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Topic Review
Alkenyl Succinic Anhydride
Alkenyl Succinic Anhydride (ASA) is a sizing agent used in papermaking to increase the water repellency of paper. Almost 60 years after the introduction of the chemical in papermaking, scientists still have differing views on how ASA interacts with cellulose. Several experiments were conducted to bring more clarity to the ASA sizing mechanism, especially on the contentious question of ASA-cellulose covalent bonding or the esterification reaction between ASA and cellulose during papermaking.
  • 2.2K
  • 07 Jul 2023
Topic Review
Foodborne Pathogens
There are millions of reported cases of foodborne illness in developed and developing countries annually making identification of foodborne pathogens a global concern. Testing for foodborne pathogens is essential to ensuring a safe food supply, quality assurance in the food industry, treating illness, and controlling outbreaks. In this article, several methods for the detection and identification of foodborne pathogens are discussed and a triplex PCR high-resolution melt assay for detecting Vibrio parahaemolyticus, Shigella flexneri, and Escherichia coli is presented.
  • 2.2K
  • 30 Oct 2020
Topic Review
Phytosterols in Human Nutrition
A healthy diet combined with physical activity have been shown to ameliorate glycaemic levels and insulin sensitivity, reduce body weight and the risk of chronic diseases, and contribute to an overall improvement in quality of life. Among nutrients, phytosterols have become the focus of growing attention as novel functional foods in the management of metabolic disorders. Phytosterols are natural plant compounds belonging to the triterpene family and are structurally similar to cholesterol. They are known for their cholesterol-lowering effects, anti-inflammatory and antioxidant properties,and the benefits they offer to the immune system.
  • 2.2K
  • 30 Dec 2020
Topic Review
Bayesian Analysis in Social Sciences
Given the reproducibility crisis (or replication crisis), more psychologists and social-cultural scientists are getting involved with Bayesian inference. Therefore, the current article provides a brief overview of programs (or software) and steps to conduct Bayesian data analysis in social sciences. 
  • 2.2K
  • 23 Jul 2021
Topic Review
Receptor for Advanced Glycation End Products (RAGE)
As a critical molecule in the onset and sustainment of inflammatory response, the receptor for advanced glycation end products (RAGE) has a variety of ligands, such as advanced glycation end products (AGEs), S100/calcium granule protein, and high-mobility group protein 1 (HMGB1). An increasing number studies have shown that RAGE ligand binding can initiate the intracellular signal cascade, affect intracellular signal transduction, stimulate the release of cytokines, and play a vital role in the occurrence and development of immune-related diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and Alzheimer’s disease. In addition, other RAGE signaling pathways can play crucial roles in life activities, such as inflammation, apoptosis, autophagy, and endoplasmic reticulum stress. Therefore, the strategy of targeted intervention in the RAGE signaling pathway may have significant therapeutic potential, attracting increasing attention.
  • 2.2K
  • 25 Aug 2022
Topic Review
Measurement and Signature Intelligence
Measurement and signature intelligence (MASINT) is a technical branch of intelligence gathering, which serves to detect, track, identify or describe the distinctive characteristics (signatures) of fixed or dynamic target sources. This often includes radar intelligence, acoustic intelligence, nuclear intelligence, and chemical and biological intelligence. MASINT is defined as scientific and technical intelligence derived from the analysis of data obtained from sensing instruments for the purpose of identifying any distinctive features associated with the source, emitter or sender, to facilitate the latter's measurement and identification. MASINT specialists themselves struggle with providing simple explanations of their field. One attempt calls it the “CSI” of the intelligence community, in imitation of the television series CSI: Crime Scene Investigation. This emphasizes how MASINT depends on a great many sciences to interpret data. Another possible definition calls it "astronomy except for the direction of view." The allusion here is to observational astronomy being a set of techniques that do remote sensing looking away from the earth (contrasted with how MASINT employs remote sensing looking toward the earth). Astronomers make observations in multiple electromagnetic spectra, ranging through radio waves, infrared, visible, and ultraviolet light, into the X-ray spectrum and beyond. They correlate these multispectral observations and create hybrid, often “false-color” images to give a visual representation of wavelength and energy, but much of their detailed information is more likely a graph of such things as intensity and wavelength versus viewing angle.
  • 2.2K
  • 04 Nov 2022
Topic Review
Heat Management Strategies for an Induction Motor
Induction motors have gained a renewed interest due to this new shift from conventional power sources to electric power. These motors are known for their high commencing torque, adequate speed control, and reasonable overload capacity. However, induction motors have an innate thermal issue wherein their lifespan and performance are strongly temperature dependent. Hence, it is highly essential to focus on the thermal management aspect of these motors to ensure reliability and enhance performance. This research suggests an integrated approach with two or more cooling strategies and help to serve members of the scientific community, manufacturers or motors users who are interested in the thermal management of induction motors
  • 2.2K
  • 15 Nov 2022
Topic Review Peer Reviewed
The Metaverse Territorial Brand: A Contemporary Concept
The “Metaverse Territorial Brand” integrates core and interconnected elements into a virtual, interactional, experiential, and immersive space known as the metaverse. This type of brand encompasses the connection with immersive territories that may or may not be digital twins of real territories. It also encompasses two interconnected physical scales: the territorial and the regional, involved in another type of emerging territorial scale, known as the metaversal scale. Therefore, the “Metaverse Territorial Brand” is a digital-immersive extension of the territorial brand of physical territories, encompassing specific geographical and cultural aspects, but directed to the metaverse environment. This brand is a symbolic digital construction, but also a multifaceted one that incorporates discursive and visual elements, articulated by the social actors of the immersive territory, aiming to create a specific and distinct identity for a space in the metaverse. When talking about social actors in the metaverse (users), we highlight that this set of actors may or may not be the same as the physical territory. It is also important to highlight that both the territorial brand directed to physical territories and the “Metaverse Territorial Brand” are formed from the power relations of a given set of social actors. Therefore, without the strategic intention of a plurality of social actors that stimulate these relationships, there is no type of territorial brand involved.
  • 2.2K
  • 29 Sep 2024
Topic Review
Hydrosilylation Reactions Catalyzed by Rhenium
Hydrosilylation is a very versatile transformation consisting of the addition of a hydrosilane (H-SiR3) to an unsaturated bond. Organosilicon compounds have found widespread applications in our daily lives in silicon-based materials such as silicon rubbers, adhesives, paper release coating, and so forth. In addition, hydrosilylation is an atom economic reaction to access valuable organosilane intermediates for fine chemical synthesis
  • 2.2K
  • 20 May 2021
Topic Review
Medicinal Mushrooms and COVID-19
Many mushroom species are consumed as food, while significant numbers are also utilised medicinally. Mushrooms are rich in nutrients and bioactive compounds. A growing body of in vitro, in vivo, and human research has revealed their therapeutic potentials, which include such properties as anti-pathogenic, antioxidant, anti-inflammatory, immunomodulatory, gut microbiota enhancement, and angiotensin-converting enzyme 2 specificity. The uses of medicinal mushrooms (MMs) as extracts in nutraceuticals and other functional food and health products are burgeoning. COVID-19 presents an opportunity to consider how, and if, specific MM compounds might be utilised therapeutically to mitigate associated risk factors, reduce disease severity, and support recovery. As vaccines become a mainstay, MMs may have the potential as an adjunct therapy to enhance immunity. 
  • 2.2K
  • 19 Apr 2022
Topic Review
S-PRG Filler for Dental Treatment and Care
Surface Pre-Reacted Glass-ionomer (S-PRG) filler, which releases strontium (Sr2+), borate (BO33−), fluoride (F−), sodium (Na+), silicate (SiO32−), and aluminum (Al3+) ions at high concentrations, is a unique glass filler that are utilized in dentistry. Because of its multiple-ion releasing characteristics, S-PRG filler exhibits several bioactivities such as tooth strengthening, acid neutralization, promotion of mineralization, inhibition of bacteria and fungi, inhibition of matrix metalloproteinases, and enhancement of cell activity. Therefore, S-PRG filler per se and S-PRG filler-containing materials have the potential to be beneficial for various dental treatments and care.
  • 2.2K
  • 28 Jun 2023
Topic Review
City Cargo Transportation by Trams
A city’s transport and distribution system requires the effective organization of urban freight deliveries that take into consideration the economic, ecological, and social impact. Implementation of the concept of green logistics necessitates the use of environmentally friendly and energy-efficient modes of transport, which consider the existing infrastructure and the possibility of its development.
  • 2.2K
  • 09 Jun 2026
Topic Review
Therapeutic Potential of Royal Jelly in Gastrointestinal Diseases
Royal jelly (RJ), a natural bee product rich in bioactive components, as an alternative strategy for managing metabolic diseases. RJ exhibits diverse therapeutic properties, including antimicrobial, estrogen-like, anti-inflammatory, hypotensive, anticancer, and antioxidant effects. 
  • 2.2K
  • 08 Feb 2024
Topic Review
Nanoparticle Exsolution on Perovskite-Based Catalysts
In heterogeneous catalysis, surfaces decorated with uniformly dispersed, catalytically-active (nano)particles are a key requirement for excellent performance. Besides standard catalyst preparation routines—with limitations in controlling catalyst surface structure (i.e., particle size distribution or dispersion)—exsolution is a potential novel and time efficient route to precisely tailor catalyst surface morphology and composition of perovskites: Perovskite-type oxides of nominal composition ABO3 with transition metal cations on the B-site can exsolve the B-site transition metal upon controlled reduction. In this exsolution process, the transition metal emerges from the oxide lattice and migrates to the surface where it forms catalytically active nanoparticles. Doping the B-site with reducible and catalytically highly active elements, offers the opportunity of tailoring properties of exsolution catalysts.
  • 2.2K
  • 01 Nov 2020
Topic Review
Virus-like Particles
Nanotechnology is a fast-evolving field focused on fabricating nanoscale objects for industrial, cosmetic, and therapeutic applications. Virus-like particles (VLPs) are self-assembled nanoparticles whose intrinsic properties, such as heterogeneity, and highly ordered structural organization are exploited to prepare vaccines; imaging agents; construct nanobioreactors; cancer treatment approaches; or deliver drugs, genes, and enzymes. However, depending upon the intrinsic features of the native virus from which they are produced, the therapeutic performance of VLPs can vary. 
  • 2.2K
  • 15 Aug 2022
Topic Review
2021 Peptides and Oligonucleotides Harvest
From the medical, pharmaceutical, and social perspectives, 2021 has been a year dominated by the COVID-19 pandemic. However, despite this global health crisis, the pharmaceutical industry has continued its endeavors, and 2021 could be considered an excellent year in terms of the drugs accepted by the US Food and Drug Administration (FDA). Thus, during this year, the FDA has approved 50 novel drugs, of which 36 are new chemical entities and 14 biologics. It has also authorized 10 TIDES (8 peptides, 2 oligonucleotides), in addition to 2 antibody-drug conjugates (ADCs) whose structures contain peptides.
  • 2.2K
  • 17 Feb 2022
Topic Review
Environmental and Lifestyle Risk Factors in Gallbladder Carcinogenesis
Gallbladder cancer (GBC) is an aggressive neoplasm that in an early stage is generally asymptomatic and, in most cases, is diagnosed in advanced stages with a very low life expectancy because there is no curative treatment. Therefore, understanding the early carcinogenic mechanisms of this pathology is crucial to proposing preventive strategies for this cancer. The main risk factor is the presence of gallstones, which are associated with some environmental factors such as a sedentary lifestyle and a high-fat diet. Other risk factors such as autoimmune disorders and bacterial, parasitic and fungal infections have also been described. All these factors can generate a long-term inflammatory state characterized by the persistent activation of the immune system, the frequent release of pro-inflammatory cytokines, and the constant production of reactive oxygen species that result in a chronic damage/repair cycle, subsequently inducing the loss of the normal architecture of the gallbladder mucosa that leads to the development of GBC.
  • 2.2K
  • 18 Feb 2022
Topic Review
Organic and Inorganic Nanoparticles in Foods
Inorganic or organic nanoparticles are often incorporated into foods to enhance their quality, stability, nutrition, or safety. When they pass through the gastrointestinal environment, the properties of these nanoparticles are altered, which impacts their biological effects and potential toxicity. Consequently, there is a need to understand how different kinds of nanoparticles behave within the gastrointestinal tract.
  • 2.2K
  • 07 Apr 2022
Topic Review
Genetically-Encoded Probes for Live-Cell Imaging of Histone Modifications
Epigenetic modifications of histones (methylation, acetylation, phosphorylation, etc.) are of great importance in determining the functional state of chromatin. There are various fluorescent probes for histone modification detection. Various types of live-cell imaging epigenetic sensors suitable for conventional as well as super-resolution fluorescence microscopy are described.
  • 2.2K
  • 25 Aug 2022
Biography
James Van Allen
James Alfred Van Allen (September 7, 1914 – August 9, 2006) was an American space scientist at the University of Iowa. He was instrumental in establishing the field of magnetospheric research in space. The Van Allen radiation belts were named after him, following their discovery by his Geiger–Müller tube instruments on the 1958 satellites: (Explorer 1, Explorer 3, and Pioneer 3)[1][2][3]
  • 2.2K
  • 17 Nov 2022
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