Your browser does not fully support modern features. Please upgrade for a smoother experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
Application of Natural Language Processing in Stock Forecasting
The invention of Natural Language Processing (NLP) has provided a solution to develop computational models that enable the machine to understand human languages and automatically solve practical problems. Therefore, the application of NLP is becoming an important tool to reveal the investor behavioral information to explain the market variability and improve the stock prediction performance.
  • 1.9K
  • 21 Jul 2022
Topic Review
Schizotypal Personality Disorder
Schizotypal personality disorder (STPD), also known as schizotypal disorder, is a mental and behavioural disorder. DSM classification describes the disorder specifically as a personality disorder characterized by thought disorder, paranoia, a characteristic form of social anxiety, derealization, transient psychosis, and unconventional beliefs. People with this disorder feel pronounced discomfort in forming and maintaining social connections with other people, primarily due to the belief that other people harbour negative thoughts and views about them. Peculiar speech mannerisms and socially unexpected modes of dress are also characteristic. Schizotypal people may react oddly in conversations, not respond, or talk to themselves. They frequently interpret situations as being strange or having unusual meaning for them; paranormal and superstitious beliefs are common. Schizotypal people usually disagree with the suggestion their thoughts and behaviour are a 'disorder', and seek medical attention for depression or anxiety instead. Schizotypal personality disorder occurs in approximately 3% of the general population and is more common in males. The term "schizotype" was first coined by Sandor Rado in 1956 as an abbreviation of "schizophrenic phenotype". STPD is classified as a cluster A personality disorder, also known as the "odd or eccentric" cluster.
  • 1.9K
  • 07 Nov 2022
Topic Review
Avalanche (Protocol)
Avalanche is a protocol for solving consensus in a network of unreliable machines, where failures may be crash-fault or Byzantine. The protocol was anonymously introduced on IPFS on May 16, 2018 and was formalized in more detail by Cornell University researchers in 2019. Protocol currently provides system operation of the Avalanche (platform) and his platform. The protocol has four basic interrelated mechanisms that compose structural support of the consensus tool. These four mechanisms are Slush, Snowflake, Snowball, and Avalanche. By using randomized sampling and metastability to ascertain and persist transactions, It represents a new protocol family. Although the original paper focused on a single protocol, namely Avalanche, it implicitly introduced a broad spectrum of voting-based, or quorum-based consensus protocols, called the Snow family. While Avalanche is a single instantiation, the Snow family seems to be able to generalize all quorum-based voting protocols for replica control. Unlike prior quorum-based work, the Snow family enables arbitrarily parametrizable failure probability at the quorum intersection level. Standard quorum-based protocols define this failure probability to be precisely zero, but by introducing errors in the quorum intersection, a larger set of consensus protocol design is available.
  • 1.9K
  • 02 Dec 2022
Topic Review
Application of Thermoelectric Generator (TEG) in IoT Sensors
The Internet-of-Things (IoT) combines various sensors and the internet to form an expanded network, realizing the interconnection between human beings and machines anytime and anywhere. Nevertheless, the problem of energy supply limits the large-scale implementation of IoT. Fortunately, thermoelectric generators (TEGs), which can directly convert thermal gradient into electricity, have attracted extensive attention in the field of IoT due to their unique benefits, such as small size, long maintenance cycle, high stability, and no noise. Therefore, it is vital to integrate the significantly advanced research on TEGs into IoT. The authors first outlined the basic principle of the thermoelectricity effect and summarized the common preparation methods for thermoelectric functional parts in TEGs. Then, the application of TEG-powered sensors in the human body was wearable and implantable medical electronic devices. It is followed by a discussion on the application of scene sensors for IoTs, for example, building energy management and airliners. Finally, researchers provided a further outlook on the current challenges and opportunities.
  • 1.9K
  • 01 Feb 2023
Topic Review
Haemophilus influenzae HP1 Bacteriophage
Haemophilus influenzae is an obligate commensal of the upper respiratory tract in humans and may be responsible for upper respiratory tract infections and even meningitis. Seven biologically active H. influenzae dsDNA phages have been currently described: HP1, HP2, HP3, S2A, S2B, S2C, N3 and Mu-like phage φflu. The most studied is the group of HP1/S2 phages. The temperate H. influenzae phage HP1 belongs to the Myoviridae family of phages and infects Rd strains of H. influenzae. HP1 has a head-tail structure. Its genome is about 32 kb long and encodes 41 potential proteins. Early promoters, which control the lysis-versus-lysogeny decision seem to be located toward the 5’ end of the genome. The late promoter is located between orf16 and orf17, and regulates the expression of late genes, including the lys and hol genes, encoding a SAR-endolysin and a pinholin. Endolysin alone is responsible for cell lysis. The control of endolysin activity seems to be related to conformational changes in holin structure. HP1 phages encodes Dam methyltransferase, which role in HP1 life cycle remains unknown.
  • 1.9K
  • 06 Nov 2020
Topic Review
Construction Rework Cost Prediction Using Machine Learning
Predicting the construction cost of rework (COR) allows for the advanced planning and prompt implementation of appropriate countermeasures. Machine learning (ML) offers a data-oriented solution that can be utilized in different construction project contexts. ML approaches can predict COR by learning the complex patterns within the quality dataset.
  • 1.9K
  • 09 Dec 2022
Topic Review
Anthranilic Acid and Beyond
Anthranilic acid, a kynurenine metabolite produced by host and microbe alike, is a bioactive compound with potential systemic neurological effects. Though in the past much research has focused on the kynurenine pathway at large, the role of anthranilic acid in the gut–brain axis is emerging as an important piece of the puzzle. Anthranilic acid is a direct metabolic product of kynurenine digestion in humans and microbes and represents an alternate branch to two other immediate products (i.e., 3-hydroxykynurenine and kynurenic acid). Kynurenine is hydrolyzed to anthranilic acid and L-alanine with the help of kynureninase. With the transfer of an amino group, kynurenine becomes the alternate product kynurenic acid, and the addition of an oxygen by kynurenine-3-monoxygenase turns kynurenine into 3-hydroxykynurenine. Anthranilic acid, through non-specific hydroxylation, becomes 3-hydroxyanthranilic acid, which is the precursor for quinolinic acid, picolinic acid, and the terminal product NAD+. The ratio of anthranilic acid to the downstream 3-hydroxyanthranilic acid has been suggested as one potential biomarker for both neurological and physiological disorders. 
  • 1.9K
  • 07 Aug 2023
Topic Review
Software for Mass Spectrometry-based Lipidomics
Mass spectrometry (MS) is a state-of-the-art analytical technology, which enables the rapid and consistent identification and quantification of lipids in lipidomics, metabolites in metabolomics and proteins in proteomics for biomedical and biochemical research purposes.
  • 1.9K
  • 01 Jul 2022
Topic Review
Antinuclear Antibodies in Systemic Sclerosis
Systemic sclerosis is a systemic autoimmune rheumatic disease characterized by immune abnormalities, leading to vasculopathy and fibrosis. Autoantibody testing has become an increasingly important part of diagnosis and prognostication. Clinicians have been limited to antinuclear antibody (ANA), antitopoisomerase I (also known as anti-Scl-70) antibody, and anticentromere antibody testing. ANA are common in the general population, occurring in up to 20% of women. The presence of an ANA is not necessarily suggestive of a pathologic process, particularly at low titers.
  • 1.9K
  • 06 Mar 2023
Topic Review
Cells Fusion
The biological phenomenon of cell fusion remains a mystery. Even though it is mandatory for several physiological and pathopyhsiological processes considerably less is still known how the merging of two (and more) cells is regulated. Cells are not fusogenic per se. They first have to be converted into a pro-fusogenic state and have to re-enter to a non-fusogenic state after hybridisation. Likewise, different cell fusion mechanisms have been developed during evolution depending on different proteins and different membrane merging strategies. This entry gives a brief overview about those molecules and conditions that direct cell fusion.
  • 1.9K
  • 27 Oct 2020
Topic Review
Viable Bacteria in Dust-Generating Area
The distribution of microorganisms in the atmospheric circulation affects the animals that inhabit the area. Also, many organisms that share the environment also influence the distribution of environmental bacteria. In this paper, we focused on microbes that survive on the surface of Asian Dust, and clarified their topographical features and distribution. The characteristics of microorganisms that are easily influenced by environmental factors, and their effects on the atmospheric circulation are considered as issues of the One Health Concept.
  • 1.9K
  • 16 Sep 2020
Topic Review
Lipid Bilayers on Silicon Substrates
Artificial membranes are models for biological systems that are important for several applications. In the present entry we talk about artificial membranes such as supported lipid bilayers (SLB) and ways to self- assemble them. We mainly focus on the results of a new dry evaporation process in high vacuum, i.e., physical vapor deposition, to make samples of dipalmitoylphosphatidylcholine (DPPC) on silicon substrates. We have characterized the main phase transitions and adhesion of our SLBs using high-resolution ellipsometry and AFM techniques. The finding of this new SLB fabrication approach is relevant for the understanding the interaction of lipid bilayers in contact with surfaces in dry environments, with the aim to develop new kinds of lab-on-chip bionanosensors. This discovery is especially relevant in the context of the viability of organisms covered with lipid bilayer structures. An example of this kind of interaction occurs between bilayer-protected viruses, e.g., corona viruses, and solid surfaces, allowing the virus to stay active during long periods of time. The prolonged stability of SLBs on dry SiO2/Si substrates detected in our research can explain the long-term stability of some viruses deposited or adsorbed on dry surfaces, including the SARS-CoV-2 virus. 
  • 1.9K
  • 03 Nov 2020
Topic Review
Fc-Engineered Antibodies
Monoclonal antibody (mAb) therapy has rapidly changed the field of cancer therapy. In 1997, the CD20-targeting mAb rituximab was the first mAb to be approved by the U.S. Food and Drug Administration (FDA) for treatment of cancer. Within two decades, dozens of mAbs entered the clinic for treatment of several hematological cancers and solid tumors, and numerous more are under clinical investigation. The success of mAbs as cancer therapeutics lies in their ability to induce various cytotoxic machineries against specific targets. These cytotoxic machineries include antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytotoxicity (CDC), which are all mediated via the fragment crystallizable (Fc) domain of mAbs. In this review article we will outline the novel approaches of engineering these Fc domains of mAbs to enhance their Fc-effector function and thereby their anti-tumor potency, with specific focus to summarize their (pre-) clinical status for the treatment of B-cell malignancies, including chronic lymphocytic leukemia (CLL), B-cell Non-Hodgkin lymphoma (B-NHL), and multiple myeloma (MM).
  • 1.9K
  • 01 Dec 2020
Topic Review
Paroxetine Molecular Mechanisms of Action
In the 21st century and especially during a pandemic, the diagnosis and treatment of depression is an essential part of the daily practice of many family doctors. It mainly affects patients in the age category 15–44 years, regardless of gender. Anxiety disorders are often diagnosed in children and adolescents. Social phobias can account for up to 13% of these diagnoses. Social anxiety manifests itself in fear of negative social assessment and humiliation, which disrupts the quality of social functioning. Treatment of the above-mentioned disorders is based on psychotherapy and phar-macotherapy. Serious side effects or mortality from antidepressant drug overdose are currently rare. Recent studies indicate that paroxetine (ATC code: N06AB), belonging to the selective sero-tonin reuptake inhibitors, has promising therapeutic effects and is used off-label in children and adolescents.
  • 1.9K
  • 26 Feb 2021
Topic Review
Mango Peel Pectin: Recovery, Functionality and Sustainable Uses
Mango peel is the byproduct of agro-processing and has been used for high value-added components such as polysaccharide biopolymers. Pectin derived from the peel is yet to be exploited to its greatest extent, particularly in terms of its separation and physiochemical properties, which limit its applicability to dietary fiber in culinary applications. The functionality of the mango peel pectin (MPP) strongly depends on the molecular size and degree of esterification which highlight the importance of isolation and characterisation of pectin from this novel resource.
  • 1.9K
  • 29 Mar 2022
Topic Review
Zirconium and Titanium Phosphates
Zirconium and titanium phosphates are a group of laminar tetravalent metal phosphates that have attracted intensive investigation interests. Unlike zirconium phosphates, titanium phosphates can be also synthesized in another morphology, exhibiting the form of nanorods, and thus are known as nanofibrous titanium phosphates.  The different synthetic routes of zirconium and titanium phosphates and their current and prospective applications with a special mention to the their plausible applications in the field of biotechnology are discussed. 
  • 1.9K
  • 25 Mar 2022
Topic Review
Diaporthe citri
Citrus melanose is a fungal disease caused by Diaporthe citri F.A. Wolf. It is found in various citrus-growing locations across the world. The host range of D. citri is limited to plants of the Citrus genus. The most economically important hosts are Citrus reticulata (mandarin), C. sinensis (sweet orange), C. grandis or C. maxima (pumelo), and C. paradisi (grapefruit). In the life cycle of D. citri throughout the citrus growing season, pycnidia can be seen in abundance on dead branches, especially after rain, with conidia appearing as slimy masses discharged from the dead twigs. Raindrops can transmit conidia to leaves, twigs, and fruits, resulting in disease dispersion throughout small distances. Persistent rains and warm climatic conditions generally favor disease onset and development. The melanose disease causes a decline in fruit quality, which lowers the value of fruits during marketing and exportation. High rainfall areas should avoid planting susceptible varieties.
  • 1.9K
  • 04 Jul 2022
Topic Review
Drosophila Glue is a Promising Model for Bioadhesion
Before entering metamorphosis, the larvae of Drosophila flies expel a transparent glue from their mouth, which solidifies in contact with air within seconds and fixes the animal to a substrate (wood, leaves, fruits, stones, etc.) for several days until the adult emerges. This glue displays interesting adhesive properties, as it can adhere to various substrates with strengths similar to strongly adhesive commercial tapes. 
  • 1.9K
  • 05 Sep 2022
Topic Review
Electrochemistry
Electrochemistry is the branch of physical chemistry concerned with the relationship between electrical potential difference, as a measurable and quantitative phenomenon, and identifiable chemical change, with the potential difference as an outcome of a particular chemical change, or vice versa. These reactions involve electrons moving via an electronically-conducting phase (typically an external electrical circuit, but not necessarily, as in electroless plating) between electrodes separated by an ionically conducting and electronically insulating electrolyte (or ionic species in a solution). When a chemical reaction is driven by an electrical potential difference, as in electrolysis, or if a potential difference results from a chemical reaction as in a battery or fuel cell, it is called an electrochemical reaction. Unlike in other chemical reactions, in electrochemical reactions electrons are not transferred directly between atoms, ions, or molecules, but via the aforementioned electronically-conducting circuit. This phenomenon is what distinguishes an electrochemical reaction from a conventional chemical reaction.
  • 1.9K
  • 14 Oct 2022
Topic Review
Wastewater Treatment Technologies
Freshwater is in limited supply, and the growing population further contributes to its scarcity. The effective treatment of wastewater is essential now more than ever, because waterborne infections significantly contribute to global deaths, and millions of people are deprived of safe drinking water. The wastewater treatment technologies include preliminary, primary, secondary, and tertiary treatments, which are effective in removing several contaminants.
  • 1.9K
  • 30 Nov 2022
  • Page
  • of
  • 2728
Featured Entry Collections
>>

Featured Reprints

>>
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Medieval Royal Iconography
Academic Video Service
Feedback