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Topic Review
Applications of Biodegradable Poly Blends/Composites
Biodegradable poly(ɛ-caprolactone) (PCL) and its composites or blends have received a lot of attention in the past because of their potential applications in human life and environmental remediation. Greater efforts have been made to develop biodegradable chemical materials as adsorbents that do not pollute the environment in order to replace traditional materials. 
  • 1.6K
  • 09 Nov 2023
Topic Review
Inherited Thrombocytopenias (IT)
Inherited thrombocytopenias (IT) are a group of hereditary disorders characterized by a reduced platelet count sometimes associated with abnormal platelet function, which can lead to bleeding but also to syndromic manifestations and predispositions to other disorders. 
  • 1.6K
  • 25 Apr 2021
Topic Review
Soluble Factors and Receptors in Skin Innate Immunity
The pattern recognition receptors, complement system, inflammasomes, antimicrobial peptides, and cytokines are innate immunity soluble factors. They sense, either directly or indirectly, the potential threats and produce inflammation and cellular death. High interest in their modulation has emerged lately, acknowledging they are involved in many cutaneous inflammatory, infectious, and neoplastic disorders. We extensively reviewed the implication of soluble factors in skin innate immunity. Furthermore, we showed which molecules target these factors, how these molecules work and how they've been used in dermatological practice. Cytokine inhibitors have paved the way to a new era in treating moderate to severe psoriasis and atopic dermatitis. 
  • 1.6K
  • 13 Dec 2021
Topic Review
Rhina (Genus)
The bowmouth guitarfish (Rhina ancylostoma), also called the shark ray or mud skate, is a species of ray and a member of the family Rhinidae. Its evolutionary affinities are not fully resolved, though it may be related to true guitarfishes and skates. This rare species occurs widely in the tropical coastal waters of the western Indo-Pacific, at depths of up to 90 m (300 ft). Highly distinctive in appearance, the bowmouth guitarfish has a wide and thick body with a rounded snout and large shark-like dorsal and tail fins. Its mouth forms a W-shaped undulating line, and there are multiple thorny ridges over its head and back. It has a dorsal color pattern of many white spots over a bluish gray to brown background, with a pair of prominent black markings over the pectoral fins. This large species can reach a length of 2.7 m (8.9 ft) and weight of 135 kg (298 lb). Usually found near the sea floor, the bowmouth guitarfish prefers sandy or muddy areas near underwater structures. It is a strong-swimming predator of bony fishes, crustaceans, and molluscs. This species gives live birth to litters of two to eleven pups, which are nourished during gestation by yolk. The International Union for Conservation of Nature (IUCN) has assessed the bowmouth guitarfish as Vulnerable because it is widely caught by artisanal and commercial fisheries for its valuable fins and meat. It is viewed as a nuisance by trawlers, however, because its bulk and thorny skin cause it to damage netted catches. Habitat degradation and destruction pose an additional, significant challenge to this ray's survival. The bowmouth guitarfish adapts well to captivity and is displayed in public aquariums.
  • 1.6K
  • 18 Oct 2022
Topic Review
Adult Post-Transplant Lymphoproliferative Disorder
Post-transplant lymphoproliferative disorder (PTLD) is a rare but severe complication of hematopoietic or solid organ transplant recipients, with variable incidence and timing of occurrence depending on different patient-, therapy-, and transplant-related factors. The pathogenesis of PTLD is complex, with most cases of early PLTD having a strong association with Epstein–Barr virus (EBV) infection and the iatrogenic, immunosuppression-related decrease in T-cell immune surveillance. Without appropriate T-cell response, EBV-infected B cells persist and proliferate, resulting in malignant transformation. Classification is based on the histologic subtype and ranges from nondestructive hyperplasias to monoclonal aggressive lymphomas, with the most common subtype being diffuse large B-cell lymphoma-like PTLD. Management focuses on prevention of PTLD development, as well as therapy for active disease. Treatment is largely based on the histologic subtype.
  • 1.6K
  • 09 Dec 2022
Topic Review
Natural Antibacterial Additives in Bioactive Wound Dressings
Wound care is a global health issue with a financial burden of up to US $96.8 billion annually in the USA alone. Chronic non-healing wounds which show delayed and incomplete healing are especially problematic. Natural products and their derivatives have long been a significant source of pharmaceuticals against AMR. Scrutinising the data of newly approved drugs has identified plants as one of the biggest and most important sources in the development of novel antibacterial drugs.
  • 1.6K
  • 10 Mar 2023
Topic Review
16S rRNA Sequencing vs. Metagenome Sequencing
Microbiome research has revolutionized our understanding of complex microbial communities, and two pivotal techniques at the forefront of this exploration are 16S rRNA sequencing and metagenome sequencing.
  • 1.6K
  • 31 Oct 2024
Topic Review
Otter
Otters are small to medium-sized carnivorous mammals belonging to the family Mustelidae, which also includes weasels, badgers, martens, and ferrets. Otters are known for their playful nature, streamlined bodies, and semi-aquatic habits. There are 13 extant species of otters that inhabit a range of environments from freshwater rivers to coastal marine ecosystems. Otters are remarkable for their adaptations to an aquatic lifestyle, including webbed feet, dense fur, and specialized behavior patterns related to hunting and social interaction.
  • 1.6K
  • 28 May 2025
Topic Review
New Breeding Techniques in Citrus
The development of novel citrus varieties with improved quality and resistance to biotic and abiotic stresses is one of the main purposes of breeding programs. Thus far, the use of conventional breeding techniques in citrus has been shown to be time consuming and diffcult due to the many limitations of typical of tree crops, such as the long juvenility and high heterozygosity. The application of NPBTs could overcome these problems, offering new tools that combine site-specific and targeted editing with a reduction in the time for plant breeding, thus leading to lower production costs. Many aspects need to be considered to apply transgenesis to citrus, among them transformation efficiency, and regeneration potential of citrus commercial varieties
  • 1.6K
  • 05 Nov 2020
Topic Review
Photodynamic Therapy
Photodynamic therapy (PDT) is a promising therapeutic strategy for cancers where surgery and radiotherapy cannot be effective. PDT relies on the photoactivation of photosensitizers, most of the time by lasers to produced reactive oxygen species and notably singlet oxygen. The major drawback of this strategy is the weak light penetration in the tissues. To overcome this issue, recent studies proposed to generate visible light in situ with radioactive isotopes emitting charged particles able to produce Cerenkov radiation. In vitro and preclinical results are appealing, but the existence of a true, lethal phototherapeutic effect is still controversial.
  • 1.6K
  • 15 Dec 2020
Topic Review
Aryl Hydrocarbon Receptor
The aryl hydrocarbon receptor (AhR) was first identified as the intracellular protein that 14 bound and mediated the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and 15 dioxin-like compounds (DLCs). Subsequent studies show that the AhR plays an important role in 16 maintaining cellular homeostasis and in pathophysiology and there is increasing evidence that the 17 AhR is a important drug target. The AhR binds structurally diverse compounds including 18 pharmaceuticals, phytochemicals, endogenous biochemicals some of which may serve as 19 endogenous ligands. Classification of DLCs and non-DLCs based on their persistence (metabolism), 20 toxicities, binding to wild-type/mutant AhR and structural similarities have been reported. This 21 review provides data suggesting that ligands for the AhR are selective AhR modulators (SAhRMs) 22 which exhibit tissue/cell-specific AhR agonist and antagonist activities and their functional diversity 23 is similar to selective receptor modulators that target steroid hormone and other nuclear receptors.
  • 1.6K
  • 10 Feb 2021
Topic Review Peer Reviewed
Exsolution Catalysts—Increasing Metal Efficiency
Exsolution catalysts are perovskite oxide-based materials that can exsolve catalytically active dopant elements as nanoparticles covering the surface, while the perovskite backbone can act as a stable support material. Thus, under proper conditions, a highly catalytically active and stable catalyst surface can be achieved. For many catalytic materials, precious metals or non-abundant elements play a key role in high catalytic activity. As these elements are often expensive or their supply is ecologically and ethically problematic, the replacement, or at the least reduction in the necessary amount used, is a common aim of current research. One strategy to do so is utilizing exsolution catalysts, as the active elements can be very selectively exsolved, and hence only very small doping amounts are sufficient for excellent results. This approach enables catalyst design with very high active metal efficiency.
  • 1.6K
  • 13 Apr 2022
Topic Review
Agricultural Soils
Globally, agricultural soils are being evaluated for their role in climate change regulation as a potential sink for atmospheric carbon dioxide (CO2) through sequestration of organic carbon as soil organic matter. Scientists and policy analysts increasingly seek to develop programs and policies which recognize the importance of mitigation of climate change and insurance of ecological sustainability when managing agricultural soils.
  • 1.6K
  • 09 Aug 2021
Topic Review
Allosteric GABAA Receptor Modulators
Among the mammalian ligand-gated ion channels, the GABAA receptor family comprises the largest family with subunits encoded by 19 different genes. Some of these undergo alternative splicing, and, thereby, increase the variety. Their endogenous ligand known as the gamma-aminobutyric acid (GABA) has been established as the main inhibitory neurotransmitter in the central nervous system.
  • 1.6K
  • 29 Nov 2021
Topic Review
Microbially Induced Carbonate Precipitation
 Microbially induced carbonate precipitation (MICP) is a promising technology for solidifying sandy soil, ground improvement, repairing concrete cracks, and remediation of polluted land. By solidifying sand into soil capable of growing shrubs, MICP can facilitate peak and neutralization of CO2 emissions because each square meter of shrub can absorb 253.1 grams of CO2 per year.
  • 1.6K
  • 01 Dec 2021
Topic Review
The Pharmaceutical Industry in 2021
2021 will be remembered for the COVID-19 pandemic. Although five vaccines have been approved by the two most important drug regulatory agencies, namely the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA), the pandemic has still not been brought under control. However, despite the context of a global pandemic, 2021 has been an excellent year with respect to drug approvals by the FDA. In 2021, 50 drugs have been authorized, making it the fourth-best year after 2018 (59 drugs) and 1996 and 2020 (53 each). Regarding biologics, 2021 has been the third-best year to date, with 14 approvals, and it has also witnessed the authorization of 36 small molecules.
  • 1.6K
  • 21 Mar 2022
Topic Review
CXCL1 in Noncancerous Diseases of the Nervous System
Chemokines are chemotactic cytokines, whose most important function is the chemoattraction of immune cells. CXC motif chemokine ligand 1 (CXCL1), a CXC chemokine, is also known as growth-regulated (or -related) oncogene-α (Gro-α) and melanoma growth-stimulatory activity (MGSA). The role CXCL1 plays in the physiology of the nervous system is described. 
  • 1.6K
  • 10 Jun 2022
Topic Review
Vision-Based Autonomous Vehicle Systems
Autonomous vehicle systems (AVS) have advanced at an exponential rate, particularly due to improvements in artificial intelligence, which have had a significant impact on social as well as road safety and the future of transportation systems. Deep learning is fast becoming a successful alternative approach for perception-based AVS as it reduces both cost and dependency on sensor fusion.
  • 1.6K
  • 12 Jul 2022
Topic Review
Short Bowel Syndrome
Short bowel syndrome (SBS) in children is defined as “the need for parenteral nutrition (PN) for >60 days after intestinal resection or a bowel length of less than 25% of expected” by the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN). 
  • 1.6K
  • 04 Aug 2022
Topic Review
SAPO-34 Zeolite Membranes
In the zeolite family, the silicoaluminophosphate (SAPO)-34 zeolite has a unique chemical structure, distinctive pore size, adsorption characteristics, as well as chemical and thermal stability, has attracted much research attention. Increasing global carbon dioxide (CO2) emissions pose a serious environmental threat to humans, animals, plants, and the entire environment.
  • 1.6K
  • 20 Mar 2023
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