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Topic Review
Intel Fortran Compiler
Intel Fortran Compiler, is a group of Fortran compilers from Intel for Windows, macOS, and Linux.
  • 1.9K
  • 11 Oct 2022
Topic Review
Fracture Conductivity Damage on Post Hydrofrac Well Productivity
Hydraulic fracturing or hydro-frac fluids can impede well production due to the damage caused to the reservoir formation and fracture face, generated from adverse interactions with reservoir rock. Understanding the mechanisms of hydraulic fracturing, optimum treatment designs, and pumping/pressure profiles is critical for hydro-frac success.
  • 1.9K
  • 28 Oct 2022
Topic Review
Nosler Proprietary Cartridges
Nosler produces various high performance hollow point and soft point hunting bullets.
  • 1.9K
  • 02 Nov 2022
Topic Review
Global Buddhist Network
The Global Buddhist Network (GBN), previously known as the Dhammakaya Media Channel (DMC) is a Thai online television channel concerned with Buddhism. The channel's taglines were "The secrets of life revealed" and "The only one", but these were later replaced by "Channel for the path to the cessation of suffering and attainment of Dhamma". The channel features many types of programs with Buddhist content, and has programs in several languages. The channel started in 2002, as a means to reach remote provinces in Thailand. Controversially, the channel made international headlines in 2012 when it featured a teaching on the afterlife of Steve Jobs. On 26 December 2016, Thai authorities withdrew the permit for the satellite channel permanently, during the legal investigations into the temple by the Thai junta. In April 2017, it was reported, however, that the channel's programming had continued, but broadcast through the Internet only. In its online format, the channel has been renamed Global Buddhist Network.
  • 1.9K
  • 03 Nov 2022
Biography
Clemens Herschel
Clemens Herschel (March 23, 1842 – March 1, 1930) was an American hydraulic engineer. His career extended from about 1860 to 1930, and he is best known for developing the Venturi meter, which was the first large-scale, accurate device for measuring water flow.[1][2] Clemens was born in Vienna in 1842. His family immigrated to Davenport, Iowa in 1850. He spent most of his life practicing his
  • 1.9K
  • 24 Nov 2022
Topic Review
Grandidier's Mongoose
Grandidier's mongoose (Galidictis grandidieri) (Figure 1) is a rare and elusive carnivore native to Madagascar. Named after the French naturalist Alfred Grandidier, this mongoose species is distinguished by its slender body, short legs, and long, bushy tail. Endemic to Madagascar's dry deciduous forests, Grandidier's mongoose is known for its solitary and nocturnal habits, making it a challenging species to study in its natural habitat.
  • 1.9K
  • 15 Mar 2024
Topic Review
Quinoa
Quinoa (Chenopodium quinoa Willd.) is native to the Andean region and has attracted a global growing interest due its unique nutritional value. The protein content of quinoa grains is higher than other cereals while it has better distribution of essential amino acids. It can be used as an alternative to milk proteins. Additionally, quinoa contains a high amount of essential fatty acids, minerals, vitamins, dietary fibers, and carbohydrates with beneficial hypoglycemic effects while being gluten-free. Furthermore, the quinoa plant is resistant to cold, salt, and drought, which leaves no doubt as to why it has been called the “golden grain”. On that account, production of quinoa and its products followed an increasing trend that gained attraction in 2013, as it was proclaimed to be the international year of quinoa. In this respect, this review provides an overview of the published results regarding the nutritional and biological properties of quinoa that have been cultivated in different parts of the world during the last two decades.
  • 1.9K
  • 27 Oct 2020
Topic Review
Infectious Diseases Associated with and Causing Disaster
In 2019, 396 natural disasters were recorded in the Emergency Events Database (EM-DAT), with 11,755 deaths, 95 million people affected, and USD 103 billion in economic losses worldwide. This burden was not shared equally since Asia suffered the highest impact, accounting for 40% of disaster events, 45% of deaths and 74% of the total affected. During disasters, a lack of safe water access and inadequate sanitation facilities allow the transmission of water-borne and food-borne pathogens. Diarrheal diseases such as cholera, typhoid fever, and shigellosis cause epidemics with high mortality rates. Malaria and other vector-borne diseases in risk areas include arboviruses, such as dengue, yellow fever, Japanese encephalitis, Rift Valley fever, and tick-borne illnesses, including Crimean–Congo hemorrhagic fever and typhus. Diseases associated with overcrowding, such as measles in unvaccinated areas and tuberculosis, can occur after natural disasters.
  • 1.9K
  • 09 Mar 2022
Topic Review
Molecular Mechanisms of Viroids
Viroids are one of the most inscrutable single-stranded, structured, circular RNA pathogens of plants as well as the smallest infectious agents ever known. Despite being incapable of coding for any proteins, viroids affect susceptible plant hosts with visually discernible symptoms resembling those induced by several plant viruses. Diener, 1967, 1971 discovered and exemplified the Potato Spindle Tuber Viroid (PSTVd), the first viroid ever known. He coined the term “viroid” to represent this diminutive, naked, protein-free, circular RNA plant pathogen. This conceptualization of the viroid was further substantiated by Sänger, 1972 as well as Semancik and Weathers, 1972, who identified the citrus exocortis viroid (CEVd) that is responsible for causing the citrus exocortis disease. Another viroid, the chrysanthemum stunt viroid (CSVd) is also one of the viroids initially identified. 
  • 1.9K
  • 04 Nov 2022
Topic Review
Megakaryocytes
Megakaryocytes (MKs), a kind of functional hematopoietic stem cell, form platelets to maintain platelet balance through cell differentiation and maturation. The incidence of blood diseases such as thrombocytopenia has increased, but these diseases cannot be fundamentally solved.
  • 1.9K
  • 05 May 2023
Topic Review
Cancer Cell Lines
Cell lines are in vitro model systems that are widely used in different fields of medical research, especially basic cancer research and drug discovery. Their usefulness is primarily linked to their ability to provide an indefinite source of biological material for experimental purposes. Under the right conditions and with appropriate controls, authenticated cancer cell lines retain most of the genetic properties of the cancer of origin. During the last few years, comparing genomic data of most cancer cell lines has corroborated this statement and those that were observed studying the tumoral tissue equivalents included in the The Cancer Genome Atlas (TCGA) database.
  • 1.9K
  • 03 Sep 2021
Topic Review
Lipid Bilayers on Silicon Substrates
Artificial membranes are models for biological systems that are important for several applications. In the present entry we talk about artificial membranes such as supported lipid bilayers (SLB) and ways to self- assemble them. We mainly focus on the results of a new dry evaporation process in high vacuum, i.e., physical vapor deposition, to make samples of dipalmitoylphosphatidylcholine (DPPC) on silicon substrates. We have characterized the main phase transitions and adhesion of our SLBs using high-resolution ellipsometry and AFM techniques. The finding of this new SLB fabrication approach is relevant for the understanding the interaction of lipid bilayers in contact with surfaces in dry environments, with the aim to develop new kinds of lab-on-chip bionanosensors. This discovery is especially relevant in the context of the viability of organisms covered with lipid bilayer structures. An example of this kind of interaction occurs between bilayer-protected viruses, e.g., corona viruses, and solid surfaces, allowing the virus to stay active during long periods of time. The prolonged stability of SLBs on dry SiO2/Si substrates detected in our research can explain the long-term stability of some viruses deposited or adsorbed on dry surfaces, including the SARS-CoV-2 virus. 
  • 1.9K
  • 03 Nov 2020
Topic Review
Antioxidant Agents Against the Neurotoxicity
Cancer represents one of the most pernicious public health problems with a high mortality rate among patients worldwide. Chemotherapy is one of the major therapeutic approaches for the treatment of various malignancies. Platinum-based drugs (cisplatin, oxaliplatin, carboplatin, etc.) are highly effective chemotherapeutic drugs used for the treatment of several types of malignancies, but their application and dosage are limited by their toxic effects on various systems, including neurotoxicity. Simultaneously, researchers have tried to improve the survival rate and quality of life of cancer patients and decrease the toxicity of platinum-containing drugs by combining them with non-chemotherapy-based drugs, dietary supplements and/or antioxidants. Additionally, recent studies have shown that the root cause for the many side effects of platinum chemotherapeutics involves the production of reactive oxygen species (ROS) in naive cells. Therefore, suppression of ROS generation and their inactivation with antioxidants represents an appropriate approach for platinum drug-induced toxicities. The aim of this paper is to present an updated review of the protective effects of different antioxidant agents (vitamins, dietary antioxidants and supplements, medicaments, medicinal plants and their bioactive compounds) against the neurotoxicity induced by platinum-based chemotherapeutics. This review highlights the high potential of plant antioxidants as adjuvant strategies in chemotherapy with platinum drugs.
  • 1.9K
  • 01 Apr 2021
Topic Review
Osteocyte
Osteocytes are the most abundant bone cells, entrapped inside the mineralized bone matrix. They derive from osteoblasts through a complex series of morpho-functional modifications; such modifications not only concern the cell shape (from prismatic to dendritic) and location (along the vascular bone surfaces or enclosed inside the lacuno-canalicular cavities, respectively) but also their role in bone processes (secretion/mineralization of preosseous matrix and/or regulation of bone remodeling). Osteocytes are connected with each other by means of different types of junctions, among which the gap junctions enable osteocytes inside the matrix to act in a neuronal-like manner, as a functional syncytium together with the cells placed on the vascular bone surfaces (osteoblasts or bone lining cells), the stromal cells and the endothelial cells, i.e., the bone basic cellular system (BBCS). Within the BBCS, osteocytes can communicate in two ways: by means of volume transmission and wiring transmission, depending on the type of signals (metabolic or mechanical, respectively) received and/or to be forwarded. The capability of osteocytes in maintaining skeletal and mineral homeostasis is due to the fact that it acts as a mechano-sensor, able to transduce mechanical strains into biological signals and to trigger/modulate the bone remodeling, also because of the relevant role of sclerostin secreted by osteocytes, thus regulating different bone cell signaling pathways.
  • 1.9K
  • 09 Apr 2021
Topic Review
Photoelectrochemical Reduction of CO2
Photoelectrochemical reduction of CO2 is a chemical process whereby carbon dioxide is reduced to carbon monoxide or hydrocarbons by the energy of incident light. This process needs to be catalyzed either homogeneously or heterogeneously in order to proceed, and current research is aimed at developing these catalysts, most of which are semiconducting materials. Semiconducting catalysts provide favourable electron transfer kinetics. The feasibility of this chemical reaction was first theorised by Giacomo Luigi Ciamician, an Italian photochemist. Already in 1912 he stated that "By  using  suitable catalyzers,  it  should  be  possible  to  transform  the mixture  of  water  and  carbon dioxide into oxygen and methane, or to cause other endo-energetic processes." Motivation for research in this area is strong due to the current attention to atmospheric carbon dioxide as the reduction of carbon dioxide would be one route for removal and sequestration. Furthermore, the reduced species may prove to be a valuable feedstock for other processes. If the incident light utilized is solar in nature then this process also potentially represents energy routes which combine renewable energy with CO2 reduction.
  • 1.9K
  • 02 Nov 2022
Topic Review
Avalanche (Protocol)
Avalanche is a protocol for solving consensus in a network of unreliable machines, where failures may be crash-fault or Byzantine. The protocol was anonymously introduced on IPFS on May 16, 2018 and was formalized in more detail by Cornell University researchers in 2019. Protocol currently provides system operation of the Avalanche (platform) and his platform. The protocol has four basic interrelated mechanisms that compose structural support of the consensus tool. These four mechanisms are Slush, Snowflake, Snowball, and Avalanche. By using randomized sampling and metastability to ascertain and persist transactions, It represents a new protocol family. Although the original paper focused on a single protocol, namely Avalanche, it implicitly introduced a broad spectrum of voting-based, or quorum-based consensus protocols, called the Snow family. While Avalanche is a single instantiation, the Snow family seems to be able to generalize all quorum-based voting protocols for replica control. Unlike prior quorum-based work, the Snow family enables arbitrarily parametrizable failure probability at the quorum intersection level. Standard quorum-based protocols define this failure probability to be precisely zero, but by introducing errors in the quorum intersection, a larger set of consensus protocol design is available.
  • 1.9K
  • 02 Dec 2022
Topic Review
Biological Actions of Curcumin
Curcumin (CCM) is one of the most frequently explored plant compounds with various biological actions such as antibacterial, antiviral, antifungal, antineoplastic, and antioxidant/anti-inflammatory properties. The laboratory data and clinical trials have demonstrated that the bioavailability and bioactivity of curcumin are influenced by the feature of the curcumin molecular complex types. Curcumin has a high capacity to form molecular complexes with proteins (such as whey proteins, bovine serum albumin, β-lactoglobulin), carbohydrates, lipids, and natural compounds (e.g., resveratrol, piperine, quercetin).
  • 1.9K
  • 02 Feb 2023
Topic Review
Basic Principles of Bioprocess Monitoring and Viability Determination
Bioprocesses involve multiple steps, including upstream processing, downstream processing and product formulation. Each of these steps must be monitored and regulated precisely, which requires suitable sensors that meet specific demands. Both the process itself and the process monitoring can be arranged differently. Likewise, this applies to the determination of viability, with each method possessing advantages and disadvantages.
  • 1.9K
  • 08 Feb 2023
Biography
Florence Bell
Florence Ogilvy Bell (1 May 1913 – 23 November 2000), later Florence Sawyer, was a British scientist who contributed to the discovery of the structure of DNA. She was an X-ray crystallographer in the lab of William Astbury. In 1938 they published a paper in Nature that described the structure of DNA as a "Pile of Pennies".[1] Florence Ogilvy Bell was born at 47 Hanover Road, Brondesbury Par
  • 1.9K
  • 02 Dec 2022
Topic Review
Cellular Neurobiology of Psychedelics
Psychedelic substances have gained significant attention in recent years for their potential therapeutic effects on various psychiatric disorders.
  • 1.9K
  • 07 Nov 2023
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