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Topic Review
Pyrido[2,3-d], [3,2-d], [3,4-d] and [4,3-d]pyrimidine Derivatives
The structures composed of a pyridopyrimidine moiety which have shown a therapeutic interest or have already been approved for use as therapeutics, including pyrido[2,3-d]pyrimidines, pyrido[3,4-d]pyrimidines, pyrido[4,3-d]pyrimidines and pyrido[3,2-d]pyrimidines.
  • 6.8K
  • 06 Apr 2022
Topic Review
Pine Ridge Indian Reservation
The Pine Ridge Indian Reservation (Template:Lang-lkt), also called Pine Ridge Agency, is an Oglala Lakota Native American reservation located in the U.S. state of South Dakota. Originally included within the territory of the Great Sioux Reservation, Pine Ridge was created by the Act of March 2, 1889, 25 Stat. 888. in the southwest corner of South Dakota on the Nebraska border. Today it consists of 3,468.85 sq mi (8,984.3 km2) of land area and is the eighth-largest reservation in the United States, larger than Delaware and Rhode Island combined. The reservation encompasses the entirety of Oglala Lakota County and Bennett County, the southern half of Jackson County, and a small section of Sheridan County added by Executive Order No. 2980 of February 20, 1904. Of the 3,142 counties in the United States, these are among the poorest. Only 84,000 acres (340 km2) of land are suitable for agriculture. The 2000 census population of the reservation was 15,521; but a study conducted by Colorado State University and accepted by the United States Department of Housing and Urban Development has estimated the resident population to reach 28,787. Pine Ridge is the site of several events that mark milestones in the history between the Sioux of the area and the United States (U.S.) government. Stronghold Table—a mesa in what is today the Oglala-administered portion of Badlands National Park—was the location of the last of the Ghost Dances. The U.S. authorities' attempt to repress this movement eventually led to the Wounded Knee Massacre on December 29, 1890. A mixed band of Miniconjou Lakota and Hunkpapa Sioux, led by Chief Spotted Elk, sought sanctuary at Pine Ridge after fleeing the Standing Rock Agency, where Sitting Bull had been killed during efforts to arrest him. The families were intercepted by a heavily armed detachment of the Seventh Cavalry, which attacked them, killing many women and children as well as warriors. This was the last large engagement between U.S. forces and Native Americans and marked the end of the western frontier. Changes accumulated in the last quarter of the 20th century; in 1971 the Oglala Sioux Tribe (OST) started Oglala Lakota College, a tribal college, which offers 4-year degrees. In 1973 decades of discontent at the Pine Ridge Reservation resulted in a grassroots protest that escalated into the Wounded Knee Incident, gaining national attention. Members of the Oglala Lakota, the American Indian Movement and supporters occupied the town in defiance of federal and state law enforcement in a protest that turned into an armed standoff lasting 71 days. This event inspired American Indians across the country and gradually led to changes at the reservation, with a revival of some cultural traditions. In 1981 the Lakota Tim Giago started the Lakota Times at Pine Ridge, the first independent Native American newspaper in the nation; he published it until selling it in 1998. Located at the southern end of the Badlands, the reservation is part of the mixed grass prairie, an ecological transition zone between the short-grass and tall-grass prairies; all are part of the Great Plains. A great variety of plant and animal life flourishes on and adjacent to the reservation, including the endangered black-footed ferret. The area is also important in the field of paleontology; it contains deposits of Pierre Shale formed on the seafloor of the Western Interior Seaway, evidence of the marine Cretaceous–Paleogene boundary, and one of the largest deposits of fossils of extinct mammals from the Oligocene epoch.
  • 6.8K
  • 07 Oct 2022
Topic Review
List of Mergers and Acquisitions by IBM
IBM has undergone a large number of mergers and acquisitions during a corporate history lasting over a century; the company has also produced a number of spinoffs during that time. The acquisition date listed is the date of the agreement between IBM and the subject of the acquisition. The value of each acquisition is listed in USD because IBM is based in the United States . If the value of an acquisition is not listed, then it is undisclosed. Many of the companies listed in this article had subsidiaries of their own who had subsidiaries who ... For examples, see Pugh's book Building IBM, page 26.
  • 6.8K
  • 17 Oct 2022
Topic Review
Classification of the Marine Selective Catalytic Reduction Systems
The marine SCR system is mainly composed of a urea solution injection system, mixer, SCR reactor, measurement system, and soot blowing system. The urea solution injection system is composed of a urea storage tank, urea injection pump, nozzle, valve, and pipeline. Additionally, a static mixer is arranged in the exhaust pipe of the marine SCR system to improve the mixing uniformity of exhaust gas and ammonia gas. 
  • 6.8K
  • 18 May 2022
Topic Review
Smart Waste Management and Classification Systems
Waste management requires necessary processes and activities to dominate from its inception to demolition. Waste comes in solid, liquid, or gaseous form, and every type of waste demands a different method of classification, disposal, and management. Waste management deals with every waste category, including household, organic, industrial, municipal, biomedical, organic, biological, and radioactive waste. Any unnecessary substance or substance with no use is called “waste”. Waste management involves the collection of the waste and its transport and disposal to appropriate locations. In the European Union (EUROPA), 423 million tons or 56% of domestic waste was recycled in 2016. Reports reflect the need for proper household waste management for the recycling process. Most of the Earth’s population will emigrate from rural to urban areas in the coming years. Therefore, bigger cities will require a highly sustainable infrastructure and smart waste management system to fulfill the fundamental needs of its citizens and provide them with a good service for the future.
  • 6.8K
  • 06 Sep 2022
Topic Review
The Subretinal Space of the Eye
The subretinal space is located between the retinal pigment epithelium (RPE) and the photoreceptive cells. The majority of the retina is a delicate matrix of photoreceptive cells and their support network which are responsible for human vision. These cells are separated from the choroid by a layer of pigment epithelium. The RPE has tight junctions, effectively insulating the inside of the retina from systemic circulation; the contents of the retina can then be controlled by transcellular transport.
  • 6.8K
  • 03 May 2025
Topic Review
Burnside-Butler Syndrome Genotype-Phenotype Associations
The 15q11.2 BP1-BP2 deletion (Burnside-Butler) syndrome is emerging as the most common cytogenetic finding in patients with neurodevelopmental or autism spectrum disorders (ASD) presenting for microarray genetic testing. Clinical findings in Burnside-Butler syndrome include developmental and motor delays, congenital abnormalities, learning and behavioral problems, and abnormal brain findings. To better define symptom presentation, we performed comprehensive cognitive and behavioral testing, collected medical and family histories, and conducted clinical genetic evaluations. The 15q11.2 BP1-BP2 region includes the TUBGCP5, CYFIP1, NIPA1, and NIPA2 genes. To determine if additional genomic variation outside of the 15q11.2 region influences expression of symptoms in Burnside-Butler syndrome, whole-exome sequencing was performed on the parents and affected children for the first time in five families with at least one parent and child with the 15q1l.2 BP1-BP2 deletion. In total, there were 453 genes with possibly damaging variants identified across all of the affected children. Of these, 99 genes had exclusively de novo variants and 107 had variants inherited exclusively from the parent without the deletion. There were three genes (APBB1, GOLGA2, and MEOX1) with de novo variants that encode proteins evidenced to interact with CYFIP1. In addition, one other gene of interest (FAT3) had variants inherited from the parent without the deletion and encoded a protein interacting with CYFIP1. The affected individuals commonly displayed a neurodevelopmental phenotype including ASD, speech delay, abnormal reflexes, and coordination issues along with craniofacial findings and orthopedic-related connective tissue problems. Of the 453 genes with variants, 35 were associated with ASD. On average, each affected child had variants in 6 distinct ASD-associated genes (x¯ = 6.33, sd = 3.01). In addition, 32 genes with variants were included on clinical testing panels from Clinical Laboratory Improvement Amendments (CLIA) approved and accredited commercial laboratories reflecting other observed phenotypes. Notably, the dataset analyzed in this study was small and reported results will require validation in larger samples as well as functional follow-up. Regardless, we anticipate that results from our study will inform future research into the genetic factors influencing diverse symptoms in patients with Burnside-Butler syndrome, an emerging disorder with a neurodevelopmental behavioral phenotype.
  • 6.8K
  • 25 Mar 2021
Topic Review
Volkswagen Passat NMS
The 2012 Volkswagen Passat (internally designated Volkswagen New Midsize Sedan, or NMS while under development) is a mid-sized sedan that debuted in January 2011 at the Detroit Auto Show, is manufactured at the Volkswagen Chattanooga Assembly Plant, replaces the Passat B6 in the North American market, and is marketed also in South Korea. At its introduction, the Passat NMS was part of Volkswagen Group's strategy to sell over 800,000 vehicles per year in the North American market. The vehicle was developed by Shanghai Volkswagen Automotive and Volkswagen Passenger Cars, and is partially based on the PQ46 platform used by the European Passat.
  • 6.8K
  • 18 Oct 2022
Topic Review
Overcurrent Relays and Their Usage
Overcurrent relays (OCR) are used as the main protection device due to their lower cost compared to other types of relays. Overcurrent relays can be divided roughly into two types, judging by their time–current characteristic: definite-time OCRs and inverse-time OCRs.
  • 6.8K
  • 18 Feb 2022
Topic Review
Grand Duchy
A grand duchy is a country or territory whose official head of state or ruler is a monarch bearing the title of grand duke or grand duchess. Relatively rare until the abolition of the Holy Roman Empire in 1806, the term was often used in the official name of countries smaller than most continental kingdoms of modern Europe (e.g., Denmark, Spain, United Kingdom) yet larger than most of the sovereign duchies in the Holy Roman Empire, Italy or Scandinavia (e.g. Anhalt, Lorraine, Modena, Schleswig-Holstein). During the 19th century there were as many as 14 grand duchies in Europe at once (a few of which were first created as exclaves of the Napoleonic empire but later re-created, usually with different borders, under another dynasty). Some of these were sovereign and nominally independent (Baden, Hesse and by Rhine, Mecklenburg-Schwerin, Mecklenburg-Strelitz, Oldenburg, Saxe-Weimar and Tuscany), some sovereign but held in personal union with larger realms by a monarch whose grand-dukedom was borne as a subsidiary title (Finland, Luxembourg, Transylvania), some of which were client states of a more powerful realm (Cleves and Berg), and some whose territorial boundaries were nominal and the position purely titular (Frankfurt). In the 21st century, only Luxembourg remains a grand duchy.
  • 6.8K
  • 17 Oct 2022
Topic Review
Triangulation Station
A triangulation station, also known as a triangulation pillar, trigonometrical station, trigonometrical point, trig station, trig beacon, or trig point, and sometimes informally as a trig, is a fixed surveying station, used in geodetic surveying and other surveying projects in its vicinity. The nomenclature varies regionally: they are generally known as trigonometrical or triangulation stations in North America, trig points in the United Kingdom, trig pillars in Ireland, trig stations or points in Australia and New Zealand, and trig beacons in South Africa; triangulation pillar is the more formal term for the concrete columns found in the UK.
  • 6.8K
  • 02 Dec 2022
Topic Review
Palmitoylethanolamide in Autism Spectrum Disorder
Palmitoylethanolamide (PEA) is a naturally occurring saturated N-acylethanolamine that has proven to be effective in controlling inflammation, depression, epilepsy, and pain, possibly through a neuroprotective role against glutamate toxicity. Here, we systematically reviewed all human and animal studies examining PEA and its biobehavioral correlates in ASD. Studies indicate altered serum/brain levels of PEA and other endocannabinoids (ECBs)/acylethanolamines (AEs) in ASD. Altered PEA signaling response to social exposure and altered expression/activity of enzymes responsible for the synthesis and catalysis of ECBs/AEs, as well as downregulation of the peroxisome proliferator activated receptor-α (PPAR-α) and cannabinoid receptor target GPR55 mRNA brain expression, have been reported. Stress and exposure to exogenous cannabinoids may modulate ECBs/AEs levels and expression of candidate genes for neuropsychiatric disorders, with implications for ASD. Limited research suggests that PEA supplementation reduces overall autism severity by improving language and social and nonsocial behaviors. Potential neurobiological underpinnings include modulation of immune response, neuroinflammation, neurotrophy, apoptosis, neurogenesis, neuroplasticity, neurodegeneration, mitochondrial function, and microbiota activity, possibly through peroxisome proliferator-activated receptor-α (PPAR-α) activation.
  • 6.8K
  • 08 Sep 2021
Topic Review
Li7La3Zr2O12 (LLZO): An Overview
Li7La3Zr2O12 (LLZO) is an inorganic garnet type solid electrolyte which has proven to be one of the most promising electrolytes because of its high ionic conductivity at room temperature, low activation energy, good chemical and electrochemical stability, and wide potential window.
  • 6.8K
  • 03 Aug 2021
Topic Review
Red Panda
The Red Panda (Ailurus fulgens) is a charismatic and endangered mammal native to the eastern Himalayas and southwestern China. With its distinctive red fur, bushy tail, and cat-like face, the Red Panda is often described as a living symbol of biodiversity conservation. Despite its name, the Red Panda is not closely related to the Giant Panda but shares similar bamboo-dominated habitats and a diet primarily consisting of bamboo leaves and shoots.
  • 6.8K
  • 28 Feb 2024
Topic Review
Nanotechnology in Warfare
Nanotechnology in Warfare is a branch of nano-science in which molecular systems are designed, produced and created to fit a nano-scale (1-100nm). The application of such technology, specifically in the area of warfare and defence, has paved the way for future research in the context of weaponisation. Nanotechnology unites a variety of scientific fields including material science, chemistry, physics, biology and engineering. Advancements in this area, have led to categorised development of such nano-weapons with classifications varying from; small robotic machines, hyper-reactive explosives, and electromagnetic super-materials. With this technological growth, has emerged implications of associated risks and repercussions, as well as regulation to combat these effects. These impacts give rise to issues concerning global security, safety of society, and the environment. Legislation may need to be constantly monitored to keep up with the dynamic growth and development of nano-science, due to the potential benefits or dangers of its use. Anticipation of such impacts through regulation, would 'prevent irreversible damages' of implementing defence related nanotechnology in warfare.
  • 6.8K
  • 02 Nov 2022
Topic Review
Uterosacral Ligament
The uterosacral ligaments (USLs) are extraperitoneal structures that extend backward from the posterior surface of the cervix and upper vagina to the second-to-fourth sacral vertebrae, forming the lateral boundaries of the rectouterine and rectovaginal spaces. They are composed mainly of connective tissue along with vessels and splanchnic nerve fibers.
  • 6.8K
  • 08 Feb 2021
Topic Review
Social Inertia
Social inertia refers to the tendency of social systems to resist change and maintain their existing state of equilibrium. It encompasses the collective reluctance or resistance within a society to adopt new ideas, practices, or norms, even in the face of external pressures or opportunities for change. Social inertia can arise from various factors, including cultural traditions, institutional structures, and psychological biases, and it often presents challenges for efforts to enact social reform or innovation.
  • 6.8K
  • 08 Feb 2024
Topic Review
Cathode Ray Tube
The cathode ray tube (CRT) is a vacuum tube that contains one or more electron guns and a phosphorescent screen, and is used to display images. It modulates, accelerates, and deflects electron beam(s) onto the screen to create the images. The images may represent electrical waveforms (oscilloscope), pictures (television, computer monitor), radar targets, or other phenomena. CRTs have also been used as memory devices, in which case the visible light emitted from the fluorescent material (if any) is not intended to have significant meaning to a visual observer (though the visible pattern on the tube face may cryptically represent the stored data). In television sets and computer monitors, the entire front area of the tube is scanned repetitively and systematically in a fixed pattern called a raster. An image is produced by controlling the intensity of each of the three electron beams, one for each additive primary color (red, green, and blue) with a video signal as a reference. In all modern CRT monitors and televisions, the beams are bent by magnetic deflection, a varying magnetic field generated by coils and driven by electronic circuits around the neck of the tube, although electrostatic deflection is commonly used in oscilloscopes, a type of electronic test instrument. A CRT is constructed from a glass envelope which is large, deep (i.e., long from front screen face to rear end), fairly heavy, and relatively fragile. The interior of a CRT is evacuated to approximately 0.01 pascals (9.9×10−8 atm) to 133 nanopascals (1.31×10−12 atm), evacuation being necessary to facilitate the free flight of electrons from the gun(s) to the tube's face. The fact that it is evacuated makes handling an intact CRT potentially dangerous due to the risk of breaking the tube and causing a violent implosion that can hurl shards of glass at great velocity. As a matter of safety, the face is typically made of thick lead glass so as to be highly shatter-resistant and to block most X-ray emissions, particularly if the CRT is used in a consumer product. Since the late 2000s, CRTs have been largely superseded by newer "flat panel" display technologies such as LCD, plasma display, and especially OLED displays, which in the case of LCD and OLED displays have lower manufacturing costs and power consumption, as well as significantly less weight and bulk. Flat panel displays can also be made in very large sizes; whereas 38 to 40 in (97 to 102 cm) was about the largest size of a CRT television, flat panels are available in 60 in (150 cm) and larger sizes.
  • 6.8K
  • 02 Dec 2022
Topic Review
Bṛhaspati
Bṛhaspati (Sanskrit: बृहस्पति; meaning spati of briha, the spirit of vastness of the universe written as Brihaspati) is an Indian name, and refers to different mythical figures depending on the age of the text. In ancient Hindu literature Brihaspati is a Vedic era sage who counsels the gods, while in some medieval texts the word refers to the largest planet of the solar system, Jupiter. He taught Bhishma the duties of a king which he later taught it to Vidura.
  • 6.8K
  • 18 Oct 2022
Topic Review
Fresh Fruit and Vegetable Waste in Human Health
Food supply disruption and shortage verified during the current pandemic events are a scenario that many anticipate for the near future. The impact of climate changes on food production, the continuous decrease in arable land, and the exponential growth of the human population are important drivers for this problem. 
  • 6.8K
  • 19 Jan 2023
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