Your browser does not fully support modern features. Please upgrade for a smoother experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
CFBDSIR 1458+10
CFBDSIR J145829+101343 (Coordinates: 14h 58m 29.0s, +10° 13′ 43″, designation abbreviated to CFBDSIR 1458+10, or CFBDSIR J1458+1013) is a binary system of two brown dwarfs of spectral classes T9 + Y0 orbiting each other, located in constellation Boötes about 104 light-years away from Earth. The smaller companion, CFBDSIR 1458+10B, has a surface temperature of approx 370 K (≈100 °C) and used to be known as the coolest known brown dwarf until the discovery of WISE 1828+2650 in August 2011.
  • 1.6K
  • 09 Oct 2022
Topic Review
Mechanisms of CLL Cell Stimulation via BcR
The engagement of the B cell receptor (BcR) on the surface of leukemic cells represents a key event in chronic lymphocytic leukemia (CLL) since it can lead to the maintenance and expansion of the neoplastic clone. This notion was initially suggested by observations of the CLL BcR repertoire and of correlations existing between certain BcR features and the clinical outcomes of single patients. Based on these observations, tyrosine kinase inhibitors (TKIs), which block BcR signaling, have been introduced in therapy with the aim of inhibiting CLL cell clonal expansion and of controlling the disease. Indeed, the impressive results obtained with these compounds provided further proof of the role of BcR in CLL.
  • 1.6K
  • 01 Dec 2022
Topic Review
The Physiological and Pathological Role of Acyl-CoA Oxidation
Fatty acid metabolism, including β-oxidation (βOX), plays an important role in human physiology and pathology. βOX is an essential process in the energy metabolism of most human cells. Moreover, βOX is also the source of acetyl-CoA, the substrate for (a) ketone bodies synthesis, (b) cholesterol synthesis, (c) phase II detoxication, (d) protein acetylation, and (d) the synthesis of many other compounds, including N-acetylglutamate—an important regulator of urea synthesis. 
  • 1.6K
  • 20 Oct 2023
Topic Review
Mitochondrial-Derived Vesicles
Mitophagy is crucial for maintaining mitochondrial quality. The endosomal–lysosomal system is a more accessible pathway through which subtypes of extracellular vesicles, which also contain mitochondrial constituents, are released for disposal. The inclusion of mitochondrial components into extracellular vesicles occurs in the setting of mild mitochondrial damage and during impairment of lysosomal function. By releasing mitochondrial-derived vesicles, cells limit the unload of mitochondrial damage-associated molecular patterns with proinflammatory activity.
  • 1.6K
  • 17 Nov 2023
Topic Review
Cathodes for PCFCs
In a protonic ceramic fuel cell (PCFC), the cathode is a porous oxide material where electrochemical reduction takes place involving the reduction of oxygen and combination with protons from the electrolyte to form water. The cathode is generally recognised as critical for the performance of solid oxide fuel cells, and even more so for the proton-conducting class of ceramic devices. PCFCs are promising electrochemical devices for the efficient and clean conversion of hydrogen and low hydrocarbons into electrical energy. Their intermediate operation temperature (500–800 °C) proffers advantages in terms of greater component compatibility, unnecessity of expensive noble metals for the electrocatalyst, and no dilution of the fuel electrode due to water formation. Nevertheless, the lower operating temperature, in comparison to classic solid oxide fuel cells, places significant demands on the cathode as the reaction kinetics are slower than those related to fuel oxidation in the anode or ion migration in the electrolyte. Cathode design and composition are therefore of crucial importance for the cell performance at low temperature. The different approaches that have been adopted for cathode materials research can be broadly classified into the categories of protonic–electronic conductors, oxide-ionic–electronic conductors, triple-conducting oxides, and composite electrodes composed of oxides from two of the other categories. 
  • 1.6K
  • 06 Jul 2021
Topic Review
Surface Plasmon Resonance-Based Biosensors for Advanced Bioprocess Monitoring
Biomanufacturers are being incited by regulatory agencies to transition from a quality by testing framework, where they extensively test their product after their production, to more of a quality by design or even quality by control framework. This requires powerful analytical tools and sensors enabling measurements of key process variables and/or product quality attributes during production, preferably in an online manner. As such, the demand for monitoring technologies is rapidly growing. In this context, researchers believe surface plasmon resonance (SPR)-based biosensors can play a role in enabling the development of improved bioprocess monitoring and control strategies.
  • 1.6K
  • 22 Dec 2021
Topic Review
Eurobonds
European bonds are proposed government bonds issued in euros jointly by the 19 eurozone nations. The idea was first raised by the European Commission in 2011. Eurobonds would be debt investments whereby an investor loans a certain amount of money, for a certain amount of time, with a certain interest rate, to the eurozone bloc altogether, which then forwards the money to individual governments. Eurobonds have been suggested as a way to tackle the European sovereign debt crisis as the indebted states could borrow new funds at better conditions as they are supported by the rating of the non-crisis states. Because Eurobonds would allow already highly indebted states access to cheaper credit thanks to the strength of other eurozone economies, they are controversial, and may suffer from the free rider problem.
  • 1.6K
  • 14 Nov 2022
Topic Review
Physiologically Based Pharmacokinetic Modeling of Nanoparticle Biodistribution
Cancer treatment and pharmaceutical development require targeted treatment and less toxic therapeutic intervention to achieve real progress against this disease. In this scenario, nanomedicine emerged as a reliable tool to improve drug pharmacokinetics and to translate to the clinical biologics based on large molecules. However, the ability of body to recognize foreign objects together with carrier transport heterogeneity derived from the combination of particle physical and chemical properties, payload and surface modification, make the designing of effective carriers very difficult. In this scenario, physiologically based pharmacokinetic modeling can help to design the particles and eventually predict their ability to reach the target and treat the tumor. This effort is performed by scientists with specific expertise and skills and familiarity with artificial intelligence tools such as advanced software that are not usually in the “cords” of traditional medical or material researchers. 
  • 1.6K
  • 04 Nov 2022
Topic Review
Food Implications in Central-Sensitization Syndromes
Fibromyalgia (FM), chronic fatigue syndrome (CFS) and multiple chemical sensitivity (MCS) are some of the central sensitization syndromes (CSSs). The complexity of their diagnosis, the high interindividual heterogeneity and the existence of multi-syndromic patients requires a multifaceted treatment.
  • 1.6K
  • 30 Jan 2021
Topic Review
Pulsed Laser Ablation in Liquids
Laser synthesis emerges as a suitable technique to produce ligand-free nanoparticles, alloys and functionalized nanomaterials for catalysis, imaging, biomedicine, energy and environmental applications. In the last decade, laser ablation and nanoparticle generation in liquids has proven to be a unique and efficient technique to generate, excite, fragment and conjugate a large variety of nanostructures in a scalable and clean way. 
  • 1.6K
  • 19 Feb 2021
Topic Review
Digital Twin Technologies for Turbomachinery
Turbomachinery from a life cycle perspective involves sustainability-oriented development activities such as design, production, and operation. Digital Twin is a technology with great potential for improving turbomachinery, which has a high volume of investment and a long lifespan. 
  • 1.6K
  • 11 Mar 2021
Topic Review
Edible Flowers
Edible flowers have been widely consumed for ages until now. The attractive colors and shapes, exotic aroma, and delightful taste make edible flowers very easy to attain. Moreover, they also provide health benefits for consumers due to the unique composition and concentration of antioxidant compounds in the matrices. Knowing the bioactive compounds and their functional properties from edible flowers is necessary to diversify the usage and reach broader consumers.
  • 1.6K
  • 01 Jun 2021
Topic Review
Liquid Biopsy-Based Biosensors
Globally, non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths. The 5-year survival rate has remained at 16% for the past forty years despite advancements in chemotherapy and targeted therapies. Minimal residual disease (MRD) is described as the existence of either isolated tumour cells or circulating tumour cells in biological liquid of patients after removal of the primary tumour without any clinical signs of cancer. Recently, liquid biopsy has been promising as a non-invasive method of disease monitoring and treatment guidelines as an MRD marker. Liquid biopsy could be used to detect and assessment of earlier stages of NSCLC, post-treatment MRD, resistance to targeted therapies, immune checkpoint inhibitors (ICIs) and tumour mutational burden. MRD surveillance has been proposed as a potential marker for lung cancer relapse. Principally biosensors provide the quantitative analysis of various materials by converting biological functions into quantifiable signals. Biosensors are usually operated to detect antibodies, enzymes, DNA, RNA, EVs, and whole cells. Here we present a category of biosensors based on the signal transduction method for identifying biosensor-based biomarkers in liquid biopsy specimens to monitor lung cancer treatment
  • 1.6K
  • 22 Oct 2021
Topic Review
Benefits of the Phytoestrogen Resveratrol for Perimenopausal Women
Endometriosis, characterized by macroscopic lesions in the ovaries, is a serious problem for women who desire conception. Damage to the ovarian cortex is inevitable when lesions are removed via surgery, which finally decreases the ovarian reserve, thereby accelerating the transition to the menopausal state. Resveratrol, a plant-derived molecule that promotes the function and expression of the sirtuin, SIRT1, has been attracting attention, and many reports have shown that resveratrol might exert cardiovascular protective effects. 
  • 1.6K
  • 17 Nov 2021
Topic Review
The Effect of Music on Livestock
The welfare of animals, especially those kept in intensive production systems, is a priority for modern agriculture. This stems from the desire to keep animals healthy, to obtain a good-quality final product, and to meet the demands of today’s consumers, who have been increasingly persuaded to buy organic products. As a result, new sound-based methods have been pursued to reduce external stress in livestock. Music therapy has been known for thousands of years, and sounds were believed to improve both body and spirit. Today, they are mostly used to distract patients from their pain, as well as to treat depression and cardiovascular disorders. However, recent studies have suggested that appropriately selected music can confer some health benefits, e.g., by increasing the level and activity of natural killer cells. For use in livestock, the choice of genre, the loudness of the music and the tempo are all important factors. Some music tracks promote relaxation (thus improving yields), while others have the opposite effect. 
  • 1.6K
  • 11 Jan 2022
Topic Review
Mixed-Matrix Membranes for Gas Separation
Nanocomposite membranes, obtained by dispersing solid particles within a polymeric matrix, are referred to as mixed-matrix membranes (MMMs) and are potentially capable to exceed the trade-off restrictions between membrane permeability and selectivity, that is an intrinsic trait for polymeric membranes applied to gas separation. Making the most appropriate combination of filler and polymer is an exciting challenge for materials scientists.
  • 1.6K
  • 28 Jan 2022
Topic Review
Atypical Depression
Atypical depression as it has been known in the DSM IV, is depression that shares many of the typical symptoms of the psychiatric syndromes of major depression or dysthymia but is characterized by improved mood in response to positive events. In contrast to atypical depression, people with melancholic depression generally do not experience an improved mood in response to normally pleasurable events. Atypical depression also features significant weight gain or an increased appetite, hypersomnia, a heavy sensation in the limbs, and interpersonal rejection sensitivity that results in significant social or occupational impairment. Despite its name, "atypical" depression does not mean it is uncommon or unusual. The reason for its name is twofold: it was identified with its "unique" symptoms subsequent to the identification of melancholic depression and its responses to the two different classes of antidepressants that were available at the time were different from melancholic depression (i.e., MAOIs had clinically significant benefits for atypical depression, while tricyclics did not). Atypical depression is four times more common in females than in males. Individuals with atypical features tend to report an earlier age of onset (e.g. while in high school) of their depressive episodes, which also tend to be more chronic and only have partial remission between episodes. Younger individuals may be more likely to have atypical features, whereas older individuals may more often have episodes with melancholic features. Atypical depression has high comorbidity of anxiety disorders, carries more risk of suicidal behavior, and has distinct personality psychopathology and biological traits. Atypical depression is more common in individuals with bipolar I, bipolar II, cyclothymia and seasonal affective disorder. Depressive episodes in bipolar disorder tend to have atypical features, as does depression with seasonal patterns.
  • 1.6K
  • 02 Nov 2022
Topic Review
Influence of Peanut Variety on Peanut Butter Flavor
For peanut butter, flavor is one of the most important quality attributes, with strong influence on consumer acceptance. There are numerous peanut cultivars on the market, with widely differing chemical compositions and metabolite profiles, which can significantly affect the sensory quality attributes of peanut butter.
  • 1.6K
  • 22 Dec 2022
Topic Review
Metformin and Polycystic Ovary Syndrome
Metformin (MF), a first-line drug to treat type 2 diabetes mellitus (T2DM), alone and in combination with other drugs, restores the ovarian function in women with polycystic ovary syndrome (PCOS) and improves fetal development, pregnancy outcomes and offspring health in gestational diabetes mellitus (GDM) and T2DM.
  • 1.6K
  • 23 Aug 2023
Topic Review
Aspartame Safety as a Food Sweetener
Aspartame is the methyl-ester of the aspartate-phenylalanine dipeptide. Over time, it has become a very popular artificial sweetener. However, since its approval by the main food safety agencies, several concerns have been raised related to neuropsychiatric effects and neurotoxicity due to its ability to activate glutamate receptors, as well as carcinogenic risks due to the increased production of reactive oxygen species. 
  • 1.6K
  • 13 Sep 2023
  • Page
  • of
  • 2800
Featured Entry Collections
>>

Featured Reprints

>>
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Medieval Royal Iconography
Academic Video Service
Feedback