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Topic Review
Molluscivorous and Vermivorous Conus Species
It is generally believed that more than 700 Conus species have evolved during the last 50 million years. With the highest species abundance occurring in southeast Asia, most Conus can be found in the shallow waters of tropical and subtropical oceans. Conus is widely distributed in rocky shores, sandy beaches, coral reefs and intertidal waters, with depths reaching up to over 600 m. Nowadays, Conus species are generally overexploited, and some species are now endangered. Exploring these waters of potentially high species diversity could enrich our understanding of their population’s genetic structure and provide the missing pieces for clarifying Conus evolution. As the conotoxin compounds vary greatly throughout the growth stages and across geolocations within the same species, further investigation of these species-specific regional distribution differences may provide crucial insights for artificial breeding and harvesting specific bioactive compounds in the future.
  • 1.9K
  • 18 Feb 2022
Topic Review
Strategies for Reversing Senescence and the Mechanisms
Ageing can be defined as a time-dependent decline in the functionality of the body. At the cellular level, its essence can be seen as a gradual loss of normal cell function accompanied by a series of ageing phenotypes. Breaking the dominance of the senescent microenvironment in the senescent organism and changing this balance to one dominated by the rejuvenating microenvironment has the opportunity to reprogram the metabolism of senescent cells and thus break the characteristic cycle of senescence within senescent cells. 
  • 1.9K
  • 09 Mar 2022
Topic Review
Microencapsulation Technology of Phycocyanin
Phycocyanin (PC) is a blue fluorescent protein with multi-bioactive functions. The multi-bioactivities and spectral stability of phycocyanin are susceptible to external environmental conditions, which limit its wide application. Microencapsulation is a micro-packaging technology that encapsulates trace substances with polymer films. Multifarious strategies have been successfully investigated for the microencapsulation of PC.
  • 1.9K
  • 28 Sep 2022
Topic Review
Digital Subtraction Angiography Technical in Lower Limb Arteries
Cardiovascular diseases represent one of the most frequent diseases worldwide; among these, lower limb ischemia is a threatening condition, which can lead to permanent disability if not promptly and correctly diagnosed and treated. A patient’s clinical evaluation and diagnostic imaging (e.g., color-Doppler ultrasound, computed tomography angiography (CTA), and magnetic resonance imaging (MRI)) are mandatory to carefully assess arterial lesion extension and severity. Digital subtraction angiography (DSA) is a minimally invasive technique that represents the gold standard for percutaneous revascularization treatment of symptomatic patients who are refractory to medical management.
  • 1.9K
  • 21 Nov 2022
Topic Review
Wide Field Infrared Survey Telescope
The Wide Field Infrared Survey Telescope (WFIRST) is a NASA infrared space observatory currently under development. WFIRST was recommended in 2010 by United States National Research Council Decadal Survey committee as the top priority for the next decade of astronomy. On February 17, 2016, WFIRST was approved for development and launch. WFIRST is based on an existing 2.4 m wide field-of-view telescope and will carry two scientific instruments. The Wide-Field Instrument is a 288-megapixel multi-band near-infrared camera, providing a sharpness of images comparable to that achieved by the Hubble Space Telescope (HST) over a 0.28 square degree field of view, 100 times larger than that of the HST. The Coronagraphic Instrument is a high-contrast, small field-of-view camera and spectrometer covering visible and near-infrared wavelengths using novel starlight-suppression technology. The design of WFIRST is based on one of the proposed designs for the Joint Dark Energy Mission between NASA and DOE. WFIRST adds some extra capabilities to the original JDEM proposal, including a search for extra-solar planets using gravitational microlensing. In its present incarnation (2015), a large fraction of its primary mission will be focused on probing the expansion history of the Universe and the growth of cosmic structure with multiple methods in overlapping redshift ranges, with the goal of precisely measuring the effects of dark energy, the consistency of general relativity, and the curvature of spacetime. On February 12, 2018, development on the WFIRST mission was proposed to be terminated in the President's FY19 budget request, due to a reduction in the overall NASA astrophysics budget and higher priorities elsewhere in the agency. However, in March 2018 Congress approved funding to continue making progress on WFIRST until at least September 30, 2018, in a bill stating that Congress "rejects the cancellation of scientific priorities recommended by the National Academy of Sciences decadal survey process".[needs update] In testimony before Congress in July 2018, NASA administrator Jim Bridenstine proposed slowing down the development of WFIRST in order to accommodate a cost increase in the James Webb Space Telescope (JWST), which would result in decreased[clarification needed] funding for WFIRST in 2020/2021. In the President's FY2020 budget request, termination of WFIRST was proposed again, due to cost overruns and higher priority for JWST.. The telescope received $511 million for FY2020.
  • 1.9K
  • 29 Nov 2022
Topic Review
Population Stratification
Population stratification (or population structure) is the presence of a systematic difference in allele frequencies between subpopulations in a population, possibly due to different ancestry, especially in the context of association studies.
  • 1.9K
  • 02 Dec 2022
Topic Review
Membrane Biofouling
Water scarcity is an increasing problem on every continent, which instigated the search for novel ways to provide clean water suitable for human use; one such way is desalination. Desalination refers to the process of purifying salts and contaminants to produce water suitable for domestic and industrial applications. Due to the high costs and energy consumption associated with some desalination techniques, membrane-based technologies have emerged as a promising alternative water treatment, due to their high energy efficiency, operational simplicity, and lower cost. However, membrane fouling is a major challenge to membrane-based separation as it has detrimental effects on the membrane’s performance and integrity. Based on the type of accumulated foulants, fouling can be classified into particulate, organic, inorganic, and biofouling. Biofouling is considered the most problematic among the four fouling categories.
  • 1.9K
  • 27 Dec 2022
Topic Review
Role of Marine Drugs in Cardiovascular Diseases Management
Cardiovascular diseases (CVDs) are among the most impactful illnesses globally. The available therapeutic option has several side effects, including hypotension, bradycardia, arrhythmia, and alteration in different ion concentrations. Recently, bioactive compounds from natural sources, including plants, microorganisms, and marine creatures, have gained a lot of interest. Marine sources serve as reservoirs for new bioactive metabolites with various pharmacological activities. The marine-derived compound such as omega-3 acid ethyl esters, xyloketal B, asperlin, and saringosterol showed promising results in several CVDs. 
  • 1.9K
  • 28 Mar 2023
Topic Review
Silver Nanoparticles for Waste Water Management
Rapidly increasing industrialisation has human needs, but the consequences have added to the environmental harm. The pollution caused by several industries, including the dye industries, generates a large volume of wastewater containing dyes and hazardous chemicals that drains industrial effluents. The growing demand for readily available water, as well as the problem of polluted organic waste in reservoirs and streams, is a critical challenge for proper and sustainable development. Remediation has resulted in the need for an appropriate alternative to clear up the implications. Nanotechnology is an efficient and effective path to improve wastewater treatment/remediation. The effective surface properties and chemical activity of nanoparticles give them a better chance to remove or degrade the dye material from wastewater treatment. AgNPs (silver nanoparticles) are an efficient nanoparticle for the treatment of dye effluent that have been explored in many studies. The antimicrobial activity of AgNPs against several pathogens is well-recognised in the health and agriculture sectors.
  • 1.9K
  • 05 May 2023
Topic Review
Chitosan and Its Derivatives for Anticancer Drug Delivery
Chitosan is a polycationic polymer generated from chitin with various characteristics such as biocompatibility, biodegradability, non-toxicity, and mucoadhesiveness, making it an ideal polymer to fabricate drug delivery systems. However, chitosan is poorly soluble in water and soluble in acidic aqueous solutions. Furthermore, owing to the presence of reactive amino groups, chitosan can be chemically modified to improve its physiochemical properties. Chitosan and its modified derivatives can be employed to fabricate nanoparticles, which are used most frequently in the pharmaceutical sector due to their possession of various characteristics such as nanosize, appropriate pharmacokinetic and pharmacodynamic properties, non-immunogenicity, improved stability, and improved drug loading capacity. Furthermore, it is capable of delivering nucleic acids, chemotherapeutic medicines, and bioactives using modified chitosan. Chitosan and its modified derivative-based nanoparticles can be targeted to specific cancer sites via active and passive mechanisms. Based on chitosan drug delivery systems, many anticancer drugs now have better effectiveness, potency, cytotoxicity, or biocompatibility.
  • 1.9K
  • 13 Jul 2023
Topic Review
Semiochemicals and Entomopathogenic Microbials
Biological control agents and semiochemicals have become essential parts of the integrated pest management of insect pests over the last several years, as the incorporation of semiochemicals with natural enemies and entomopathogenic microbials has been gaining significance. Semiochemicals can enable the successful dispersal of entomopathogenic microbials. Using semiochemicals to disseminate microbial pathogens is still at the initial stage. For dispersal of entomopathogenic fungus semiochemicals have been successfully used in field conditions, however same can not be said about the other microbials such as  specially for bacterial and viral entomopathogens. 
  • 1.9K
  • 30 Oct 2020
Topic Review
Scanning Electrochemical Microscopy
Scanning electrochemical microscopy (SECM) is a powerful scanning probe technique for measuring the in situ electrochemical reactions occurring at various sample interfaces, such as the liquid-liquid, solid-liquid, and liquid-gas. The tip/probe of SECM is usually an ultramicroelectrode (UME) or a nanoelectrode that can move towards or over the sample of interest controlled by a precise motor positioning system. Remarkably, electrocatalysts play a crucial role in addressing the surge in global energy consumption by providing sustainable alternative energy sources. Therefore, the precise measurement of catalytic reactions offers profound insights for designing novel catalysts as well as for enhancing their performance. SECM proves to be an excellent tool for characterization and screening catalysts as the probe can rapidly scan along one direction over the sample array containing a large number of different compositions. These features make SECM more appealing than other conventional methodologies for assessing bulk solutions. SECM can be employed for investigating numerous catalytic reactions including the oxygen reduction reaction (ORR), oxygen evolution reaction (OER), hydrogen evolution reaction (HER), water oxidation, glucose oxidation reaction (GOR), and CO2 reduction reaction (CO2RR) with high spatial resolution. Moreover, for improving the catalyst design, several SECM modes can be applied based on the catalytic reactions under evaluation.
  • 1.9K
  • 11 May 2021
Topic Review
Donnan Membrane Process
Donnan membrane processes (DMPs) are driven by a potential gradient across an ion exchange membrane and have an advantage over fouling in conventional pressure driven membrane technologies, which are gaining attention. DMP is a removal, recovery and recycling technology that is commonly used for separation, purification and the concentrating of metals in different water and waste streams.
  • 1.9K
  • 01 Jun 2021
Topic Review
History and Updates of the GROINSS-V Studies
GROINSS-V-I showed that omitting inguinofemoral lymphadenectomy was safe in early-stage vulvar cancer patients with a negative sentinel lymph node, with an impressive reduction in treatment-related morbidity. GROINSS-V-II, a prospective multicenter phase II single-arm treatment trial (from 2005 to 2016) investigated whether radiotherapy could be a safe alternative for inguinofemoral lymphadenectomy in patients with a metastatic sentinel lymph node. This research showed that radiotherapy in patients with sentinel lymph node micrometastases (≤2 mm) was safe in terms of groin recurrence rate and with less treatment-related morbidity. These results, published in August 2021, should be implemented in (inter)national treatment guidelines for vulvar cancer. GROINSS-V-III recently started including patients. This research investigates the effectiveness and safety of chemoradiation in patients with a macrometastasis (>2 mm) in the sentinel lymph node. 
  • 1.9K
  • 24 Apr 2022
Topic Review
Artificial Lightweight Aggregates Made from Pozzolanic Material
Production of artificial lightweight aggregate incorporating waste materials or pozzolanic materials is advantageous and beneficial in terms of being environmentally friendly, as well as lowering carbon dioxide emissions. Moreover, additives, such as geopolymer, have been introduced as one of the alternative construction materials that have been proven to have excellent properties.
  • 1.9K
  • 16 Jun 2022
Topic Review
Global Climate Coalition
The Global Climate Coalition (GCC) (1989–2001) was an international lobbyist group of businesses that opposed action to reduce greenhouse gas emissions and publicly challenged the science behind global warming. The GCC was the largest industry group active in climate policy and the most prominent industry advocate in international climate negotiations. The GCC was involved in opposition to the Kyoto Protocol, and played a role in blocking ratification by the United States. The coalition knew it could not deny the scientific consensus, but sought to sow doubt over the scientific consensus on climate change and create manufactured controversy. The GCC dissolved in 2001 after membership declined in the face of improved understanding of the role of greenhouse gases in climate change and of public criticism.
  • 1.9K
  • 24 Nov 2022
Topic Review Video Peer Reviewed
Flash Radiotherapy: Innovative Cancer Treatment
Flash radiotherapy (Flash-RT) is an innovative technique used in radiotherapy for cancer treatment because it delivers an extremely high dose of radiation (>40 Gy/s) to the tumour in a very short period of time, typically within a fraction of a second. This ultra-fast delivery of radiation distinguishes Flash-RT from conventional radiotherapy, which typically involves the delivery of radiation over a longer time period, often several minutes. Studies conducted in cell and preclinical models suggested that Flash-RT may spare normal tissues from radiation-related side effects, such as skin toxicity, gastrointestinal complications, and damage to organs-at-risk. This is believed to be due to the unique normal tissue response to the ultra-high dose rate. Nevertheless, while Flash-RT shows promising results in preclinical and early clinical studies, one should note that the technique is still in the early stages of development. This entry provides a comprehensive exploration of the immense potentials of Flash-RT, covering its background, mechanisms, radiation sources, recent experimental findings based on cell and preclinical models, and future prospects. It aims to provide valuable insights into this innovative radiotherapy technology for anyone interested in the subject.
  • 1.9K
  • 27 Jun 2023
Topic Review
Boötes
Boötes, recognized by the International Astronomical Union (IAU), is a constellation in the northern celestial hemisphere. It is known for its prominent shape resembling a kite or an ice cream cone, with its brightest star, Arcturus, marking one corner.
  • 1.9K
  • 29 Feb 2024
Topic Review
Cenozoic Basins-evolution Eastern-External Betic Zone
Four main unconformities (1-4) were recognized in the sedimentary record of the Cenozoic basins of the eastern External Betic Zone. More in detail, they are located at different stratigraphic levels as follows: (1) Cretaceous-Paleogene boundary even if this unconformity was also recorded at the early Paleocene (Murcia sector) and early Eocene (Alicante sector); (2) Eocene-Oligocene boundary and quite synchronous in the whole considered area; (3) early Burdigalian, and quite synchronous (recognized in the Murcia sector); (4) middle Tortonian (recognized in Murcia and Alicante sectors). These unconformities correspond to stratigraphic gaps of different temporal extensions with different meanings, which allowed recognizing minor sedimentary cycles in the Paleocene-Miocene time span. The Cenozoic marine sedimentation started over the oldest unconformity (i.e. the principal one), above the Mesozoic marine deposits. Paleocene-Eocene sedimentation shows numerous tectofacies (such as: turbidites, slumps, olistostromes, mega-olistostromes and pillow-beds) interpreted as related to an early, blind and deep-seated tectonic activity, acting in the more internal subdomains of the External Betic Zone as a result of the geodynamic processes related to the evolution of the westernmost branch of the Tethys. The second unconformity resulted from a Oligocene to Aquitanian sedimentary evolution in the Murcia Sector from marine realms to continental environments. This last time interval is characterized as the previous one by a gentle tectonic activity. On the other hand, the Miocene sedimentation was totally controlled by the development of superficial thrusts and/or bend zones of strike-slip faults both related to the regional geodynamic evolutionary framework linked to the Mediterranean opening. These bends of strike-slip faults created subsidence areas (pull-apart basin-type) and affected the sedimentation lying above the third unconformity. By contrast, the subsidence areas were bounded by structural highs affected by thrusts and folds. After the third unconformity, the Burdigalian-Serravallian sedimentation occurred mainly in shallow- to deep-water marine environments (Tap Fm). During the late Miocene, after the fourth unconformity, the activation of the bend zones of strike-slip faults caused a shallow marine environment sedimentation in the Murcia sector and a continental (lacustrine and fluvial) deposition in the Alicante sector represented, the latter resulting in alluvial fan deposits. Furthermore, the location of these fans changed over time according to the activation of faults responsible for the tectonic rising of Triassic salt deposits, which fed the fan themselves.
  • 1.9K
  • 10 Oct 2020
Topic Review
Manufacturing Sectors Supply Chain 4.0
The search for sustainability in the Supply Chain (SC) is one of the tasks that most concerns business leaders in all manufacturing sectors because of the importance that the Supply Chain has as a transversal tool and due to the leading role that it has been playing lately.
  • 1.9K
  • 18 Dec 2020
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