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Topic Review
Google App Engine
Google App Engine (often referred to as GAE or simply App Engine) is a cloud computing platform as a service for developing and hosting web applications in Google-managed data centers. Applications are sandboxed and run across multiple servers. App Engine offers automatic scaling for web applications—as the number of requests increases for an application, App Engine automatically allocates more resources for the web application to handle the additional demand. Google App Engine primarily supports Go, PHP, Java, Python, Node.js, .NET, and Ruby applications, although it can also support other languages via "custom runtimes". The service is free up to a certain level of consumed resources and only in standard environment but not in flexible environment. Fees are charged for additional storage, bandwidth, or instance hours required by the application. It was first released as a preview version in April 2008 and came out of preview in September 2011.
  • 2.0K
  • 17 Oct 2022
Topic Review
Mast Cell Activation Syndrome
Mast cell activation syndrome (MCAS) is a medical condition recognised relatively recently, over whose definition and inclusion criteria there is still much debate in the literature. Some authors view it as a set of acute and severe systemic symptoms originating in mast cells’ abnormal number or reactivity, with clear laboratory inclusion criteria, while others see it as an immune/inflammatory systemic condition, acute and/or chronic, with manifestations ranging from mild to severe, including anaphylaxis, caused by mediators released from activated mast cells. At present the established diagnostic criteria are still a matter of debate, and there is still no certainty whether cases of MCAS are not missed versus the possibility of over-diagnosis.
  • 2.0K
  • 24 Jul 2023
Topic Review Peer Reviewed
From Churn to Earn: Mitigating Turnover for Better Performance
The occurrence of human resource churning results in financial, time and effort losses for organisations, which creates a problem for organisations that lose the most experienced human resources that they have invested in training. The human resources that leave organisations are known as churners. Churning is the costly, time-consuming and difficult process of replacing workers who have left voluntarily. Given the multiplicity of definitions attributed to the subject of churning, we follow the approach that human resource churning is a component of turnover, which is related to analysing the costs associated with voluntary departures. As a result of this problem, this entry was created with the aim of theoretically explaining the effects that the churning of human resources has on organisations of origin. In order to meet this objective, various topics are covered with the aim of characterising churners, their backgrounds and their aspirations, referring to the effect of the mobility of human resources on organisations, in other words, the effect of churning on organisations and the urgent need for action.
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  • 11 Mar 2025
Topic Review
Pyridone Disperse Dyes Provide Added-Value
This entry provides a description of some of the disperse dyes based on pyridone and the uses of these disperse dyes as antioxidants and anticancer, as well as the use of polyester fabrics dyed with these dyes in various activities, especially medical activities. It is blamed that the textile industry is one of the major generators of industrial waste due to large quantities of water that contains a variety of pollutants, including dyes. So, our aim in this review is to explain that the dyeing process using high temperature and high pressure method was an environmentally friendly process. Therefore, this review provides a good data for chemists, biologists and interested people working in textile chemistry, public health and environment research areas.
  • 2.0K
  • 14 Sep 2020
Topic Review
Copper Complexes as Topoisomerases Inhibitors
Organometallics, such as copper compounds, are cancer chemotherapeutics used alone or in combination with other drugs. A group of copper complexes exerts an effective inhibitory action on topoisomerases, which participate in the regulation of DNA topology. Copper complexes of topoisomerase inhibitors work by different molecular mechanisms that have repercussions on the cell cycle checkpoints and death effectors. 
  • 2.0K
  • 14 Oct 2020
Topic Review
Transcription Factors
Transcription factors (TFs) are regulatory proteins that are responsible for the mechanistic control of gene transcription.
  • 2.0K
  • 25 Jan 2021
Biography
Clemens Winkler
Clemens Alexander Winkler (December 26, 1838 – October 8, 1904) was a German chemist who discovered the element germanium in 1886, solidifying Dmitri Mendeleev's theory of periodicity. Winkler was born in 1838 in Freiberg, Kingdom of Saxony the son of a chemist who had studied under Berzelius. Winkler's early education was at schools in Freiberg, Dresden, and Chemnitz. In 1857 he entered th
  • 2.0K
  • 17 Nov 2022
Topic Review
Dynamic Crosslinking Hydrogel Dressings
One of the most advanced, promising and commercially feasible research issues in the field of hydrogel dressings is to obtain functions to achieve improved therapeutic effects and even intelligent wound repair. In addition to the advantages of ordinary hydrogel dressings, functional hydrogel dressings can also adjust their chemical/physical properties to meet different wound types, respond accordingly, actively create a healing environment conducive to wound repair, and control drug release to provide lasting benefits.
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  • 12 May 2023
Topic Review
Regulation of CD36 Expression and Activity in Cancer
Cluster of differentiation 36 (CD36) is a cell surface scavenger receptor that plays critical roles in many different types of cancer, notably breast, brain, and ovarian cancers. While it is arguably most well-known for its fatty acid uptake functions, it is also involved in regulating cellular adhesion, immune response, and apoptosis depending on the cellular and environmental contexts.
  • 2.0K
  • 15 Jun 2023
Topic Review
Competitive Swimwear
Competitive swimwear refers to the swimsuit, clothing, equipment, and accessories used in the aquatic sports of swimming, diving, synchronized swimming, triathlon, and water polo. Some swimsuits are designed specifically for swimming competitions where they may be constructed of a special low resistance fabric that reduces skin drag. For some kinds of swimming and diving, special bodysuits called "diveskins" are worn. These suits are made from spandex and provide little thermal protection, but they do protect the skin from stings and abrasion. Most competitive swimmers also wear special swimsuits including partial bodysuits, racerback styles, jammers and racing briefs to assist their glide through the water thus gaining a speed advantage. Unlike regular swimsuits, which are designed mainly for the aesthetic appearances, swimsuits designed to be worn during competitions are manufactured to assist the athlete in swim competitions. They reduce friction and drag in the water, increasing the efficiency of the swimmer's forward motion. The tight fits allow for easy movement and are said to reduce muscle vibration, thus reducing drag. This also reduces the possibility that a high forwards dive will remove a divers swimwear. Starting around 2000, in an effort to improve the effectiveness of the swimsuits, engineers have taken to designing them to replicate the skin of sea-based animals, sharks in particular. In July 2009, FINA voted to ban non-textile (non-woven) swimsuits in competitive events from 2010. The new policy was implemented to combat the issues associated with performance enhancing swimsuits, hindering the ability to accurately measure the performance of swimmers. Subsequently, the new ruling states that men's swimsuits may maximally cover the area from the navel to the knee, and women's counterparts from the shoulder to the knee. Some swimmers use a specialized training suit called drag suits to artificially increase drag during practice. Drag suits are swimwear with an outer layer of looser fabric – often mesh or nylon – to increase resistance against the water and build up the swimmer's endurance. They come in a variety of styles, but most resemble a looser fitting square-cut or swim brief.
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  • 06 Oct 2022
Topic Review
Working Memory Models in Language and Bilingualism Research
Working memory (WM) generally refers to our ability to ‘mentally maintain information in an active and readily accessible state while concurrently and selectively processing new information’. WM, as the primary memory, plays a fundamental role in multiple facets of human cognitive life, including language learning and processing.
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  • 09 Jun 2022
Topic Review
Groundwater dynamics
Analytical solutions of groundwater dynamics in an elongated aquifer subjected to general time-dependent recharge are presented. The lateral boundaries are specified heads with the head variations governed by general time-dependent functions.  General recharge function was not considered in previous works of this kind. Both single and double-porosity aquifers are considered. The solution is obtained using Fourier sine and Laplace transformations, followed by an inverse Fourier-Laplace transform involving residue theorem and convolutional integral. For the unconfined single-porosity aquifer case, the exact time-domain solution is obtained using the residue theorem; for the unconfined double-porosity aquifer case, the time-domain head is calculated using the de Hoog inverse Laplace algorithm. The presented solution can be used to estimate the hydraulic parameters of 1) groundwater head variation of a river basin aquifer subjected to general lateral head variation and recharge; 2) groundwater head variation in a double-porosity elongated fractured anticline; 3) groundwater depletion of an elongated fractured anticline subjected to recharge due to rainfall or snowmelt to its adjacent alluvial aquifer.  In addition, the presented solution can be utilized to optimize the irrigation pattern in a cropland between two trench drains to control the groundwater mound.
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  • 23 Dec 2020
Topic Review
VI-based Inverters
The transition from the synchronous generator (SG)-based conventional power generation to converter-based renewable energy sources (RES) deteriorates the frequency stability of the power system due to the intermittency of wind and photovoltaic (PV) generation. Unlike conventional power generation, the lack of rotational inertia becomes the main challenge to interface RES with the electrical grid via power electronic converters. In the past several years, researchers have addressed this issue by emulating the behavior of SG mathematically via pulse width modulation (PWM) controller linked to conventional inverter systems. These systems are technically known as VI-based inverters, which consist of virtual synchronous machine (VSM), virtual synchronous generator (VSG), and synchronverter.
  • 2.0K
  • 30 Oct 2020
Topic Review
English on EU Countries' Websites
The English language is the most dominant language in the western world and its influence can be noticed in every aspect of human communication. This article presents data about the prevalence of the English language in the different countries and regions of the European Union. By analyzing and processing the findings from over 100000 websites from every country in the EU, a solid foundation is set that is used to explore the dominance of the English language in the European World Wide Web in general. The results of this process demonstrate that the English language is not only available on more than one quarter of all websites of non-English speaking EU countries, but is also available in the vast majority of multilingual and bilingual websites of the EU, while at the same time being the only available language in a number of monolingual websites and shown preference over the national language in a significant number of cases.
  • 2.0K
  • 30 Oct 2020
Topic Review
Natural Antimicrobial Products
Drug-resistant bacteria pose a serious threat to human health worldwide. Current antibiotics are losing efficacy and new antimicrobial agents are urgently needed. Living organisms are an invaluable source of antimicrobial compounds. The antimicrobial activity of the most representative natural products of animal, bacterial, fungal and plant origin are reviewed in this article. Their activity against drug-resistant bacteria, their mechanisms of action, the possible development of resistance against them, their role in current medicine and their future perspectives are discussed. Natural compounds of heterogeneous origins have been shown to possess antimicrobial capabilities, including against antibiotic-resistant bacteria. The most commonly found mechanisms of antimicrobial action are related to protein biosynthesis and alteration of cell walls and membranes. Various natural compounds, especially phytochemicals, have shown synergistic capacity with antibiotics. There is little literature on the development of specific resistance mechanisms against natural antimicrobial compounds. New technologies such as -omics, network pharmacology and informatics have the potential to identify and characterize new natural antimicrobial compounds in the future. This knowledge may be useful for the development of future therapeutic strategies.
  • 2.0K
  • 05 Jan 2021
Topic Review
Nutrition in Elderly Cancer Therapy
The continuous increase in life expectancy results in a steady increase of cancer risk, which consequently increases the population of older adults with cancer. Older adults have their age-related nutritional needs and often suffer from comorbidities that may affect cancer therapy. They frequently are malnourished and present advanced-stage cancer. Therefore, this group of patients requires a special multidisciplinary approach to optimize their therapy and increase quality of life impaired by aging, cancer, and the side effects of therapy. Evaluation strategies, taking advantage of comprehensive geriatric assessment tools, including the comprehensive geriatric assessment (CGA), can help individualize treatment. As epigenetics, an emerging element of the regulation of gene expression, is involved in both aging and cancer and the epigenetic profile can be modulated by the diet, it seems to be a candidate to assist with planning a nutritional intervention in elderly populations with cancer.
  • 2.0K
  • 09 Nov 2020
Topic Review
Benzil
Benzil (BZ) can be converted almost quantitatively to benzoyl peroxide (BP) in aerated polymer films upon irradiation at >400 nm (i.e., the long-wavelength edge of the n→π* absorption band of BZ, where BP does not absorb).
  • 2.0K
  • 20 Sep 2021
Topic Review
Biological Detoxification of Mycotoxins
The continuous occurrence of food contaminants worldwide poses a critical threat to the health of human and livestock. One of the major contaminants in food and feed products are mycotoxins, the secondary metabolites synthesized by toxigenic fungi strains, mainly those belonging to Penicillium, Aspergillus, Alternaria and Fusarium genera. Both acute and chronic exposure to mycotoxin-contaminated food may cause deleterious health effects including retarded growth, suppression of the immune response, vomiting, infertility and gastrointestinal and carcinogenic diseases. These mycotoxins occur in various products, from raw agricultural products such as corn, barley, oats, fruits and herbs, to commercial commodities including aquafeeds, beverages, fruit and vegetable-derived products. The contamination of mycotoxins can occur during any part of the complex food chain, including harvest, industry processing, transportation and/or storage, imposing social burdens on the food industry due to the waste created by contaminated products. This creates an urgent demand for mycotoxin removal methods to minimize economic loss and hazards to consumers.
  • 2.0K
  • 22 Apr 2022
Topic Review
Crop Plants with Silicon Application
Silicon (Si) is present in soil mainly in three different phases such as solid, liquid, and adsorbed. Solid phases can be either amorphous or crystalline. Plants take up Si from the soil which impacts their growth and nutrient accumulation. It increases plant resistance to abiotic and biotic stresses such as drought, salinity, and heavy metal, diseases, and pest infestation.
  • 2.0K
  • 29 Apr 2022
Topic Review
Therapeutic Potential of Carica papaya Leaf against Thrombocytopenia
Thrombocytopenia is a clinical manifestation that refers to the low platelet count, i.e., <150 × 103/μL, of blood, resulting in imbalanced hemostasis, which leads to several fatal complications. The causative factors vary greatly, but, as a consequence, they interfere with platelet production and promote destruction, leading to death. Carica papaya leaf has unique therapeutic and medicinal characteristics against thrombocytopenia, and this is supported by scientific studies. Secondary metabolites and minerals in the leaf, such as carpaine and quercetin, promote platelet production, inhibit platelet destruction, and maintain platelet membrane through gene expression activity and the ceasing of viral proteases, respectively. Phytochemical profiles of C. papaya leaf revealed the presence of flavonoids, alkaloids, phenols, cardiac glycosides, tannins, terpenes, and saponins, which impart therapeutic potential to the leaf. The therapeutic benefits of the leaf include immunomodulatory, antiviral, antidiabetic, anticancer, antimalarial, antiangiogenic, antibacterial, and antioxidant activities. Several conducted scientific research studies have proved the efficacy of C. papaya leaf against thrombocytopenia, expanding the implication of natural sources to eradicate numerous ailments.
  • 2.0K
  • 24 May 2022
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