industrial applications. The applications of Marine collagen in pharmacological, biomedical fields and regenerative medicine are discussed. 
  • 1.5K
  • 28 Feb 2023
Topic Review
Materials for 3D Bioprinting
Three-dimensional (3D) bioprinting has emerged as a promising scaffold fabrication strategy for tissue engineering with excellent control over scaffold geometry and microstructure. Nanobiomaterials as bioinks play a key role in manipulating the cellular microenvironment to alter its growth and development.
  • 1.5K
  • 12 Apr 2023
Topic Review
Fenamates for Neurodegenerative Disorders
Neurodegenerative disorders are desperately lacking treatment options. It is imperative that drug repurposing be considered in the fight against neurodegenerative diseases. Fenamates have been studied for efficacy in treating several neurodegenerative diseases. 
  • 1.5K
  • 06 May 2021
Topic Review
Perilipin 5 in NAFLD
Perilipins are a family of five closely related proteins expressed on the surface of lipid droplets (LD) in several tissues acting in several pathways involved in lipid metabolism. Recent studies have shown that Plin5 depletion acts protectively in the pathogenesis of liver injury underpinning the importance of pathways associated with PLIN5. PLIN5 expression is involved in pro-inflammatory cytokine regulation and mitochondrial damage, as well as endoplasmic reticulum (ER) stress, making it critical target of the NAFLD-HCC studies. 
  • 1.5K
  • 23 Jun 2021
Topic Review
By-Products for the Agri-Food Industry
In Europe, around 31 million tonnes of food by-products are generated during primary production and trade. The management of these by-products may cause a negative impact, both at the economic and environmental levels, for both industry and society. In this regard, taking into consideration that these by-products retain the dietary fibre compositions and the bioactive compounds of the starting materials, plant food agro-industries have an interest in taking advantage of them, from a nutritional point of view. Using different extraction techniques they can be used as the source of insoluble and soluble dietary fibre, polyphenols, carotenoids, and other bioactive compounds.
  • 1.5K
  • 06 May 2023
Topic Review
Integration of Photovoltaic
Electric vehicles are promising and essential to reduce the carbon footprint from the transport sector. Grid power is the primary source to charge the EV. Currently, grid power which comes from burning fossil fuel is not environmentally benevolent. Solar-powered electric vehicles are promising as the required power to charge the EV comes from the PV system, which generates benign energy. PV system can be installed in the car shed or rooftop of a building. For commercial buildings, vehicles are mainly parked during the peak solar radiation time, which can be utilised to charge the EV by employing PV.
  • 1.5K
  • 28 Oct 2020
Topic Review
Vitamin D-dependent Rickets
Vitamin D-dependent rickets is a disorder of bone development that leads to softening and weakening of the bones (rickets).
  • 1.5K
  • 23 Dec 2020
Topic Review
Superconducting YBCO Foams
Superconducting foams of YBa2Cu3Oy (YBCO) are proposed as trapped field magnets or supermagnets. The foams with an open-porous structure are light-weight, mechanically strong and can be prepared in large sample sizes. The trapped field distributions were measured using a scanning Hall probe on various sides of an YBCO foam sample after field-cooling in a magnetic field of 0.5 T produced by a square Nd-Fe-B permanent magnet. The maximum trapped field (TF) measured is about 400 G (77 K) at the bottom of the sample. Several details of the TF distribution, the current flow and possible applicatons of such superconducting foam samples in space applications, e.g., as active elements in flux-pinning docking interfaces (FPDI) or as portable strong magnets to collect debris in space, are outlined.
  • 1.5K
  • 20 Jun 2023
Topic Review
AuNPs and Fibrous Materials
The use of nanoparticles is a multidisciplinary approach to provide UV blocking, antimicrobial, water repellent, colorant, flame retardant, sensing, and self-cleaning properties to textiles. Particularly, the antimicrobial textiles with improved functionalities find several applications, namely, in health and hygiene products, infection control, and barrier material. Depositing nanoparticles in textiles have been a promising strategy to achieve multifunctional materials. Particularly, antimicrobial properties are highly valuable due to the emergence of new pathogens and the spread of existing ones. Various techniques have been used by researchers to functionalize natural and synthetic fibers with AuNPs such as sputtering, electrostatic assembly, chemical reduction in solution, dip-coating, electroless plating, drop and dry, biosynthesis, and print pasting method.
  • 1.5K
  • 11 May 2021
Topic Review
SnRK2 in Plants
Reversible phosphorylation is a major mechanism for regulating protein function and controls a wide range of cellular functions including responses to external stimuli. The plant-specific SNF1-related protein kinase 2s (SnRK2s) function as central regulators of plant growth and development, as well as tolerance to multiple abiotic stresses. 
  • 1.5K
  • 26 Jul 2021
Topic Review
IALUSET VITAL® Cream Improves Adults Atopic Dermatitis
Atopic dermatitis (AD) is a chronic relapsing skin disease, associated with impaired skin barrier function and characterized by poorly defined pruritic, erythematous lesions. In this study, the efficacy of a new topical cream (IALUSET VITAL®), containing hyaluronic acid and the extract of Salvia haenkei, in reducing symptoms of moderate AD in adults was investigated. This study was a randomized, double blind, vehicle-controlled clinical study. Treatment efficacy was evaluated considering both objective parameters (Scoring Atopic Dermatitis, SCORAD) and subjective pa-rameters (Patient Oriented Eczema Measure, POEM, and an itching sensation) and through non-invasive bioengineering techniques to measure skin moisturization and Trans Epidermal Water Loss (TEWL).
  • 1.5K
  • 05 Nov 2021
Topic Review
Nanoliposomes and Tocosomes as Nanocarriers in Food Industry
Nanoscale lipid bilayers, or nanoliposomes, are generally spherical vesicles formed by the dispersion of phospholipid molecules in a water-based medium by energy input. Nanoliposomes and tocosomes are able to provide protection and release of sensitive food-grade bioactive materials in a sustained manner. They are being utilized for the encapsulation of different types of bioactive materials (such as drugs, vaccines, antimicrobials, antioxidants, minerals and preservatives), for the enrichment and fortification of different food and nutraceutical formulations and manufacturing of functional products.
  • 1.5K
  • 11 Nov 2021
Topic Review
Bioactive Glasses in Bone Regeneration
Mesoporous bioactive glasses (MBGs) is a category of bioceramics that, as will be explained, can be considered intermediate between traditional bioactive glasses—obtained by quenching of a melt or by the sol-gel method—and silica mesoporous materials. These bioactive glasses can be considered a spin-off of silica mesoporous materials because they are designed with a similar technical approach. Mesoporous glasses in addition to SiO2 contain significant amounts of other oxides, particularly CaO and P2O5 and therefore, they exhibit quite different properties and clinical applications than mesoporous silica compounds. Both materials exhibit ordered mesoporous structures with a very narrow pore size distribution that are achieved by using surfactants during their synthesis. The characteristics of mesoporous glasses made them suitable to be enriched with various osteogenic agents, namely inorganic ions and biopeptides as well as mesenchymal cells. 
  • 1.5K
  • 19 Apr 2022
Topic Review
Taraxerol
Taraxerol, an oleanane-type pentacyclic triterpene, is one of the natural compounds that have been investigated extensively for its potential utilization in drug development. It has received major attention for its potential use as a therapeutic agent for the treatment of various diseases. Plants containing taraxerol are Hypericum perforatum, Clitoria ternatea, Mangifera indica, and Strobilanthes crispus.
  • 1.5K
  • 11 Apr 2022
Topic Review
Lean Integrated Project Delivery for Construction Procurement
The choice of proper procurement methods has an impact on the overall productivity and sustainability of construction projects. The current procurement methods have alerted the construction industry (CI) due to the exacerbating fragmentation among parties and the resulting low level of productivity. Therefore, introducing a new procurement system to eliminate the above challenges is imperative to the CI.
  • 1.5K
  • 16 May 2022
Topic Review
Immunotherapeutic Approaches for Angioimmunoblastic T-cell Lymphoma
Escaping the immune system is the main characteristic of a tumor cell. In order to limit the anarchic proliferation of cancer cells, chemotherapies are often used in tumors that have no specific treatment yet, such as AITL. These therapies are proposed to limit the proliferation of dividing cells, i.e., healthy cells as well as tumor cells. This explains the poor benefits of such treatment and the major risk of relapse or even the absence of signs of remission. Importantly, targeting a specific cancer cell type without inducing an effect on healthy cells requires an in-depth knowledge of its phenotype and its surface markers, which can serve as an asset for the development of specific therapies, in particular immunotherapies. If some healthy cells are affected, it is called on-target off-target effects because certain cancer epitopes are partially expressed on non-malignant cells. These therapies include, for example, monoclonal antibodies and chimeric antigen receptors. 
  • 1.5K
  • 25 May 2022
Topic Review
Source Analysis of Heavy Metal Pollution in Soils
Eight types of heavy metals in the soil on the banks of Shuimo River in Urumqi were analysed via X-ray fluorescence spectrometry and national standard detection methods. The UNMIX and positive matrix factorisation (PMF) models were comprehensively used to analyse the sources and contribution rates of potential pollutants. The soil samples were collected from three layers: 0–20, 20–40, and 40–60 cm. Each sample point in each layer was located 5 m, 1 km, and 2 km from the riverbank. The results showed that only the average concentration of Mn in each layer of soil was lower than the background value, and the average concentrations of other heavy metals were higher than their background values. Among them, Ni concentration highly exceeded the background value in the 40–60 cm soil layer, reaching 1.92 times. The similarities and differences between the sources and contributions estimated by the UNMIX and PMF models were also clarified. The similarities of the two common sources (natural source and artificial source) for each soil layer were relatively large, and the analysis results of the two models were within model reliability range. By comparing the Pearson correlation coefficients and distribution maps of heavy metal concentrations in surface soil, Zn, Pb, Cr, and Cu were from human sources, and Mn, Ni, and V were from natural sources. In future studies, multiple models should be comprehensively used to determine the potential pollutant sources and estimate contribution rates.
  • 1.5K
  • 23 Sep 2022
Topic Review
Carterton, New Zealand
Carterton (Māori: Taratahi) is a small town in the Wellington Region of New Zealand and the seat of the Carterton District (a territorial authority or local government district). It lies in a farming area of the Wairarapa in New Zealand's North Island. It is located 14 km (8.7 mi) southwest of Masterton and 80 km (50 mi) northeast of Wellington. The town has a population of 5,850 (June 2021), out of a total district population of 10,050. Carterton was founded in 1857. Originally known as Three Mile Bush, it served as housing for workers building the road between Wellington and Masterton. It was later renamed after Charles Carter, who was in charge of the building of the Black Bridge over the Waiohine River south of the town. The town describes itself as New Zealand's daffodil capital, holding a Daffodil Festival each year on the second Sunday in September, with the main event taking place at Middle Run along Gladstone Road.
  • 1.5K
  • 27 Oct 2022
Topic Review
Derailleur Gears
Derailleur gears are a variable-ratio transmission system commonly used on bicycles, consisting of a chain, multiple sprockets of different sizes, and a mechanism to move the chain from one sprocket to another. Although referred to as gears in the bike world, these bicycle gears are technically sprockets since they drive or are driven by a chain, and are not driven by one another. Modern front and rear derailleurs typically consist of a moveable chain-guide that is operated remotely by a Bowden cable attached to a shifter mounted on the down tube, handlebar stem, or handlebar. When a rider operates the lever while pedalling, the change in cable tension moves the chain-guide from side to side, "derailing" the chain onto different sprockets. For more information about the choice of particular gear ratios and sprocket sizes, see Bicycle gearing.
  • 1.5K
  • 16 Nov 2022
Topic Review
Near-Earth Object Surveillance Mission
The Near-Earth Object Surveillance Mission (NEOSM), formerly called Near-Earth Object Camera (NEOCam) is a planned space-based infrared telescope designed to survey the Solar System for potentially hazardous asteroids. The NEO Surveillance Mission will be carried out by the NEO Surveyor spacecraft, which will survey from the Sun–Earth L1 (inner) Lagrange point, allowing it to look close to the Sun and see objects inside Earth's orbit. The mission will be a successor to the NEOWISE mission; the principal investigator is also NEOWISE's principal investigator, Amy Mainzer at the University of Arizona. Since first proposed in 2006, the concept unsuccessfully competed repeatedly for NASA funding against science missions unrelated to planetary defense, despite a 2005 US Congressional directive to NASA. In 2019, it was decided to implement this mission by the Planetary Defense Coordination Office since it is a public safety issue. The Jet Propulsion Laboratory will lead development of the mission.
  • 1.5K
  • 05 Dec 2022
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