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Topic Review
Value Innovation
Value innovation, as defined by Kim and Mauborgne, and Kim and Mauborgne, is making “the competition irrelevant by offering fundamentally new and superior buyer value in existing markets and by enabling a quantum leap in buyer value to create new markets”. The concept of value innovation is a summation of analytical outcomes from 150 strategic moves spanning more than 30 companies, worldwide, in approximately 30 industries, as well as a study for the business launched of approximately 100 companies to quantify the influence of value innovation on a company’s growth in revenues and profits. From a company perspective, Mohanty, Mele, Mele, Russo Spenaviewed value innovation as resource integration and superior competency development; meanwhile, Setijonodescribed value innovation as “creating stakeholder value through radical (disruptive)-attractive quality”, where the logic behind it is to provide a total solution, extraordinary experiences, and cost reduction through product, service, and delivery platforms.
  • 2.3K
  • 26 Oct 2021
Topic Review
Fire Knife
The fire knife is a traditional Samoan cultural implement that is used in ceremonial dances. It was originally composed of a machete wrapped in towels on both ends with a portion of the blade exposed in the middle. Tribal performers of fire knife dancing (or Siva Afi or even "Ailao Afi" as it is called in Samoa) dance while twirling the knife and doing other acrobatic stunts. The towels are set afire during the dances thus explaining the name.
  • 2.3K
  • 31 Oct 2022
Topic Review
Disability Studies
Disability studies is an academic discipline that examines the meaning, nature, and consequences of disability. Initially, the field focused on the division between "impairment" and "disability", where impairment was an impairment of an individual's mind or body, while disability was considered a social construct. This premise gave rise to two distinct models of disability: the social and medical models of disability. In 1999 the social model was universally accepted as the model preferred by the field. However, in recent years, the division between the social and medical models has been challenged. Additionally, there has been an increased focus on interdisciplinary research. For example, recent investigations suggest using "cross-sectional markers of stratification" may help provide new insights on the non-random distribution of risk factors capable of acerbating disablement processes.[clarification needed] Disability studies courses include work in disability history, theory, legislation, policy, ethics, and the arts. However, students are taught to focus on the lived experiences of individuals with disabilities in practical terms. The field is focused on increasing individuals with disabilities access to civil rights and improving their quality of life. Disability studies emerged in the 1980s primarily in the US, the UK, and Canada. In 1986, the Section[clarification needed] for the Study of Chronic Illness, Impairment, and Disability of the Social Science Association (United States) was renamed the Society for Disability Studies. The first US disabilities studies program emerged in 1994, at Syracuse University. The first edition of the Disabilities Studies Reader (one of the first collections of academic papers related to disability studies) was published in 1997. The field grew rapidly over the next ten years. In 2005, the Modern Language Association established disability studies as a "division of study". While Disability Studies primarily emerged in the US, the UK and Canada, disability studies were also conducted in other countries through different lens. For instance Germany, looks at Queer Disability Studies since the beginning of the early 20th century. The Disability Studies in Germany are influenced by the written literary works of feminist sexologist who study how being disabled affects one's sexuality and ability to feel pleasure. In Norway, Disability Studies are focused in the literary context. A variation emerged in 2017 with the first Accessibility Studies program at Central Washington Univeristy with an interdisciplinary focus on social justice, universal design and international Web Accessibility Guidelines (WAG3) as a general education knowledge base.
  • 2.3K
  • 14 Nov 2022
Topic Review
ICANN
The Internet Corporation for Assigned Names and Numbers (ICANN /ˈaɪkæn/ EYE-kan) is an American multistakeholder group and nonprofit organization responsible for coordinating the maintenance and procedures of several databases related to the namespaces and numerical spaces of the Internet, ensuring the network's stable and secure operation. ICANN performs the actual technical maintenance work of the Central Internet Address pools and DNS root zone registries pursuant to the Internet Assigned Numbers Authority (IANA) function contract. The contract regarding the IANA stewardship functions between ICANN and the National Telecommunications and Information Administration (NTIA) of the United States Department of Commerce ended on October 1, 2016, formally transitioning the functions to the global multistakeholder community. Much of its work has concerned the Internet's global Domain Name System (DNS), including policy development for internationalization of the DNS system, introduction of new generic top-level domains (TLDs), and the operation of root name servers. The numbering facilities ICANN manages include the Internet Protocol address spaces for IPv4 and IPv6, and assignment of address blocks to regional Internet registries. ICANN also maintains registries of Internet Protocol identifiers. ICANN's primary principles of operation have been described as helping preserve the operational stability of the Internet; to promote competition; to achieve broad representation of the global Internet community; and to develop policies appropriate to its mission through bottom-up, consensus-based processes. ICANN's creation was announced publicly on September 17, 1998, and it formally came into being on September 30, 1998, incorporated in the U.S. state of California. Originally headquartered in Marina del Rey in the same building as the University of Southern California's Information Sciences Institute (ISI), its offices are now in the Playa Vista neighborhood of Los Angeles in Facebook's old office.
  • 2.3K
  • 10 Nov 2022
Topic Review
Supercomputer Operating Systems
Since the end of the 20th century, supercomputer operating systems have undergone major transformations, as fundamental changes have occurred in supercomputer architecture. While early operating systems were custom tailored to each supercomputer to gain speed, the trend has been moving away from in-house operating systems and toward some form of Linux, with it running all the supercomputers on the TOP500 list in November 2017. Given that modern massively parallel supercomputers typically separate computations from other services by using multiple types of nodes, they usually run different operating systems on different nodes, e.g., using a small and efficient lightweight kernel such as Compute Node Kernel (CNK) or Compute Node Linux (CNL) on compute nodes, but a larger system such as a Linux-derivative on server and input/output (I/O) nodes. While in a traditional multi-user computer system job scheduling is in effect a tasking problem for processing and peripheral resources, in a massively parallel system, the job management system needs to manage the allocation of both computational and communication resources, as well as gracefully dealing with inevitable hardware failures when tens of thousands of processors are present. Although most modern supercomputers use the Linux operating system, each manufacturer has made its own specific changes to the Linux-derivative they use, and no industry standard exists, partly because the differences in hardware architectures require changes to optimize the operating system to each hardware design.
  • 2.3K
  • 29 Nov 2022
Topic Review
Pesticide Residues in Peppers
Pesticides are chemicals that are used to control pests such as insects, fungi, and weeds. Pesticide residues can remain on crops after application. Peppers are popular and versatile foods that are valued for their flavor, nutrition, and medicinal properties. The consumption of raw or fresh peppers (bell and chili) can have important health benefits due to their high levels of vitamins, minerals, and antioxidants. Therefore, it is crucial to consider factors such as pesticide use and preparation methods to fully realize these benefits. 
  • 2.3K
  • 02 Jun 2023
Topic Review
Popular Influenza Antiviral Drugs
Influenza viruses cause acute respiratory infections responsible for significant mortality and morbidity around the world. Various factors, such as antigenic drift, allow influenza strains to avoid being fully suppressed by seasonal vaccines. This has led to the increased scrutiny of antivirals as treatment and prophylaxis options for seasonal outbreaks and potential pandemics. Unfortunately, many influenza antivirals suffer from a lack of adequate clinical trials, as well as a lack of toxicity data. This is especially true of umifenovir (arbidol), a drug popularly used for the prevention and treatment of influenza strains in China and Russia. Neuraminidase inhibitors, though widely prescribed, display a potential for future resistance. Adamantanes, while proven to be effective in treating influenza A, are already encountering rapid and widespread cross-resistance and are effectively obsolete. Baloxavir marboxil, a newer antiviral, shows promise in treating acute uncomplicated influenza and may avoid the development of resistance when co-administered with other antiviral drugs. Indeed, the low genetic barrier to resistance associated with influenza antivirals could potentially be overcome by co-administration with other antivirals.
  • 2.3K
  • 31 Oct 2024
Topic Review
Klebsiella pneumoniae
Klebsiella pneumoniae is an opportunistic pathogen that causes nosocomial and community-acquired infections. The spread of resistant strains of K. pneumoniae represents a growing threat to human health, due to the exhaustion of effective treatments. K. pneumoniae releases outer membrane vesicles (OMVs). OMVs are a vehicle for the transport of virulence factors to host cells, causing cell injury. Previous studies have shown changes of gene expression in human bronchial epithelial cells after treatment with K. pneumoniae OMVs. These variations in gene expression could be regulated through microRNAs (miRNAs), which participate in several biological mechanisms. Thereafter, miRNA expression profiles in human bronchial epithelial cells were evaluated during infection with standard and clinical K. pneumoniae strains. Microarray analysis and RT-qPCR identified the dysregulation of miR-223, hsa-miR-21, hsa-miR-25 and hsa-let-7g miRNA sequences. Target gene prediction revealed the essential role of these miRNAs in the regulation of host immune responses involving NF-ĸB (miR-223), TLR4 (hsa-miR-21), cytokine (hsa-miR-25) and IL-6 (hsa-let-7g miRNA) signalling pathways. The current study provides the first large scale expression profile of miRNAs from lung cells and predicted gene targets, following exposure to K. pneumoniae OMVs. Our results suggest the importance of OMVs in the inflammatory response.
  • 2.3K
  • 29 Dec 2020
Topic Review
DNA Damage Repair for Cancer
DDR is activated in response to different endogenous and exogenous stresses(). When aberrantly repaired, DNA damage might be associated with clinical outcomes such as neurodegeneration, infertility, and genomic instability, being a key contributing factor to neoplastic transformation and tumour development(). Due to the complexity underneath detection and repair of DNA damage, cells evolved an intricate DDR network that, together with cell cycle regulation, promotes the maintenance of genomic stability and cellular viability().
  • 2.3K
  • 02 Aug 2021
Topic Review
Autophagy in Cancer Cell Death
Autophagy has important functions in maintaining energy metabolism under conditions of starvation and to alleviate stress by removal of damaged and potentially harmful cellular components. Therefore, autophagy represents a pro-survival stress response in the majority of cases. An alternative pro-death function of autophagy has been consistently observed in different settings, in particular, in developmental cell death of lower organisms and in drug-induced cancer cell death. This cell death is referred to as autophagic cell death (ACD) or autophagy-dependent cell death (ADCD), a type of cellular demise that may act as a backup cell death program in apoptosis-deficient tumors. 
  • 2.3K
  • 15 Jun 2022
Topic Review
DICONDE
Digital Imaging and Communication for Nondestructive Evaluation (DICONDE) is a vendor-neutral digital data storage and transmission protocol that defines the organization of nondestructive testing (NDT) inspection data and associated metadata in a standard format. DICONDE is based on and inherits from the universally adopted medical standard, DICOM, which facilitates the interoperability of imaging, video, and signal data acquisition equipment through data storage, query, and network communication protocols. The ASTM International standards organization maintains and holds the copyright to the relevant DICONDE published standards, including a tutorial guide designated as E3169. Development and maintenance of the standard is handled by committee E07 on nondestructive testing. Subcommittee E07.11 on DICONDE is concerned with the formulation of standards for the communication and storage of data generated by all nondestructive testing methodologies capable of handling data in an electronic format. ASTM maintains a page dedicated to DICONDE and openly provides resources on the ASTM DICONDE home page.
  • 2.3K
  • 08 Oct 2022
Topic Review
Fault-tolerant Computer System
Fault-tolerant computer systems are systems designed around the concepts of fault tolerance. In essence, they must be able to continue working to a level of satisfaction in the presence of errors or breakdowns. Fault tolerance is not just a property of individual machines; it may also characterise the rules by which they interact. For example, the Transmission Control Protocol (TCP) is designed to allow reliable two-way communication in a packet-switched network, even in the presence of communications links which are imperfect or overloaded. It does this by requiring the endpoints of the communication to expect packet loss, duplication, reordering and corruption, so that these conditions do not damage data integrity, and only reduce throughput by a proportional amount. Recovery from errors in fault-tolerant systems can be characterised as either 'roll-forward' or 'roll-back'. When the system detects that it has made an error, roll-forward recovery takes the system state at that time and corrects it, to be able to move forward. Roll-back recovery reverts the system state back to some earlier, correct version, for example using checkpointing, and moves forward from there. Roll-back recovery requires that the operations between the checkpoint and the detected erroneous state can be made idempotent. Some systems make use of both roll-forward and roll-back recovery for different errors or different parts of one error.
  • 2.3K
  • 09 Nov 2022
Topic Review
Mathematical Modeling to Estimate Photosynthesis
Photosynthesis is a process that indicates the productivity of crops. The estimation of this variable can be achieved through methods based on mathematical models.
  • 2.3K
  • 22 Jun 2022
Topic Review
Nutritional Value of Plant Proteins
The quality and nutritional value of dietary proteins are determined by the quantity, digestibility and bioavailability of essential amino acids (EAA), which play a critical role in human growth, longevity and metabolic health. Plant-source protein is often deficient in one or more EAAs (e.g., branched-chain amino acids, lysine, methionine and/or tryptophan) and, in its natural form, is less digestible than animal-source protein. Nevertheless, dietary intake of plant-source protein has been promoted because of its potential health benefits, lower cost of production and lower environmental impact compared to animal-source protein. Implementation of dietary strategies that improve both human and planetary health are of critical importance and subject to growing interest from researchers and consumers. 
  • 2.3K
  • 05 Nov 2020
Topic Review
Bile Acid Signaling
Bile acids are digestive agents synthesized in the liver and released into the gastrointestinal track during normal physiological conditions to aid in the emulsification of lipids and fat-soluble vitamins. These bile acids are highly regulated via enterohepatic circulation, a process which minimizes bile acid loss through a wide network of organs and bile acid transporters. Beyond this, bile acids and the activation of bile acid receptors has been observed in extrahepatic tissues, in particular the central nervous system. Certain bile acids, through the use of specific bile acid transporters, can also gain entry into the brain via the blood brain barrier. Furthermore, there has been an increase in recent literature highlighting bile acids and the presence of bile acid signaling in the brain and neural cells. This entry is a current overview of these topics.
  • 2.3K
  • 21 Aug 2020
Topic Review
Traditional Bulgarian Dairy Products
Dairy products are nutritionally indispensable, consumed daily and one of the most desired foods by a large part of the world population. 
  • 2.3K
  • 01 Jun 2021
Topic Review
Pallas' Cat
Pallas' Cat (Otocolobus manul) is a small wild felid native to the grasslands and montane steppes of Central Asia, known for its unique appearance and elusive nature. With its stocky build, dense fur, and expressive facial features, the Pallas' Cat captivates the fascination of wildlife enthusiasts and researchers alike. Despite its diminutive size, this elusive felid plays a crucial ecological role as an apex predator, regulating prey populations and shaping ecosystem dynamics in its native habitat.
  • 2.3K
  • 08 Mar 2024
Topic Review
Stroke
Stroke is the second leading cause of death and a major contributor to disability worldwide. The prevalence of stroke is highest in developing countries, with ischemic stroke being the most common type. Considerable progress has been made in our understanding of the pathophysiology of stroke and the underlying mechanisms leading to ischemic insult. Stroke therapy primarily focuses on restoring blood flow to the brain and treating stroke-induced neurological damage. Lack of success in recent clinical trials has led to significant refinement of animal models, focus-driven study design and use of new technologies in stroke research. Simultaneously, despite progress in stroke management, post-stroke care exerts a substantial impact on families, the healthcare system and the economy. Improvements in pre-clinical and clinical care are likely to underpin successful stroke treatment, recovery, rehabilitation and prevention. In this review, we focus on the pathophysiology of stroke, major advances in the identification of therapeutic targets and recent trends in stroke research.
  • 2.3K
  • 07 Apr 2021
Topic Review
Chitosan
Chitosan is a random copolymer comprising d-glucosamine (the deacetylated ones) and N-acetyl-d-glucosamine units.
  • 2.3K
  • 12 Apr 2021
Topic Review
Range Extender
A range extender is an auxiliary power unit that provides an electric vehicle with additional energy to complement the primary battery in propelling the vehicle.
  • 2.3K
  • 14 Apr 2021
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