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Topic Review
Ribosome-Inactivating Proteins
Ribosome-inactivating proteins (RIPs) are rRNA N-glycosylases from plants (EC 3.2.2.22) that inactivate ribosomes thus inhibiting protein synthesis.
  • 646
  • 25 Feb 2021
Topic Review
5-Oxo-Eicosatetraenoic Acid
5-Oxo-eicosatetraenoic acid (i.e. 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid; also termed 5-oxo-ETE and 5-oxoETE) is a Nonclassic eicosanoid metabolite of arachidonic acid and the most potent naturally occurring member of the 5-HETE family of cell signaling agents. Like other cell signaling agents, 5-oxo-ETE is made by a cell and then feeds back to stimulate its parent cell (see Autocrine signaling) and/or exits this cell to stimulate nearby cells (see paracrine signaling). 5-Oxo-ETE can stimulate various cell types particularly human leukocytes but possesses its highest potency and power in stimulating the human eosinophil type of leukocyte. It is therefore suggested to be formed during and to be an important contributor to the formation and progression of eosinophil-based allergic reactions; it is also suggested that 5-oxo-ETE may also contribute inflammation, cancer cell growth, and other pathophysiological responses.
  • 645
  • 30 Nov 2022
Topic Review
Phycobilisomes and Phycobiliproteins
Eukaryotic photosynthesis arose in the course of evolution as a result of the incorporation of an unstored cyanobacterium and its transformation into chloroplasts by an ancestral heterotrophic eukaryotic cell. The pigment apparatus of earlier evolved  Archaeplastida algae and other later algal phyla turned out to be arranged in the same way having pigment-protein complexes of photosystem I (PS I), photosystem II (PS II) and antenna complex. PS I and PS II are characterized by uniform structures, while the light-harvesting antennae have undergone a number  of changes.
  • 645
  • 14 Feb 2023
Topic Review
Nobiletin and Derivatives
The search for effective methods of cancer treatment and prevention has been a continuous effort since the disease was discovered. Recently, there has been increasing interest in exploring plants and fruits for molecules that may have potential as either adjuvants or as chemopreventive agents against cancer. One of the promising compounds under extensive research is nobiletin (NOB), a polymethoxyflavone (PMF) extracted exclusively from citrus peel. Not only does NOB itself exhibit anti-cancer properties, but its derivatives are also promising chemopreventive agents; examples of derivatives with anti-cancer activity include 3′-demethylnobiletin (3′-DMN), 4′-demethylnobiletin (4′-DMN), 3′,4′-didemethylnobiletin (3′,4′-DMN) and 5-demethylnobiletin (5-DMN). In vitro studies have demonstrated differential efficacies and mechanisms of NOB and its derivatives in inhibiting and killing of colon cancer cells. The chemopreventive potential of NOB has also been well demonstrated in several in vivo colon carcinogenesis animal models. NOB and its derivatives target multiple pathways in cancer progression and inhibit several of the hallmark features of colorectal cancer (CRC) pathophysiology, including arresting the cell cycle, inhibiting cell proliferation, inducing apoptosis, preventing tumour formation, reducing inflammatory effects and limiting angiogenesis. However, these substances have low oral bioavailability that limits their clinical utility, hence there have been numerous efforts exploring better drug delivery strategies for NOB and these are part of this review. We also reviewed data related to patents involving NOB to illustrate the extensiveness of each research area and its direction of commercialisation. Furthermore, this review also provides suggested directions for future research to advance NOB as the next promising candidate in CRC chemoprevention.
  • 644
  • 31 Aug 2021
Topic Review
Lateral Flow Technologies Detect COVID-19
Lateral flow technology (also known as lateral flow assay) plays a critical role in POC testing, as the technique is rapid, cost-effective, and can be operated by untrained personnel. Lateral flow technologies can be classified as follows: lateral flow immunoassay (LFIA), nucleic acid lateral flow assay (NLFA), and nucleic acid lateral flow immunoassay (NALFIA). LFIA is able to detect antibodies/antigens, while NLFA uses a DNA or RNA probe to detect nucleic acid. Moreover, NALFIA uses both antibodies/antigens and nucleic acid as biomarkers for the detection of antigens/antibodies or amplicons.
  • 644
  • 15 Sep 2021
Topic Review
Mineral Nutrient Biomarkers and Its Applications in Epidemiology
Minerals are dietary supplements that are essential for preserving healthy physiology and function. Mineral elements such as iron (Fe), zinc (Zn), iodine (I), and selenium (Se) are highly valued in modern healthy diets as they have special roles in cellular metabolism. In addition, the oxidative or antioxidant properties of certain metals may affect cardiovascular health, and reduce the risk of anemia, cancer and so on. Therefore, adequate intake of essential minerals through diet and/or supplements is recommended to promote health. 
  • 644
  • 03 Mar 2023
Topic Review
Plastidial Starch Phosphorylase in Starch Metabolism
Starch phosphorylase is a member of the GT35-glycogen-phosphorylase superfamily. Glycogen phosphorylases have been researched in animals thoroughly when compared to plants. Genetic evidence signifies the integral role of plastidial starch phosphorylase (PHO1) in starch biosynthesis in model plants. The counterpart of PHO1 is PHO2, which specifically resides in cytosol and is reported to lack L80 peptide in the middle region of proteins as seen in animal and maltodextrin forms of phosphorylases. The function of this extra peptide varies among species and ranges from the substrate of proteasomes to modulate the degradation of PHO1 in Solanum tuberosum to a non-significant effect on biochemical activity in Oryza sativa and Hordeum vulgare.
  • 643
  • 14 Oct 2021
Topic Review
TaNACs in Wheat Crop Improvement
Wheat (Triticum aestivum) is one of the main staple food crops cultivated around the world. Although it is a very important cereal crop, it is underexplored compared to rice, barley, and maize. The main reason is its large and complex hexaploid genome, AABBDD (2n = 6x = 42), which has three homoeologous sets of genes that make research more demanding. The genome of rice is diploid, 33 times smaller than that of wheat; therefore, this species is very well explored and treated as a model among cereals. Barley and maize are diploid species. However, the first one is more closely related to wheat, thus reports on the cis-regulation of genes in these two species, rice, and barley, by NAC TFs are also discussed and compared with wheat.
  • 643
  • 27 Dec 2022
Topic Review
Integrin-Based Therapeutics in Diseases
Integrins are heterodimeric glycoproteins crucial to the physiology and pathology of many biological functions. As adhesion molecules, they mediate immune cell trafficking, migration, and immunological synapse formation during inflammation and cancer. The recognition of the vital roles of integrins in various diseases revealed their therapeutic potential. 
  • 643
  • 31 Jan 2023
Topic Review
Aerobic Exercise-Induced Cardiac Regeneration
The leading cause of heart failure is cardiomyopathy and damage to the cardiomyocytes. Adult mammalian cardiomyocytes have the ability to regenerate, but this cannot wholly compensate for myocardial cell loss after myocardial injury. Studies have shown that exercise has a regulatory role in the activation and promotion of regeneration of healthy and injured adult cardiomyocytes. However, current research on the effects of aerobic exercise in myocardial regeneration is not comprehensive. This study discusses the relationships between aerobic exercise and the regeneration of cardiomyocytes with respect to complex molecular and cellular mechanisms, paracrine factors, transcriptional factors, signaling pathways, and microRNAs that induce cardiac regeneration. The topics discussed herein provide a knowledge base for physical activity-induced cardiomyocyte regeneration, in which exercise enhances overall heart function and improves the efficacy of cardiac rehabilitation.
  • 642
  • 04 Jan 2021
Topic Review
Fluorescent Biosensors for Chemotherapy Development
Genetically-encoded fluorescent sensors have been actively developed over the last few decades and used in live imaging and drug screening. Real-time monitoring of drug action in a specific cellular compartment, organ, or tissue type; the ability to screen at the single-cell resolution; and the elimination of false-positive results caused by low drug bioavailability that is not detected by in vitro testing methods are a few of the obvious benefits of using genetically-encoded fluorescent sensors in drug screening. In combination with high-throughput screening (HTS), some genetically encoded fluorescent sensors may provide high reproducibility and robustness to assays. Here, we provide an overview of attempts at using genetically encoded fluorescent sensors in HTS of anticancer compounds.
  • 642
  • 21 Jan 2021
Topic Review
Polyethyleneimine-Based Lipopolyplexes
Lipopolyplexes based on poliethylenimine are an interesting platform for future anti-cancer gene therapies. The carrier consists of nucleic acids condensed with poliethylenimine chains and enclosed in lipid vesicles. Lipopolyplexes could be very versatile, what enables tailoring the carrier for specific thereapeutic needs, however the preparation process is a multistage and fairly sensitive one, which additionally requires a specific balance to be maintained between its stability in the body, which would allow the appropriate dose of the preparation to reach the target site, and the ability to release nucleic acid at the right place and time.
  • 642
  • 10 Jan 2022
Topic Review
Phosphorylation Signals Downstream of Dopamine Receptors in NAc
Dopamine regulates emotional behaviors, including rewarding and aversive behaviors, through the mesolimbic dopaminergic pathway, which projects dopamine neurons from the ventral tegmental area to the nucleus accumbens (NAc). Protein phosphorylation is critical for intracellular signaling pathways and physiological functions, which are regulated by neurotransmitters in the brain. Previous studies have demonstrated that dopamine stimulated the phosphorylation of intracellular substrates, such as receptors, ion channels, and transcription factors, to regulate neuronal excitability and synaptic plasticity through dopamine receptors. Recent advances in proteomics techniques have clarified the mechanisms through which dopamine controls rewarding and aversive behaviors through signal pathways in the NAc.
  • 642
  • 27 Oct 2022
Topic Review
Mammalian Unfolded Protein Response Transducers
The unfolded protein response (UPR) bears an evolutionary conserved, dual sensitivity to both protein-folding imbalances in the endoplasmic reticulum (ER) lumen and aberrant compositions of the ER membrane, referred to as lipid bilayer stress (LBS). Through transcriptional and non-transcriptional mechanisms, the UPR upregulates the protein folding capacity of the ER and balances the production of proteins and lipids to maintain a functional secretory pathway.
  • 641
  • 03 Nov 2021
Topic Review
Role of Coenzyme Q
Coenzyme Q is a unique lipidic molecule highly conserved in evolution and essential to maintaining aerobic metabolism. It is endogenously synthesized in all cells by a very complex pathway involving a group of nuclear genes that share high homology among species. This pathway is tightly regulated at transcription and translation, but also by environment and energy requirements. Dysfunction in CoQ synthesis produces mitochondrial diseases that can partially reverted by CoQ supplementation. The main function of CoQ10 in human metabolism and antioxidant protection of membranes against oxidation and ferroptosis makes CoQ10 as an essential factor in many metabolic, chronic diseases and also in aging.
  • 641
  • 29 Mar 2022
Topic Review
Mesenchymal Stem Cells in Targeting Triple-Negative Breast Cancer
Triple-negative breast cancer (TNBC) lacks estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expressions, making targeted therapies ineffective. Mesenchymal stem cells (MSCs) have emerged as a promising approach for TNBC treatment by modulating the tumor microenvironment (TME) and interacting with cancer cells.
  • 641
  • 08 May 2023
Topic Review
Bioactivity of Steroidal Arylidene Derivatives
Steroids constitute a unique class of chemical compounds, playing an important role in physiopathological processes, and have high pharmacological interest. Due to their straightforward preparation and intrinsic chemical reactivity, steroidal arylidene derivatives are important synthetic intermediates for the preparation of other compounds, particularly bearing heterocyclic systems, in addition to their relevant bioactivity with potential pharmacological interest. 
  • 640
  • 29 Apr 2021
Topic Review
The Zinc-Sensing Receptor GPR39
GPR39, also known as ZnR (zinc sensing receptor), is a member of a large family A of 7-transmembrane (7-TM) containing G protein-coupled receptors (GPCRs).
  • 640
  • 05 May 2021
Topic Review
Immune Receptors Glycosylation in Cancer
Glycosylation, which is defined as the association of a carbohydrate moiety to the substrate protein, is the most frequent type of post-translational modification (PTM). More than 50% of human proteins are subjected to the glycosylation machinery for maturation [4]. Protein glycosylation is a conserved kind of PTM that makes indispensable contributions to a wide range of biological processes including protein folding, stability, and interaction with other molecules [5,6,7]. Most membrane and secreted proteins, including immune receptors and ligands, are modified by glycosylation. Furthermore, glycan alterations on the cell surface are universally seen in cancers [8]. Immune cells recognize the abnormal glycosylation on cancer cells, and this recognition often leads to an inhibitory immune process. Thus, the glycosylation of immune receptors and ligands plays a vital role in cancer immunity.
  • 640
  • 25 May 2021
Topic Review
18F-Fluorodeoxyglucose (FDG) in Atherosclerosis
18F-Fluorodeoxyglucose (FDG) is a glucose analogue and the most-validated radiotracer for imaging high metabolically active inflammatory cells (e.g., macrophages) and tissues (e.g., atherosclerotic plaques) in animal models and humans [10]. The results have proven to be reproducible and modifiable via interventions that are anti-inflammatory [11]. FDG-PET imaging may mirror inflammatory activity in atherosclerosis due to the consumption of large amounts of glucose by inflammatory cells compared to other plaque cells.
  • 640
  • 28 Oct 2021
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