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Topic Review
Systems Thinking
Systems thinking is an evolving field, and there is growing demand to integrate systems thinking into many fields. As this demand increases, so does the need for and importance of identifying systems thinkers.
  • 2.3K
  • 16 May 2022
Topic Review
m6A Demethylases Inhibitors
N6-methyladenosine (m6A) is a post-transcriptional RNA modification and one of the most abundant types of RNA chemical modifications. m6A functions as a molecular switch and is involved in a range of biomedical aspects, including cardiovascular diseases, the central nervous system, and cancers.
  • 2.3K
  • 06 Jun 2022
Topic Review
Gaspee Affair
Script error: No such module "Infobox military conflict". The Gaspee Affair was a significant event in the lead-up to the American Revolution. HMS Gaspee was a British customs schooner that had been enforcing the Navigation Acts in and around Newport, Rhode Island in 1772. It ran aground in shallow water while chasing the packet ship Hannah on June 9 near Gaspee Point in Warwick, Rhode Island. A group of men led by Abraham Whipple and John Brown attacked, boarded, and torched the ship. The event increased tensions between the American colonists and British officials, following the Boston Massacre in 1770. British officials in Rhode Island wanted to increase their control over trade—legitimate trade as well as smuggling—in order to increase their revenue from the small colony. But Rhode Islanders increasingly protested the Stamp Act, the Townshend Acts, and other British impositions that had clashed with the colony's history of rum manufacturing, maritime trade, and slave trading. This event and others in Narragansett Bay marked the first acts of violent uprising against the British crown's authority in America, preceding the Boston Tea Party by more than a year and moving the Thirteen Colonies as a whole toward the war for independence.
  • 2.3K
  • 18 Oct 2022
Topic Review
Verrucomicrobia
Verrucomicrobia is a phylum of Gram-negative bacteria that contains only a few described species. The species identified have been isolated from fresh water, marine and soil environments and human faeces. A number of as-yet uncultivated species have been identified in association with eukaryotic hosts including extrusive explosive ectosymbionts of protists and endosymbionts of nematodes residing in their gametes. Verrucomicrobia are abundant within the environment, though relatively inactive. This phylum is considered to have two sister phyla: Chlamydiae and Lentisphaerae within the PVC group. The Verrucomicrobia phylum can be distinguished from neighbouring phyla within the PVC group by the presence of several conserved signature indels (CSIs). These CSIs represent unique, synapomorphic characteristics that suggest common ancestry within Verrucomicrobia and an independent lineage amidst other bacteria. CSIs have also been found that are shared by Verrucomicrobia and Chlamydiae exclusively of all other bacteria. These CSIs provide evidence that Chlamydiae is the closest relative to Verrucomicrobia, and that they are more closely related to one another than to the Planctomycetales. Verrucomicrobia might belong in the clade Planctobacteria in the larger clade Gracilicutes. In 2008, the whole genome of Methylacidiphilum infernorum (2.3 Mbp) was published. On the single circular chromosome, 2473 predicted proteins were found, 731 of which had no detectable homologs. These analyses also revealed many possible homologies with Proteobacteria.
  • 2.3K
  • 21 Oct 2022
Topic Review
Wireless Power Transfer Systems for Charging Portable Electronics
High-frequency operation of wireless power transfer (WPT) systems leads to miniaturization of the components and a higher efficiency. For this reason, various soft-switched topologies such as Class D, E, EF, etc., are used to operate the WPT systems at high frequencies in the megahertz range. Wide band gap (WBG)  and ultra-WBG devices can be used for very high frequency operation. Compensation topologies reduce the VA rating of the transmitter and can also infer voltage source or constant source characteristics to the inverters. Constant current source inverters are particularly useful when using multiple receivers since they ensure decoupled power transfer to the receivers.
  • 2.3K
  • 15 May 2023
Topic Review
Enzyme Immobilization with Fibrous Membranes
Fibrous membranes offer broad opportunities to deploy immobilized enzymes in new reactor and application designs, including multiphase continuous flow-through reactions. Enzyme immobilization is a technology strategy that simplifies the separation of otherwise soluble catalytic proteins from liquid reaction media and imparts stabilization and performance enhancement. Flexible immobilization matrices made from fibers have versatile physical attributes, such as high surface area, light weight, and controllable porosity, which give them membrane-like characteristics, while simultaneously providing good mechanical properties for creating functional filters, sensors, scaffolds, and other interface-active biocatalytic materials.
  • 2.3K
  • 29 May 2023
Topic Review
Cold-Tolerant Microbes
Cold adapted microorganisms represent a large fraction of biomass on earth due to the dominance of low temperature environments. Himalaya is one of the most important low temperature environments on Earth because it possess environmental similarities to Polar Regions. The extreme cold environments of Himalaya are mainly dependent on the tiny life forms because of climatic restrictions to higher plants and animals. These cold loving microbes are known to possess several structural and functional adaptations in order to perform various life processes under the stressful low temperature environments. Their biological activities maintain the nutrient flux in environment and contribute in the global biogeochemical cycles. The culture dependent and culture independent studies revealed their diversity in community structure and functional potential. Apart from the ecological importance, these microorganisms have been recognized as a source of cold active enzymes and novel bioactive compounds. These products have several applications in biotechnological industries. 
  • 2.3K
  • 27 Oct 2020
Topic Review
Technology Solutions for Circular Economy
The concept of circular economy (CE) is becoming progressively popular with academia, industry, and policymakers, as a potential path towards a more sustainable economic system. CE comes as an alternative to the linear economy model, embracing and incorporating a series of ideas in various so-called “R” frameworks (e.g. “reduce”, “reuse”, and “recycle”). Information and communication technology (ICT) systems have influenced every aspect of modern life and the CE is no exception. Cutting-edge technologies, such as big data, cloud computing, cyber-physical systems, internet of things, virtual and augmented reality, and blockchain, can play an integral role in the embracing of CE concepts and the rollout of CE programs by governments, organizations, and society as a whole. There are many ICT solutions found in the literature, which can pave the way towards a CE. The categorization of these solutions can be done either from a technological perspective (e.g., communications, computing, data analysis, etc.), or from the viewpoint of the main CE concept(s) (i.e., reduce, reuse, recycle and restore) that each solution is most relevant to. ICT solutions related to data collection and data analysis, and in particular to the Internet of Things, blockchain, digital platforms, artificial intelligence algorithms, and software tools, are amongst the most popular solutions proposed by academic researchers. Also, greater emphasis is placed on the “reduce” component of the CE, although ICT solutions for the other “R” components, as well as holistic ICT-based solutions, do exist as well. Specific important challenges impeding the adoption of ICT solutions for the CE also exist, especially related to consumer and business attitude, economic costs, possible environmental impacts, lack of education around the CE, and lack of familiarization with modern technologies being found among the most prominent ones.
  • 2.3K
  • 20 Nov 2020
Topic Review
Stroke
Stroke is the second leading cause of death and a major contributor to disability worldwide. The prevalence of stroke is highest in developing countries, with ischemic stroke being the most common type. Considerable progress has been made in our understanding of the pathophysiology of stroke and the underlying mechanisms leading to ischemic insult. Stroke therapy primarily focuses on restoring blood flow to the brain and treating stroke-induced neurological damage. Lack of success in recent clinical trials has led to significant refinement of animal models, focus-driven study design and use of new technologies in stroke research. Simultaneously, despite progress in stroke management, post-stroke care exerts a substantial impact on families, the healthcare system and the economy. Improvements in pre-clinical and clinical care are likely to underpin successful stroke treatment, recovery, rehabilitation and prevention. In this review, we focus on the pathophysiology of stroke, major advances in the identification of therapeutic targets and recent trends in stroke research.
  • 2.3K
  • 07 Apr 2021
Topic Review
Vegetation Dynamics and Climate Change
Climate extremes and their impacts on vegetation dynamics have been of great concern to the ecosystem and environmental conservation and the policy-decision makers. Of great concern now is that climate change impacts on vegetation dynamics have influenced the global terrestrial ecosystem adversely, thus making ecosystems vulnerability one of the current issues in ecological studies. For instance, the negative consequences attributed to natural hazards associated with climate extremes have been estimated to be billions of dollars across the globe. Accordingly, vegetation dynamics are influenced by several factors including climate change, environmental and climatic components among others. These can expend considerable impact on the water balance by evapotranspiration, interception and development strategy which has the potential to lead to vegetation degradation in a wide variety of ecosystems and biodiversity.
  • 2.3K
  • 30 Sep 2021
Topic Review
Methanol Economy—Fuel Cell Route
It explores the renewable ways of obtaining methanol and its use in efficient energy systems for a net zero-emission carbon cycle, with a special focus on fuel cells. It investigates the different parts of the carbon cycle from a methanol and fuel cell perspective. In recent years, the potential for a methanol economy has been shown and there has been significant technological advancement of its renewable production and utilization. Even though its full adoption will require further development, it can be produced from renewable electricity and biomass or CO2 capture and can be used in several industrial sectors, which make it an excellent liquid electrofuel for the transition to a sustainable economy. By converting CO2 into liquid fuels, the harmful effects of CO2 emissions from existing industries that still rely on fossil fuels are reduced. The methanol can then be used both in the energy sector and the chemical industry, and become an all-around substitute for petroleum. 
  • 2.3K
  • 09 Oct 2021
Topic Review
Boron Essentiality in Humans and Animals
Boron (B) is considered a prebiotic chemical element with a role in both the origin and evolution of life, as well as an essential micronutrient for some bacteria, plants, fungi, and algae. B has beneficial effects on the biological functions of humans and animals, such as reproduction, growth, calcium metabolism, bone formation, energy metabolism, immunity, and brain function. Naturally organic B (NOB) species may become promising novel prebiotic candidates. NOB-containing compounds have been shown to be essential for the symbiosis between organisms from different kingdoms. New insights into the key role of NOB species in the symbiosis between human/animal hosts and their microbiota will influence the use of natural B-based colon-targeting nutraceuticals. The mechanism of action (MoA) of NOB species is related to the B signaling molecule (autoinducer-2-borate (AI-2B)) as well as the fortification of the colonic mucus gel layer with NOB species from B-rich prebiotic diets. Both the microbiota and the colonic mucus gel layer can become NOB targets. The evidence supporting the essentiality of the NOB species in the symbiosis between the microbiota and the human/animal hosts is reviewed, with the stated aim of highlighting the MoA and targets of these species.
  • 2.3K
  • 13 Sep 2022
Topic Review
DICONDE
Digital Imaging and Communication for Nondestructive Evaluation (DICONDE) is a vendor-neutral digital data storage and transmission protocol that defines the organization of nondestructive testing (NDT) inspection data and associated metadata in a standard format. DICONDE is based on and inherits from the universally adopted medical standard, DICOM, which facilitates the interoperability of imaging, video, and signal data acquisition equipment through data storage, query, and network communication protocols. The ASTM International standards organization maintains and holds the copyright to the relevant DICONDE published standards, including a tutorial guide designated as E3169. Development and maintenance of the standard is handled by committee E07 on nondestructive testing. Subcommittee E07.11 on DICONDE is concerned with the formulation of standards for the communication and storage of data generated by all nondestructive testing methodologies capable of handling data in an electronic format. ASTM maintains a page dedicated to DICONDE and openly provides resources on the ASTM DICONDE home page.
  • 2.3K
  • 08 Oct 2022
Topic Review Peer Reviewed
Intellectual Humility in the Workplace
Intellectual humility (IH), defined as the extent to which one is aware of one’s own intellectual limitations, is an understudied construct in organizational research. As a moral virtue, IH has been studied in philosophy and religion for decades. As a psychological and behavioral tendency construct, IH has gained significant attention among psychology researchers over the past decade due to rising extremism regarding social and political issues in the US and around the world. One reason for the increased research interest in IH includes the potential benefits from IH in terms of reducing social and political polarization and reducing stress and anxiety, which may improve individual overall well-being. This entry provides an overview of IH as a multi-dimensional construct, its psychometric properties and nomological network, and its potential benefits in organizations and employee well-being. The entry concludes with a call for more interdisciplinary research on improving our knowledge and theories of IH as well as its construct measurement considering the recent coming-of-age adoption of artificial intelligence (AI) models to harness the power of IH in sustaining individual well-being.
  • 2.3K
  • 19 Dec 2024
Topic Review
Poly ADP-ribosylation in DNA Damage Response and Repair
Poly ADP-ribosylation (PARylation) is a post-translational modification process. Following the discovery of PARP-1, numerous studies have demonstrated the role of PARylation in the DNA damage and repair responses for cellular stress and DNA damage.
  • 2.3K
  • 08 Oct 2022
Topic Review
Bile Acid Signaling
Bile acids are digestive agents synthesized in the liver and released into the gastrointestinal track during normal physiological conditions to aid in the emulsification of lipids and fat-soluble vitamins. These bile acids are highly regulated via enterohepatic circulation, a process which minimizes bile acid loss through a wide network of organs and bile acid transporters. Beyond this, bile acids and the activation of bile acid receptors has been observed in extrahepatic tissues, in particular the central nervous system. Certain bile acids, through the use of specific bile acid transporters, can also gain entry into the brain via the blood brain barrier. Furthermore, there has been an increase in recent literature highlighting bile acids and the presence of bile acid signaling in the brain and neural cells. This entry is a current overview of these topics.
  • 2.3K
  • 21 Aug 2020
Topic Review
Polymeric Membranes for CO2 Capture
CO2 capture from coal- or natural gas-derived flue gas has been widely considered as the next opportunity for the large-scale deployment of gas separation membranes.  Despite the tremendous progress made in the synthesis of polymeric membranes with high CO2/N2 separation performance, only a few membrane technologies were advanced to the bench-scale study or above from a highly idealized laboratory setting.  Therefore, recent progress in polymeric membranes is reviewed in the perspectives of capture system energetics, process synthesis, membrane scale-up, modular fabrication, and field tests.  These engineering considerations can provide a holistic approach to better guide membrane research and accelerate the commercialization of gas separation membranes for post-combustion carbon capture.
  • 2.3K
  • 08 Dec 2020
Topic Review
Two-Dimensional Materials in Photodetector
A photodetector converts optical signals to detectable electrical signals. Lately, self-powered photodetectors have been widely studied because of their advantages in device miniaturization and low power consumption, which make them preferable in various applications, especially those related to green technology and flexible electronics. Since self-powered photodetectors do not have an external power supply at zero bias, it is important to ensure that the built-in potential in the device produces a sufficiently thick depletion region that efficiently sweeps the carriers across the junction, resulting in detectable electrical signals even at very low-optical power signals. Therefore, two-dimensional (2D) materials are explored as an alternative to silicon-based active regions in the photodetector. In addition, plasmonic effects coupled with self-powered photodetectors will further enhance light absorption and scattering, which contribute to the improvement of the device’s photocurrent generation.
  • 2.3K
  • 06 May 2021
Topic Review
Emotional Labor and Burnout among Teachers
A significant amount of emotional labor and burnout takes place during teaching. Teaching is a multitasking profession that consists of both cognitive and emotional components, with teachers engaging in emotional labor on a daily basis as an instrumental part of achieving teaching goals and positive learning outcomes. 
  • 2.3K
  • 28 Dec 2021
Topic Review
Efficiency of Chinese Prefabricated Building Industry
China is a world leader in capital construction. In the construction field, the shift toward prefabricated construction has become an important path for industrial transformation.China's prefabricated building industry has a moderate micro-level efficiency. This means that it is necessary to further rationalize industrial planning; strengthen technological innovation; and improve standardization, mechanization, and automation levels. At the macro level, China’s prefabricated buildings have a low industrial efficiency and remain at the initial stage of industrial development. A series of problems, such as small industrial scale and unsound policies, are restricting the industry’s rapid and efficient development.
  • 2.3K
  • 26 Sep 2022
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