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HandWiki. Population Stratification. Encyclopedia. Available online: https://encyclopedia.pub/entry/37816 (accessed on 23 September 2026).
HandWiki. Population Stratification. Encyclopedia. Available at: https://encyclopedia.pub/entry/37816. Accessed September 23, 2026.
HandWiki. "Population Stratification" Encyclopedia, https://encyclopedia.pub/entry/37816 (accessed September 23, 2026).
HandWiki. (2022, December 02). Population Stratification. In Encyclopedia. https://encyclopedia.pub/entry/37816
HandWiki. "Population Stratification." Encyclopedia. Web. 02 December, 2022.
Population Stratification
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The content is sourced from: https://handwiki.org/wiki/Biology:Population_stratification

Population stratification (or population structure) is the presence of a systematic difference in allele frequencies between subpopulations in a population, possibly due to different ancestry, especially in the context of association studies.

allele frequencies population subpopulations

References

  1. Pritchard, J.K. and Rosenberg, N.A. (1999). Use of unlinked genetic markers to detect population stratification in association studies. American Journal of Human Genetics 65:220–228. doi https://doi.org/10.1086/302449
  2. Devlin, B. and Roeder, K. (1999). Genomic control for association studies, Biometrics 55(4): 997–1004.
  3. Pritchard, JK, Stephens, M, Rosenberg NA, and Donnelly P. (2000) Association mapping in structured populations. American Journal of Human Genetics 67: 170–181
  4. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. (2006) Principal components analysis corrects for stratification in genome-wide association. Nature Genetics 38:904–909
  5. Lander, E. S. and Schork, N. J. (1994). Genetic dissection of complex traits, Science 265(5181): 2037–2048.
  6. Devlin, B. and Roeder, K. (1999). Genomic control for association studies, Biometrics 55(4): 997–1004.
  7. Bacanu, S.-A., Devlin, B. and Roeder, K. (2002). Association studies for quantitative traits in structured populations, Genet Epidemiol 22(1): 78–93.
  8. Reich, D. E. and Goldstein, D. B. (2001). Detecting association in a case-control study while correcting for population stratification, Genet Epidemiol 20(1): 4–16.
  9. Bacanu, S. A., Devlin, B. and Roeder, K. (2000). The power of genomic control, Am J Hum Genet 66(6): 1933–1944.
  10. Devlin, B. and Roeder, K. (1999). Genomic control for association studies, Biometrics 55(4): 997–1004.
  11. Marchini, J., Cardon, L. R., Phillips, M. S. and Donnelly, P. (2004). The effects of human population structure on large genetic association studies, Nat Genet 36(5): 512–517.
  12. Scerri, Eleanor M.L.; Thomas, Mark G.; Manica, Andrea; Gunz, Philipp; Stock, Jay T.; Stringer, Chris; Grove, Matt; Groucutt, Huw S. et al. (August 2018). "Did Our Species Evolve in Subdivided Populations across Africa, and Why Does It Matter?". Trends in Ecology & Evolution 33 (8): 582–594. doi:10.1016/j.tree.2018.05.005. PMID 30007846.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6092560
  13. Rodríguez, Willy; Mazet, Olivier; Grusea, Simona; Arredondo, Armando; Corujo, Josué M.; Boitard, Simon; Chikhi, Lounès (December 2018). "The IICR and the non-stationary structured coalescent: towards demographic inference with arbitrary changes in population structure". Heredity 121 (6): 663–678. doi:10.1038/s41437-018-0148-0. ISSN 0018-067X. PMID 30293985.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=6221895
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