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Biography
Eugene Kleiner
Eugene Kleiner (12 May 1923 – 20 November 2003) was an Austrian-born American engineer and venture capitalist. He is considered the pioneer of Silicon Valley.[1] He was one of the original founders of Kleiner Perkins, the Silicon Valley venture capital firm which later became Kleiner Perkins Caufield & Byers. The company was an early investor in more than 300 information technology and biotech
  • 1.6K
  • 27 Dec 2022
Topic Review
Diffusion of Solar PV Energy
Solar photovoltaic energy (solar PV) is considered a very attractive solution among renewable energy sources (RES), especially for households. According to the most recent IEA report on renewables, the growth of renewable power capacity at the world level has reached another record in 2021, driven by solar photovoltaic energy; solar PV alone has accounted for more than half of all renewable power expansion in 2021, followed by wind and hydropower.
  • 1.6K
  • 28 Apr 2022
Topic Review
Power Grid Infrastructures
This content presents a comprehensive review of protection systems with the penetration of microgrids in the distribution network. The expansion of a microgrid affects the coordination and protection by a change in the current direction in the distribution network. 
  • 1.6K
  • 01 Dec 2020
Topic Review
AI&ML for Medical Sector
This work represents a comprehensive analysis of the potential AI, ML, and IoT technologies for defending against the COVID-19 pandemic. The existing and potential applications of AI, ML, and IoT, along with a detailed analysis of the enabling tools and techniques are outlined. A critical discussion on the risks and limitations of the aforementioned technologies are also included.
  • 1.6K
  • 21 Jan 2021
Topic Review
Photosensitive Substances
Photodynamic therapy (PDT) is part of photochemotherapy and requires the presence of a photosensitive substance (drug, PS), oxygen, and a powerful light source in the area of absorption of the PS used.
  • 1.6K
  • 13 Apr 2021
Topic Review
MiRNA-7
MicroRNAs (miRNAs, miRs) are small non-coding RNA (ncRNA) molecules capable of regulating post-transcriptional gene expression. Imbalances in the miRNA network have been associated with the development of many pathological conditions and diseases, including cancer. Recently, miRNAs have also been linked to the phenomenon of multidrug resistance (MDR). MiR-7 is one of the extensively studied miRNAs and its role in cancer progression and MDR modulation has been highlighted. MiR-7 is engaged in multiple cellular pathways and acts as a tumor suppressor in the majority of human neoplasia. Its depletion limits the effectiveness of anti-cancer therapies, while its restoration sensitizes cells to the administered drugs.
  • 1.6K
  • 25 Feb 2021
Topic Review
ER Stress
Recent studies undoubtedly show the importance of inter-organellar connections to maintain cellular homeostasis. In normal physiological conditions or in the presence of cellular and environmental stress, each organelle responds alone or in coordination to maintain cellular function. The Endoplasmic reticulum (ER) and mitochondria are two important organelles with very specialized structural and functional properties. These two organelles are physically connected through very specialized proteins in the region called the mitochondria-associated ER membrane (MAM). The molecular foundation of this relationship is complex and involves not only ion homeostasis through the shuttling of calcium but also many structural and apoptotic proteins. IRE1alpha and PERK are known for their canonical function as an ER stress sensor controlling unfolded protein response during ER stress. The presence of these transmembrane proteins at the MAM indicates its potential involvement in other biological functions beyond ER stress signaling. Many recent studies have now focused on the non-canonical function of these sensors. 
  • 1.6K
  • 06 Apr 2021
Topic Review
VEGF/VEGFR in tumour anti-angiogenic therapy
It is now known that vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptors (VEGFRs) play a pivotal role in angiogenesis process. Nowadays, the use of inhibitors of angiogenesis promoting factors is a powerful tool in anticancer combination therapeutic strategies, especially in cancer anti-angiogenic therapy (AAT).
  • 1.6K
  • 19 Apr 2021
Topic Review
Low Calcium Fly Ash/Slag Geopolymer
Geopolymer materials consist primarily of an aluminosilicate source and liquid alkaline constituents. Geopolymer has a lower footprint in terms of CO2 emissions and has been considered as an alternative for ordinary portland cement (OPC), which is known for its significant contribution to carbon dioxide emissions.
  • 1.6K
  • 28 Feb 2022
Topic Review
Senescent Fibroblasts and Skin Aging
Skin aging is a multi-factorial process that affects nearly every aspect of skin biology and function. The processes developing in the skin during aging are based on fundamental molecular mechanisms associated with fibroblasts, the main cellular population of the dermis. It has been revealed that the amount of fibroblasts decreases markedly with age and their functional activity is also reduced. This inevitably leads to a decrease in the regenerative abilities of the skin and the progression of its aging.
  • 1.6K
  • 16 Jun 2022
Topic Review
Waste Tire Management Practice
Montenegro faces serious challenges in terms of waste tire management. The financial and economic justification of the implementation of the first phase of the project of collection, takeover and transport, sorting, and storage of waste tires from the three municipalities in Montenegro.
  • 1.6K
  • 08 Oct 2022
Topic Review
Cortes of Cádiz
The Cortes of Cádiz was a revival of the traditional cortes (Spanish parliament), which as an institution had not functioned for many years, but it met as a single body, rather than divided into estates as with previous ones. The General and Extraordinary Cortes that met in the port of Cádiz starting 24 September 1810 "claimed legitimacy as the sole representative of Spanish sovereignty", following the French invasion and occupation of Spain during the Napoleonic Wars and the abdication of the monarch Ferdinand VII and his father Charles IV. It met as one body, and its members represented the entire Spanish Empire, that is, not only Spain but also Spanish America and the Philippines. The Cortes of Cádiz was seen then, and by historians today, as a major step towards liberalism and democracy in the history of Spain and Spanish America. The liberal Cortes drafted and ratified the Spanish Constitution of 1812, which established a constitutional monarchy and eliminated many institutions that privileged some groups over others.
  • 1.6K
  • 25 Oct 2022
Topic Review
Applications of Bioplastics and Reinforced Bioplastics
The introduction of bioplastics has been an evolution for plastic industry since conventional plastics have been claimed to cause several environmental issues. Apart from its biodegradability, one of the advantages can be identified of using bioplastic is that they are produced by renewal resources as the raw materials for synthesis. Nevertheless, bioplastics can be classified into two types, which are biodegradable and non-biodegradable, depending on the type of plastic that is produced. Although some of the bioplastics are non-biodegradable, the usage of biomass in synthesising the bioplastics helps in preserving non-renewable resources, which are petrochemical, in producing conventional plastics. However, the mechanical strength of bioplastic still has room for improvement as compared to conventional plastics, which is believed to limit its application. Ideally, bioplastics need to be reinforced for improving their performance and properties to serve their application. Synthetic reinforcement has been used to reinforce conventional plastic to achieve its desire properties to serve its application, such as glass fiber.
  • 1.6K
  • 05 Jun 2023
Topic Review
Heavy Metals in Foods and Beverages
Heavy metals are chemical elements with a toxic effect on the human body. The expansion of industries has led to significant increasing levels of these constituents in the environment. Intensive agriculture can also lead to an increased concentration of heavy metals as a result of using different fertilizers and pesticides. Heavy metal accumulation in soil and plants represents a serious issue because of the potential risks to consumers. There are several methods available for the removal of these toxic components from different substrates (chemical precipitation, electrodialysis, coagulation and flocculation, photocatalytic removal, and adsorption-based processes), but most procedures are expensive and difficult to perform. Thus, more research is needed on the development of low-cost methods in foods. 
  • 1.6K
  • 13 Oct 2023
Topic Review
Noise Exposure, Prevention, and Control in Agriculture
Noise is a major physical hazard in agricultural activities, and numerous research activities have managed to detect its effects, resulting in surveys and measurements which help to define exposure limits, prevention methods, and control strategies.
  • 1.6K
  • 08 Mar 2024
Topic Review
PENG-Based Non-Invasive Medical Sensors
Piezoelectric nanogenerators (PENGs) not only are able to harvest mechanical energy from the ambient environment or body and convert mechanical signals into electricity but can also inform people about pathophysiological changes and communicate this information using electrical signals, thus acting as medical sensors to provide personalized medical solutions to patients.
  • 1.6K
  • 19 Jan 2023
Topic Review
Shark Barrier
A shark barrier (otherwise known as a "shark-proof enclosure" or "beach enclosure") is seabed-to-surface protective barrier that is placed around a beach to protect people from shark attacks. Often confused with shark nets, shark barriers form a fully enclosed swimming area that prevents sharks from entering (nets aim to reduce shark populations). Shark barrier design has evolved from rudimentary fencing materials to netted structures held in place with buoys and anchors. Recent designs have used plastics to increase strength, versatility and to reduce the environmental damage of bycatch.
  • 1.6K
  • 27 Sep 2022
Topic Review
Structural Glial–Neuronal Mechanisms of Mitochondrial Transfer
Glial–neuronal mitochondrial transfer is mediated via a number of active processes including the release of extracellular vesicles, the formation of tunnelling nanotubes, and potentially other mechanisms.
  • 1.6K
  • 07 Dec 2022
Topic Review
Electrically Excited Doubly Salient Variable Reluctance Machine
The Electrically Excited Doubly Salient Variable Reluctance Machine (EEDSVRM) is a new type of brushless machine designed according to the principle of air gap reluctance change.
  • 1.6K
  • 14 Jan 2022
Topic Review
Atrial Fibrillation Diagnosis Measurements
Atrial Fibrillation (AF) is a heart rhythm disorder. Hence, AF diagnosis is based on measurements which reflect the activity of the heart. Detectable symptoms of the disease might not be present all the time. Therefore, the measurement duration is positively correlated with the AF detection rate. Suitable measurements include photoplethysmogram, electrocardiogram, and heart rate. The data volume, produced through long term measurement, mandates computer support to automate the AF detection task.
  • 1.6K
  • 30 Oct 2020
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