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Topic Review
UV-C Irradiation
Amongst the surface treatment technologies to emerge in the last few decades, UV-C radiation surface treatment is widely used in food process industries for the purpose of shelf life elongation, bacterial inactivation, and stimulation.
  • 1.9K
  • 21 Jun 2022
Topic Review
Lower Limb Joint Kinematics
The use of inertial measurement units (IMUs) has gained popularity for the estimation of lower limb kinematics. However, implementations in clinical practice are still lacking. This review shows that methods for lower limb joint kinematics are inherently application dependent. Sensor restrictions are generally compensated with biomechanically inspired assumptions and prior information. Awareness of the possible adaptations in the IMU-based kinematic estimates by incorporating such prior information and assumptions is necessary, before drawing clinical decisions. Future research should focus on alternative validation methods, subject-specific IMU-based biomechanical joint models and disturbed movement patterns in real-world settings.
  • 1.9K
  • 01 Nov 2020
Topic Review
Deubiquitinating Enzyme Inhibition in Cancer
Since the discovery of the ubiquitin proteasome system (UPS), the roles of ubiquitinating and deubiquitinating enzymes (DUBs) have been widely elucidated. The ubiquitination of proteins regulates many aspects of cellular functions such as protein degradation and localization, and also modifies protein-protein interactions. DUBs cleave the attached ubiquitin moieties from substrates and thereby reverse the process of ubiquitination. The dysregulation of these two paramount pathways has been implicated in numerous diseases, including cancer. Attempts are being made to identify inhibitors of ubiquitin E3 ligases and DUBs that potentially have clinical implications in cancer, making them an important target in the pharmaceutical industry. Therefore, studies in medicine are currently focused on the pharmacological disruption of DUB activity as a rationale to specifically target cancer-causing protein aberrations. Here, we briefly discuss the pathophysiological and physiological roles of DUBs in key cancer-related pathways. We also discuss the clinical applications of promising DUB inhibitors that may contribute to the development of DUBs as key therapeutic targets in the future.
  • 1.9K
  • 09 Oct 2020
Topic Review
Fall Risk Assessment Scales
Falls are recognized globally as a major public health problem. Although the elderly are the most affected population, it should be noted that the pediatric population is also very susceptible to the risk of falling. The fall risk approach is the assessment tool. There are different types of tools used in both clinical and territorial settings. 
  • 1.9K
  • 24 Jun 2021
Topic Review
Added-Value Chemicals from Lignin Oxidation
Lignocellulosic biomass, including hardwood, softwood, and herbaceous crops, is an abundant renewable resource mainly composed of cellulose, hemicellulose, and lignin. The typical lignin content may vary from 18 to 33% in softwoods, 15 to 30% in hardwoods, and 5 to 30% in herbaceous crops. However, most biorefineries are currently focused on the valorization of cellulose and hemicellulose, a so-called sugar-based platform. In this context, lignin is usually considered as a low-value residual product and has significant potential as a renewable resource to produce bio-based materials, fuels, and valuable chemicals.
  • 1.9K
  • 23 Aug 2021
Topic Review
Molecular Mechanisms of Parthanatos
Differential evolution of apoptosis, programmed necrosis, and autophagy, parthanatos is a form of cell death mediated by poly(ADP-ribose) polymerase 1 (PARP1), which is caused by DNA damage. PARP1 hyper-activation stimulates apoptosis-inducing factor (AIF) nucleus translocation, and accelerates nicotinamide adenine dinucleotide (NAD+) and adenosine triphosphate (ATP) depletion, leading to DNA fragmentation. The mechanisms of parthanatos mainly include DNA damage, PARP1 hyper-activation, PAR accumulation, NAD+ and ATP depletion, and AIF nucleus translocation. Parthanatos, a kind of new programmed death mode, has been put forward by Professors Ted and Valina Dawson to indicate a caspase-independent cell death subroutine that critically relies on the hyper-activation of poly(ADP-ribose) polymerase 1 (PARP1).
  • 1.9K
  • 18 Jul 2022
Topic Review
Development and Application of Underground Intelligent Load-Haul-Dump Vehicle
Load-haul-dump vehicle (LHD) is an important and necessary piece of mining equipment, which plays a key role in the transportation of underground ores. Traditional LHD vehicles usually complete ore shoveling, transporting and unloading through manual operation.
  • 1.9K
  • 27 Sep 2022
Topic Review
Solarisation
Pseudo-solarisation (or pseudo-solarization) is a phenomenon in photography in which the image recorded on a negative or on a photographic print is wholly or partially reversed in tone. Dark areas appear light or light areas appear dark. The term is synonymous with the Sabatier effect when referring to negatives. Solarisation and pseudo-solarisation are quite distinct effects. In short, the mechanism is due to halogen ions released within the halide grain by exposure diffusing to the grain surface in amounts sufficient to destroy the latent image.
  • 1.9K
  • 17 Oct 2022
Topic Review
Point Set Registration
In computer vision, pattern recognition, and robotics, point set registration, also known as point cloud registration or scan matching, is the process of finding a spatial transformation (e.g., scaling, rotation and translation) that aligns two point clouds. The purpose of finding such a transformation includes merging multiple data sets into a globally consistent model (or coordinate frame), and mapping a new measurement to a known data set to identify features or to estimate its pose. Raw 3D point cloud data are typically obtained from Lidars and RGB-D cameras. 3D point clouds can also be generated from computer vision algorithms such as triangulation, bundle adjustment, and more recently, monocular image depth estimation using deep learning. For 2D point set registration used in image processing and feature-based image registration, a point set may be 2D pixel coordinates obtained by feature extraction from an image, for example corner detection. Point cloud registration has extensive applications in autonomous driving, motion estimation and 3D reconstruction, object detection and pose estimation, robotic manipulation, simultaneous localization and mapping (SLAM), panorama stitching, virtual and augmented reality, and medical imaging. As a special case, registration of two point sets that only differ by a 3D rotation (i.e., there is no scaling and translation), is called the Wahba Problem and also related to the orthogonal procrustes problem.
  • 1.9K
  • 19 Oct 2022
Topic Review
Atomic Commit
In the field of computer science, an atomic commit is an operation that applies a set of distinct changes as a single operation. If the changes are applied, then the atomic commit is said to have succeeded. If there is a failure before the atomic commit can be completed, then all of the changes completed in the atomic commit are reversed. This ensures that the system is always left in a consistent state. The other key property of isolation comes from their nature as atomic operations. Isolation ensures that only one atomic commit is processed at a time. The most common uses of atomic commits are in database systems and version control systems. The problem with atomic commits is that they require coordination between multiple systems. As computer networks are unreliable services, this means no algorithm can coordinate with all systems as proven in the Two Generals Problem. As databases become more and more distributed, this coordination will increase the difficulty of making truly atomic commits.
  • 1.9K
  • 07 Nov 2022
Topic Review
Anchorite
An anchorite or anchoret (female: anchoress; adj. anchoritic; from Ancient Greek:, anachōrētḗs, "one who has retired from the world", from the verb ἀναχωρέω, anachōréō, signifying "to withdraw", "to retire") is someone who, for religious reasons, withdraws from secular society so as to be able to lead an intensely prayer-oriented, ascetic, or Eucharist-focused life. Whilst anchorites are frequently considered to be a type of religious hermit, unlike hermits they were required to take a vow of stability of place, opting instead for permanent enclosure in cells often attached to churches. Also unlike hermits, anchorites were subject to a religious rite of consecration that closely resembled the funeral rite, following which they would be considered dead to the world, a type of living saint. Anchorites had a certain autonomy, as they did not answer to any ecclesiastical authority other than the bishop. The anchoritic life is one of the earliest forms of Christian monasticism. In the Catholic Church today, it is one of the "Other Forms of Consecrated Life" and governed by the same norms as the consecrated eremitic life. From the 12th to the 16th centuries, female anchorites consistently outnumbered their male equivalents, sometimes by as many as four to one (in the 13th century), dropping eventually to two to one (in the 15th century). The sex of a high number of anchorites, however, is not recorded for these periods.
  • 1.9K
  • 13 Nov 2022
Topic Review
Lipid Metabolism and Melanoma Progression
Melanoma is a devastating skin cancer characterized by an impressive metabolic plasticity. Melanoma cells are able to adapt to the tumor microenvironment by using a variety of fuels that contribute to tumor growth and progression. In this review, the authors summarize the contribution of the lipid metabolic network in melanoma plasticity and aggressiveness, with a particular attention to specific lipid classes such as glycerophospholipids, sphingolipids, sterols and eicosanoids. They also highlight the role of adipose tissue in tumor progression as well as the potential antitumor role of drugs targeting critical steps of lipid metabolic pathways in the context of melanoma.
  • 1.9K
  • 13 Nov 2020
Topic Review
Plant Non-Coding RNAs
Plant non coding RNA review paper highlight the current knowledge of plant microRNAs, siRNAs, and lncRNAs, focussing on their origin, biogenesis, mode of actions, and their fundamental roles in plant response to abiotic stresses.
  • 1.9K
  • 17 Dec 2020
Topic Review
Ultracentrifugation Techniques for Nanoparticles Ordering
A centrifugal field can provide an external force for the ordering of nanoparticles. Especially with the knowledge from in-situ characterization by analytical (ultra)centrifugation, nanoparticle ordering can be rationally realized in preparative (ultra)centrifugation. This study summarizes the work back to the 1990s, where intuitive use of centrifugation was achieved for the fabrication of colloidal crystals to the very recent work where analytical (ultra)centrifugation is employed to tailor-make concentration gradients for advanced materials. This review is divided into three main parts. In the introduction part, the history of ordering microbeads in gravity is discussed and with the size of particles reduced to nanometers, a centrifugal field is necessary. In the next part, the research on the ordering of nanoparticles in analytical and preparative centrifugation in recent decades is described. In the last part, the applications of the functional materials, fabricated from centrifugation-induced nanoparticle superstructures are briefly discussed.
  • 1.9K
  • 05 Feb 2021
Topic Review Peer Reviewed
Pyramidal Systems in Resistance Training
Pyramidal systems refer to a particular type of resistance training in which sets are performed with increasing (or decreasing) weight, in such a way that the number of repetitions is low when the weight is high (and vice versa). Multiple implementations exist such as the light-to-heavy, triangle or asymmetric triangle system. They are similar to traditional training, but with slightly different impact on training volume, endurance or power outcome. Therefore, pyramidal systems are ideal candidates for practitioners willing to tune their training routine. 
  • 1.9K
  • 18 Apr 2022
Topic Review
Endogenous Opioid Peptides
There exist three main types of endogenous opioid peptides, enkephalins, dynorphins and β-endorphin, all of which are derived from their precursors. These endogenous opioid peptides act through opioid receptors, including mu opioid receptor (MOR), delta opioid receptor (DOR) and kappa opioid receptor (KOR), and play important roles not only in analgesia, but also many other biological processes such as reward, stress response, feeding and emotion. 
  • 1.9K
  • 08 May 2021
Topic Review
Hadron Therapy Achievements and Challenges
Protons and carbon ions (hadrons) have useful properties for the treatments of patients affected by oncological pathologies. They are more precise than conventional X-rays and possess radiobiological characteristics suited for treating radio-resistant or inoperable tumours. 
  • 1.9K
  • 07 Mar 2022
Topic Review
Wastewater Treatment in Developing Nations
Water is the founding fundamental of life and hence is a basic need of life. Due to poor water quality and sanitation problems, most health issues are caused by water-borne infections. In developing countries, untreated wastewater is released into water bodies or the ground, thereby polluting natural resources. This is due to the lack of sufficient infrastructure, planning, funding, and technologies to overcome these problems. Additionally, the urbanization of megacities in developing countries is highly accelerated, but it is disproportionate to the required resources for treating wastewater. 
  • 1.9K
  • 31 Aug 2022
Topic Review
Geomatics Engineering
Geomatics is defined in the ISO/TC 211 series of standards as the "discipline concerned with the collection, distribution, storage, analysis, processing, presentation of geographic data or geographic information". Under another definition, it "consists of products, services and tools involved in the collection, integration and management of geographic data". It includes geomatics engineering (and surveying engineering) and is related to geospatial science (also geospatial engineering and geospatial technology).
  • 1.9K
  • 17 Nov 2022
Topic Review
Video Super Resolution
Video Super Resolution is the process of generating high-resolution video frames from the given low-resolution ones. The main goal is to restore more fine details, while saving coarse ones. There are many approaches for this task, but it's still popular and challenging problem.
  • 1.9K
  • 17 Nov 2022
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