47,XYY Syndrome

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Yang, C. 47,XYY Syndrome. Encyclopedia. Available online: https://encyclopedia.pub/entry/4171 (accessed on 24 September 2026).

Yang C. 47,XYY Syndrome. Encyclopedia. Available at: https://encyclopedia.pub/entry/4171. Accessed September 24, 2026.

Yang, Catherine. "47,XYY Syndrome" Encyclopedia, https://encyclopedia.pub/entry/4171 (accessed September 24, 2026).

Yang, C. (2020, December 23). 47,XYY Syndrome. In Encyclopedia. https://encyclopedia.pub/entry/4171

Yang, Catherine. "47,XYY Syndrome." Encyclopedia. Web. 23 December, 2020.

47,XYY Syndrome

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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/47xyy-syndrome

47,XYY syndrome is characterized by an extra copy of the Y chromosome in each of a male's cells. Although many males with this condition are taller than average, the chromosomal change sometimes causes no unusual physical features. Most males with 47,XYY syndrome have normal production of the male sex hormone testosterone and normal sexual development, and they are usually able to father children.

genetic conditions

References

Bardsley MZ, Kowal K, Levy C, Gosek A, Ayari N, Tartaglia N, Lahlou N, Winder B, Grimes S, Ross JL. 47,XYY syndrome: clinical phenotype and timing ofascertainment. J Pediatr. 2013 Oct;163(4):1085-94. doi:10.1016/j.jpeds.2013.05.037.
Geerts M, Steyaert J, Fryns JP. The XYY syndrome: a follow-up study on 38boys. Genet Couns. 2003;14(3):267-79.
Lalatta F, Folliero E, Cavallari U, Di Segni M, Gentilin B, Fogliani R,Quagliarini D, Vizziello P, Monti F, Gargantini L. Early manifestations in acohort of children prenatally diagnosed with 47,XYY. Role of multidisciplinarycounseling for parental guidance and prevention of aggressive behavior. Ital JPediatr. 2012 Oct 3;38:52. doi: 10.1186/1824-7288-38-52.
Robinson DO, Jacobs PA. The origin of the extra Y chromosome in males with a47,XYY karyotype. Hum Mol Genet. 1999 Nov;8(12):2205-9.
Ross JL, Roeltgen DP, Kushner H, Zinn AR, Reiss A, Bardsley MZ, McCauley E,Tartaglia N. Behavioral and social phenotypes in boys with 47,XYY syndrome or47,XXY Klinefelter syndrome. Pediatrics. 2012 Apr;129(4):769-78. doi:10.1542/peds.2011-0719.
Tartaglia NR, Wilson R, Miller JS, Rafalko J, Cordeiro L, Davis S, Hessl D,Ross J. Autism Spectrum Disorder in Males with Sex Chromosome Aneuploidy:XXY/Klinefelter Syndrome, XYY, and XXYY. J Dev Behav Pediatr. 2017Apr;38(3):197-207. doi: 10.1097/DBP.0000000000000429.

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Subjects: Genetics & Heredity

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Update Date: 23 Dec 2020

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