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Topic Review
Bacterial Ghosts-Based Vaccine
Bacterial ghosts (BGs) are empty bacterial envelopes of Gram-negative bacteria produced by controlled expressions of cloned gene E, forming a lysis tunnel structure within the envelope of the living bacteria.
  • 1.6K
  • 22 Dec 2021
Topic Review
Waste Heat Recovery Technologies Revisited with New Solutions
Waste heat recovery (WHR) has been a challenge for industries, as it can lead to energy savings, higher energy efficiency, and sustainability. WHR technologies are usually classified based on the output provided, namely heat recovery (HR) or heat-to-power (H2P) conversion. 
  • 1.6K
  • 18 Jan 2022
Topic Review
Herman Cain
Herman Cain (born December 13, 1945) is an American politician, business executive, syndicated columnist, and Tea Party activist from Georgia. Cain grew up in Georgia and graduated from Morehouse College in 1967 with a Bachelor of Science in Mathematics. He pursued graduate studies at Purdue University and graduated with a Master of Science in Computer Science in 1971, while also working full-time for the U.S. Department of the Navy. In 1977, he joined the Pillsbury Company in Minneapolis where he later became vice president. During the 1980s, Cain's success as a business executive at Burger King prompted Pillsbury to appoint him as chairman and CEO of Godfather's Pizza, in which capacity he served from 1986 to 1996. Cain was chairman of the Federal Reserve Bank of Kansas City Omaha Branch from 1989 to 1991. He was deputy chairman, from 1992 to 1994, and then chairman until 1996, of the Federal Reserve Bank of Kansas City. In 1995, he was appointed to the Kemp Commission, and in 1996, he served as a senior economic adviser to Bob Dole's presidential campaign. Cain became the CEO of the National Restaurant Association, in which he served as president and CEO from 1996 to 1999. In May 2011, Cain announced his presidential candidacy. By the fall, his proposed 9–9–9 tax plan and debating performances had made him a serious contender for the Republican nomination. In November, however, his campaign faced five allegations of sexual misconduct—all denied by Cain—and he announced its suspension on December 3. In April 2019, Cain was considered by President Donald Trump for a vacancy on the Federal Reserve Board before withdrawing his name the same month.
  • 1.6K
  • 19 Oct 2022
Topic Review
Salmonella Biofilm Formation Process
Salmonella can form biofilms that contribute to its resistance in food processing environments. Biofilms are a dense population of cells that adhere to the surface, creating a matrix composed of extracellular polymeric substances (EPS) consisting mainly of polysaccharides, proteins, and extracellular DNA (eDNA). 
  • 1.6K
  • 13 Jan 2023
Topic Review
Deubiquitinase (DUB)
Ubiquitination is one of the most important regulatory machinery of post-translational modification of intracellular proteins. The cellular reversible ubiquitination regulatory machinery consisting of ubiquitinating cassette and deubiquitinating enzymes can change intracellular homeostasis to modulate cell fate. Modifiers involved in these regulations include monomers of ubiquitin (Ub), homopolymeric and heteropolymeric Ub chains. Ub protein, is a highly conserved small protein consisting of 76 amino acids throughout eukaryotes.
  • 1.6K
  • 01 Nov 2020
Topic Review
Crystallization Phase-Transition Processes Real-Time Observation
We have used the fluorescence detection of phase transformation dynamics of organic compounds by photochemical methods to observe a real-time symmetry breaking process. The organic fluorescent molecules vary the fluorescence spectra depending on molecular aggregated states, implying fluorescence spectroscopy can be applied to probe the evolution of the molecular-assembling process. As an example, the amorphous-to-crystal phase transformation and crystallization with symmetry breaking at droplet during the solvent evaporation of mechanofluorochromic molecules are represented in this review.
  • 1.6K
  • 11 Nov 2020
Topic Review
Thymoquinone
Thymoquinone (TQ), the chief active constituent of Nigella sativa (NS), shows very valuable biomedical properties such as antioxidant, antimicrobial, anticancer, anti-inflammatory, antihypertensive, hypoglycemic, antiparasitic and anti-asthmatic effects. Several studies have examined the pharmacological actions of TQ in the treatment of oral diseases but its potential role in periodontal therapy and regeneration is not yet fully defined.
  • 1.6K
  • 17 Dec 2020
Topic Review
Honey in Reversing Metabolic Syndrome
Honey is a natural by-product from the flower nectar and aerodigestive tract of honey bees, which contains various complex biochemical components. Fructose (36%) and glucose (31%) are the main carbohydrate constituents of honey.
  • 1.6K
  • 18 Mar 2021
Topic Review
Giant Unilamellar Vesicle Electroformation
Since its inception more than thirty years ago, electroformation has become the most commonly used method for growing giant unilamellar vesicles (GUVs). Although the method seems quite straightforward at first, researchers must consider the interplay of a large number of parameters, different lipid compositions, and internal solutions in order to avoid artifactual results or reproducibility problems.
  • 1.6K
  • 23 Nov 2021
Topic Review
Hyaluronan
Hyaluronan (HA) is a major component of the ECM that consists of repeated disaccharide units of N-acetylglucosamine and glucuronic acid. HA is synthesized as a high molecular weight molecule but is degraded into heterogeneous fragments by hyaluronidases and reactive oxygen or nitrogen species. The biological activity of HA depends on its molecular weight. HA fragments stimulate tissue inflammation and fibrosis. In contrast, high molecular weight HA suppresses these processes and maintains tissue homeostasis. This functional duality is particularly important during wound repair where HA sequentially promotes then suppresses inflammation and fibrosis. In contrast, in tumors, HA effects are often co-opted to increase growth and invasion.  
  • 1.6K
  • 29 Nov 2021
Topic Review
Transarterial Chemoembolization for Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. It is principally associated with liver cirrhosis and chronic liver disease. The major risk factors for the development of HCC include viral infections (HBV, HCV), alcoholic liver disease (ALD,) and non-alcoholic fatty liver disease (NAFLD). The optimal treatment choice is dictated by multiple variables such as tumor burden, liver function, and patient’s health status. Surgical resection, transplantation, ablation, transarterial chemoembolization (TACE), and systemic therapy are potentially useful treatment strategies. TACE is considered the first-line treatment for patients with intermediate stage HCC. 
  • 1.6K
  • 24 Mar 2022
Topic Review
Stilbenoids
Stilbenoids are well-known phytoalexins in the group of polyphenolic compounds. Because of their potent bioactivities, including antioxidant, antityrosinase, photoprotective, and antibacterial activities, stilbenoids are utilized as pharmaceutical active ingredient in cosmetic products. Thus, the demand for stilbenoids in the cosmetic industry is increasing. 
  • 1.6K
  • 26 Sep 2022
Topic Review
Methods Used for Activation of Silent Biosynthetic Genes
Antibiotic resistance is becoming a burning issue due to the frequent use of antibiotics for curing common bacterial infections, indicating that we are running out of effective antibiotics. Enhancement of antimicrobial resistance (AMR) is strengthening the pathogenicity and virulence of infectious microbes. Endophytes have shown expression of various new many bioactive compounds with significant biological activities. Specifically, in endophytic fungi, bioactive metabolites with unique skeletons have been identified which could be helpful in the prevention of increasing antimicrobial resistance. The major classes of metabolites reported include anthraquinone, sesquiterpenoid, chromone, xanthone, phenols, quinones, quinolone, piperazine, coumarins and cyclic peptides. Various methods including epigenetic modifications, co-culture, and OSMAC to induce silent gene clusters for the production of noble bioactive compounds in endophytic fungi were discussed.
  • 1.6K
  • 10 Oct 2023
Topic Review
Applications of Sustainable Hybrid Energy Harvesting
The potential usage of self-powered wireless sensor (WSN) systems has drawn a lot of attention to sustainable energy harvesting. Hybrid energy harvesting involves collecting energy from multiple sources and converting it into electrical energy using various transduction mechanisms. By properly integrating different energy conversion technologies, hybridization can significantly increase power outputs and improve space utilization efficiency.
  • 1.6K
  • 28 Nov 2023
Topic Review
Photoplethysmography for the Assessment of Arterial Stiffness
There is growth in assessing arterial stiffness using photoplethysmography (PPG) and propose PPG as a potential tool for assessing vascular ageing in the future. Blood vessels deteriorate with age, losing elasticity and forming deposits. This raises the likelihood of developing cardiovascular disease (CVD), widely reported as the global leading cause of death. The ageing process induces structural modifications in the vascular system, such as increased arterial stiffness, which can cause various volumetric, mechanical, and haemodynamic alterations. Numerous techniques have been investigated to assess arterial stiffness, some of which are currently used in commercial medical devices and some, such as PPG, of which still remain in the research space.
  • 1.6K
  • 26 Dec 2023
Topic Review
Ebola Virus
Viral protein VP24 (VP24) from Ebola virus (EBOV) has been termed the minor matrix protein but its lipid-binding properties have not been investigated. Here, we found that VP24 lacks direct lipid-binding properties regardless of post-translational modification. VP24 interaction with the major matrix protein VP40 and selective plasma membrane localization were not detected, suggesting VP24 biological functions are not likely dependent on direct lipid binding.
  • 1.6K
  • 26 Oct 2020
Topic Review
Transformers Health
Due to the large number of distribution transformers in the distribution grid, the status of distribution transformers plays an important role in ensuring the safe and reliable operation of the these grids. To evaluate the distribution transformer health, many assessment techniques have been studied and developed. These tools will support the transformer operators in predicting the status of the distribution transformer and responding effectively. A group of authors from University of Hawaii at Manoa and University of Palermo have reviewed the literature in the area, analyzed the latest techniques as well as highlighted the advantages and disadvantages of current methodologies. This gives the other researchers an overview of the development process of distribution transformer condition assessment technologies, thereby continuing to develop new effective evaluation techniques.
  • 1.6K
  • 24 Nov 2020
Topic Review
Macrophage Polarization States
The M1/M2 macrophage paradigm plays a key role in tumor progression. M1 macrophages are historically regarded as anti-tumor, while M2-polarized macrophages, commonly deemed tumor-associated macrophages (TAMs), are contributors to many pro-tumorigenic outcomes in cancer through angiogenic and lymphangiogenic regulation, immune suppression, hypoxia induction, tumor cell proliferation, and metastasis.
  • 1.6K
  • 21 Jul 2021
Topic Review
CNS Glial Cells FA Synthesis
The central nervous system (CNS) has an exceptionally high lipid content. The brain contains the highest diversity of lipids than any other organ. Fatty acids (FA) are essential monomeric components that define the structural diversity of lipids and determine their functional properties in the CNS. FAs and their metabolites are critical for brain homeostasis and influence many neural functions, including cell survival, neurogenesis and synaptogenesis. Glial cells are a highly heterogeneous population of cells and predominate the mammalian brain. Astrocytes, oligodendrocytes and microglia are the major types of glial cells in the CNS. Their main function is to sustain a homeostatic environment for neuronal circuits, providing not only structural or trophic support but also controlling neuronal function and plasticity. To do so, glial cells heavily rely on transient and temporal changes in the FA and lipid metabolism.
  • 1.6K
  • 23 Aug 2021
Topic Review
Indirect Structural Muscle Injuries
Indirect structural muscle injuries (commonly referred as “muscle tears”) are the more commonly found in everyday clinical practice and represent the biggest challenge in rehabilitation, since these lack a precise therapeutic strategy. Structural muscle injuries classification is shown in.
  • 1.6K
  • 27 Oct 2021
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