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Topic Review
Quantum Dots for Optoelectronic Applications
Quantum dots (QDs) are tiny semiconductor particles that typically range in size from 2 to 10 nanometers. Because of their small size, they have unique optical and electrical properties, resulting in quantum confinement of electrons and holes within the material. This confinement results in discrete energy levels, and the energy of the confined particles is determined by the size of the QDs QDs could be used in a variety of applications, including displays, solar cells, medical imaging, and quantum computing.. They are typically only a few nanometers in size. QDs can be employed as a light-sensitive substance, also referred to as a photoconductive substance, in a photodetector.
  • 1.7K
  • 06 Apr 2023
Topic Review
Types of Liquid Crystal Biosensors
Interactions between liquid crystal molecules and target analytes open up various biosensing applications for quick screening and point-of-care applications. There exist different kinds of biosensors, such as electrochemical, wearable, amperometric, potentiometric, optical, impedimetric and thermometric. Liquid crystal (LC) biosensors belong to the type of optical biosensors, which employ its anisotropy and sensitivity to external stimuli. As it is known, LCs are highly sensitive to environment changes, e.g., temperature, electric fields and surface interactions. The inherent property of LCs to respond to external stimuli gives LC biosensors a high potential to contribute to the new biosensing era. 
  • 1.7K
  • 02 Jan 2024
Topic Review
Antibiotics Related to Nonalcoholic Fatty Liver Disease
Nonalcoholic fatty liver disease, recently re-named metabolic dysfunction-associated steatotic fatty liver disease, is considered the most prevalent liver disease worldwide. Its molecular initiation events are multiple and not always well-defined, comprising insulin resistance, chronic low-grade inflammation, gut dysbiosis, and mitochondrial dysfunction, all of them acting on genetic and epigenetic grounds.
  • 1.7K
  • 26 Jul 2024
Topic Review
Analysis of Latin American Theme Parks
Latin American theme parks are not as well-known as North American, European, Asian and Pacific theme parks such as Disneyland, Universal Studios, Europa Park, Legoland, Chimelong Ocean Kingdom, Ocean Park and Nagashima Spa Land, but they have become an integral tourist attraction within the Latin American tourism industry, which attracts millions of visitors annually with the help of airports and airlines, public transport networks, accommodations and the wider population. Theme parks contribute significantly to the sustainability of destinations in numerous areas, including investments in infrastructures, tourism revenues, tax revenues, job creation and community sustenance.
  • 1.7K
  • 22 Feb 2024
Topic Review
SFKs in intestine
Src, originally identified as an oncogene, is a membrane-anchored tyrosine kinase (TK) and the Src family kinase (SFK) prototype. SFKs regulate the signalling induced by a wide range of cell surface receptors leading to epithelial cell growth and adhesion. In the intestine, the SFK members Src, Fyn and Yes regulate epithelial cell proliferation and migration during tissue regeneration and transformation, thus implicating conserved and specific functions. In patients with colorectal cancer (CRC), SFK activity is a marker of poor clinical prognosis and a potent driver of metastasis formation. These tumorigenic activities are linked to SFK capacity to promote the dissemination and tumour-initiating capacities of epithelial tumour cells. However, it is unclear how SFKs promote colon tumour formation and metastatic progression because SFK-encoding genes are unfrequently mutated in human cancer. Here, we review recent findings on SFK signalling during intestinal homeostasis, regeneration and tumorigenesis, and discuss about therapeutic strategies to efficiently target Src signalling in CRC
  • 1.7K
  • 03 Aug 2020
Topic Review
Crosslinking of Electrospun Gelatin Nanofibers
Electrospinning can be used to prepare nanofiber mats from diverse polymers, polymer blends, or polymers doped with other materials. Amongst this broad range of usable materials, biopolymers play an important role in biotechnological, biomedical, and other applications. Biopolymers like gelatin, however, need to be crosslinked for most applications.
  • 1.7K
  • 24 Jun 2021
Topic Review
Failure Detection for Pipeline Networks
Pipeline networks have been widely utilised in the transportation of water, natural gases, oil and waste materials efficiently and safely over varying distances with minimal human intervention. In order to optimise the spatial use of the pipeline infrastructure, pipelines are either buried underground, or located in submarine environments. Due to the continuous expansion of pipeline networks in locations that are inaccessible to maintenance personnel, research efforts have been ongoing to introduce and develop reliable detection methods for pipeline failures, such as blockages, leakages, cracks, corrosion and weld defects.
  • 1.7K
  • 28 Jul 2021
Topic Review
Regenerative Treatment for Osteoarthritis Disease
Osteoarthritis (OA) is a chronic debilitating disorder causing pain and gradual degeneration of weight-bearing joints with detrimental effects on cartilage volume as well as cartilage damage, generating inflammation in the joint structure. The etiology of OA is multifactorial. Currently, therapies are mainly addressing the physical and occupational aspects of osteoarthritis using pharmacologic pain treatment and/or surgery to manage the symptomatology of the disease with no specific regard to disease progression or prevention.
  • 1.7K
  • 14 Jun 2022
Topic Review
The Age of Reason
The Age of Reason; Being an Investigation of True and Fabulous Theology is a work by English and American political activist Thomas Paine, arguing for the philosophical position of deism. It follows in the tradition of 18th-century British deism, and challenges institutionalized religion and the legitimacy of the Bible. It was published in three parts in 1794, 1795, and 1807. It was a best-seller in the United States, where it caused a short-lived deistic revival. British audiences, fearing increased political radicalism as a result of the French Revolution , received it with more hostility. The Age of Reason presents common deistic arguments; for example, it highlights what Paine saw as corruption of the Christian Church and criticizes its efforts to acquire political power. Paine advocates reason in the place of revelation, leading him to reject miracles and to view the Bible as an ordinary piece of literature, rather than a divinely-inspired text. It promotes natural religion and argues for the existence of a creator-god. Most of Paine's arguments had long been available to the educated elite, but by presenting them in an engaging and irreverent style, he made deism appealing and accessible to the masses. Originally distributed as unbound pamphlets, the book was also cheap, putting it within the reach of a large number of buyers. Fearing the spread of what it viewed as potentially-revolutionary ideas, the British government prosecuted printers and booksellers who tried to publish and distribute it. Nevertheless, Paine's work inspired and guided many free thinkers.
  • 1.7K
  • 27 Sep 2022
Topic Review
Arms Control
Arms control is a term for international restrictions upon the development, production, stockpiling, proliferation and usage of small arms, conventional weapons, and weapons of mass destruction. Arms control is typically exercised through the use of diplomacy which seeks to impose such limitations upon consenting participants through international treaties and agreements, although it may also comprise efforts by a nation or group of nations to enforce limitations upon a non-consenting country.
  • 1.7K
  • 25 Nov 2022
Topic Review
Dysmetabolic Iron Overload Syndrome
Dysmetabolic iron overload syndrome (DIOS) corresponds to the increase in iron stores associated with components of metabolic syndrome (MtS) and in the absence of an identifiable cause of iron excess. DIOS is usually asymptomatic and can be diagnosed by investigating MtS and steatosis. About 50% of the patients present altered hepatic biochemical tests (increased levels of γ-glutamyl transpeptidase itself or associated with increased levels of alanine aminotransferase). The liver may present parenchymal and mesenchymal iron overload, but the excess of iron is commonly mild. Steatosis or steatohepatitis is observed in half of the patients. Fibrosis is observed in about 15% of patients. Hyperferritinemia may damage the myocardium, liver, and several other tissues, increasing morbidity and mortality.
  • 1.7K
  • 31 Jan 2023
Topic Review
Cardiovascular Involvement in Tuberculosis
Approximately 60% of patients with tuberculosis (TB) have a cardiovascular disease, the most common associated pathological entities being pericarditis, myocarditis, and coronary artery disease.
  • 1.7K
  • 08 May 2023
Topic Review
Zn-Pb Metallurgical Slags as Source of Metal Recovery
The mineralogical and chemical characteristics of zinc and lead smelting slags are presented, with particular reference to the slags formed during the simultaneous production of Zn and Pb by the Imperial Smelting Process. These slags, because of the presence of many metals in their composition, mainly in the form of crystalline phases, are a valuable source for their extraction. Slags from Zn-Pb metallurgy are processed on an industrial scale using pyrometallurgical and hydrometallurgical methods, alongside which a number of experiments conducted to recover metals as efficiently as possible, including bioleaching experiments.
  • 1.7K
  • 03 Jan 2024
Topic Review
Perineuronal Nets
During restricted time windows of postnatal life, called critical periods, neural circuits are highly plastic and are shaped by environmental stimuli. In several mammalian brain areas, from the cerebral cortex to the hippocampus and amygdala, the closure of the critical period is dependent on the formation of perineuronal nets (PNNs). PNNs are condensed aggregates of an extracellular matrix (ECM) enwrapping the cell body, dendrites, and axon initial segments of several neurons in the adult central nervous system (CNS). They represent one form of an ECM in the CNS, together with the ECM that is loosely distributed in the parenchyma, the ECM that constitutes the basal lamina (which separates the CNS tissue from meningeal and vascular tissues), and the ECM that is located at the nodes of Ranvier.
  • 1.7K
  • 11 Mar 2021
Topic Review
Viral Purification in Vaccine Processing
Viral vectors and viral vaccines are invaluable tools in prevention and treatment of diseases. About 14% of vaccines approved by the FDA involve enveloped viruses, while out of the 15 gene therapy products approved worldwide in 2019, six of them use enveloped viruses, and 39% of gene therapy clinical trials are using enveloped viruses. Enveloped viruses are encased in a lipid bilayer which, in most cases, fuses with the target host cell membrane to infect cells. These enveloped viruses are produced in various systems, including traditional embryonated chicken eggs or more advanced cell culture technologies such as MRC-5 cells, Vero cells and HEK293-derived cell lines. The manufacturing of viral vector and viral vaccine products has always been paved with challenges related to the downstream processing. Purification process unit operations usually start with harvest and clarification, followed by intermediate purification steps, before polishing and formulation steps. Although techniques have greatly improved over the years to generate purer high-quality products and reproducible processes while maintaining or decreasing the cost of goods, regulatory agencies are increasingly stringent regarding product identity and characterization of the end products and level of acceptable impurities as a way to ensure public safety and maintain public trust in this class of medicine.
  • 1.7K
  • 09 Aug 2021
Topic Review
Vehicle Exhaust Particle Number Regulations
In vehicle solid particle number (SPN) regulations, solid (nonvolatile) particles are defined as particles surviving thermal pre-treatment at 300-400 °C and large enough to be detected with a particle counter having approximately 50% counting efficiency at approximately 23 nm or 10 nm (depending on the regulation).
  • 1.7K
  • 23 Dec 2021
Topic Review
Small-Molecule Semiconductor-Based OFET Temperature Sensors
Organic small-molecule semiconductors offer many benefits over their polymer equivalents, including ease of production, greater purity, and increased charge carrier mobility. OFETs based on small-molecule semiconductors have been intensively investigated as sensors for a variety of applications, including gas sensing, chemical sensing, biosensors, and pressure sensing.
  • 1.7K
  • 17 Jan 2022
Topic Review
Strengthening Collaborative Food Waste Prevention in Peru
Inefficient management and handling of organic waste generated by the food service sector is a big global challenge. In addition to the negative environmental impacts of food waste, the effect of the amount of food that is wasted when it is not handled properly is even more alarming. 
  • 1.7K
  • 28 Jan 2022
Topic Review
Cadmium Recovery from Spent Ni-Cd Batteries
The significant increase in the demand for efficient electric energy storage during the last decade has promoted an increase in the production and use of Cd-containing batteries. On the one hand, the amount of toxic Cd-containing used batteries is growing, while on the other hand, Cd is on a list of critical raw materials (for Europe). Both of these factors call for the development of effective technology for Cd recovery from spent batteries. Alkaline nickel-cadmium (Ni-Cd) batteries are widely used as autonomous sources of industrial and household current (power banks) due to a successful combination of feasibility studies and achieved sustainable electrical characteristics. In recent decades, the market of secondary current sources for portable equipment has undergone significant changes, which leads to an intensive replacement of Ni-Cd batteries with lithium-ion (LIB) and nickel-metal-hydride.
  • 1.7K
  • 07 Feb 2022
Topic Review
Negative Reversibly Switchable Fluorescent Proteins
The advancement of super-resolution imaging (SRI) relies on fluorescent proteins with novel photochromic properties. Using light, the reversibly switchable fluorescent proteins (RSFPs) can be converted between bright and dark states for many photocycles and their emergence has inspired the invention of advanced SRI techniques. The general photoswitching mechanism involves the chromophore cis-trans isomerization and proton transfer for negative and positive RSFPs and hydration–dehydration for decoupled RSFPs. However, a detailed understanding of these processes on ultrafast timescales (femtosecond to millisecond) is lacking, which fundamentally hinders the further development of RSFPs. For a negative RSFP such as Dronpa, the light used to induce fluorescence can often switch the protein from the on to off state; whereas for a positive RSFP like Padron, the same light can turn more proteins on. In contrast, the decoupled RSFPs can use separate light with different wavelengths for fluorescence excitation and photoswitching.
  • 1.7K
  • 23 Jun 2022
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