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Topic Review
Antimicrobial Activity of Curcumin
Curcumin (CUR) is a natural substance extracted from turmeric that has antimicrobial properties. Due to its ability to absorb light in the blue spectrum, CUR is also used as a photosensitizer (PS) in antimicrobial Photodynamic Therapy (aPDT). 
  • 1.8K
  • 23 Jul 2021
Topic Review
Ethnobotanical Properties and Phytochemistry of Picrorhiza kurroa
Traditional remedies for the treatment of various ailments are gaining popularity. Traditionally, one of the most valuable therapeutic herbs has been Picrorhiza kurroa (P. kurroa) Royle ex Benth. Traditional and folk uses of P. kurroa include chronic constipation, skin-related problems, burning sensation, chronic reoccurring fever, jaundice, heart problems, breathing, digestion, allergy, tuberculosis, blood-related problems, prediabetes and obesity, laxative, cholagogue, and liver stimulatory.
  • 1.8K
  • 12 Dec 2022
Topic Review
Glutamatergic Neurotransmission in Alzheimer’s Disease
Alzheimer’s disease (AD) is an age-related dementia and neurodegenerative disorder, characterized by Aβ and tau protein deposition impairing learning, memory, and suppressing synaptic plasticity of neurons. Increasing evidence suggests that there is a link between the glucose and glutamate alterations with age that down-regulates glucose utilization reducing glutamate levels in AD patients. Deviations in brain energy metabolism reinforce the development of AD by hampering glutamate levels in the brain. Glutamate is a nonessential amino acid and the major excitatory neurotransmitter synthesized from glucose. Alterations in cerebral glucose and glutamate levels precede the deposition of Aβ plaques. In the brain, over 40% of neuronal synapses are glutamatergic and disturbances in glutamatergic function have been implicated in the pathophysiology of AD. Nevertheless, targeting the glutamatergic system seems to be a promising strategy to develop novel, improved therapeutics for AD. Thus, the present review will extensively cover recent findings on the dysregulation of glutamatergic signaling in AD and will highlight the molecular mechanisms through which the modulation of glutamatergic receptors and transporters might exert beneficial effects in AD treatment.
  • 1.8K
  • 10 Nov 2020
Topic Review
TiO2-Based Nanostructures for Microbial Inactivation
Pathogenic microorganisms can spread throughout the world population, as the current COVID-19 pandemic has dramatically demonstrated. In this scenario, a protection against pathogens and other microorganisms can come from the use of photoactive materials as antimicrobial agents able to hinder, or at least limit, their spreading by means of photocatalytically assisted processes activated by light—possibly sunlight—promoting the formation of reactive oxygen species (ROS) that can kill microorganisms in different matrices such as water or different surfaces without affecting human health. Here, we focus the attention on TiO2 nanoparticle-based antimicrobial materials, intending to provide an overview of the most promising synthetic techniques, toward possible large-scale production, critically review the capability of such materials to promote pathogen (i.e., bacteria, virus, and fungi) inactivation, and, finally, take a look at selected technological applications.
  • 1.8K
  • 08 Dec 2020
Topic Review
CIPA
Congenital insensitivity to pain with anhidrosis (CIPA) has two characteristic features: the inability to feel pain and temperature, and decreased or absent sweating (anhidrosis). This condition is also known as hereditary sensory and autonomic neuropathy type IV. The signs and symptoms of CIPA appear early, usually at birth or during infancy, but with careful medical attention, affected individuals can live into adulthood.
  • 1.8K
  • 04 Jan 2021
Topic Review
Molecular Mechanism of Autophagy
Autophagy (self-eating) is a multifaceted and evolutionarily preserved sequence of actions that is activated in response to dysfunctional organelles and aggregated protein to sustain cellular homeostasis.
  • 1.8K
  • 02 Mar 2021
Topic Review
Alginate/Chitosan Microparticles for Agricultural Application
Encapsulation into biopolymer microparticles ensures the protection and targeted delivery of active agents while offering controlled release with higher efficiency and environmental safety for ecological and sustainable plant production. Encapsulation of biological agents provides protection and increases its survivability while providing an environment safe for growth. The application of microparticles loaded with chemical and biological agents presents an innovative way to stimulate plant metabolites synthesis. This enhances plants’ defense against pests and pathogens and results in the production of higher quality food (i.e., higher plant metabolites share). Ionic gelation was presented as a sustainable method in developing biopolymeric microparticles based on the next-generation biopolymers alginate and chitosan. 
  • 1.8K
  • 21 May 2021
Topic Review
Homologous Recombination Deficiency in Cancer
Homologous Recombination Deficiency (HRD) is associated with sensitivity towards PARP inhibitors (PARPi) and its determination is used as a biomarker for therapy decision making.
  • 1.8K
  • 26 Jul 2021
Topic Review
Melatonin and Chronic Pain
Preclinical as well as human studies indicate that melatonin is essential for a physiological sleep state, promotes analgesia and is involved in immunometabolic signaling by regulating neuroinflammatory pathways. Experimental and clinical neuromodulation studies for chronic pain treatment suggest that neurostimulation therapies such as spinal cord stimulation, vagus nerve stimulation and dorsal root ganglion stimulation have an impact on circulating inflammatory mediators in blood, cerebrospinal fluid and saliva. 
  • 1.8K
  • 23 Aug 2021
Topic Review
Iris Species
The genus Iris from the Iridaceae family consists of more than 262 recognized species. It is an ornamental and medicinal plant widely distributed in the Northern Hemisphere. Iris species convey a long history as valuable traditional drugs with a wide variety of applications in various cultures, having been recorded since medieval times. 
  • 1.8K
  • 29 Mar 2022
Topic Review
NRF2-Activating Compounds Bearing α,β-Unsaturated Moiety
The surge of scientific interest in the discovery of Nuclear Factor Erythroid 2 (NFE2)-Related Factor 2 (NRF2)-activating molecules underscores the importance of NRF2 as a therapeutic target especially for oxidative stress. The chemical reactivity and biological activities of several bioactive compounds have been linked to the presence of α,β-unsaturated structural systems. The α,β-unsaturated carbonyl, sulfonyl and sulfinyl functional groups are reportedly the major α,β-unsaturated moieties involved in the activation of the NRF2 signaling pathway. The carbonyl, sulfonyl and sulfinyl groups are generally electron-withdrawing groups, and the presence of the α,β-unsaturated structure qualifies them as suitable electrophiles for Michael addition reaction with nucleophilic thiols of cysteine residues within the proximal negative regulator of NRF2, Kelch-like ECH-associated protein 1 (KEAP1). The physicochemical property such as good lipophilicity of these moieties is also an advantage because it ensures solubility and membrane permeability required for the activation of the cytosolic NRF2/KEAP1 system.
  • 1.8K
  • 02 Sep 2022
Topic Review
Audi E-tron
The Audi e-tron family is a series of electric and hybrid concept cars shown by Audi from 2009 onwards. In 2012 Audi unveiled a plug-in hybrid version, the Audi A3 Sportback e-tron, released to retail customers in Europe in August 2014, and slated for the U.S. in 2015.
  • 1.8K
  • 12 Aug 2023
Topic Review
Endangered Species Recovery Plan
An endangered species recovery plan, also known as a species recovery plan, species action plan, species conservation action, or simply recovery plan, is a document describing the current status, threats and intended methods for increasing rare and endangered species population sizes. Recovery plans act as a foundation from which to build a conservation effort to preserve animals which are under threat of extinction.
  • 1.8K
  • 11 Oct 2022
Topic Review
Memory Consolidation
Memory consolidation is a category of processes that stabilize a memory trace after its initial acquisition. A memory trace is a change in the nervous system caused by memorizing something. Consolidation is distinguished into two specific processes. The first, synaptic consolidation, which is thought to correspond to late-phase long-term potentiation, occurs on a small scale in the synaptic connections and neural circuits within the first few hours after learning. The second process is systems consolidation, occurring on a much larger scale in the brain, rendering hippocampus-dependent memories independent of the hippocampus over a period of weeks to years. Recently, a third process has become the focus of research, reconsolidation, in which previously consolidated memories can be made labile again through reactivation of the memory trace.
  • 1.8K
  • 17 Oct 2022
Topic Review
God in the Bahá'í Faith
The Bahá'í view of God is essentially monotheistic. God is the imperishable, uncreated being who is the source of all existence. He is described as "a personal God, unknowable, inaccessible, the source of all Revelation, eternal, omniscient, omnipresent and almighty". Though transcendent and inaccessible directly, his image is reflected in his creation. The purpose of creation is for the created to have the capacity to know and love its creator. God communicates his will and purpose to humanity through intermediaries, known as Manifestations of God, who are the prophets and messengers that have founded religions from prehistoric times up to the present day.
  • 1.8K
  • 15 Nov 2022
Topic Review
Intranasal Liposomes for Vaccine Delivery
Liposomes are safe, biocompatible, and biodegradable spherical nanosized vesicles produced from cholesterol and phospholipids. Liposomes have been widely administered intranasally for systemic and brain delivery. Intranasal liposomes are also a potential approach for vaccine delivery. Liposomes can be used as a platform to load antigens and as vaccine adjuvants to induce a robust immune response. 
  • 1.8K
  • 29 Jan 2023
Topic Review
Pyrethrins and Pyrethroids
Pyrethrins and pyrethroids are a dominating group of insecticidal compounds that have been used for a long time and are still being used today, due to their potency and their variability. From natural pyrethrins, which can be utilized especially for their biodegradable properties, to the synthetic derivatives, pyrethroids, which may be used for their potency, this class of organic insecticides displays a lot of variability. It must be acknowledged that without plants, and plant metabolites, a great area of the insecticide compound class would be missing.
  • 1.8K
  • 15 Jan 2024
Topic Review Peer Reviewed
Balanced Scorecard: History, Implementation, and Impact
The Balanced Scorecard (BSC) is a strategic management framework introduced by Kaplan and Norton in 1992 to address the limitations of traditional performance measurement systems. It integrates financial and non-financial performance measures across four perspectives—financial, customer, internal processes, and learning and growth. Over three decades, the BSC has evolved into a comprehensive strategic tool adopted across industries and sectors worldwide. While its adaptability and integrative approach are strengths, criticisms include challenges in implementation, assumed cause–effect relationships, and relevance in decentralized organizations. Future research should investigate cultural adaptation; the incorporation of environmental, social, and governance metrics; and advancements driven by artificial intelligence to maintain ongoing relevance.
  • 1.8K
  • 25 Mar 2025
Topic Review
Invasion of African Clarias gariepinus in Bangladesh
The African catfish Clarias gariepinus has been introduced for aquaculture in Bangladesh due to the scarcity of indigenous C. batrachus fingerlings. The African catfish Clarias gariepinus is a highly carnivorous species and predates small indigenous freshwater fishes when escaping into natural water bodies. However, the government of Bangladesh has banned the farming of C. gariepinus due to the carnivorous nature of this species. The introduction of C. gariepinus caused native biodiversity loss due to its predatory nature.
  • 1.8K
  • 25 Feb 2022
Topic Review
IL-7 and IL-7R in Cancer
Interleukin-7 (IL-7) is a multipotent cytokine that maintains the homeostasis of the immune system. IL-7 plays a vital role in T-cell development, proliferation, and differentiation, as well as in B cell maturation through the activation of the IL-7 receptor (IL-7R). IL-7 is closely associated with tumor development and has been used in cancer clinical research and therapy.
  • 1.8K
  • 21 Sep 2022
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