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Topic Review
Magnesium and COVID-19
Magnesium is the fourth most common mineral in the human body and the second richest intracellular cation. This element is necessary for many physiological reactions, especially in the cardiovascular and respiratory systems. COVID-19 is an infectious disease caused by SARS-CoV-2. The majority of people who become ill as a result of COVID-19 have mild-to-moderate symptoms and recover without specific treatment. Moreover, there are people who develop severe forms of COVID-19, which require highly specialized medical assistance. Magnesium deficiency may play a role in the pathophysiology of infection with SARS-CoV-2. The primary manifestation of COVID-19 remains respiratory, but the virus can spread to other organs and tissues, complicating the clinical picture and culminating in multiorgan failure. The key mechanisms involved in the disease include direct viral cytotoxicity, endothelial dysfunction, and exaggerated release of inflammatory cytokines. 
  • 1.8K
  • 24 Feb 2023
Topic Review
Ethiopian Wolf
The Ethiopian Wolf (Canis simensis) is a highly specialized and critically endangered canid species endemic to the Afroalpine ecosystems of the Ethiopian Highlands. With its distinctive russet-colored coat and slender build, this medium-sized wolf stands as Africa's most endangered carnivore, facing numerous threats to its survival. As a top predator and keystone species, the Ethiopian Wolf plays a crucial role in regulating prey populations and maintaining ecosystem balance in its unique Afroalpine habitat.
  • 1.8K
  • 08 Mar 2024
Topic Review
Quinoxaline-Based Photoinitiators of Polymerization
Photopolymerization offers a unique opportunity to convert liquid monomers to polymers using light as the activation source. Major efforts have been devoted to developing visible light photo-initiating systems, and the search for new dyes that can be incorporated into photocurable resins and polymerize a resin within a few seconds is still ongoing.
  • 1.8K
  • 24 Apr 2023
Topic Review
AI and Robotics Future of Technology and Society
AI and Robotics are at the forefront of technological innovation, transforming industries and reshaping the way we live and work. These cutting-edge technologies hold immense potential to revolutionize various aspects of society, from healthcare to manufacturing. This article delves into the dynamic landscape of AI and Robotics, exploring their current applications, recent advancements, ethical challenges, and future implications. By examining the intersection of artificial intelligence and robotics, we aim to uncover how these technologies are shaping the future of technology and society. This article explores the transformative potential of Artificial Intelligence (AI) and robotics, tracing their historical evolution, current applications, and future implications. AI and robotics are reshaping industries, from healthcare and manufacturing to logistics and defense, bringing unprecedented efficiency and precision. However, these advancements also raise significant ethical and societal questions, including job displacement, regulatory gaps, and safety challenges. As we progress toward increased automation and intelligent robotics, this article examines the evolving role of AI, the challenges of integrating autonomous systems, and the future of human-robot collaboration. By addressing the technical, ethical, and social impacts of these technologies, the discussion highlights the critical balance required to leverage AI and robotics responsibly.
  • 1.8K
  • 11 Apr 2025
Topic Review
Avian Sex Reversal
Sex determination and differentiation are processes by which a bipotential gonad adopts either a testicular or ovarian cell fate, and secondary sexual characteristics adopt either male or female developmental patterns. In birds, although genetic factors control the sex determination program, sex differentiation is sensitive to hormones, which can induce sex reversal when disturbed. Although these sex-reversed birds can form phenotypes opposite to their genotypes, none can experience complete sex reversal or produce offspring under natural conditions. Promising evidence indicates that the incomplete sex reversal is associated with cell autonomous sex identity (CASI) of avian cells, which is controlled by genetic factors. 
  • 1.8K
  • 16 May 2023
Topic Review
Microbiota for HPV Infection
The microbiome is able to modulate immune responses, alter the physiology of the human organism, and increase the risk of viral infections and development of diseases such as cancer. Herein, we address changes in the cervical microbiota as potential biomarkers to identify the risk of cervical intraepithelial neoplasia (CIN) development and invasive cervical cancer in the context of human papillomavirus (HPV) infection.
  • 1.8K
  • 30 Oct 2020
Topic Review
Local Anesthesia in Cancer Surgeries
The application of local anaesthetics is frequently involved in anaesthesia in the surgical treatment of various cancers. It is used in addition to or instead of general anaesthesia as a way to provide control of sensation and pain to specific regions or parts of the patients' bodies. They are thought to reduce the requirement for volatile anaesthetics and opioids used in the surgery.
  • 1.8K
  • 28 Feb 2021
Topic Review
Cerebral Asymmetry
Human functions and traits are linked to cerebral networks serving different emotional and cognitive control systems, some of which rely on hemispheric specialization and integration to promote adaptive goal-directed behavior. Among the neural systems discussed in this context are those underlying pro- and antisocial behaviors. The diverse functions and traits governing our social behavior have been associated with lateralized neural activity. However, as with other complex behaviors, specific hemispheric roles are difficult to elucidate. This is due largely to environmental and contextual influences, which interact with neural substrates in the development and expression of pro and antisocial functions. This paper will discuss the reciprocal ties between environmental factors and hemispheric functioning in the context of antisocial behavior. The paper will attempt to familiarize readers with the prominent literature and primary questions to encourage further research and in-depth discussion in this field.
  • 1.8K
  • 22 Oct 2020
Topic Review
Genetically Encoded Fluorescent Redox Biosensors
In the most general sense of this term, a genetically encoded fluorescent redox biosensor is a kind of genetic system that changes a fluorescence in response to a redox event. Most often, such a tool is a chimeric protein consisting of a sensory domain that responds to a redox stimulus, and a domain whose fluorescence changes depending on alterations occurring with the sensory domain. It can also be a single-domain fluorescent protein, the structure of which changes when exposed to a redox stimulus, and the change in the structure leads to a change in fluorescence. In addition, there are transcriptional reporters, the principle of which is based on the alteration of the transcription of the fluorescent protein gene upon exposure to a redox stimulus. This article will focus on protein genetically encoded fluorescent redox biosensors that are currently used in in vivo research.
  • 1.8K
  • 11 Dec 2020
Topic Review
Cancer and Neurodegenerative Diseases
Conditions such as Alzheimer’s (AD) and Parkinson’s diseases (PD) are less prevalent in cancer survivors and, overall, cancer is less prevalent in subjects with these neurodegenerative disorders. In addition to epidemiologic data, there is also evidence of a complex biological interconnection, with genes, proteins, and pathways often showing opposite dysregulation in cancer and neurodegenerative diseases.
  • 1.8K
  • 04 Jun 2021
Topic Review
3D Cell Culture Technology
Unlike the 2D cultures, which grow by attaching to the bottom as a monolayer, 3D cell culture refers to cells aggregated and expressed as a single tissue or form. Moreover, the 3D-cultured cells are attached to an artificially created ECM environment to interact with or grow with the surrounding environment. Therefore, unlike 2D cell cultures, cell growth in a 3D environment allows cells to grow in multiple directions rather than in a single direction in vitro, which is similar to in vivo conditions. Upon comparison, the 3D cell culture exhibits several advantages: (1) A similar biomimetic model, which is more physiologically relevant. (2) A 3D culture exhibits a high level of structural complexity and maintains homeostasis for longer. (3) 3D models can indicate how different types of cells interact. (4) 3D cultures can reduce the use of animal models. (5) They are a good simulator for the treatment of disease groups including cancer tumors.
  • 1.8K
  • 17 Nov 2021
Topic Review
Tissue Inhibitor of Metalloproteases 3
The proteolytical cleavage of transmembrane proteins with subsequent release of their extracellular domain, so-called ectodomain shedding, is a post-translational modification that plays an essential role in several biological processes, such as cell communication, adhesion and migration. Metalloproteases are major proteases in ectodomain shedding, especially the disintegrin metalloproteases (ADAMs) and the membrane-type matrix metalloproteases (MT-MMPs), which are considered to be canonical sheddases for their membrane-anchored topology and for the large number of proteins that they can release. The unique ability of tissue inhibitor of metalloproteases 3 (TIMP-3) to inhibit different families of metalloproteases, including the canonical sheddases (ADAMs and MT-MMPs), renders it a master regulator of ectodomain shedding. 
  • 1.8K
  • 16 Mar 2022
Topic Review
Neutrophil Extracellular Traps and Human Disease
The first description of a new form of neutrophil cell death distinct from that of apoptosis or necrosis was discovered in 2004 and coined neutrophil extracellular traps “(NETs)” or “NETosis”. Different stimuli for NET formation, and pathways that drive neutrophils to commit to NETosis have been elucidated in the years that followed. Critical enzymes required for NET formation have been discovered and targeted therapeutically. It has become clear that although this mechanism is thought to enhance host defense by ensnaring bacteria within large webs of DNA to increase bactericidal killing capacity, it is also injurious to innocent bystander tissue. Proteases and enzymes released from NETs injure epithelial and endothelial cells, perpetuating inflammation. In the context of autoimmunity, NETs release over 70 well-known autoantigens. NETs are associated with pathology in multiple diseases: lung diseases, vasculitis, autoimmune kidney diseases, atherosclerosis, rheumatoid arthritis, cancer, and psoriasis. Defining these pathways that drive NET release will provide insight into mechanisms of pathological insult and provide potential therapeutic targets.
  • 1.8K
  • 25 Apr 2022
Topic Review
Regulatory Pathway of Biosimilar
While most biosimilars have rigidly followed the WAC pricing of 3–30% below the reference product in the US, we can anticipate significant price drops in the future. Since the US market represents 40% of the world market, price drops in the US are pivotal in presenting the overall benefits of biosimilars. In the EU, the pricing of biosimilars is a regional issue, presenting a range of 30 to 70% of market share and price drops of up to 85%, with Norway, Denmark, and Italy leading the reductions. The success of biosimilars in Europe was due to them achieving widespread acceptance by payers, providers, and patients as an integral part of medicine through an extensive program involving preparing stakeholders, investing in evidence generation (e.g., the NorSwitch trial), and introducing incentive models to share payer savings with hospitals. A key component of this success was forced switching, which is not possible on legal grounds in some countries and due to commercial interest in others.
  • 1.8K
  • 27 Apr 2022
Topic Review
Malignant Superficial Mesenchymal Tumors in Children
Malignant superficial mesenchymal tumors are a very diverse group of neoplasms with few clinical and radiological discriminatory factors. Hence, some of these cancers are rarely suspected based on clinical and radiological grounds, others may be easily misdiagnosed, and the histological analysis of a biopsy or resection is central in the diagnostic process. In children, the age at presentation is a major element of the differential diagnosis. Some tumors have a very distinct epidemiology, while others may be seen at any age. More recently, the advances in molecular biology have greatly improved the diagnosis of mesenchymal tumors and new entities are still being described. 
  • 1.8K
  • 02 Jun 2022
Topic Review
Corium (Nuclear Reactor)
Corium, also called fuel-containing material (FCM) or lava-like fuel-containing material (LFCM), is a material that is created in the core of a nuclear reactor during a meltdown accident. It resembles natural lava in its consistency. It consists of a mixture of nuclear fuel, fission products, control rods, structural materials from the affected parts of the reactor, products of their chemical reaction with air, water and steam, and, in the event that the reactor vessel is breached, molten concrete from the floor of the reactor room.
  • 1.8K
  • 28 Oct 2022
Topic Review
Computer Vision and Artificial Intelligence for Fish Recognition
Computer vision has been applied to fish recognition. With the inception of deep learning techniques in the early 2010s, the use of digital images grew strongly, and this trend is likely to continue. As the number of articles published grows, it becomes harder to keep track of the state of the art and to determine the best course of action for new studies.
  • 1.8K
  • 24 Nov 2022
Topic Review
Minority Influence
Minority influence, a form of social influence, takes place when a member of a minority group influences the majority to accept the minority's beliefs or behavior. This occurs when a small group or an individual acts as an agent of social change by questioning established societal perceptions, and proposing alternative, original ideas which oppose the existing social norms. There are two types of social influence: majority influence (resulting in conformity and public compliance) and minority influence (resulting in conversion). Majority influence refers to the majority trying to produce conformity on the minority, while minority influence is converting the majority to adopt the thinking of the minority group. Unlike other forms of influence, minority influence is often thought of as a more innovative form of social change, because it usually involves a personal shift in private opinion. Examples of minority influence include the Civil Rights Movement in America and the anti-apartheid movement in South Africa .
  • 1.8K
  • 23 Nov 2022
Topic Review
Myeloperoxidase Regulation of Neutrophil Function
Neutrophils, the most abundant white blood cells in humans, are critical for host defense against invading pathogens. Equipped with an array of antimicrobial molecules, neutrophils can eradicate bacteria and clear debris. Among the microbicide proteins is the heme protein myeloperoxidase (MPO), stored in the azurophilic granules, and catalyzes the formation of the chlorinating oxidant HOCl and other oxidants (HOSCN and HOBr). Evolving evidence indicates that MPO can directly modulate the function and fate of neutrophils, thereby shaping immunity. These actions include MPO orchestration of neutrophil trafficking, activation, phagocytosis, lifespan, formation of extracellular traps, and MPO-triggered autoimmunity.
  • 1.8K
  • 29 Nov 2022
Topic Review
Elastomer–Hydrogel Systems
Elastomers are a class of polymeric materials that can repeatedly and easily undergo large, reversible deformations with complete recovery. They are usually composed of long-chain molecules, extremely flexible due to their ability to reconfigure themselves and dissipate an applied force. Hydrogels (HGs) are macromolecular structures consisting of polymer networks with the ability to absorb water without any dissolution. By applying sophisticated design and engineering methods, various elastomer–hydrogel systems (EHS) with outstanding performance have been developed. These systems composed of elastomers and hydrogels are very attractive due to their high biocompatibility, injectability, controlled porosity and often antimicrobial properties. Moreover, their elastomeric properties and bioadhesiveness are making them suitable for soft tissue engineering.
  • 1.8K
  • 28 Dec 2022
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