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Topic Review
Anthocyanins in Whole Grain Cereals
Anthocyanins are water-soluble phenolic pigments responsible for red, purple, blue, or even black colours in fruits, vegetables, grains, flowers, and other pigmented plant tissues. All anthocyanins share the same core structure, a flavylium ion, consisting of two aromatic ring structures linked by a three-carbon heterocyclic ring that contains oxygen. The anthocyanidin (aglycone form) is the core structure of the anthocyanin. The addition of a sugar side chain results in the glycosidic form of the anthocyanidin molecule, called an anthocyanin.
  • 1.8K
  • 26 Oct 2020
Topic Review
Modified Citrus Pectin Pleiotropic Effects
Modified citrus pectin (MCP) has a low-molecular-weight degree of esterification to allow absorption from the small intestinal epithelium into the circulation. MCP produces pleiotropic effects, including but not limited to its antagonism of galectin-3, which have shown benefit in preclinical and clinical models. Regarding cancer, MCP modulates several rate-limiting steps of the metastatic cascade. MCP can also affect cancer cell resistance to chemotherapy. Regarding fibrotic diseases, MCP modulates many of the steps involved in the pathogenesis of aortic stenosis. MCP also reduces fibrosis to the kidney, liver, and adipose tissue. Other benefits of MCP include detoxification and improved immune function.
  • 1.8K
  • 10 Aug 2021
Topic Review
Advanced Glycation End Products
Diabetes mellitus (DM) is considered one of the most massive epidemics of the twenty-first century due to its high mortality rates caused mainly due to its complications; therefore, the early identification of such complications becomes a race against time to establish a prompt diagnosis. The research of complications of DM over the years has allowed the development of numerous alternatives for diagnosis. Among these emerge the quantification of advanced glycation end products (AGEs) given their increased levels due to chronic hyperglycemia, while also being related to the induction of different stress-associated cellular responses and proinflammatory mechanisms involved in the progression of chronic complications of DM. Additionally, the investigation for more valuable and safe techniques has led to developing a newer, noninvasive, and effective tool, termed skin fluorescence (SAF).
  • 1.8K
  • 10 Aug 2021
Topic Review
Non-Coding RNAs and Hereditary Hemorrhagic Telangiectasia
Non-coding RNAs (ncRNAs) are functional ribonucleic acid (RNA) species that include microRNAs (miRs), a class of short non-coding RNAs (∼21–25 nucleotides), and long non-coding RNAs (lncRNAs) consisting of more than 200 nucleotides. They regulate gene expression post-transcriptionally and are involved in a wide range of pathophysiological processes. Hereditary hemorrhagic telangiectasia (HHT) is a rare disorder inherited in an autosomal dominant fashion characterized by vascular dysplasia. Patients can develop life-threatening vascular malformations and experience severe hemorrhaging.
  • 1.8K
  • 05 Nov 2021
Topic Review
Mesenchymal Stem Cells and Exosomes in Corneal Diseases
The corneal functions (transparency, refractivity and mechanical strength) deteriorate in many corneal diseases but can be restored after corneal transplantation (penetrating and lamellar keratoplasties). Various studies have shown the differentiation of multipotent mesenchymal stem cells (MSCs) into various corneal cell types. With the unique properties of immunomodulation, anti-angiogenesis and anti-inflammation, they offer the advantages in corneal reconstruction. These effects are widely mediated by MSC differentiation and paracrine signaling via exosomes. Besides the cell-free nature of exosomes in circumventing the problems of cell-fate control and tumorigenesis, the vesicle content can be genetically modified for optimal therapeutic affinity. 
  • 1.8K
  • 20 Dec 2021
Topic Review
Organizational Self-Management
Organizational Self-management, also referred to as Workers' Self-management, Labor Management and Autogestión (see also workers' control, industrial democracy, democratic management and worker cooperative), is a form of organizational management based on self-directed work processes on the part of an organization's workforce. Self-management is a characteristic of many forms of socialism, with proposals for Self-management having appeared many times throughout the history of the socialist movement, advocated variously by libertarian and market socialists, communists and anarchists. There are many variations of Self-management. In some variants, all the worker-members manage the enterprise directly through assemblies while in other forms workers exercise management functions indirectly through the election of specialist managers. Self-management may include worker supervision and oversight of an organization by elected bodies, the election of specialized managers, or self-directed management without any specialized managers as such. The goals of self-management are to improve performance by granting workers greater autonomy in their day-to-day operations, boosting morale, reducing alienation and eliminating exploitation when paired with employee ownership. An enterprise that is self-managed is referred to as a labour-managed firm. Self-management refers to control rights within a productive organization, being distinct from the questions of ownership and what economic system the organization operates under. Self-management of an organization may coincide with employee ownership of that organization, but Self-management can also exist in the context of organizations under public ownership and to a limited extent within private companies in the form of co-determination and worker representation on the board of directors.
  • 1.8K
  • 09 Oct 2022
Topic Review
NewsRx
NewsRx is a media and technology company focusing on digital media, printed media, news services, and knowledge discovery through its BUTTER platform. In 1995 the company was the world's largest producer of health news. The company publishes 194 newsweeklies in health and other fields, which are distributed to subscribers and partners including Factiva, the Wall Street Journal Professional Edition, Thomson Reuters, ProQuest, and Cengage Learning. C W Henderson founded the company in 1984 and its first publication was AIDS Weekly. In the early 2000s, the firm added the imprint, VerticalNews to publish newsweeklies in non-health fields. Now based in Atlanta, Georgia, the company reports through its daily news service and publishes reference books through its partner, ScholarlyEditions. NewsRx launched its BUTTER platform in 2015, which is a knowledge discovery engine that delivers its content to academics, researchers, and professionals.
  • 1.8K
  • 26 Oct 2022
Topic Review
Formic Acid as Liquid Carrier for H2 Storage
The development of low-carbon technologies that will facilitate the efficient use of hydrogen (H2) as an energy carrier is a critical requirement of contemporary society. To this end, it is anticipated that the cost of H2 production will become a key factor in tandem with production efficiency, process safety, and transport. Much effort has been made to create and develop new, reversible, and sustainable H2 storage systems. Among current techniques, formic acid (FA) has been identified as an efficient energy carrier for H2 storage. Numerous homogeneous catalysts based on transition metals with high activity and selectivity have been reported for selective FA dehydrogenation. 
  • 1.8K
  • 20 Apr 2023
Topic Review
Oxidative Stress and Cardiovascular Disease
Oxidative stress plays a key role in many physiological and pathological conditions. The intracellular oxidative homeostasis is tightly regulated by the reactive oxygen species production and the intracellular defense mechanisms. Increased oxidative stress could alter lipid, DNA, and protein, resulting in cellular inflammation and programmed cell death. Evidences show that oxidative stress plays an important role in the progression of various cardiovascular diseases, such as atherosclerosis, heart failure, cardiac arrhythmia, and ischemia-reperfusion injury. There are a number of therapeutic options to treat oxidative stress-associated cardiovascular diseases. Well known antioxidants, such as nutritional supplements, as well as more novel antioxidants have been studied. In addition, novel therapeutic strategies using miRNA and nanomedicine are also being developed to treat various cardiovascular diseases.
  • 1.8K
  • 03 Feb 2021
Topic Review
TIGIT
TIGIT is a transmembrane glycoprotein comprising one immunoglobulin variable (IgV) domain, a type I transmembrane domain, and a cytoplasmic tail with an immunoreceptor tyrosine-based inhibitory motif (ITIM) and immunoglobulin tyrosine tail (ITT)-like motif.
  • 1.8K
  • 08 Apr 2021
Topic Review
Intestinal Barrier Dysfunction in Gut Dysbiosis and Diseases
The intestinal mucosal barrier, also referred to as intestinal barrier, is widely recognized as a critical player in gut homeostasis maintenance as it ensures the complex crosstalk between gut microbes (both commensals and pathogens) and the host immune system. Highly specialized epithelial cells constantly cope with several protective and harmful agents to maintain the multiple physiological functions of the barrier as well as its integrity. However, both genetic defects and environmental factors can break such equilibrium, thus promoting gut dysbiosis, dysregulated immune-inflammatory responses, and even the development of chronic pathological conditions.
  • 1.8K
  • 17 Feb 2022
Topic Review
Space Weather on Human Physiopathology
While the exact nature and mechanisms of action still need to be better understood, some adverse effects of space weather have been related to the occurrence of magnetic storms. Triggered by solar emissions, it takes about one to three days for the effects to be felt on Earth, thus leaving enough time for a warning to be issued. Such a warning system is already in place, for instance in aviation and other human endeavors. Applications in the healthcare system have also emerged. Precisely because non-photic environmental cycles are notoriously wobbly, mapping their non-stationary characteristics in specific frequency ranges as they change over time may lay the foundation to research which features of space weather may influence what aspects of human physio-pathology. Mapping long-term periodicities shared between the environment and biota will facilitate making connections between the presence of non-photic cycles in the cosmos, how they may be affecting the ionosphere and influence weather on Earth, and how these changes can impact agriculture, nutrition, the presence of pathogens, and overall human health.
  • 1.8K
  • 30 Oct 2020
Topic Review
Acinetobacter Baumannii Infections
Antibiotic resistance is one of the biggest challenges for the clinical sector and industry, environment and societal development. One of the most important pathogens responsible for severe nosocomial infections is Acinetobacter baumannii, a Gram-negative bacterium from the Moraxellaceae family, due to its various resistance mechanisms. The enormous adaptive capacity of A. baumannii and the acquisition and transfer of antibiotic resistance determinants contribute to the ineffectiveness of most current therapeutic strategies, including last-line or combined antibiotic therapy. In this review, we will present the current progress in developing innovative strategies for combating multidrug-resistant A. baumannii (MDRAB) infections.
  • 1.8K
  • 26 Oct 2020
Topic Review
DNA Loading Using Extracellular Vesicles
Gene therapy is a therapeutic strategy of delivering foreign genetic material (encoding for an important protein) into a patient’s target cell to replace a defective gene. Nucleic acids are embedded within the adeno-associated virus (AAVs) vectors; however, preexisting immunity to AAVs remains a significant concern that impairs their clinical application. Extracellular vesicles (EVs) hold great potential for therapeutic applications as vectors of nucleic acids due to their endogenous intercellular communication functions through their cargo delivery, including lipids and proteins. So far, small RNAs (siRNA and micro (mi)RNA) have been mainly loaded into EVs to treat several diseases, but the potential use of EVs to load and deliver exogenous plasmid DNA has not been thoroughly described.
  • 1.8K
  • 02 Sep 2020
Topic Review
The Keap1–Nrf2 Pathway
The Nrf2 is a transcription factor and it belongs to cap ‘n’ collar (CNC) basic leucine zipper (bZIP) protein subfamilies.
  • 1.8K
  • 23 Dec 2020
Topic Review
Potential Usage of Edible Mushrooms
Currently, the food and agricultural sectors are concerned about environmental problems caused by raw material waste, and they are looking for strategies to reduce the growing amount of waste disposal. Now, approaches are being explored that could increment and provide value-added products from agricultural waste to contribute to the circular economy and environmental protection. Edible mushrooms have been globally appreciated for their medicinal properties and nutritional value, but during the mushroom production process nearly one-fifth of the mushroom gets wasted. Therefore, improper disposal of mushrooms and untreated residues can cause fungal disease. The residues of edible mushrooms, being rich in sterols, vitamin D2, amino acids, and polysaccharides, among others, makes it underutilized waste. Most of the published literature has primarily focused on the isolation of bioactive components of these edible mushrooms; however, utilization of waste or edible mushrooms themselves, for the production of value-added products, has remained an overlooked area. Waste of edible mushrooms also represents a disposal problem, but they are a rich source of important compounds, owing to their nutritional and functional properties. Researchers have started exploiting edible mushroom by-products/waste for value-added goods with applications in diverse fields. Bioactive compounds obtained from edible mushrooms are being used in media production and skincare formulations. Furthermore, diverse applications from edible mushrooms are also being explored, including the synthesis of biosorbent, biochar, edible films/coating, probiotics, nanoparticles and cosmetic products. 
  • 1.8K
  • 08 Jun 2021
Topic Review
Veterinary Drug Residues
Veterinary drugs are substances or mixtures used for the prevention, treatment, or diagnosis of animal diseases or for purposeful regulation of animal physiological functions
  • 1.8K
  • 10 Jun 2021
Topic Review Video Peer Reviewed
Next Generation of AMR Network
Antimicrobial resistance (AMR) is one of the top 10 global public health threats facing humanity, especially in low-resource settings, and requires an interdisciplinary response across academia, government, countries, and societies. If unchecked, AMR will hamper progress towards reaching the United Nations Sustainable Development Goals (SDGs), including ending poverty and hunger, promoting healthy lives and well-being, and achieving sustained economic growth. There are many global initiatives to curb the effects of AMR, but significant gaps remain. New ways of thinking and operating in the context of the SDGs are essential to making progress. In this entry, we define the next generation of the AMR research network, its composition, and strategic activities that can help mitigate the threats due to AMR at the local, regional, and global levels. This is supported by a review of recent literature and bibliometric and network analyses to examine the current and future state of AMR research networks for global health and sustainable development. 
  • 1.8K
  • 13 Apr 2022
Topic Review
Commercialization of Electric Vehicles
Electric Vehicles (EVs) are a promising alternative to internal combustion engine vehicles as the city is transitioning to clean energy.
  • 1.8K
  • 10 Feb 2022
Topic Review
Digitalization for Energy Saving and Emission Reduction
Digital technologies find a wide use on the energy market both on the energy supply and demand side. Many digital technologies such as smart home systems reduce the production of the energy necessary to produce goods and services in all aspects of our lives.
  • 1.8K
  • 18 Mar 2022
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