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Topic Review
Paradigm Shift for Transition to Sustainable Urban Transport
The traffic-engineering methods of planning based on the predict-and-provide principle have self-enforcing effects of induced traffic and an unhealthy environment for humans as well as for the planet. Regardless of the huge negative effects and the recognition that a paradigm shift is emerging as the sum of methods and achievements developed by the community of academics, experts, practitioners, policymakers, and urban communities. Findings can have practical, effective implications as the determinants of a new transport policy paradigm that shows the way out of the trap of path dependency. The originality of the approach lies in having expanded and applied the concept of anomalies of the theory to the adverse effects of technologies and the mismatch between people and the modern urban environment. 
  • 1.6K
  • 14 Mar 2022
Topic Review
Osgood-Schlatter Disease
Osgood-Schlatter disease is the most common osteochondritis of the lower limb in sport-practicing children and adolescents. Its manifestation usually coincides with the appearance of the secondary ossification center of the tibia and is linked to the practice of sports with an explosive component. 
  • 1.6K
  • 08 Jun 2022
Topic Review
Regulation of Mitochondrial Ca2+
Mitochondria, as the main site of cellular energy metabolism and the generation of oxygen free radicals, are the key switch for mitochondria-mediated endogenous apoptosis. Ca2+ is not only an important messenger for cell proliferation, but it is also an indispensable signal for cell death. Ca2+ participates in and plays a crucial role in the energy metabolism, physiology, and pathology of mitochondria. Mitochondria control the uptake and release of Ca2+ through channels/transporters, such as the mitochondrial calcium uniporter (MCU), and influence the concentration of Ca2+ in both mitochondria and cytoplasm, thereby regulating cellular Ca2+ homeostasis. Mitochondrial Ca2+ transport-related processes are involved in important biological processes of tumor cells including proliferation, metabolism, and apoptosis.
  • 1.6K
  • 30 Jun 2022
Topic Review
Effects of Particulate Matter on Inflammation and Thrombosis
Ambient air pollution has become a common problem worldwide. Exposure to pollutant particles causes many health conditions, having a particular impact on pulmonary and cardiovascular disease. Increased understanding of the pathological processes related to these conditions may facilitate the prevention of the adverse impact of air pollution on our physical health. 
  • 1.6K
  • 04 Aug 2022
Topic Review
Timeline of Telescope Technology
The following timeline lists the significant events in the invention and development of the telescope.
  • 1.6K
  • 18 Nov 2022
Biography
Harold Arlin
Template:Infobox presenter Harold Wampler Arlin (December 8, 1895[1]–March 14, 1986) was an American engineer and foreman and was arguably the world's first full-time and salaried announcer in broadcast radio.[2][3] Arlin originally worked as an engineer and later foreman for the Westinghouse Electric and Manufacturing Company when he was hired as a part-time announcer by KDKA, the nation's
  • 1.6K
  • 08 Dec 2022
Topic Review
Crop Resilience to Drought Stress
Among all the abiotic factors, drought is likely to have one of the most detrimental effects on soil organisms and plants. Drought is a major problem for crops because it limits the availability of water, and consequently nutrients which are crucial for plant growth and survival. This results in reduced crop yields, stunted growth, and even plant death, according to the severity and duration of the drought, the plant’s developmental stage, and the plant’s genetic background. The ability to withstand drought is a highly complex characteristic that is controlled by multiple genes, making it one of the most challenging attributes to study, classify, and improve.
  • 1.6K
  • 21 Jun 2023
Topic Review
Respiratory System and its Microbiome
Several studies suggest the importance of preserving the micro-ecosystem of commensal, symbiotic and pathogenic microbes of the respiratory system, and, more recently, its relationship with the intestinal microbiome. However, recent studies investigate how it leads to the maintenance of human health, also in relation to some factors such as the effect of age, diet and others, making its composition and stability better understood.  
  • 1.6K
  • 09 Nov 2020
Topic Review
Diabetic Cardiac Fibroblast Phenotype
Diabetic cardiomyopathy involves remodeling of the heart in response to diabetes that includes microvascular damage, cardiomyocyte hypertrophy, and cardiac fibrosis. Cardiac fibrosis is a major contributor to diastolic dysfunction that can ultimately result in heart failure with preserved ejection fraction. Under high glucose conditions cardiac fibroblasts, the final effector cell in the process of cardiac fibrosis, respond by making increased amounts of extracellular matrix. This process involves multiple molecular pathways.
  • 1.6K
  • 27 Oct 2020
Topic Review
Hepatitis C Virus
HCV leads to chronic infection in many patients that may progress to liver cirrhosis and hepatocellular carcinoma (HCC). The interferon (IFN) response is a critical component of the antiviral innate immune response against HCV infection. IFN signaling promotes the expression of many factors that can block the viral replication cycle. These IFN-induced antiviral factors can act at every level of HCV infection by decreasing viral entry, replication, transcription, translation, packaging and release. However, the antiviral state can generate significant collateral damage to the cell, requiring very tight control over the magnitude and duration of the IFN response. This is partially achieved through IFN-mediated negative self-regulation that helps in the termination of the IFN response and the return to homeostasis. However, these negative regulatory mechanisms can be hijacked by HCV to increase viral replication and promote productive infections.
  • 1.6K
  • 28 Oct 2020
Topic Review
Diet: DNA Methylation and Cancer
Cancer initiation and progression is an accumulation of genetic and epigenetic modifications. DNA methylation is a common epigenetic modification that regulates gene expression, and aberrant DNA methylation patterns are considered a hallmark of cancer. The human diet is a source of micronutrients, bioactive molecules, and mycotoxins that have the ability to alter DNA methylation patterns and are thus a contributing factor for both the prevention and onset of cancer. In this review, we summarize the literature on dietary micronutrients, bioactive compounds, and food-borne mycotoxins that affect DNA methylation patterns and identify their potential in the onset and treatment of cancer.
  • 1.6K
  • 09 Oct 2020
Topic Review
Oral Bacteria and OSCC
Oral squamous cell carcinoma (OSCC) is an invasive epithelial neoplasm that is influenced by various risk factors, with a low survival rate and an increasing death rate. In the past few years, with the verification of the close relationship between different types of cancers and the microbiome, research has focused on the compositional changes of oral bacteria and their role in OSCC. Generally, oral bacteria can participate in OSCC development by promoting cell proliferation and angiogenesis, influencing normal apoptosis, facilitating invasion and metastasis, and assisting cancer stem cells. The study findings on the association between oral bacteria and OSCC may provide new insight into methods for early diagnosis and treatment development. 
  • 1.6K
  • 02 Nov 2020
Topic Review
Type I Interferons
Interferons (IFNs) are a heterogenous group of proteins that can be classified into three families (Type I, II, and III) based on distinct functions and characteristics. The family of human type I IFN is composed of 5 subgroups: IFN-α, -β, -κ, -ε, and -ω, whereas the type II IFN group only contains IFN-γ. Type III IFNs are composed of four IFN-λ proteins.
  • 1.6K
  • 06 Mar 2021
Topic Review
HBV
Hepatitis B virus (HBV) infection is the major risk factor for hepatocellular carcinoma (HCC). Understanding the unique features for HBV-induced HCC can shed new light on the unmet needs in its early diagnosis and effective therapy. During decades of chronic hepatitis B, hepatocytes undergoing repeated damage and regeneration accumulate genetic changes predisposing to HCC development. In addition to traditional mutations in viral and cellular oncogenes, HBV integration into the cell chromosomes is an alternative genetic change contributing to hepatocarcinogenesis. A striking male dominance in HBV-related HCC further highlights an interaction between androgen sex hormone and viral factors, which contributes to the gender difference via stimulating viral replication and activation of oncogenes preferentially in male patients. Meanwhile, a novel circulating tumor biomarker generated by HBV integration shows great potential for the early diagnosis of HCC. These unique HBV-induced hepatocarcinogenic mechanisms provide new insights for the future development of superior diagnosis and treatment strategies. 
  • 1.6K
  • 15 Jun 2021
Topic Review
Valuable Organic Acids
A ruminant-based carboxylate platform based on mixed or undefined anaerobic co-cultures of rumen microorganisms can convert the carbohydrate polymers in the lignocellulosic part of organic waste streams to carboxylic acids that can be upgraded to biofuels or green chemicals.
  • 1.6K
  • 27 Sep 2021
Topic Review
Acne Inversa
Acne inversa, namely, Hidradenitis suppurativa (HS), is a chronic inflammatory skin disease affecting ~1% of the global population. HS typically occurs after puberty, with the average age of onset in the second or third decades of life and with a female predominance. Approximately one third of patients are genetically predisposed. Moreover, lifestyle factors, such as smoking and obesity, play a crucial role in the clinical course of HS.
  • 1.6K
  • 29 Sep 2021
Topic Review
Urban Heat Island Analysis
Urban Heat Island （UHI ) studies have been conducted for over 200 years, since the first conceptualization by Luke Howard in 1818. Generally, an urban heat island (UHI) is an urban area or metropolitan area that is significantly warmer than its surrounding rural areas because of human activities. The temperature difference is usually greater at night than during the day and is most apparent when winds are weak.
  • 1.6K
  • 08 Dec 2021
Topic Review
Edible Aquatic Insects: Diversities, Nutrition, and Safety
Edible insects have great potential to be human food; among them, aquatic insects have unique characteristics. In contrast with the role of plant feeders that most terrestrial edible insect species play, most aquatic edible insects are carnivorous animals. Besides the differences in physiology and metabolism, there are differences in fat, fatty acid, limiting/flavor amino acid, and mineral element contents between terrestrial and aquatic insects.
  • 1.6K
  • 04 Jan 2022
Topic Review
Snow Leopard Landscapes
High Asia, the high-altitude habitat of the snow leopard (Panthera uncia), covers the mountainous regions of Asia’s twelve countries, including Afghanistan, Bhutan, China, India, Kazakhstan, Kyrgyzstan, Mongolia, Nepal, Pakistan, Russia, Tajikistan, and Uzbekistan. The transboundary landscape occupied by snow leopards covers an area of about 3.0247 million square kilometers. China possesses about 60% of the global snow leopard landscape, and China shares its border with 10 (the only exception being Uzbekistan) out of the total 12 snow leopard range countries. The snow leopard is an umbrella species from the high-altitude transboundary Asian regions. It is a threatened carnivore of an elusive and secretive nature. Globally, the population of snow leopards is estimated to be 4500–7500 animals in the wild.
  • 1.6K
  • 14 Feb 2022
Topic Review
Biotechnological Approaches for Production of Artemisinin
Medicinal plants have long been a component of human civilization. Plants are utilized to heal ailments and have saved people from countless pandemics, according to Ayurvedic writings and kindred scriptures. Medicinal plants are high in pharmacologically significant bioactive chemicals that define the plant’s medicinal properties. Artemisinin is one such medicinally important metabolite derived principally from the aerial parts of the medicinal herb Artemisia annua (L.). Artemisinin is a sesquiterpene lactone molecule with an endoperoxide structure that has anti-malarial properties. A. annua is a member of the Asteraceae family that grows in tropical and subtropical climates. The plant is native to China and it is known as qinghao, commonly called sweet annie and worm wood in English. The plant is recorded in ancient Chinese texts as being used to cure fevers
  • 1.6K
  • 30 May 2022
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