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Topic Review
Different Schiff Bases
Schiff bases are a vast group of compounds characterized by the presence of a double bond linking carbon and nitrogen atoms, the versatility of which is generated in the many ways to combine a variety of alkyl or aryl substituents.
  • 1.8K
  • 18 Feb 2022
Topic Review
Root Cultures in the Production of Valuable Compounds
Medicinal plants are an inevitable source of pharmaceutical drugs and most of the world population depends on these plants for health benefits. The increasing global demand for bioactive compounds from medicinal plants has posed a great threat to their existence due to overexploitation. Adventitious root and hairy root culture systems are an alternative approach to the conventional method for mass production of valuable compounds from medicinal plants owing to their rapid growth, biosynthetic and genetic stability.
  • 1.8K
  • 17 Mar 2022
Topic Review
Sex/Gender Differences in Uses and Effects of Metformin
Metformin (MTF) occupies a major and fundamental position in the therapeutic management of type 2 diabetes mellitus (T2DM). Gender differences in some effects and actions of MTF have been reported. Women are usually prescribed lower MTF doses compared to men and report more gastrointestinal side effects. The incidence of cardiovascular events in women on MTF has been found to be lower to that of men on MTF. 
  • 1.8K
  • 22 Mar 2022
Topic Review
Phytochemicals and Nano-Phytopharmaceuticals
Nanomedicines emerged from nanotechnology and have been introduced to bring advancements in treating multiple diseases. Nano-phytomedicines are synthesized from active phytoconstituents or plant extracts. Advancements in nanotechnology also help in the diagnosis, monitoring, control, and prevention of various diseases. The field of nanomedicine and the improvements of nanoparticles has been of keen interest in multiple industries, including pharmaceutics, diagnostics, electronics, communications, and cosmetics. In herbal medicines, these nanoparticles have several attractive properties that have brought them to the forefront in searching for novel drug delivery systems by enhancing efficacy, bioavailability, and target specificity. 
  • 1.8K
  • 17 May 2022
Biography
Jun Ye
Jun Ye (Chinese: 叶军; pinyin: Yè Jūn; born 1967) is a Chinese-American physicist at JILA, National Institute of Standards and Technology, and the University of Colorado at Boulder, working primarily in the field of atomic, molecular and optical physics. Ye was born in Shanghai, China, shortly after the beginning of the Cultural Revolution. His father was a naval officer and his mother an
  • 1.8K
  • 24 Nov 2022
Biography
Philip M. Morse
Philip McCord Morse (August 6, 1903 – 5 September 1985), was an American physicist, administrator and pioneer of operations research (OR) in World War II.[1] He is considered to be the father of operations research in the U.S. Morse graduated from the Case School of Applied Science in 1926 with a B.S. in physics.[2] He earned his Ph.D. in physics from Princeton University in 1929.[3] In 19
  • 1.8K
  • 26 Dec 2022
Topic Review
Wave Energy Generation in Brazil
Seas and oceans offer great potential as a widely available source of clean and renewable energy near high energy consumption centers. This source of energy is a valuable option in the energy transition and in energy matrix decarbonization. Wave energy and an oscillating water column (OWC) device stand out as the types of ocean energy with the most potential. An onshore OWC requires locations with rocky outcrops and steeper slopes as the device needs to be physically installed and has lower energy dissipation due to friction with the seabed. However, Brazil has approximately 7490 km of coastlines, with various shoreline geometries and geomorphologies, some of which are very suitable for OWC implementation.
  • 1.8K
  • 27 Oct 2023
Topic Review
Bioactive Peptides Derived from Hen Egg Proteins
Hen eggs, characterized by high protein and digestibility, are an excellent source of food-derived bioactive peptides. Some peptides comprising fewer than six amino acids may resist gastrointestinal digestion and remain intact as they cross the intestinal epithelium.
  • 1.8K
  • 22 Mar 2024
Topic Review
Breast cancer cell growth/motility is influenced by metal compounds
Triple-negative breast cancer (TNBC) is a  highly "aggressive" malignant neoplasm with limited treatment options due to the lack of expression of estrogen and progesterone receptors and HER2/neu. In search of novel molecules displaying anti-TNBC activities, the TNBC cell line MDA-MB231 was exposed to cadmium chloride and/or manganese chloride, and a biological characterization of the effect observed was performed. The data obtained demonstrate a cytotoxic effect exerted by cadmium chloride with drastic changes affecting gene expressions and production of reactive oxygen species. Conversely, manganese chloride was effective in increasing cell number and promoting cell invasive ability.  Such effect was reverted by coexposure with cadmium chloride. Thus, metal compounds appear to be able to modulate the biological behavior of TNBC cells, although addressing them to different fates. The data obtained suggest that high environmental pollution with manganese chloride might increase the risk of breast tumorigenesis. On the other hand, the restraining modulatory property of cadmium chloride looks promising and deserves a more detailed mechanistic study aimed to the identification of possible molecular targets instrumental in inhibiting the expansion of malignant breast cancer.
  • 1.8K
  • 30 Oct 2020
Topic Review
Cuff-Less Blood Pressure Monitoring Technology
Initial calibration is a great challenge for cuff-less blood pressure (BP) measurement. The traditional one point-to-point (oPTP) calibration procedure had a strong sensitivity in the selection of initial value because of only using one sample/point to obtain unknown parameters of specific model in a calm state. In this study, a mean point-to-point (mPTP) paring calibration method through averaging and balancing calm or peaceful state was proposed for the first time. Thus, based on mPTP, a factor point-to-point (fPTP) paring calibration method through introducing the penalty factor was further proposed to improve and optimize the performance of BP estimation.
  • 1.8K
  • 29 Oct 2020
Topic Review
Microwave-Assisted Pyrolysis of Biomass
Pyrolysis is one of the thermal treatments for biomass wastes that results in the production of liquid, solid and gaseous products. Unfortunately, the complex structure of the biomass materials matrix needs elevated heating to convert these materials into useful products. Microwave heating is a promising alternative to conventional heating approaches. Recently, it has been widely used in pyrolysis due to easy operation and its high heating rate. This review tries to identify the microwave-assisted pyrolysis treatment process fundamentals and discusses various key operating parameters which have an effect on product yield. It was found that several operating parameters govern this process such as microwave power and the degree of temperature, microwave absorber addition and its concentration, initial moisture content, initial sweep gas flow rate/residence time. Moreover, this study highlighted the most attractive products of the microwave pyrolysis process. These products include synthesis gas, bio-char, and bio-oil.
  • 1.8K
  • 27 Sep 2020
Topic Review
Optimizing Sustainability Opportunities for Biochar
Biochar is most commonly considered for its use as a soil amendment, where it has gained attention for its potential to improve agricultural production and soil health. Twenty years of near exponential growth in investigation has demonstrated that biochar does not consistently deliver these benefits, due to variables in biochar, soil, climate, and cropping systems. While biochar can provide agronomic improvements in marginal soils, it is less likely to do so in temperate climates and fertile soils. Here, biochar and its coproducts may be better utilized for contaminant remediation or the substitution of nonrenewable or mining-intensive materials. 
  • 1.8K
  • 18 Oct 2021
Topic Review
Sensory Memory
During every moment of an organism's life, sensory information is being taken in by sensory receptors and processed by the nervous system. Sensory information is stored in sensory memory just long enough to be transferred to short-term memory. Humans have five traditional senses: sight, hearing, taste, smell, touch. Sensory memory (SM) allows individuals to retain impressions of sensory information after the original stimulus has ceased. A common demonstration of SM is a child's ability to write letters and make circles by twirling a sparkler at night. When the sparkler is spun fast enough, it appears to leave a trail which forms a continuous image. This "light trail" is the image that is represented in the visual sensory store known as iconic memory. The other two types of SM that have been most extensively studied are echoic memory, and haptic memory; however, it is reasonable to assume that each physiological sense has a corresponding memory store. Children for example have been shown to remember specific "sweet" tastes during incidental learning trials but the nature of this gustatory store is still unclear. However, sensory memories might be related to a region of the thalamus, which serves as a source of signals encoding past experiences in the neocortex.
  • 1.8K
  • 30 Nov 2022
Topic Review
Application of MXenes Material for Sensors
MXenes are a class of 2D early transition nitride, metal carbides, and carbonitrides that are created by the group that selectively etches IIIA/IVA elements from three-dimensional (3D) MAX -phases. MXenes, a rising star of 2D materials, are unique in that they combine the hydrophilicity of their terminating surfaces with the metallic conductivity of transition metal carbonitrides or carbides. Because of its unusual accordion-like structure and the functional groups that are added to the surface during their synthesis, MXenes have enticing electrical, optical, and magnetic properties that can be used for sensing, energy storage, and electromagnetic shielding.
  • 1.8K
  • 15 Feb 2023
Topic Review
Sustainable Supply Chain Initiatives
The supply chain initiatives can be described as a set of activities performed by the firms for smooth functioning of the holistic supply chain system with the socio-economic and environmental needs in a long term period. The traditional supply chain management (SCM) practices replaced in favor of the sustainable supply chain management (SSCM) initiatives in most of the Asian industries. Nowadays, the adoption of sustainable supply chain initiatives (SSCIs) is critical for the organization to mitigate risk, handle complexities, and business dynamics of the global outsourcing. For managing supply chains smoothly, it is the very important for industries to integrate supply chains through networks designed for achieving higher business volume. This synergistic linking of sustainable supply chain practices moves the organization towards the building of the competitive edge in the global market.
  • 1.8K
  • 09 Jul 2021
Topic Review
Engineered Bacteriophages
Engineered bacteriophages (phages) are bacteriophages that have been genetically or chemically altered in some way to create or improve a property for an application, although it would be equally valid to use this term for phages altered for research.   Application-directed properties can include: enhanced bacterial killing to improve phage therapy; insertion of reporter genes to facilitate biosensor-mediated detection; insertion of targeting peptides to a virion surface protein to enhance binding properties to bacteria or other types of cells; attachment of non-protein molecules (e.g. antibiotics or nanoparticles) to phage capsid surface proteins to facilitate phage-mediated delivery; anchoring of phages to a surface to improve target capture.  It is also possible to combine modifications to develop, for example, a phage-based cancer treatment that has binding peptides for cancer cell targeting and is conjugated to either a radioisotope nanoparticle or chemotherapy drug to improve delivery.
  • 1.8K
  • 14 Jul 2021
Topic Review
Prognosis in Pre-Fibrotic Primary Myelofibrosis
The 2016 WHO classification recognized pre-fibrotic primary myelofibrosis (pre-PMF) as a distinct entity. Nevertheless, a prognostic model specific for pre-PMF is still lacking. 
  • 1.8K
  • 08 Apr 2022
Topic Review
Antimicrobial Compounds from Microorganisms
Antimicrobial resistance is an exigent public health concern owing to the emergence of novel strains of human resistant pathogens and the concurrent rise in multi-drug resistance. An influx of new antimicrobials is urgently required to improve the treatment outcomes of infectious diseases and save lives. 
  • 1.8K
  • 22 Apr 2022
Topic Review
Rigid Templates for Fabricating 3D Nanostructures
Rigid templates are defined as opposed to soft templates, and are made of hard materials. Rigid templates have good chemical stability and mechanical rigidity, which are mostly used for the fabrication of nanostructure arrays. A wide choice of rigid templates is available, such as silicon, anodic aluminum oxide, carbon, silica spheres, biological structures, and so forth.
  • 1.8K
  • 14 Jun 2022
Topic Review
Different Pathophysiological Mechanisms of HIF-1α in Renal Disease
Partial pressure of oxygen (pO2) in the kidney is maintained at a relatively stable level by a unique and complex functional interplay between renal blood flow, glomerular filtration rate (GFR), oxygen consumption, and arteriovenous oxygen shunting. The vulnerability of this interaction renders the kidney vulnerable to hypoxic injury leading to different renal diseases. Hypoxia has long been recognized as an important factor in the pathogenesis of acute kidney injury (AKI), especially renal ischemia/reperfusion injury. Accumulating evidence suggests that hypoxia also plays an important role in the pathogenesis and progression of chronic kidney disease (CKD) and CKD-related complications, such as anemia, cardiovascular events, and sarcopenia. In addition, renal cancer is linked to deregulation of hypoxia pathways. Renal utilizes various molecular pathways to respond and adapt to changes in renal oxygenation. Particularly, hypoxia-inducible factor (HIF) (including HIF-1, 2, 3) has been shown to be activated in renal disease and plays a major role in the protective response to hypoxia. HIF-1 is a heterodimer that is composed of an oxygen-regulated HIF-1α subunit and a constitutively expressed HIF-1β subunit. In renal diseases, the critical characteristic of HIF-1α is protective, but it also has a negative effect, such as in sarcopenia. This review summarizes the mechanisms of HIF-1α regulation in renal disease.
  • 1.8K
  • 02 Nov 2022
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