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Topic Review
Claws and Denticles of Coconut Crabs
The exoskeleton of the pinching side of claws with denticles and of the outer side without them on the coconut crab, Birgus latro, which is a rare organism, were studied using a materials science approach. The mechanical resistance of three claws of different sizes was investigated along the exoskeleton thickness from the outer surface to the inner surface, and the results were compared, including the contribution of the microstructure and chemical compositions. Mechanical properties, hardness (H) and stiffness (Er), were probed through nanoindentation tests.
  • 1.9K
  • 28 Mar 2022
Topic Review
Architectures of Polyacrylic Acid
Polyacrylic acid (PAA) is a non-toxic, biocompatible, and biodegradable polymer that gained lots of interest in recent years. PAA nano-derivatives can be obtained by chemical modification of carboxyl groups with superior chemical properties in comparison to unmodified PAA.
  • 1.9K
  • 01 Apr 2022
Topic Review
Function
In evolutionary biology, function is the reason some object or process occurred in a system that evolved through natural selection. That reason is typically that it achieves some result, such as that chlorophyll helps to capture the energy of sunlight in photosynthesis. Hence, the organism that contains it is more likely to survive and reproduce, in other words the function increases the organism's fitness. A characteristic that assists in evolution is called an adaptation; other characteristics may be non-functional spandrels, though these in turn may later be co-opted by evolution to serve new functions. In biology, function has been defined in many ways. In physiology, it is simply what an organ, tissue, cell or molecule does. In the philosophy of biology, talk of function inevitably suggests some kind of teleological purpose, even though natural selection operates without any goal for the future. All the same, biologists often use teleological language as a shorthand for function. In contemporary philosophy of biology, there are three major accounts of function in the biological world: theories of causal role, selected effect, and goal contribution.
  • 1.9K
  • 28 Oct 2022
Topic Review
Single Molecule Real Time Sequencing
Single molecule real time sequencing (SMRT) is a parallelized single molecule DNA sequencing method. Single molecule real time sequencing utilizes a zero-mode waveguide (ZMW). A single DNA polymerase enzyme is affixed at the bottom of a ZMW with a single molecule of DNA as a template. The ZMW is a structure that creates an illuminated observation volume that is small enough to observe only a single nucleotide of DNA being incorporated by DNA polymerase. Each of the four DNA bases is attached to one of four different fluorescent dyes. When a nucleotide is incorporated by the DNA polymerase, the fluorescent tag is cleaved off and diffuses out of the observation area of the ZMW where its fluorescence is no longer observable. A detector detects the fluorescent signal of the nucleotide incorporation, and the base call is made according to the corresponding fluorescence of the dye.
  • 1.9K
  • 01 Nov 2022
Topic Review
Cells Fusion
The biological phenomenon of cell fusion remains a mystery. Even though it is mandatory for several physiological and pathopyhsiological processes considerably less is still known how the merging of two (and more) cells is regulated. Cells are not fusogenic per se. They first have to be converted into a pro-fusogenic state and have to re-enter to a non-fusogenic state after hybridisation. Likewise, different cell fusion mechanisms have been developed during evolution depending on different proteins and different membrane merging strategies. This entry gives a brief overview about those molecules and conditions that direct cell fusion.
  • 1.9K
  • 27 Oct 2020
Topic Review
Viable Bacteria in Dust-Generating Area
The distribution of microorganisms in the atmospheric circulation affects the animals that inhabit the area. Also, many organisms that share the environment also influence the distribution of environmental bacteria. In this paper, we focused on microbes that survive on the surface of Asian Dust, and clarified their topographical features and distribution. The characteristics of microorganisms that are easily influenced by environmental factors, and their effects on the atmospheric circulation are considered as issues of the One Health Concept.
  • 1.9K
  • 16 Sep 2020
Topic Review
Paroxetine Molecular Mechanisms of Action
In the 21st century and especially during a pandemic, the diagnosis and treatment of depression is an essential part of the daily practice of many family doctors. It mainly affects patients in the age category 15–44 years, regardless of gender. Anxiety disorders are often diagnosed in children and adolescents. Social phobias can account for up to 13% of these diagnoses. Social anxiety manifests itself in fear of negative social assessment and humiliation, which disrupts the quality of social functioning. Treatment of the above-mentioned disorders is based on psychotherapy and phar-macotherapy. Serious side effects or mortality from antidepressant drug overdose are currently rare. Recent studies indicate that paroxetine (ATC code: N06AB), belonging to the selective sero-tonin reuptake inhibitors, has promising therapeutic effects and is used off-label in children and adolescents.
  • 1.9K
  • 26 Feb 2021
Topic Review
Fasciae
The fascia can be defined as a dynamic highly complex connective tissue network composed of different types of cells embedded in the extracellular matrix and nervous fibers: each component plays a specific role in the fascial system changing and responding to stimuli in different ways.
  • 1.9K
  • 18 Mar 2021
Topic Review
Technologies and Industry 4.0 in Forest Supply Chain
Forestry products and forestry organizations play an essential role in our lives and significantly contribute to the global economy. They are also being impacted by the rapid development of advanced technologies and Industry 4.0. More specifically, several technologies associated with Industry 4.0 have been identified for their potential to optimize traditional forest supply chains. This research systematically investigated these technologies and the scientific evidence on their impact on forest supply chains. 
  • 1.9K
  • 16 Jan 2022
Topic Review
Deep Eutectic Solvents for Biomass-Based Waste Valorization
Biomass waste streams are potential feedstocks for a variety of products such as fuels, polymers, and building blocks. The deep eutectic solvents (DESs), eutectic mixtures of Lewis (or Brønsted) acids and bases with incomplete proton transfer, were intentionally designed by choosing two or more distinct components that could interact via hydrogen bonding. The DESs, often with non-stoichiometric ratios between components, present melting points significantly lower than the starting materials and produce mixtures of charged and neutral species. 
  • 1.9K
  • 14 Oct 2022
Topic Review
Alpha-Amanitin
alpha-Amanitin or α-amanitin is a cyclic peptide of eight amino acids. It is possibly the most deadly of all the amatoxins, toxins found in several species of the mushroom genus Amanita, one being the death cap (Amanita phalloides) as well as the destroying angel, a complex of similar species, principally A. virosa and A. bisporigera. It is also found in the mushrooms Galerina marginata and Conocybe filaris. The oral -1">50 of amanitin is 100 μg/kg for rats. Unlike most cyclic peptides, amatoxins (and phallotoxins) are synthesized on ribosomes. The genes encoding the proprotein for α-amanitin belong to the same family as those that encode for phallacidin (a phallotoxin).
  • 1.9K
  • 14 Oct 2022
Topic Review
4 Times Square
4 Times Square, also formerly known as the Condé Nast Building, is a skyscraper in Times Square in Midtown Manhattan, New York City . Located on Broadway between West 42nd and 43rd Streets, the structure was finished in January 2000 as part of a larger project to redevelop 42nd Street. The architects were Fox & Fowle, who also designed the Reuters Building as part of the larger project. The 809-foot (246.5 m), 52-story building is the 28th tallest building in New York City and the 59th tallest in the United States. Owned by the Durst Organization, the building contains 1,600,000 square feet (150,000 m2) of floor space.
  • 1.9K
  • 04 Nov 2022
Topic Review
Schizotypal Personality Disorder
Schizotypal personality disorder (STPD), also known as schizotypal disorder, is a mental and behavioural disorder. DSM classification describes the disorder specifically as a personality disorder characterized by thought disorder, paranoia, a characteristic form of social anxiety, derealization, transient psychosis, and unconventional beliefs. People with this disorder feel pronounced discomfort in forming and maintaining social connections with other people, primarily due to the belief that other people harbour negative thoughts and views about them. Peculiar speech mannerisms and socially unexpected modes of dress are also characteristic. Schizotypal people may react oddly in conversations, not respond, or talk to themselves. They frequently interpret situations as being strange or having unusual meaning for them; paranormal and superstitious beliefs are common. Schizotypal people usually disagree with the suggestion their thoughts and behaviour are a 'disorder', and seek medical attention for depression or anxiety instead. Schizotypal personality disorder occurs in approximately 3% of the general population and is more common in males. The term "schizotype" was first coined by Sandor Rado in 1956 as an abbreviation of "schizophrenic phenotype". STPD is classified as a cluster A personality disorder, also known as the "odd or eccentric" cluster.
  • 1.9K
  • 07 Nov 2022
Topic Review
Macrophage, Meta-Inflammation, and Inflammaging
Macrophages are central players in systemic inflammation associated with obesity and aging, termed meta-inflammation and inflammaging. Activities of macrophages elicited by the two chronic conditions display shared and distinct patterns mechanistically, resulting in multifaceted actions for their pathogenic roles. Drastically expanded tissue macrophage populations under obesity and aging stress attribute to both enhanced recruitment and local expansion.
  • 1.9K
  • 25 Nov 2022
Biography
Fernando Holiday
Fernando Silva Bispo, better known as Fernando Holiday (September 22, 1996) is a Brazilian politician affiliated with Democratas (DEM) and councilor of the city of São Paulo.[1] He was elected with 48,055 votes in the 2016 elections,[2] and became the first openly gay councilor.[3] He is the national coordinator of the Free Brazil Movement (MBL) and a law student.[4][5] Holiday became known fo
  • 1.9K
  • 07 Dec 2022
Topic Review
Construction Rework Cost Prediction Using Machine Learning
Predicting the construction cost of rework (COR) allows for the advanced planning and prompt implementation of appropriate countermeasures. Machine learning (ML) offers a data-oriented solution that can be utilized in different construction project contexts. ML approaches can predict COR by learning the complex patterns within the quality dataset.
  • 1.9K
  • 09 Dec 2022
Topic Review
Evolution of Intelligent Vehicle Technology
The time evolution of intelligent vehicle technology is explained, which highlights the development of an intelligentvehicle and its safety applications, focusing on the various usages of perception sensors in production.
  • 1.9K
  • 25 Nov 2020
Topic Review
Wave-Structure-Seabed Interactions and Scour
Sediment transport has been the subject of extensive research over recent decades, particularly wave–structure interactions and, more importantly, their effects on the seabed. It includes mechanical models, analytical solutions of wave–structure–seabed interactions, and their verification with numerical models and experimental tests. Experimentally, both field and laboratory measurements focus on the structure foundation. Moreover, given the great progress in numerical modelling in the last decade, there is a need to put into context and focus the most widely used numerical approaches for modelling the wave-structure-seabed interaction. The numerical model selected and the resolution method depend mainly on the coastal study area, the importance and dependence of the processes involved, the temporal-spatial scale of the problem and the computational time.
  • 1.9K
  • 16 Jun 2021
Topic Review
Policy for Solar Photovoltaics in Vietnam
Vietnam becomes the world's third-largest market for photovoltaic solar in 2020 after a series of policy changes for grid-connected solar power by the Vietnamese government.
  • 1.9K
  • 06 Jun 2023
Topic Review
Matrix Vesicle-Mediated and Osteocytic Regulation of Bone Mineralization
Bone mineralization entails two mineralization phases: primary and secondary mineralization. Primary mineralization is achieved when matrix vesicles are secreted by osteoblasts, and thereafter, bone mineral density gradually increases during secondary mineralization. Nearby extracellular phosphate ions (PO43−) flow into the vesicles via membrane transporters and enzymes located on the vesicles’ membranes, while calcium ions (Ca2+), abundant in the tissue fluid, are also transported into the vesicles. The accumulation of Ca2+ and PO43− in the matrix vesicles induces crystal nucleation and growth. The calcium phosphate crystals grow radially within the vesicle, penetrate the vesicle’s membrane, and continue to grow outside the vesicle, ultimately forming mineralized nodules. The mineralized nodules then attach to collagen fibrils, mineralizing them from the contact sites (i.e., collagen mineralization). Afterward, the bone mineral density gradually increases during the secondary mineralization process.
  • 1.9K
  • 28 Sep 2022
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