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Topic Review
Stone Cultural Heritage Elements
Stones are ones of the most ancient natural materials exploited by humans, with different uses, from tools to buildings, that have endured over time in better conditions than other objects belonging to cultural heritage. Given the importance of those silent witnesses of the past, as well as our duty to preserve all parts of cultural heritage for future generations, much effort was put into the development of materials for their consolidation, protection, self-cleaning, or restoration.
  • 2.0K
  • 20 Sep 2022
Biography
George E. Waring Jr.
George E. Waring Jr. (July 4, 1833[1] – October 29, 1898) was an American sanitary engineer and civic reformer. He was an early American designer and advocate of sewer systems that keep domestic sewage separate from storm runoff. Waring was born in Pound Ridge, New York, the son of George E. Waring Sr., a wealthy stove manufacturer. Trained in agricultural chemistry, he began to lecture on
  • 2.0K
  • 22 Nov 2022
Topic Review
HSP90 inhibitors for IPF/COVID-19
Heat shock protein 90 (HSP90) is an important chaperone that assists the late stage folding of several proteins involved in cell survival in response to environmental stressors. The inhibition of HSP90 is followed by a complex modulation of the proteome and the kinome, that has proved beneficial in cancer and various neurodegenerative diseases. Additionally, accumulating literature suggests that HSP90 may be a key target during the development of pulmonary fibrosis and that its inhibition could serve as a new and exciting therapeutic approach. We have summarized the current evidence about HSP90’s role in Idiopathic Pulmonary Fibrosis (IPF), the results from preclinical studies on its inhibition and the intracellular signaling pathways involved, in a recent review article (Review). In this Article entry, we will introduce the main findings discussed in the review and focus on its translation and possible significance in the era of the SARS-CoV-2 pandemic.
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  • 07 Aug 2020
Topic Review
47,XYY Syndrome
47,XYY syndrome is characterized by an extra copy of the Y chromosome in each of a male's cells. Although many males with this condition are taller than average, the chromosomal change sometimes causes no unusual physical features. Most males with 47,XYY syndrome have normal production of the male sex hormone testosterone and normal sexual development, and they are usually able to father children.  
  • 2.0K
  • 23 Dec 2020
Topic Review
Phase Change Materials
The energy sector is one of the fields of interest for different nations around the world. Due to the current fossil fuel crisis, the scientific community develops new energy-saving experiences to address this concern. Buildings are one of the elements of higher energy consumption, so the generation of knowledge and technological development may offer solutions to this energy demand, which are more than welcome. Phase change materials (PCMs) included in building elements such as wall panels, blocks, panels or coatings, for heating and cooling applications have been shown, when heating, to increase the heat storage capacity by absorbing heat as latent heat.
  • 2.0K
  • 29 Mar 2021
Topic Review
Microbiota and Endometriosis
Imbalances in gut and reproductive tract microbiota composition, known as dysbiosis, disrupt normal immune function, leading to the elevation of proinflammatory cytokines, compromised immunosurveillance and altered immune cell profiles, all of which may contribute to the pathogenesis of endometriosis. Over time, this immune dysregulation can progress into a chronic state of inflammation, creating an environment conducive to increased adhesion and angiogenesis, which may drive the vicious cycle of endometriosis onset and progression. Recent studies have demonstrated both the ability of endometriosis to induce microbiota changes, and the ability of antibiotics to treat endometriosis. Endometriotic microbiotas have been consistently associated with diminished Lactobacillus dominance, as well as the elevated abundance of bacterial vaginosis-related bacteria and other opportunistic pathogens. Possible explanations for the implications of dysbiosis in endometriosis include the Bacterial Contamination Theory and immune activation, cytokine-impaired gut function, altered estrogen metabolism and signaling, and aberrant progenitor and stem-cell homeostasis. 
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  • 23 Jun 2021
Topic Review
Islets of Langerhans
Islets of Langerhan are a crucial group of cells that enable the metabolization, physiologic control, and utilization of glucose, the primary energy source for cells. In situ physiologic intraportal hormone delivery from the pancreatic islets of Langerhans maintains basal normoglycemia with insulin and counterbalances hypoglycemia with glucagon. Insulin output can increase up ten-fold after a meal, and return rapidly to basal levels with no hysteresis. Type 1 diabetes represents an increasing and growingly financially unsustainable disease occurring due to the destruction of pancreatic islets of Langerhans. Current injectable insulin technologies fail to recreate physiologic glycemic control that is managed by islet cells resulting in a tight 1–2 mmol/L glycemic variance. In our opinion, exogenous subcutaneous insulin delivery, even when provided by the most ideal closed loop systems, cannot recreate this degree of dynamic control. Current therapies fail to adequately achieve euglycemia, leading to significant diabetes complications and a risk of mortality. Thus, developing a cell-based cure for type 1 diabetes through islet cell generation and transplantation remains an ideal to strive for. Achieving this goal, especially with stem cell therapies, as demonstrated by the Edmonton protocol (Shapiro 2000), demands complete understanding of embryological differentiation and physiology of the islets of Langerhans.
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  • 22 Sep 2021
Topic Review
Mobility Apps for Improving Urban Travel Patterns
In recent decades cities have applied a number of policy measures aimed at reducing car use and increasing public transportation (PT) patronage. Persuasive strategies to change mobility behavior present notable limitations in economic and logistical terms and have only minor impacts. The smartphone has emerged as a promising tool to overcome these challenges, as it can host persuasion strategies through mobility apps. Simultaneously, Mobility-as-a-Service (MaaS) schemes could open up new possibilities for addressing both sustainability goals and the needs of urban travelers.
  • 2.0K
  • 25 Jan 2022
Topic Review
Divine Mercy Image
The Image of the Divine Mercy is a depiction of Jesus Christ that is based on the devotion initiated by Saint Faustina Kowalska. "I promise that the soul that will venerate this image will not perish," Jesus told Faustina, according to her diary, which has been studied and authenticated by the Catholic Church over several decades. "I also promise victory over enemies already here on earth, especially at the hour of death. I myself will defend it as My own glory." (Diary 48) Jesus is shown, in most versions, as raising his right hand in blessing and pointing with his left hand on the Sacred Heart from which flow forth two rays: one red and one pale. The depiction contains the message "Jesus I trust in you" (Polish: Jezu ufam Tobie). The rays that stream out have symbolic meanings: red for the blood of Jesus (which is the Life of Souls) and pale for the water (which justifies souls) (Diary 299). The whole image is a symbol of charity, forgiveness and love of God, referred to as the "Fountain of Mercy". According to Faustina's diary, the image is based on her 1931 vision of Jesus. Faustina directed the painting of the first image in Vilnius by the artist Eugeniusz Kazimirowski. Since then, numerous versions of the image have been painted by other artists, including a popular rendition by Adolf Hyła in Kraków. They are widely venerated worldwide and are used in the celebration of Divine Mercy Sunday, observed in Roman Catholic as well as some Anglican churches.
  • 2.0K
  • 31 Oct 2022
Topic Review
Pangolin
Pangolins are scaly, nocturnal mammals of the order Pholidota, characterized by their keratin-covered bodies and specialized myrmecophagous (ant- and termite-eating) diets. Found across Asia and Africa, pangolins are the only mammals wholly covered in protective keratin scales and are unique in their evolutionary lineage. Due to extensive illegal trafficking and habitat loss, they are among the most threatened mammals globally.
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  • 24 Jun 2025
Topic Review
Essential Oils Effect on Cucumber Powdery Mildew
Essential oils of lemongrass, lemon, thyme, peppermint, abundance blend, purification blend, and thieves blend were tested in vitro and under greenhouse conditions in two separate experiments. The effects of essential oils were tested against powdery mildew disease at concentrations of 1.0–2.5 mL/L, and the consequent impact of the oils on plant growth was evaluated. Powdery mildew fungus, Podosphaera xanthii, was identified using sequencing of the ITS region. The essential oils significantly reduced disease incidence up to 77.3% compared with the positive control (p < 0.5). 
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  • 07 Dec 2021
Topic Review
Mitochondria-Targeted, Nanoparticle-Based Drug-Delivery Systems
Mitochondria play a key role in the production of metabolic energy in eukaryotic cells. However, apart from energy production, mitochondria also perform several other functions, namely, calcium signaling, cell proliferation, cell cycle regulation, and apoptosis. With growing interest in mitochondria, significant efforts are being made in mitochondria-targeting pharmaceutical interventions, resulting in ‘mitochondrial medicine’ as an emerging area of healthcare research. Mitochondria-targeting nanoparticles (NPs) are now a promising field of drug-delivery systems.
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  • 19 May 2022
Topic Review
Venus Flytrap (Dionaea muscipula)
The Venus flytrap (Dionaea muscipula) is one of the most iconic carnivorous plants known for its rapid leaf movement and unique insect-trapping mechanism. Native to nutrient-poor bogs in the southeastern United States, D. muscipula has evolved complex morphological, physiological, and ecological adaptations that facilitate carnivory. This entry provides a comprehensive academic overview of the Venus flytrap, encompassing its taxonomy, habitat, trapping mechanism, digestive physiology, reproductive biology, genetic underpinnings, ecological role, conservation status, and evolutionary significance.
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  • 04 Jun 2025
Topic Review
Nutraceuticals for Peripheral Vestibular Pathology
The term “nutraceuticals” is the object of continuous debate, and to date they are described as “a food or part of a food, such as a dietary supplement, that has a medical or health benefit, including the prevention and treatment of disease”.
  • 2.0K
  • 28 Jan 2022
Topic Review
Hybrid and Electric Vehicles
Even though electric vehicles (EV) were invented over a century ago, their popularity has grown significantly within the last 10 years due to the development of Li-ion battery technology. This evolution created an increase in the fire risk and hazards associated with this type of high-energy battery.
  • 2.0K
  • 08 Feb 2022
Topic Review
Electrochemical Biosensors for Salmonella Detection
Salmonellosis is a major cause of foodborne infections, caused by Salmonella, posing a major health risk. It possesses the ability to infiltrate the food supply chain at any point throughout the manufacturing, distribution, processing or quality control process. Salmonella infection has increased severely and requires effective and efficient methods for early monitoring and detection.
  • 2.0K
  • 14 Jun 2022
Biography
Matthew H. Todd
Matthew Houghton Todd (born 13 January 1973) is a British chemist and the Professor and Chair of Drug Discovery of the School of Pharmacy at University College London.[1] He is the founder of Open Source Malaria (OSM) and his research focuses on drug discovery and development for this disease.[2][3][4][5][6] Recently, he has expanded to other areas, particularly neglected diseases such as tuberc
  • 2.0K
  • 23 Nov 2022
Topic Review
Gravitational Two-Body Problem
The gravitational two-body problem concerns the motion of two point particles that interact only with each other, due to gravity. This means that influences from any third body are neglected. For approximate results that is often suitable. It also means that the two bodies stay clear of each other, that is, the two do not collide, and one body does not pass through the other's atmosphere. Even if they do, the theory still holds for the part of the orbit where they don't. Apart from these considerations a spherically symmetric body can be approximated by a point mass. Common examples include the parts of a spaceflight where the spacecraft is not undergoing propulsion and atmospheric effects are negligible, and a single celestial body overwhelmingly dominates the gravitational influence. Other common examples are the orbit of a moon around a planet, and of a planet around a star, and two stars orbiting each other (a binary star).
  • 2.0K
  • 25 Nov 2022
Topic Review
Enhancing Smart Home Design with AI Models
The normal development of “smart buildings,” which calls for integrating sensors, rich data, and artificial intelligence (AI) simulation models, promises to usher in a new era of architectural concepts. AI simulation models can improve home functions and users’ comfort and significantly cut energy consumption through better control, increased reliability, and automation. 
  • 2.0K
  • 15 Mar 2023
Topic Review
SMPTE 292M
SMPTE 292 is a digital video transmission standard published by the Society of Motion Picture and Television Engineers (SMPTE) which expands upon SMPTE 259 and SMPTE 344 allowing for bit-rates of 1.485 Gbit/s, and 1.485/1.001 Gbit/s. These bit-rates are sufficient for and often used to transfer uncompressed high-definition video. This standard is usually referred to as HD-SDI; it is part of a family of standards that define a Serial Digital Interface based on a coaxial cable, intended to be used for transport of uncompressed digital video and audio in a television studio environment. The “M” designator was originally introduced to signify metric dimensions. It is no longer used in listings or filenames. Units of the International System of Units (SI) are the preferred units of measurement in all SMPTE Engineering Documents.
  • 2.0K
  • 10 Oct 2022
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