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Topic Review
Early Germanic Law
Early Germanic law was the form of law followed by the early Germanic peoples. It was an important element of early Germanic culture. Several Latin law codes of the Germanic peoples written in the Early Middle Ages after the Fall of the Western Roman Empire (also known as leges barbarorum "laws of the barbarians") survive, dating to between the 5th and 9th centuries. They are influenced by Roman law, canon law, and earlier tribal customs. Central and West European Germanic law differed from North Germanic law. Germanic law was codified in writing under the influence of Roman law; previously it was held in the memory of designated individuals who acted as judges in confrontations and meted out justice according to customary rote, based on careful memorization of precedent. Among the Franks they were called rachimburgs. "Living libraries, they were law incarnate, unpredictable and terrifying." Power, whose origins were at once said to be magical, divine, and military, was, according to Michel Rouche, exercised jointly by the "throne-worthy" elected king and his free warrior companions. Oral law sufficed as long as the warband was not settled in one place. Germanic law made no provisions for the public welfare, the res publica of Romans. The language of all these continental codes was Latin; the only known codes drawn up in any Germanic language were the Anglo-Saxon laws, beginning with the Laws of Æthelberht (7th century). In the 13th century customary Saxon law was codified in the vernacular as the Sachsenspiegel. All these laws may be described in general as codes of governmental procedure and tariffs of compositions. They all present somewhat similar features with Salic law, the best-known example, but often differ from it in the date of compilation, the amounts of fines, the number and nature of the crimes, the number, rank, duties and titles of the officers, etc. In Germanic Europe in the Early Middle Ages, every man was tried according to the laws of his own ethnicity, whether Roman, Salian or Ripuarian Frank, Frisian, Burgundian, Visigoth, Bavarian etc. A number of separate codes were drawn up specifically to deal with cases between ethnic Romans. These codes differed from the normal ones that covered cases between Germanic peoples, or between Germanic people and Romans. The most notable of these are the Lex Romana Visigothorum or Breviary of Alaric (506), the Lex Romana Curiensis and the Lex Romana Burgundionum.
  • 6.9K
  • 02 Dec 2022
Topic Review
Soaps and Syndets in Skin Cleansing
Skin cleansers generally come in one of two types: soap-based and synthetic detergents, or syndets. While the latter can effectively maintain the native skin structure, function and integrity, the former tends to negatively affect the skin by causing barrier disruption, lipid dissolution and pH alteration. Despite this, soap is still often preferred, possibly due to the negative connotations around anything that is not perceived as ‘natural’. 
  • 6.9K
  • 21 Apr 2022
Topic Review
Aquaporin Inhibitors
Aquaporins (AQPs) are water channel proteins that are essential to life, being expressed in all kingdoms. In humans, there are 13 AQPs, at least one of which is found in every organ system. The structural biology of the AQP family is well-established and many functions for AQPs have been reported in health and disease. AQP expression is linked to numerous pathologies including tumor metastasis, fluid dysregulation, and traumatic injury. The targeted modulation of AQPs therefore presents an opportunity to develop novel treatments for diverse conditions. Various techniques such as video microscopy, light scattering and fluorescence quenching have been used to test putative AQP inhibitors in both AQP-expressing mammalian cells and heterologous expression systems. The inherent variability within these methods has caused discrepancy and many molecules that are inhibitory in one experimental system (such as tetraethylammonium, acetazolamide, and anti-epileptic drugs) have no activity in others. Some heavy metal ions (that would not be suitable for therapeutic use) and the compound, TGN-020, have been shown to inhibit some AQPs. Clinical trials for neuromyelitis optica treatments using anti-AQP4 IgG are in progress. However, these antibodies have no effect on water transport. More research to standardize high-throughput assays is required to identify AQP modulators for which there is an urgent and unmet clinical need.
  • 6.9K
  • 06 Sep 2021
Topic Review
NASDAQ-100
The NASDAQ-100 (^NDX) is a stock market index made up of 103 equity securities issued by 100 of the largest non-financial companies listed on the Nasdaq stock market. It is a modified capitalization-weighted index. The stocks' weights in the index are based on their market capitalizations, with certain rules capping the influence of the largest components. It is based on exchange, and it does not have any financial companies. The financial companies were put in a separate index, the NASDAQ Financial-100.
  • 6.9K
  • 19 Oct 2022
Topic Review
Perinuclear Anti-Neutrophil Cytoplasmic Antibodies (P-ANCA)
Perinuclear anti-neutrophilic cytoplasmic antibodies (P-ANCA) recognize heterogeneous antigens, including myeloperoxidase (MPO), lactoferrin, elastase, cathepsin-G and bactericidal/permeability-increasing protein. Although P-ANCA have diagnostic utility in vasculitides, they may also be found in patients with various other systemic autoimmune rheumatic diseases (SARDs). Nevertheless, the clinical significance and the targets recognized by P-ANCA in such patients remain unclear. For this purpose, herein we investigated the occurrence of ANCA-related antigenic specificities in 82 P-ANCA-positive sera by multiplex ELISA, as well as their association with other autoantibodies. The P-ANCA-positive sera corresponded to patients with vasculitides (n = 24), systemic lupus erythematosus (n = 28), antiphospholipid syndrome (n = 5), Sjögren’s syndrome (n = 7), rheumatoid arthritis (n = 3), systemic scleroderma (n = 1), sarcoidosis (n = 1) and Hashimoto′s thyroiditis (n = 13). In most P-ANCA-positive patients studied (51/82, 62.3%), these autoantibodies occurred in high titers (>1:160). The analysis of P-ANCA-positive sera revealed reactivity to MPO in only 50% of patients with vasculitides, whereas it was infrequent in the other disease groups studied. Reactivity to other P-ANCA-related autoantigens was also rarely detected. Our findings support that high P-ANCA titers occur in SARD. The P-ANCA-positive staining pattern is associated with MPO specificity in vasculitides, while in other autoimmune diseases, it mostly involves unknown autoantigens. 
  • 6.9K
  • 27 Aug 2021
Topic Review
Areas of Mathematics
Mathematics encompasses a growing variety and depth of subjects over its history, and comprehension of it requires a system to categorize and organize these various subjects into more general areas of mathematics. A number of different classification schemes have arisen, and though they share some similarities, there are differences due in part to the different purposes they serve. A traditional division of mathematics is into pure mathematics; mathematics studied for its intrinsic interest, and applied mathematics; the mathematics that can be directly applied to real-world problems. This division is not always clear and many subjects have been developed as pure mathematics to find unexpected applications later on. Broad divisions, such as discrete mathematics, computational mathematics and so on have emerged more recently. An ideal system of classification permits adding new areas into the organization of previous knowledge, and fitting surprising discoveries and unexpected interactions into the outline. For example, the Langlands program has found unexpected connections between areas previously thought unconnected, at least Galois groups, Riemann surfaces and number theory.
  • 6.9K
  • 29 Sep 2022
Topic Review
Secretory IgA
Secretory IgA (SIgA) is the dominant antibody class in mucosal secretions, it is also present in saliva and breast milk. The majority of plasma cells producing SIgA are located within mucosal membranes lining the intestines, airway and reproductive tracts, as well as mammary gland. SIgA protects against the adhesion of pathogens and their penetration into the mucosal barriers. Moreover, SIgA regulates microbiota composition at mucosa sites and provides local homeostasis.
  • 6.9K
  • 17 Jan 2021
Topic Review
Atropa Belladonna
Atropa belladonna, commonly known as belladonna or deadly nightshade, is a toxic perennial herbaceous plant in the nightshade family Solanaceae, which also includes tomatoes, potatoes, and eggplant (aubergine). It is native to Europe, North Africa, and Western Asia. Its distribution extends from Great Britain in the west to western Ukraine and the Iranian province of Gilan in the east. It is also naturalised or introduced in some parts of Canada and the United States. The foliage and berries are extremely toxic when ingested, containing tropane alkaloids. These toxins include atropine, scopolamine, and hyoscyamine, which cause delirium and hallucinations, and are also used as pharmaceutical anticholinergics. Tropane alkaloids are of common occurrence not only in the Old World tribes Hyoscyameae (to which the genus Atropa belongs) and Mandragoreae, but also in the New World tribe Datureae - all of which belong to the subfamily Solanoideae of the plant family Solanaceae. Atropa belladonna has unpredictable effects. The antidote for belladonna poisoning is physostigmine or pilocarpine, the same as for atropine.
  • 6.9K
  • 25 Nov 2022
Topic Review
Hallmarks and Significance of Apoptosis
Apoptosis is the elimination of functionally non-essential, neoplastic, and infected cells via the mitochondrial pathway or death receptor pathway. The process of apoptosis is highly regulated through membrane channels and apoptogenic proteins. Apoptosis maintains cellular balance within the human body through cell cycle progression. Loss of apoptosis control prolongs cancer cell survival and allows the accumulation of mutations that can promote angiogenesis, promote cell proliferation, disrupt differentiation, and increase invasiveness during tumor progression. The apoptotic pathway has been extensively studied as a potential drug target in cancer treatment. 
  • 6.9K
  • 14 Feb 2023
Topic Review
Indane-1,3-Dione: From Synthetic Strategies to Applications
Indane-1,3-dione is a versatile building block used in numerous applications ranging from biosensing, bioactivity, bioimaging to electronics or photopolymerization. Indane-1-3-dione is among one of the most privileged scaffolds in chemistry, as the derivatives of this structure can find applications in various research fields ranging from medicinal chemistry, organic electronics, photopolymerization, to optical sensing and non-linear optical (NLO) applications. 
  • 6.9K
  • 29 Sep 2022
Topic Review
Urban Legend
An urban legend, urban myth, urban tale, or contemporary legend is a genre of folklore comprising stories circulated as true, especially as having happened to a friend or family member, often with horrifying or humorous elements. These legends can be entertainment, but often concern mysterious peril or troubling events, such as disappearances and strange objects. They may also be confirmation of moral standards, or reflect prejudices, or be a way to make sense of societal anxieties. Urban legends are most often circulated orally, but can be spread by any media, including newspapers, e-mail and social media. Some urban legends have passed through the years with only minor changes to suit regional variations. Recent legends tend to reflect modern circumstances: for instance, the common legend of a person being ambushed and anesthetized, only to wake up and realize that they are now missing a kidney that was supposedly surgically removed for transplantation.
  • 6.9K
  • 04 Oct 2022
Topic Review
Liquid Hydrogen
Decarbonization plays an important role in future energy systems for reducing greenhouse gas emissions and establishing a zero-carbon society. Hydrogen is believed to be a promising secondary energy source (energy carrier) that can be converted, stored, and utilized efficiently, leading to a broad range of possibilities for future applications. 
  • 6.9K
  • 27 Sep 2021
Topic Review
Wife-carrying
Wife carrying (Finnish: eukonkanto or akankanto, Estonian: naisekandmine, Swedish: kärringkånk) is a contest in which male competitors race while each carrying a female teammate. The objective is for the male to carry the female through a special obstacle track in the fastest time. The sport was first introduced at Sonkajärvi, Finland . Several types of carrying may be practised: either a classic piggyback, a fireman's carry (over the shoulder), or Estonian-style (wife upside-down on his back with her legs over the neck and shoulders).
  • 6.9K
  • 11 Oct 2022
Topic Review
Crosslinking Agent for on Cellulose-Based Hydrogels
Hydrogels are interlinked hydrophilic polymers that are insoluble in water but are capable of absorbing large amounts of water through the swelling process. During the swelling process, the polar groups in the polymer chain swiftly draw the first water molecules into the hydrogel network (bound water). The hydrogel network absorbs more water molecules due to the osmotic pressure of the interstitial water and free water. Both synthetic and natural polymers can be used to create hydrogels. Natural polymer-based hydrogels are typically chosen because of their excellent biocompatibility and biodegradability. In addition, natural polymers are less expensive than synthetic ones.  A crosslinking agent is used to strengthen the properties of the hydrogel. A chemical crosslinking agent is used more often than a physical crosslinking agent. In a chemical crosslinking agent, there are two types of crosslinking agents, which is synthetic and natural crosslinking agents. Hydrogels that utilize synthetic crosslinking agents have advantages, such as adjustable mechanical properties and easy control of the chemical composition. However, hydrogels that use natural crosslinking agents have better biocompatibility and less latent toxic effect.
  • 6.9K
  • 28 Sep 2022
Topic Review
Plasma Treatment for Seed Germination and Plant Growth
Low-temperature atmospheric pressure plasma has been used in various fields such as plasma medicine, agriculture, food safety and storage, and food manufacturing. In the field of plasma agriculture, plasma treatment improves seed germination, plant growth, and resistance to abiotic and biotic stresses, allows pesticide removal, and enhances biomass and yield.
  • 6.9K
  • 27 May 2022
Topic Review
Taxonomy
In biology, taxonomy (from grc τάξις (taxis) 'arrangement', and -νομία (-nomia) 'method') is the scientific study of naming, defining (circumscribing) and classifying groups of biological organisms based on shared characteristics. Organisms are grouped into taxa (singular: taxon) and these groups are given a taxonomic rank; groups of a given rank can be aggregated to form a more inclusive group of higher rank, thus creating a taxonomic hierarchy. The principal ranks in modern use are domain, kingdom, phylum (division is sometimes used in botany in place of phylum), class, order, family, genus, and species. The Swedish botanist Carl Linnaeus is regarded as the founder of the current system of taxonomy, as he developed a ranked system known as Linnaean taxonomy for categorizing organisms and binomial nomenclature for naming organisms. With advances in the theory, data and analytical technology of biological systematics, the Linnaean system has transformed into a system of modern biological classification intended to reflect the evolutionary relationships among organisms, both living and extinct.
  • 6.9K
  • 05 Dec 2022
Topic Review
Cydonia (Region of Mars)
Cydonia (/sɪˈdoʊniə/, /saɪˈdoʊniə/) is a region on the planet Mars that has attracted both scientific and popular interest. The name originally referred to the albedo feature (distinctively coloured area) that was visible from Earthbound telescopes. The area borders plains of Acidalia Planitia and the Arabia Terra highlands. The area includes the regions: "Cydonia Mensae", an area of flat-topped mesa-like features, "Cydonia Colles", a region of small hills or knobs, and "Cydonia Labyrinthus", a complex of intersecting valleys. As with other albedo features on Mars, the name Cydonia was drawn from classical antiquity, in this case from Kydonia, a historic polis (or "city-state") on the island of Crete. Cydonia contains the "Face on Mars", located about halfway between Arandas Crater and Bamberg Crater.
  • 6.9K
  • 25 Oct 2022
Topic Review
Kraft Lignin
After cellulose, lignin is the second most abundant biopolymer worldwide. Lignins are non-toxic and renewable, and hence may play an essential role during the change-over from a fossil-based to a bio-based economy. Lignin isolation from Kraft cooking is state of the art, the three state of the art processes are summarized and discussed, further the concept of sequerntial liquid lignin recovery is introduced.
  • 6.9K
  • 12 May 2021
Topic Review
Cybersecurity Economics
Cybersecurity economics can be defined as a field of research that utilizes a socio-technical perspective to investigate economic aspects of cybersecurity such as budgeting, information asymmetry, governance, and types of goods and services, to provide sustainable policy recommendations, regulatory options, and practical solutions that can substantially improve the cybersecurity posture of the interacting agents in the open socio-technical systems.   
  • 6.9K
  • 15 Dec 2021
Topic Review
Residential Electricity Consumption of Seoul
This entry aims to determine the relationship between residential electricity consumption and other factors by analyzing the correlation and multiple regression between residential electricity consumption and three variables which are known as the factors affecting residential electricity consumption.  
  • 6.9K
  • 03 Nov 2020
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