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Topic Review
Soil and Mushrooms
Mushrooms, like other fungi, have a strong impact on soil, both positive and negative. The compost that forms from spent mushroom substrate could be applied to soil as an organic fertilizer, which could increase soil microbial activity and the content of amino acid metabolites in studied orchard. Mushroom also could be used as a bioindicator for soil pollution, such as soil polluted with heavy metals, toxic elements, organic pollutants, radioactives, or isotopes, as well as for health risk indices. The green synthesis of nanoparticles using mushrooms and the potential of bio-nanoremediation for polluted soils. The distinguished roles of mushrooms of soil improvement are considered a crucial dimension for sustainable soil management, which may include controlling soil erosion, improving soil aggregates, increasing soil organic matter content, enhancing the bioavailability of soil nutrients, and resorting to damaged and/or polluted soils. The field of bio-nanoremediation using mushrooms still requires further investigation, particularly regarding the sustainable management of soils.
  • 2.0K
  • 13 Apr 2022
Topic Review
Innovation Capacity in Developing Countries
Innovation is an intrinsic capacity of humankind, enabling the adaptation to changes and managing probable solutions to problems regarding its welfare or its surroundings. It constitutes a key driver of sustainable growth. Moreover, innovation capacity is among the dynamic capacities leading to achieving a competitive and sustainable advantage. Hence, by adopting innovative and R&D practices, a country might enhance its growth and competitiveness, particularly for a developing country. In addition, it encompasses diverse perspectives, e.g., organizational capacity, public capacity, regional capacity, national capacity, among others. Therefore, many public and private organizations have focused their efforts on identifying and quantifying the variables that determine the innovation capacity of a country. Various mechanisms have been proposed to assess this capacity, such as the national innovation capacity, Global Innovation Index (GII), Global Competitive Index (GCI) , or European Innovation Scoreboard (EIS). These mechanisms aim at providing an objective measurement of the performance of a country regarding innovation capacity or innovation as a means to competitiveness. Each one of these presents a particular set of determinants, methods, and interpretations to assess innovation.
  • 2.0K
  • 05 Jul 2022
Topic Review
Electrochemistry
Electrochemistry is the branch of physical chemistry concerned with the relationship between electrical potential difference, as a measurable and quantitative phenomenon, and identifiable chemical change, with the potential difference as an outcome of a particular chemical change, or vice versa. These reactions involve electrons moving via an electronically-conducting phase (typically an external electrical circuit, but not necessarily, as in electroless plating) between electrodes separated by an ionically conducting and electronically insulating electrolyte (or ionic species in a solution). When a chemical reaction is driven by an electrical potential difference, as in electrolysis, or if a potential difference results from a chemical reaction as in a battery or fuel cell, it is called an electrochemical reaction. Unlike in other chemical reactions, in electrochemical reactions electrons are not transferred directly between atoms, ions, or molecules, but via the aforementioned electronically-conducting circuit. This phenomenon is what distinguishes an electrochemical reaction from a conventional chemical reaction.
  • 2.0K
  • 14 Oct 2022
Biography
Emil Kraepelin
Emil Kraepelin (/ˈkrɛpəlɪn/; German: [ˈeːmiːl ˈkʀɛːpəliːn]; 15 February 1856 – 7 October 1926) was a German psychiatrist. H. J. Eysenck's Encyclopedia of Psychology identifies him as the founder of modern scientific psychiatry, psychopharmacology and psychiatric genetics. Kraepelin believed the chief origin of psychiatric disease to be biological and genetic malfunction. His theo
  • 2.0K
  • 01 Dec 2022
Topic Review Peer Reviewed
Wavefunction Collapse Broadens Molecular Spectrum
Spectral lines in the optical spectra of atoms, molecules, and other quantum systems are characterized by a range of frequencies ω or a range of wavelengths λ=2πc/ω, where c is the speed of light. Such a frequency or wavelength range is called the width of the spectral lines (linewidth). It is influenced by many specific factors. Thermal motion of the molecules results in broadening of the lines as a result of the Doppler effect (thermal broadening) and by their collisions (pressure broadening). The electric fields of neighboring molecules lead to Stark broadening. The linewidth to be considered here is the so-called parametric broadening (PB) of spectral lines in the optical spectrum. PB can be considered the fundamental type of broadening of the electronic vibrational–rotational (rovibronic) transitions in a molecule, which is the direct manifestation of the basic concept of the collapse of a wavefunction that is postulated by the Copenhagen interpretation of quantum mechanics. Thus, that concept appears to be not only valid but is also useful for predicting physically observable phenomena.
  • 2.0K
  • 11 Apr 2023
Topic Review
Effect of Anthocyanins on Colorimetric Indicator Film Properties
Anthocyanins have attracted widespread attention as a material for manufacturing smart food packaging, as they are sensitive to changes in pH, and small changes in pH can cause changes in the color of anthocyanins. The incorporation of anthocyanins often causes different changes in the properties of the films.
  • 2.0K
  • 10 Nov 2023
Topic Review
CD38: T Cell Immuno-Metabolic Modulator
CD38 is a major mammalian NAD+ glycohydrolase (NADase), expresses on T cells following activation and appears to be an essential modulator of intracellular NAD+ levels. The enzymatic activity of CD38 in the process of generating the second messenger cADPR utilizes intracellular NAD+, and thus limits its availability to differentNAD+ consuming enzymes (PARP, ART, and sirtuins) inside the cells.
  • 2.0K
  • 27 Oct 2020
Topic Review
Cerebral Small Vessel Disease
Cerebral small vessel disease (CSVD) represents a cluster of various vascular disorders with different pathological backgrounds. The advanced vasculature net of cerebral vessels, including small arteries, capillaries, arterioles and venules, is usually affected. Processes of oxidation underlie the pathology of CSVD, promoting the degenerative status of the epithelial layer. There are several classifications of cerebral small vessel diseases; some of them include diseases such as Binswanger’s disease, leukoaraiosis, cerebral microbleeds (CMBs) and lacunar strokes.
  • 2.0K
  • 07 Jan 2021
Topic Review
Tabebuia Impetiginosa
Tabebuia impetiginosa, a plant native to the Amazon rainforest and other parts of Latin America, is traditionally used for treating fever, malaria, bacterial and fungal infections, and skin diseases.
  • 1.9K
  • 22 Oct 2020
Topic Review
Bioadhesive Biomaterials for Medical Application
This entry deliberates about the importance of polymer based bioadhesive biomaterial’s medical application in healthcare and redefining healthcare management. Nowadays application of bioadhesion in health sector is one of the great interest for various researchers, due to its recent advances in their formulation development. Actually, this area of study is considered as an active multidisciplinary research approach, where engineers, scientists—including chemists, physicists, biologists, and medical experts—materials’ producers, and manufacturers combine their knowledge in order to provide a better healthcare. Moreover, while discussing about the implications of value-based healthcare, it is necessary to mention that health comprises three main domains namely: physical, mental, and social health that prioritized not only the quality healthcare, but it also enables to measure the outcomes of medical interventions. In addition, this conceptual article provides an understanding about the consequences of natural or synthetic polymer based bioadhesion of biomaterials and its significance for redefining healthcare management as a novel approach. Furthermore, research assumptions highlights that the quality healthcare concept has recently become a burning topic where, healthcare service providers, private research institutes, government authorities, public service boards, associations and academics took initiative to restructure the health care system to create value for patients and increase their satisfaction, and lead ultimately to a healthier society.
  • 1.9K
  • 28 Sep 2021
Topic Review
London School of Economics Gaddafi Links
The affair of the LSE Libya Links refers to the various connections that existed between the London School of Economics and Political Science (LSE) and the Libyan government and its leader Muammar Gaddafi and his son Saif al-Islam Gaddafi. The NGO Gaddafi Foundation pledged to donate £1.5 million over five years to a research centre, LSE Global Governance, of which £300k were paid. In addition, LSE Enterprise established a contract worth £2.2 million to train Libyan officials. In 2008, the LSE granted a PhD degree to Saif al-Islam Gaddafi, the son of the Libyan leader, for a dissertation. Currently, allegations circulate that Gaddafi's thesis was ghost-written and/or plagiarised. In December 2010, Muammar Gaddafi addressed members of the School in a video link-up where he was addressed as "Brother Leader" and received an LSE cap previously given to Nelson Mandela. In connection with the civil uprising in Libya in February and March 2011, the links between LSE and the Gaddafi regime, and the conduct of individual members of LSE's staff, came increasingly to be questioned. As a result of the revelations, the LSE's Director, Sir Howard Davies, resigned on 3 March 2011, citing "errors of judgement". In a New York Times op-ed piece on 7 March 2011, Roger Cohen wrote, in reference to events that had transpired at the School, "It may be possible to sink to greater depths but right now I can't think how. ...The Arab Spring is also a Western Winter. ...How did we back, use and encourage the brutality of Arab dictators over so many years? To what degree did that cynical encouragement of despots foster the very jihadist rage Western societies sought to curb?"
  • 1.9K
  • 10 Oct 2022
Topic Review
Crossover Experiment
In chemistry, a crossover experiment is a method used to study the mechanism of a chemical reaction. In a crossover experiment, two similar but distinguishable reactants simultaneously undergo a reaction as part of the same reaction mixture. The products formed will either correspond directly to one of the two reactants (non-crossover products) or will include components of both reactants (crossover products). The aim of a crossover experiment is to determine whether or not a reaction process involves a stage where the components of each reactant have an opportunity to exchange with each other. The results of crossover experiments are often straightforward to analyze, making them one of the most useful and most frequently applied methods of mechanistic study. In organic chemistry, crossover experiments are most often used to distinguish between intramolecular and intermolecular reactions. Inorganic and organometallic chemists rely heavily on crossover experiments, and in particular isotopic labeling experiments, for support or contradiction of proposed mechanisms. When the mechanism being investigated is more complicated than an intra- or intermolecular substitution or rearrangement, crossover experiment design can itself become a challenging question. A well-designed crossover experiment can lead to conclusions about a mechanism that would otherwise be impossible to make. Many mechanistic studies include both crossover experiments and measurements of rate and kinetic isotope effects.
  • 1.9K
  • 28 Oct 2022
Topic Review
Information Assurance
Information assurance (IA) is the practice of assuring information and managing risks related to the use, processing, storage, and transmission of information. Information assurance includes protection of the integrity, availability, authenticity, non-repudiation and confidentiality of user data. IA encompasses not only digital protections but also physical techniques. These protections apply to data in transit, both physical and electronic forms, as well as data at rest . IA is best thought of as a superset of information security (i.e. umbrella term), and as the business outcome of information risk management.
  • 1.9K
  • 21 Nov 2022
Topic Review
Bibliometric Analysis on Energy Research
Bibliometric studies can also be applied to energy research topics, in particular, it is presented in this entry the analysis of the state of the art and publication trends on the topic of ISCC (Integrated Solar Combined Cycles) for the period covering 1990 to July 2020. The Web of Science (WOS) database was consulted, and 1277 publications from 3157 different authors and 1102 different institutions, distributed among 78 countries, were retrieved as the corpus of the study. The analysis performed in this entry concluded that the main publication source for ISCC research was Energy Conversion and Management, in terms of the total number of publications (158), but Solar Energy had the highest number of citations on the ISCC topic (4438). It was also found that China was the most productive country in terms of ISCC publications (241), and the Chinese Academy of Sciences was the most productive institution (52). Nevertheless, the author with the most publications on ISCC was I. Dincer, from Ontario Tech University (24). Based on publication keywords, a series of recommendations for future developments in the ISCC topic were derived, as well as the ways in which those ideas are connected to the global state of solar energy research.
  • 1.9K
  • 27 Oct 2020
Topic Review
Peptide Applications Using Microfluidics
Peptides possess multifunctional roles within therapeutic formulations, ranging from enhancing target specificity to acting as the active component of the medicine. By applying the platform of microfluidics, the range of applications for peptides has been seen to rise exponentially. Various therapeutic applications of peptides are listed in this review.
  • 1.9K
  • 11 May 2021
Topic Review
Breast Cancer Subtype-Specific miRNAs
Breast cancer is one of the most common malignancies, with multiple subtypes, based on clinical parameters and molecular profiling. In addition to disease staging, the expression status of hormone receptors’ estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) in tumors define the prognosis of the cancer and treatment options. Hence, clinically, breast cancers are defined as ER+/PR+, HER+, or triple-negative (i.e., those lacking expression of these three receptors). This classification system allows for the administration of endocrine therapies in the hormone expressing subtypes. Additionally, breast cancer subtyping is observed via transcriptome profiling, which has identified four major subtypes (luminal A, luminal B, HER2, and basal-like). The ER+/PR+ breast cancers are predominately luminal A/B and TNBCs are predominately basal-like. Clearly gene expression defines breast cancer; it is then not surprising that the expression of miRNAs also displays subtype-specificity.
  • 1.9K
  • 25 Mar 2022
Topic Review
Lactic Acid Bacteria and Honey Bees
Honey bees play a pivotal role in the sustainability of ecosystems and biodiversity. Many factors including parasites, pathogens, pesticide residues, forage losses, and poor nutrition have been proposed to explain honey bee colony losses. Lactic acid bacteria (LAB) are normal inhabitants of the gastrointestinal tract of honey bees and their role has been consistently reported in the literature. 
  • 1.9K
  • 19 Apr 2022
Topic Review
The Role of Ketogenic Diets in DNA Methylation
Ketogenic diets (KD) are dietary strategies low in carbohydrates, normal in protein, and high, normal, or reduced in fat with or without (Very Low-Calories Ketogenic Diet, VLCKD) a reduced caloric intake. KDs have been shown to be useful in the treatment of obesity, metabolic diseases and related disorders, neurological diseases, and various pathological conditions such as cancer, nonalcoholic liver disease, and chronic pain. The term epigenetics refers to heritable changes in gene expression without changes in DNA sequence. Major epigenetic mechanisms include DNA methylation, histone modifications, microRNA, and chromatin remodeling. 
  • 1.9K
  • 21 Sep 2022
Topic Review
Food Peptides for the Nutricosmetic Industry
Biopeptides are considered interesting for industrial application since they show numerous functional properties (e.g., anti-aging, antioxidant, anti-inflammatory, and antimicrobial properties) and technological properties (e.g., solubility, emulsifying, and foaming). Moreover, they have fewer side effects than synthetic drugs. Nevertheless, some challenges must be overcome before their administration via the oral route. The gastric, pancreatic, and small intestinal enzymes and acidic stomach conditions can affect their bioavailability and the levels that can reach the site of action. Some delivery systems have been studied to avoid these problems (e.g., microemulsions, liposomes, solid lipid particles). 
  • 1.9K
  • 31 Mar 2023
Topic Review
Anthranilic Acid and Beyond
Anthranilic acid, a kynurenine metabolite produced by host and microbe alike, is a bioactive compound with potential systemic neurological effects. Though in the past much research has focused on the kynurenine pathway at large, the role of anthranilic acid in the gut–brain axis is emerging as an important piece of the puzzle. Anthranilic acid is a direct metabolic product of kynurenine digestion in humans and microbes and represents an alternate branch to two other immediate products (i.e., 3-hydroxykynurenine and kynurenic acid). Kynurenine is hydrolyzed to anthranilic acid and L-alanine with the help of kynureninase. With the transfer of an amino group, kynurenine becomes the alternate product kynurenic acid, and the addition of an oxygen by kynurenine-3-monoxygenase turns kynurenine into 3-hydroxykynurenine. Anthranilic acid, through non-specific hydroxylation, becomes 3-hydroxyanthranilic acid, which is the precursor for quinolinic acid, picolinic acid, and the terminal product NAD+. The ratio of anthranilic acid to the downstream 3-hydroxyanthranilic acid has been suggested as one potential biomarker for both neurological and physiological disorders. 
  • 1.9K
  • 07 Aug 2023
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