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Topic Review
Lide 1993, p. 11-217.
Friday the 13th is considered an unlucky day in Western superstition. It occurs when the 13th day of the month in the Gregorian calendar falls on a Friday, which happens at least once every year but can occur up to three times in the same year—for example, in 2015, Friday the 13th occurred in February, March, and November. 2017 through 2020 will all have two Friday the 13ths each, and the years 2021 and 2022 will both have just one occurrence each. Friday the 13th occurs in any month that begins on a Sunday.
  • 1.6K
  • 26 Oct 2022
Topic Review
Quality Control in the Resistance Spot Welding Process
Resistance spot welding (RSW) is a process characterized by its high speed and adaptability for automation that renders it suitable for mass production. 
  • 1.6K
  • 11 Nov 2022
Biography
Wolfgang Rindler
Wolfgang Rindler (18 May 1924 – 8 February 2019) was a physicist working in the field of General Relativity where he is known for introducing the term "event horizon", Rindler coordinates, and (in collaboration with Roger Penrose) for popularizing the use of spinors in general relativity. An honorary member of the Austrian Academy of Sciences and foreign member of the Accademia delle Scienze d
  • 1.6K
  • 15 Nov 2022
Topic Review
Infrared Thermography in Wildlife Animals under Human Care
Ensuring the welfare of wildlife under human care requires tools to monitor their health and well-being. Infrared thermography is a non-invasive technique for assessing thermal states that measure the radiation emitted from the skin in distinct anatomical areas, known as thermal windows—anatomical regions with abundant capillaries and arteriovenous anastomosis that facilitate heat exchange with the environment.
  • 1.6K
  • 03 Jan 2023
Topic Review
Types of Solution Cocrystallization
Solution crystallization has been used in both batch and continuous modes for industrial crystallization for several decades. Solution cocrystallization is often used on a laboratory scale due to its familiarity, simple design, ease of operation, process monitoring, and control. Solvent selection and the mode of supersaturation generation are the two factors that are crucial at the early stages of solution crystallization. For cocrystallization, the solubility of coformers in a given solvent is key factor in solvent selection. Additionally, other operational parameters such as the crystallizer design, mode of agitation, cooling rate/antisolvent addition rate, seeding, or nucleation control can impact final crystal properties such as shape, size, and desired polymorphic.
  • 1.6K
  • 25 Jun 2023
Topic Review
Biofilms on Medical Devices
Biofilm is complex and consists of bacterial colonies that reside in an exopolysaccharide matrix that attaches to foreign surfaces in a living organism. Biofilm frequently leads to nosocomial, chronic infections in clinical settings. Since the bacteria in the biofilm have developed antibiotic resistance, using antibiotics alone to treat infections brought on by biofilm is ineffective. 
  • 1.6K
  • 06 Jul 2023
Topic Review
Gas-Sensing Mechanisms of MXenes and MXene-Based Heterostructures
MXenes are a class of 2D transition-metal carbides, nitrides, and carbonitrides with exceptional properties, including substantial electrical and thermal conductivities, outstanding mechanical strength, and a considerable surface area, rendering them an appealing choice for gas sensors. 
  • 1.6K
  • 08 Dec 2023
Topic Review
Yao Syndrome
Yao syndrome (formerly called NOD2-associated autoinflammatory disease) is a disorder involving episodes of fever and abnormal inflammation affecting many parts of the body, particularly the skin, joints, and gastrointestinal system.
  • 1.6K
  • 24 Dec 2020
Topic Review
Cholinergic Signaling and Epilepsy
Epilepsy is a common brain disorder characterized by recurrent epileptic seizures with neuronal hyperexcitability. Apart from the classical imbalance between excitatory glutamatergic transmission and inhibitory γ-aminobutyric acidergic transmission, cumulative evidence suggest that cholinergic signaling is crucially involved in the modulation of neural excitability and epilepsy.
  • 1.6K
  • 07 May 2021
Topic Review
Blockchain-Based Energy-Trading Systems
Blockchain is the underlying technology of cryptocurrencies, but they provide many other application areas, such as reliable machine-to-machine automatic transactions, including auctions, bidding, and payments. Nowadays, many researchers use blockchain in different electric vehicles’ transportation systems, such as payment systems, charging systems, and energy trading systems.
  • 1.6K
  • 26 Aug 2021
Topic Review
Neurotoxicity in Acute Lymphoblastic Leukemia Treatment
Immunotherapy is a milestone in the treatment of poor-prognosis pediatric acute lymphoblastic leukemia (ALL) and is expected to improve treatment outcomes and reduce doses of conventional chemotherapy without compromising the effectiveness of the therapy. However, both chemotherapy and immunotherapy cause side effects, including neurological ones. 
  • 1.6K
  • 17 May 2022
Topic Review
Oxidative Stress and Therapy in Sickle Cell Disease
Sickle cell disease (SCD) is the most common hereditary disorder of hemoglobin (Hb), which affects approximately a million people worldwide. It is characterized by a single nucleotide substitution in the β-globin gene, leading to the production of abnormal sickle hemoglobin (HbS) with multi-system consequences. HbS polymerization is the primary event in SCD. Repeated polymerization and depolymerization of Hb causes oxidative stress that plays a key role in the pathophysiology of hemolysis, vessel occlusion and the following organ damage in sickle cell patients. For this reason, reactive oxidizing species and the (end)-products of their oxidative reactions have been proposed as markers of both tissue pro-oxidant status and disease severity. Although more studies are needed to clarify their role, antioxidant agents have been shown to be effective in reducing pathological consequences of the disease by preventing oxidative damage in SCD, i.e., by decreasing the oxidant formation or repairing the induced damage. 
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  • 31 May 2022
Topic Review
Sodium Channels in Action Potentials Initiation
Living organisms react to external stimuli to adapt their activity to the environment for survival. Acquired information is encoded by neurons by action potentials (APs) in a series of discrete electrical events. Rapid initiation of the AP is critical for fast reactions and strongly relies on voltage-activated Na+-selective channels (NaVs), which are widely expressed by both invertebrate and vertebrate neurons.
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  • 02 Sep 2022
Topic Review
Shambhala Training
Shambhala Training is a secular approach to meditation developed by Tibetan Buddhist teacher Chogyam Trungpa and his students. It is based on what Trungpa calls Shambhala Vision, which sees enlightened society as not purely mythical, but as realizable by people of all faiths through practices of mindfulness/awareness, non-aggression, and sacred outlook. He writes: The Shambhala Training teachings cover art, society, and politics and the goal of creating an enlightened society. That goal is presented as not solely a social and political process, but one requiring individuals to develop an awareness of the basic goodness and inherent dignity of themselves, of others, and of the everyday details of the world around them. This is facilitated by cultivating gentleness and bravery. Shambhala Training is currently administered worldwide by Shambhala International. The Satdharma community offers a comparable "Shambhala Education" course of training in Ojai, California.
  • 1.6K
  • 01 Nov 2022
Topic Review
Electrochemical Biosensors for Pathogen Detection
Electrochemical biosensors are a family of biosensors that use an electrochemical transducer to perform their functions. In recent decades, many electrochemical biosensors have been created for pathogen detection. These biosensors for detecting infections have been comprehensively studied in terms of transduction elements, biorecognition components, and electrochemical methods. The integration of transducers and electrode changes in biosensor design is a major discussion topic. Pathogen detection methods can be categorized by sample preparation and secondary binding processes. Diagnostics in medicine, environmental monitoring, and biothreat detection can benefit from electrochemical biosensors to ensure food and water safety.
  • 1.6K
  • 02 Nov 2022
Topic Review
Microencapsulation of Fish Oil and Natural Extracts
Microencapsulation technology arose in the 1950s from the development of dye capsules to be incorporated into paper. Microencapsulation can be defined as a set of technologies aiming to protect sensitive compounds from the external environment and further control their release. For that, the labile compounds, constituting what is known as the core, are entrapped by being surrounded by a shell material (the wall). Microencapsulation has been mainly applied in the pharmaceutical industry, followed in decreasing order by food, cosmetic, textile, biomedical, agricultural and electronic sectors. The recent developments in the microencapsulation of fish oil and natural antioxidant compounds are described. 
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  • 08 Nov 2022
Topic Review
Additive Manufacturing of Intermetallic Alloys Based on Ti2AlNb
Titanium alloys based on orthorhombic titanium aluminide Ti2AlNb are promising refractory materials for aircraft engine parts in the operating temperature range from 600–700 °C. Parts made of Ti2AlNb-based alloys by traditional technologies, such as casting and metal forming, have not yet found wide application due to the sensitivity of processability and mechanical properties in chemical composition and microstructure compared with commercial solid-solution-based titanium alloys. Metal additive manufacturing (MAM) has attracted the attention of scientists and engineers for the production of intermetallic alloys based on Ti2AlNb. 
  • 1.6K
  • 23 Feb 2023
Topic Review
Serious Games and LEGO Serious Play for Scrum
As evidenced by recent literature reviews, virtual reality is being widely used for educational purposes in many knowledge fields and industrial sectors because this technology contributes to improve knowledge acquisition and skills development, engages and motivates learners, and enhances the whole learning experience.
  • 1.6K
  • 25 Jan 2024
Topic Review
Pyrometallurgical Processes
The EU steel industry accounts for a crude steel production of 140 Mt/y, provided by the integrated (57%) and electric (43%) routes, which respectively require up to 6.0 and 0.6 MWh/tCrudeSteel of energy input, and emits on average 1.85 and 0.4 tCO2/tCrudeSteel. The mitigation of such CO2 emissions is crucial, and would involve the direct avoidance of carbon, improvement of energy efficiency, and carbon capture. However, the environmental burden of the steel industry cannot be limited to this, given the very large amount (approximately 5 Mt) of residues landfilled every year in the EU. This practice cannot be sustained anymore, since it represents a detrimental waste of resources and burden to the environment. These aspects require prompt action to meet the Green Deal goals envisioned for 2030. 
  • 1.6K
  • 22 Feb 2024
Topic Review
HSP in Diabetes and Alzheimer
Type 2 diabetes (T2D) and Alzheimer’s disease (AD) are growing in prevalence worldwide. The development of T2D increases the risk of AD disease, while AD patients can show glucose imbalance due to an increased insulin resistance. T2D and AD share similar pathological features and underlying mechanisms, including the deposition of amyloidogenic peptides in pancreatic islets (i.e., islet amyloid polypeptide; IAPP) and brain (β-Amyloid; Aβ). Both IAPP and Aβ can undergo misfolding and aggregation and accumulate in the extracellular space of their respective tissues of origin. As a main response to protein misfolding, there is evidence of the role of heat shock proteins (HSPs) in moderating T2D and AD. HSPs play a pivotal role in cell homeostasis by providing cytoprotection during acute and chronic metabolic stresses. In T2D and AD, intracellular HSP (iHSP) levels are reduced, potentially due to the ability of the cell to export HSPs to the extracellular space (eHSP). The increase in eHSPs can contribute to oxidative damage and is associated with various pro-inflammatory pathways in T2D and AD.
  • 1.6K
  • 27 Jan 2021
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