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Topic Review
Oxidative Stress in Chronic Obstructive Pulmonary Disease
Since chronic obstructive pulmonary disease (COPD) is a heterogeneous disease, a specific anti-inflammatory therapy for this disease has not been established yet. Oxidative stress is recognized as a major predisposing factor to COPD related inflammatory responses, resulting in pathological features of small airway fibrosis and emphysema. 
  • 1.7K
  • 06 Feb 2023
Topic Review
Strategies for the Preparation of Phosphorus Janus Dendrimers
Dendrimers, being highly branched monodispersed macromolecules, predominantly exhibit identical terminal functionalities within their structural framework. Nonetheless, there are instances where the presence of two distinct surface functionalities becomes advantageous for the fulfilment of specific properties. To achieve this objective, one approach involves implementing Janus dendrimers, consisting of two dendrimeric wedges terminated by dissimilar functionalities.
  • 1.7K
  • 21 Aug 2023
Topic Review
Cell-Type Annotation
Multicellular organisms consist of cells that can be categorized by their function and morphology. Single-cell transcriptomics makes it possible to individually profile thousands of cells in multiple tissues and organisms within a single experiment. Determining and labeling cell types or states in single cell transcriptomic data is known as cell-type annotation or identification. Several methods are employed for cell-type annotation, including signature scoring, supervised learning, cell-integration-based label transfer, and semi-supervised annotation. Considering the lineage relationships among cell types, hierarchical classification methods are crucial for accurately identifying cell types and subtypes at an optimal clustering resolution. The use of well-curated reference datasets, implementation of quality control measures, and careful consideration of cluster resolutions heavily influence the reliability of cell-type annotation. The aim of cell-type annotation is to gain insights into cell heterogeneity in various biological processes and diseases, with the potential to drive improvements in therapeutic interventions.
  • 1.7K
  • 08 Aug 2023
Topic Review
Water in Epoxy Coatings
The absorption of water strongly affects the exploitation characteristics of epoxy coatings and their lifecycles. The models used for describing water absorption to a polymer matrix involve many parameters that can adequately describe the process with parameter tuning. However, when using multiple variable parameters, the physical essence of absorption can be obscured. Hence, one of the promising directions in this field is the development of new models with fixed physically transparent parameters, which will adequately describe the water uptake process in epoxy resins.
  • 1.7K
  • 04 Jan 2024
Topic Review
Near-Haploidy and Low-Hypodiploidy in B-Cell Acute Lymphoblastic Leukemia
B-cell acute lymphoblastic leukemia (B-ALL) is characterized by an uncontrolled proliferation of blood cells in the bone marrow. Hypodiploidy with less than 40 chromosomes is a rare genetic abnormality in B-cell acute lymphoblastic leukemia (B-ALL). This condition can be classified based on modal chromosome number as low-hypodiploidy (30–39 chromosomes) and near-haploidy (24–29 chromosomes), with unique cytogenetic and mutational landscapes. 
  • 1.7K
  • 10 Jan 2022
Topic Review
Wire Arc Additive Manufacturing for Aluminum-Lithium Alloys
Out of all the metal additive manufacturing (AM) techniques, the directed energy deposition (DED) technique, and particularly the wire-based one, are of great interest due to their rapid production. In addition, they are recognized as being the fastest technique capable of producing fully functional structural parts, near-net-shape products with complex geometry and almost unlimited size. There are several wire-based systems, such as plasma arc welding and laser melting deposition, depending on the heat source. The main drawback is the lack of commercially available wire; for instance, the absence of high-strength aluminum alloy wires. Therefore, this entry covers conventional and innovative processes of wire production and includes a summary of the Al-Cu-Li alloys with the most industrial interest in order to foment and promote the selection of the most suitable wire compositions. The role of each alloying element is key for specific wire design in WAAM; this entry describes the role of each element (typically strengthening by age hardening, solid solution and grain size reduction) with special attention to lithium. At the same time, the defects in the WAAM part limit its applicability. For this reason, all the defects related to the WAAM process, together with those related to the chemical composition of the alloy, are mentioned. Finally, future developments are summarized, encompassing the most suitable techniques for Al-Cu-Li alloys, such as PMC (pulse multicontrol) and CMT (cold metal transfer).
  • 1.7K
  • 13 Mar 2023
Topic Review
Drought and Temperature Stress Induced Flowering
Plants experience a variety of adverse environments during their vegetative growth and reproductive development, and to ensure that they complete their life cycle successfully, they have evolved specific defense mechanisms to cope with unfavorable environments. Flowering is a vital developmental stage and an important determinant of productivity in the lifetime of plants, which can be vulnerable to multiple abiotic stresses. Exposure to stress during this period can have dramatic effects on flower physiological and morphological development, which may ultimately lead to a substantial loss of yield in seed-producing plants. However, there has been increasing research evidence that diverse abiotic stresses, ranging from drought, low temperature, and heat stress can promote or delay plant flowering.
  • 1.7K
  • 25 Dec 2023
Topic Review
Sustainable Water and Energy Supply
This entry aims to reveal the economic, technical, and environmental impacts of different system configurations (centralized or decentralized, components, and technologies) on transition plans to achieve a higher share of renewable energy and desalination supplies for regions facing water scarcity. The main contribution of this research is the comparative evaluation of on-grid decentralized or distributed renewable-powered desalination systems for sustainable water and energy supply planning. Applying a novel nexus approach, an interactive multi-period planning model is developed to highlight synergies and to identify conflicts of planning both energy and water sectors at the same time as endogenous subsystems of one overall system. For studying these synergies in this study, the pace of technology deployment and the path of decline in overall costs are assumed to be a function of experience and knowledge as two-factor learning curves. Using data from 81 projects, the levelized cost and capacity factor of utility-scale photovoltaic and wind supplies in the Middle East were calculated. The results indicate that a scenario with a decentralized water sector and renewable-powered multiple-effect distillation technology has the best overall performance among the proposed scenarios. The authors consider that the current study provides novel insights: (1) Designing and planning both the water and energy sectors at the same time, (2) detailed representation of short-term operational aspects in long-run planning of the water and energy sectors to capture the inherent variability of renewable energy resources, (3) modeling the water sector with centralized and decentralized on-grid renewable-powered desalination systems, (4) proposing a new methodology to study the synergies and conflicts of designing the water and energy sectors as an integrated system/separated system, and (5) estimating the two-factor learning curves for wind, photovoltaic, reverse osmosis desalination, and multi-effect distillation desalination industries in the Middle East.
  • 1.7K
  • 27 Oct 2020
Topic Review
Medicinal Plants with Anti-Leukemic Effects
Leukemia is a leukocyte cancer that is characterized by anarchic growth of immature immune cells in the bone marrow, blood and spleen. There are many forms of leukemia, and the best course of therapy and the chance of a patient’s survival depend on the type of leukemic disease. Different forms of drugs have been used to treat leukemia. Due to the adverse effects associated with such therapies and drug resistance, the search for safer and more effective drugs remains one of the most challenging areas of research. Thus, new therapeutic approaches are important to improving outcomes. Almost half of the drugs utilized nowadays in treating cancer are from natural products and their derivatives. Medicinal plants have proven to be an effective natural source of anti-leukemic drugs. The cytotoxicity and the mechanisms underlying the toxicity of these plants to leukemic cells and their isolated compounds were investigated.
  • 1.7K
  • 18 May 2021
Topic Review
List of Dolichopodid Genera
The fly family Dolichopodidae contains approximately 200 genera.
  • 1.7K
  • 10 Oct 2022
Topic Review
Bilirubin Glucuronide
Bilirubin glucuronide is a water-soluble reaction intermediate over the process of conjugation of indirect bilirubin. Bilirubin glucuronide itself belongs to the category of conjugated bilirubin along with bilirubin di-glucuronide. However, only the latter one is primarily excreted into the bile in the normal setting. Upon macrophages spot and phagocytize the effete Red Blood Corpuscles containing hemoglobin, unconjugated bilirubin is discharged from macrophages into the blood plasma. Most often, the free and water-insoluble unconjugated bilirubin which has an internal hydrodren bonding will bind to albumin and, to a much lesser extent, high density lipoprotein in order to decrease its hydrophobicity and to limit the probability of unnecessary contact with other tissues and keep bilirubin in the vascular space from traversing to extravascular space including brain, and from ending up increasing glomerular filtration. Nevertheless, there is still a little portion of indirect bilirubins stays free-of-bound. Free unconjugated bilirubin can poison the cerebrum. Finally, albumin leads the indirect bilirubin to the liver. In the liver sinusoid, albumin disassociates with the indirect bilirubin and returns to the circulation while the hepatocyte transfers the indirect bilirubin to ligandin and glucuronide conjugates the indirect bilirubin in the endoplasmic reticulum by disrupting unconjugated bilirubin's internal hydrogen bonding, which is the thing that makes indirect bilirubin having the property of eternal half-elimination life and insoluble in water, and by attaching two molecules of glucuronic acid to it in a two step process. The reaction is a transfer of two glucuronic acid groups including UDP glucuronic acid sequentially to the propionic acid groups of the bilirubin, primarily catalyzed by UGT1A1. In greater detail about this reaction, a glucuronosyl moiety is conjugated to one of the propionic acid side chains, located on the C8 and C12 carbons of the two central pyrrole rings of bilirubin. When the first step is completely done, the substrate bilirubin glucuronide (also known as mono-glucuronide) is born at this stage and is water-soluble and readily excreted in bile. Thereafter, so long as the second step of attachment of the other glucuronic acid to it succeeds (officially called "re-glucuronidated"), the substrate bilirubin glucuronide will turn into bilirubin di-glucuronide (8,12-diglucuronide) and be excreted into bile canaliculi by way of C-MOAT[note 1] and MRP2 as normal human bile along with a little amount of unconjugated bilirubin as much as only 1 to 4 percent of total pigments in normal bile. That means up to 96%-99% of bilirubin in the bile are conjugated. Normally, there is just a little conjugated bilirubin escapes into the general circulation. Nonetheless, in the setting of severe liver disease, a significantly greater number of conjugated bilirubin will leak into circulation and then dissolve into the blood[note 2] and thereby filtered by the kidney, and only a part of the leaked conjugated bilirubin will be re-absorbed in the renal tubules, the remainder will be present in the urine making it dark-colored.
  • 1.7K
  • 12 Oct 2022
Topic Review
Stellar Constellations in Fiction
Some stellar constellations have been featured in fictional works.
  • 1.7K
  • 31 Oct 2022
Topic Review
Folk Art
Folk art covers all forms of visual art made in the context of folk culture. Definitions vary, but generally the objects have practical utility of some kind, rather than being exclusively decorative. The makers of folk art are normally trained within a popular tradition, rather than in the fine art tradition of the culture. There is often overlap, or contested ground, with naive art, but in traditional societies where ethnographic art is still made, that term is normally used instead of "folk art". The types of object covered by the term varies considerably and in particular "divergent categories of cultural production are comprehended by its usage in Europe, where the term originated, and in the United States, where it developed for the most part along very different lines." Folk arts are rooted in and reflective of the cultural life of a community. They encompass the body of expressive culture associated with the fields of folklore and cultural heritage. Tangible folk art includes objects which historically are crafted and used within a traditional community. Intangible folk arts include such forms as music, dance and narrative structures. Each of these arts, both tangible and intangible, was originally developed to address a real need. Once this practical purpose has been lost or forgotten, there is no reason for further transmission unless the object or action has been imbued with meaning beyond its initial practicality. These vital and constantly reinvigorated artistic traditions are shaped by values and standards of excellence that are passed from generation to generation, most often within family and community, through demonstration, conversation, and practice.
  • 1.7K
  • 15 Nov 2022
Topic Review
Matal V. Tam
Matal v. Tam, 582 U.S. ___ (2017) (previously known as Lee v. Tam), is a United States Supreme Court case in which the Court affirmed unanimously the judgment of the Court of Appeals for the Federal Circuit that the provisions of the Lanham Act's prohibiting the registration of trademarks that may "disparage" persons, institutions, beliefs, or national symbols with the United States Patent and Trademark Office violated the First Amendment.
  • 1.7K
  • 06 Dec 2022
Topic Review
HP QuickTest Professional
HPE Unified Functional Testing (UFT) software, formerly known as HP QuickTest Professional (QTP), provides functional and regression test automation for software applications and environments. HPE Unified Functional Testing can be used for enterprise quality assurance. HPE Unified Functional Testing supports keyword and scripting interfaces and features a graphical user interface. It uses the Visual Basic Scripting Edition (VBScript) scripting language to specify a test procedure, and to manipulate the objects and controls of the application under test. HPE Unified Functional Testing was originally written by Mercury Interactive and called QuickTest Professional. Mercury Interactive was subsequently acquired by Hewlett Packard(HP) in 2006. HP Unified Functional Testing 11.5 combined HP QuickTest Professional and HP Service Test into a single software package, which was available from the HP Software Division until 2016, when whole division was sold to Micro Focus. The integrated HPE Unified Functional Testing software allows developers to test from a single console all three layers of a program's operations: the interface, the service layer and the database layer.
  • 1.7K
  • 05 Dec 2022
Topic Review
Tackling Pandemics through Computer-Aided Drug Discovery Approaches
Since its outbreak in December 2019, the COVID-19 pandemic has caused the death of more than 6.5 million people around the world. The high transmissibility of its causative agent, the SARS-CoV-2 virus, coupled with its potentially lethal outcome, provoked a profound global economic and social crisis. The urgency of finding suitable pharmacological tools to tame the pandemic shed light on the ever-increasing importance of computer simulations in rationalizing and speeding up the design of new drugs, further stressing the need for developing quick and reliable methods to identify novel active molecules and characterize their mechanism of action. 
  • 1.7K
  • 08 Mar 2023
Topic Review
Non-Resonant Single-Wire Power Transmission Systems
A single-wire power transmission is an option for reducing the capital cost of power line construction by utilizing fewer conductors and fittings and lighter power transmission towers while lowering operational expenses.
  • 1.7K
  • 31 Jul 2023
Topic Review
Quadruped Robot
The motion state of quadruped robot in operation changes constantly. Due to the drift caused by the accumulative error, the function of inertial measurement unit (IMU) will be limited.  Even though multi-sensor fusion technology is adopted, the quadruped robot will lose its ability to respond to state changes after a while because the gain tends to be constant. To solve this problem, this paper proposes a Strong Tracking Mixed-degree Cubature Kalman Filter (STMCKF) method. According to system characteristics of the quadruped robot, this method makes fusion estimation of forward kinematics and IMU track. The combination mode of Traditional Strong Tracking CKF (TSTCKF) and strong tracking is improved through demonstration. A new method for calculating fading factor matrix is proposed, which reduces sampling times from three to one, saving 66% of calculation time. At the same time, the state estimation accuracy is improved from third-degree accuracy of Taylor series expansion to fifth-degree accuracy. The proposed algorithm can automatically switch the working mode according to real-time supervision of the motion state and greatly improve the state estimation performance of quadruped robot system, exhibiting strong robustness and excellent real-time performance.
  • 1.7K
  • 27 Oct 2020
Topic Review
Galectin-3 as Biomarker
Galectin-3, predominantly located in the cytoplasm and expressed on the cell surface, is a β-galactoside-binding lectin which is important in numerous biological activities in various organs, including cell proliferation, apoptotic regulation, inflammation, fibrosis, and host defense. Galectin-3 is often secreted into biological fluids, like serum and urine, thus used as a biomarker. It is also released from injured cells and inflammatory cells under various pathological conditions. Galectin-3 plays an important role as a diagnostic or prognostic biomarker for certain types of heart disease, kidney disease, viral infection, autoimmune disease, neurodegenerative disorders, and tumor formation. In particular, galectin-3 is extremely useful for detecting many of these diseases in their early stages.
  • 1.7K
  • 08 Jun 2021
Topic Review
Phytosterols
Phytosterols are important constituents of plant cells structural analogous of mammalian cholesterol, that have been shown to exert very important biological effects, such as hypocholesterolemic, antidiabetic, and antioxidant activities in the human body.
  • 1.7K
  • 28 Oct 2020
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