Antimicrobial resistance (AMR) happens when microorganisms no longer respond to antimicrobials to treat them. Modern medicine depends on these medical substances to protect people against infection. However, several decades of antimicrobial abuse and misuse in humans, animals, and agricultural practices have accelerated AMR and created health emergencies ^[1] with huge socioeconomic impact ^[2]. Current interventions exist, yet many are not sufficient to counteract AMR and its drivers, and the AMR community identified this as an ‘implementation gap’ ^[3]. With new AMR mechanisms spreading globally, generating greater burden in low-resource non-U.S. settings, all these consequences and threats are expected to rise more affecting the delivery of Sustainable Development Goals (SDGs)—the “blueprint to achieve a better and more sustainable future for all” ^[4]. Addressing AMR as a global public health and development challenge requires holistic, multi-sectoral, and multi-disciplinary approaches across academic institutions, government sectors, and society ^[1]. Sustained collaborations are needed to curb current and future AMR challenges and not to place SDGs at risk. In this entry, we review AMR, define its drivers, and present its impact on SDGs. We also describe current global collaborative efforts on mitigating AMR and corroborate this review with bibliometric and network analyses. We identify gaps and present our definition and views on the next generation of AMR research networks, and what this network model shall look like. We define hallmarks, strategic areas, and phase-gate milestones that countries, institutions, and networks of AMR experts need to invest in to mitigate the effects of AMR as a globally multifaceted phenomenon.