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Topic Review
Sulfated Polysaccharides from Seaweeds
Sulfated polysaccharides derived from seaweeds, considered a potential source of bioactive compounds for drug development, have shown antiviral activity against a broad spectrum of viruses, mainly including common DNA viruses and RNA viruses. In addition, sulfated polysaccharides can also improve the body’s immunity. Sulfated polysaccharides from seaweeds, including carrageenan, galactan, fucoidan, alginate, ulvan, p-KG03, naviculan, and calcium spirulan, may provide new ideas for the development of COVID-19 therapeutics and vaccines.
  • 1.6K
  • 16 May 2022
Topic Review
Physical and Mental Health Impacts of Nitrogen Oxide
Nitrogen oxides (NOx) are gaseous pollutants contributing to pollution in their primary form and are also involved in reactions forming ground-level ozone and fine particulate matter. Thus, NOx is of great interest for targeted pollution reduction because of this cascade effect. To achieve a holistic understanding of the correlation between NOx and human health, both the physical and mental health implications must be accounted for. The following content is intended to be illustrative in nature, and not exhaustive of all research conducted in the field. 
  • 1.6K
  • 24 Jun 2022
Topic Review
Emotion Regulation and Sleep
Emotion regulation refers to the process by which an individual influences the nature of his or her emotions and how emotions are experienced and expressed. Sleep deprivation may even impede the effectiveness of adaptive emotion regulation, such as distraction and cognitive reappraisal, consequently impacting emotional well-being.
  • 1.6K
  • 05 Jul 2022
Topic Review
Monoclonal Antibodies for Acute Myeloid Leukemia/Myelodysplastic Syndromes
Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) represent an unmet clinical need whose prognosis is still dismal. Alterations of immune response play a prominent role in AML/MDS pathogenesis, revealing novel options for immunotherapy. Among immune system regulators, CD47, immune checkpoints, and toll-like receptor 2 (TLR2) are major targets. Magrolimab antagonizes CD47, which is overexpressed by AML and MDS cells, thus inducing macrophage phagocytosis with clinical activity in AML/MDS. Sabatolimab, an inhibitor of T-cell immunoglobulin and mucin domain-containing protein 3 (TIM3), which disrupts its binding to galectin-9, has shown promising results in AML/MDS, enhancing the effector functions of lymphocytes and triggering tumor cell death. Several other surface molecules, namely CD33, CD123, CD45, and CD70, can be targeted with monoclonal antibodies (mAbs) that exert different mechanisms of action and include naked and conjugated antibodies, bispecific T-cell engagers, trispecific killer engagers, and fusion proteins linked to toxins. 
  • 1.6K
  • 20 Jul 2022
Topic Review
Effects of Heat Stress on Livestock
Climate change is receiving more consideration worldwide, and the impact on animal production is particularly relevant due to increasing demand and limitations to production. When predicted temperature/humidity increases as a result of climate change are added, the proportion of time that they are exposed to heat stress becomes more severe. It was concluded that the effects of heat stress are becoming critical for livestock production systems, especially during summer. Livestock responds to these changes by using different mechanisms to survive, but production efficiency is severely compromised by heat stress. Injury and death may even ensue if mitigation measures are not taken quickly. 
  • 1.6K
  • 05 Aug 2022
Topic Review
Cardiogenic Shock Complicating Acute Myocardial Infarction
Cardiogenic shock complicating acute myocardial infarction is a complex clinical condition associated with dismal prognosis. Routine early target vessel revascularization remains the most effective treatment to substantially improve outcomes, but mortality remains high. Temporary circulatory support devices have emerged with the aim to enhance cardiac unloading and improve end-organ perfusion.
  • 1.6K
  • 21 Sep 2022
Topic Review
IBM Spectrum Control
IBM Spectrum Control formerly known as Tivoli Storage Productivity Center (TPC) is a Storage Resource Management (SRM) software offering that provides a centralized point of control for managing large-scale, complex heterogeneous storage environments. IBM Tivoli Storage Productivity Center V5.2.x (5608-PC1) was renamed in V5.2.8 to IBM Spectrum Control Standard Edition V5.2.x (5608-PC1).
  • 1.6K
  • 17 Oct 2022
Topic Review
Important Plant Viruses for Plant Biotechnology
Plant viruses have traditionally been studied as pathogens in the context of understanding the molecular and cellular mechanisms of a particular disease affecting crops. In recent years, viruses have emerged as a new alternative for producing biological nanomaterials and chimeric vaccines. Plant viruses were also used to generate highly efficient expression vectors, revolutionizing plant molecular farming (PMF). 
  • 1.6K
  • 18 Jan 2023
Topic Review
Silkworm Bombyx mori
Among insects, the silkworm Bombyx mori occupies a special position, being an excellent lepidopteran species representative of numerous scientific investigations. B. mori was domesticated and developed by human-driven selection from a wild origin since ancient times. Many years ago, silkworm genetic stocks were conserved in research facilitie. The silkworm can be considered from the economic point of view to be one of the most significant insects. It has been providing important benefits to humans, and it has continued developing thanks to its many practical applications, including using it as a model organism for medical purposes.
  • 1.6K
  • 20 Jun 2023
Topic Review
Benchmarking Message Queues
Message queues are a way for different software components or applications to communicate with each other asynchronously by passing messages through a shared buffer. This allows a sender to send a message without needing to wait for an immediate response from the receiver, which can help to improve the system’s performance, reduce latency, and allow components to operate independently. The performance of four popular message queues: Redis, ActiveMQ Artemis, RabbitMQ, and Apache Kafka was compared.
  • 1.6K
  • 24 Jul 2023
Topic Review
Artifact Recovery from Social Media Platforms
Social media applications have been ubiquitous in modern society, and their usage has grown exponentially over the years. With the widespread adoption of these platforms, social media has evolved into a significant origin of digital evidence in the domain of digital forensics.
  • 1.6K
  • 05 Dec 2023
Topic Review
Sex differences in umbilical cord
Biological differences between sexes should be considered in all stages of research, but there is still a lack of stratification by sex despite primary cultured cells retain memory of the sex and of the donor. The sex of donors in biological research must be known because variations in cells and cellular components can be used as end points, biomarkers and/or targets of pharmacological studies. This selective review focuses on the current findings regarding sex differences observed in the umbilical cord, a widely used source of research samples, both in the blood and in the circulating cells, as well as in the different cellular models obtainable from it. Moreover, an overview on sex differences in fetal programming is reported. As it emerges that the sex variable is still often forgotten in experimental models, we suggest that should be mandatory to adopt a sex oriented research, because only awareness of these issues can lead to innovative research.
  • 1.6K
  • 27 Jan 2021
Topic Review
Super-Resolution Microscopy
SRM comprises optical imaging techniques that offer resolution beyond the diffraction limit of light (~250 nm).
  • 1.6K
  • 10 Feb 2021
Topic Review
Data Fusion in Agriculture
The term “data fusion” can be defined as “the process of combining data from multiple sources to produce more accurate, consistent, and concise information than that provided by any individual data source”. Other stricter definitions do exist to better fit narrower contexts. This type of approach has been applied to agricultural problems since the first half of the 1990s, and there has been an increase in the use of this approach. Arguably, the main challenge involved in the use of data fusion techniques involves finding the best approach to fully explore the synergy and complementarities that potentially exist between different types of data and data sources.
  • 1.6K
  • 07 Apr 2022
Topic Review
Next-Generation Gingival Graft Substitutes
There is a shortage of suitable tissue-engineered solutions for gingival recession, a soft tissue defect of the oral cavity. Autologous tissue grafts lead to an increase in morbidity due to complications at the donor site. Although material substitutes are available on the market, their development is early, and work to produce more functional material substitutes is underway. The latter materials along with newly conceived tissue-engineered substitutes must maintain volumetric form over time and have advantageous mechanical and biological characteristics facilitating the regeneration of functional gingival tissue.
  • 1.6K
  • 17 May 2022
Topic Review
Calcium and Vitamin D Supplementation for Periodontal Disease
Periodontal disease is a complex disease that involves an imbalance between the oral microbiota and an individual’s inflammatory response. Moreover, the inflammatory response contributes to further imbalance; if left untreated, periodontal disease may result in tooth loss. Vitamin D is intricately involved in the regulation of calcium–phosphate homeostasis and bone mineral metabolism; considering that periodontal surgery usually includes regenerative therapy, adequate vitamin D and calcium levels are essential.
  • 1.6K
  • 19 Jul 2022
Topic Review
Elite Rhizobia Strains in Africa
Grain legumes play a significant role in smallholder farming systems in Africa because of their contribution to nutrition and income security and their role in fixing nitrogen. Biological Nitrogen Fixation (BNF) serves a critical role in improving soil fertility for legumes. Dinitrogen can be reduced to ammonium (NH3) through the Haber–Bosch process or via biological nitrogen fixation (BNF) utilizing some soil bacteria or archaea (diazotrophs). Rhizobia belong to Alphaproteobacteria and Betaproteobacteria, a group of Gram-negative bacteria that forms nodules on roots (sometimes stems) of leguminous plants to fix nitrogen in a symbiotic relationship with their host plants. The rhizobia–legume symbiosis is the most studied plant–microbial mutualism because of the importance of nitrogen fixation for almost all agricultural systems.
  • 1.6K
  • 21 Jul 2022
Topic Review
Neuroprotective Role of Lactoferrin during Early Brain Development
Early adverse fetal environments can significantly disturb central nervous system (CNS) development and subsequently alter brain maturation. Nutritional status is a major variable to be considered during development and increasing evidence links neonate and preterm infant impaired brain growth with neurological and psychiatric diseases in adulthood. Breastfeeding is one of the main components required for healthy newborn development due to the many “constitutive” elements breastmilk contains. Maternal intake of specific nutrients during lactation may alter milk composition, thus affecting newborn nutrition and, potentially, brain development. Lactoferrin (Lf) is a major protein present in colostrum and the main protein in human milk, which plays an important role in the benefits of breastfeeding during postnatal development. It has been demonstrated that Lf has antimicrobial, as well as anti-inflammatory properties, and is potentially able to reduce the incidence of sepsis and necrotizing enterocolitis (NEC), which are particularly frequent in premature births. The anti-inflammatory effects of Lf can reduce birth-related pathologies by decreasing the release of pro-inflammatory factors and inhibiting premature cervix maturation (also related to commensal microbiome abnormalities) that could contribute to disrupting brain development. Pre-clinical evidence shows that Lf protects the developing brain from neuronal injury, enhances brain connectivity and neurotrophins production, and decreases inflammation in models of perinatal inflammatory challenge, intrauterine growth restriction (IUGR) and neonatal hypoxia-ischemia (HI). Lactoferrin has also been considered a potential biomarker of neurodegeneration and its mechanisms of action make it a good candidate to be tested in the prevention of neurodegenerative diseases.
  • 1.6K
  • 08 Aug 2022
Topic Review
Seductive Details
Seductive details are often used in textbooks, lectures, slideshows, and other forms of educational content to make a course more interesting or interactive. Seductive details can take the form of text, animations, photos, illustrations, sounds or music and are by definition: (1) interesting and (2) not directed toward the learning objectives of a lesson. John Dewey, in 1913, first referred to this as “fictitious inducements to attention.” While illustrated text can enhance comprehension, illustrations that are not relevant can lead to poor learning outcomes. Since the late 1980s, many studies in the field of educational psychology have shown that the addition of seductive details results in poorer retention of information and transfer of learning. Thalheimer conducted a meta-analysis that found, overall, a negative impact for the inclusion of seductive details such as text, photos or illustrations, and sounds or music in learning content. More recently, a 2020 paper found a similar effect for decorative animations This reduction to learning is called the seductive details effect. There have been criticisms of this theory. Critics cite unconvincing and contradictory evidence to argue that seductive details do not always impede understanding and that seductive details can sometimes be motivating for learners.
  • 1.6K
  • 11 Oct 2022
Topic Review
Carbon Dots Composites
Among carbon-based nanomaterials, carbon dots (CDs) have received a surge of interest in recent years due to their attractive features such as tunable photoluminescence, cost effectiveness, nontoxic renewable resources, quick and direct reactions, chemical and superior water solubility, good cell-membrane permeability, and simple operation. CDs and their composites have a large potential for sensing contaminants present in physical systems such as water resources as well as biological systems. Tuning the properties of CDs is a very important subject.
  • 1.6K
  • 17 Oct 2022
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