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Topic Review
Methods for the Production of Kilobase-Length Single-Stranded DNA
DNA nanoengineering, in particular, DNA origami has potential applications in a variety of areas including, for example, nanoelectronics, biomedical diagnostics, and therapeutics. To fully realize the potential of DNA self-assembly in these and other areas, methods must be available for economical, scalable, and reliable production of single-stranded DNA (ssDNA) scaffolds from virtually any source. Described here are four such methods.
  • 2.4K
  • 18 Apr 2022
Topic Review
Drilling Fluid Loss and Lost Circulation Control Technology
Lost circulation in fractured formation is the first major technical problem that restricts improvements in the quality and efficiency of oil and gas drilling engineering. Improving the success rate of one-time lost circulation control is an urgent demand to ensure “safe, efficient and economic” drilling in oilfields all over the world. 
  • 2.4K
  • 13 May 2022
Topic Review
NLRP3 Inflammasome in Neurodegenerative
Inflammasomes are intracellular multiprotein complexes in the cytoplasm that regulate inflammation activation in the innate immune system in response to pathogens and to host self-derived molecules. The NLRP3 belongs to the subfamily of NLRP which activates caspase 1, thus causing the production of proinflammatory cytokines (interleukin 1β and interleukin 18) and pyroptosis. This inflammasome is involved in multiple neurodegenerative and metabolic disorders including Alzheimer’s disease, multiple sclerosis, type 2 diabetes mellitus, and gout. 
  • 2.4K
  • 25 May 2022
Topic Review
Media Education
Media Education is an educational discipline focused on critical and conscious engagement with media and their languages. Regarded as complex cultural artifacts, it serves as a preparatory phase aimed at developing interpretative and critical skills regarding the media themselves. The objective is to promote a deep understanding of media as cultural and social phenomena, emphasizing that they are not merely technical tools but carriers of meanings and values that shape perceptions of reality and identity formation. This entry explores the evolution of Media Education, from the 1982 UNESCO Grünwald Declaration to recent international initiatives, highlighting the role of the Media Educator as a facilitator in integrating digital technologies into educational contexts. Key aspects include the rejection of an “apocalyptic” vision of the new media (quoting Umberto Eco), the focus on media as carriers of meaning, and the promotion of critical and creative skills essential for navigating the complexities of contemporary digital culture.
  • 2.4K
  • 21 Jan 2025
Topic Review
CXCL13 in Cancer and Other Diseases
C-X-C chemokine ligand 13 (CXCL13) and its receptor, CXCR5, make crucial contributions to this process by triggering intracellular signaling cascades in malignant cells and modulating the sophisticated TME in an autocrine or paracrine fashion. The CXCL13/CXCR5 axis has a dominant role in B cell recruitment and tertiary lymphoid structure formation, which activate immune responses against some tumors. In most cancer types, the CXCL13/CXCR5 axis mediates pro-neoplastic immune reactions by recruiting suppressive immune cells into tumor tissues. Tobacco smoke and haze (smohaze) and the carcinogen benzo(a)pyrene induce the secretion of CXCL13 by lung epithelial cells, which contributes to environmental lung carcinogenesis. 
  • 2.4K
  • 09 Dec 2021
Topic Review Peer Reviewed
Enantiomers and Their Resolution
Enantiomers share the same chemical formula but have different chemical structures, i.e., type of isomers. Enantiomers are present in several drugs, perfumes, food, and are a fundamental part of biomolecules. This subject is highly important for pharmaceutical companies. Enantiomeric drugs present different actuation in the human body; depending on the compound, one might combat the symptom, whereas its pair might cause damage. The separation of pairs of enantiomers requires a chiral environment that provokes a structural imbalance that conventional methods cannot provide. Enantioresolution is one of the most promissory studies that benefit several areas, such as pharmaceutical, biotechnology, food industry, and fine chemistry. Its resolution is of great importance, therefore, its main mechanisms of resolution will be explained herein.
  • 2.4K
  • 14 Apr 2022
Topic Review
2010 Gang Rapes in Cleveland, Texas
The 2010 gang rapes in Cleveland, Texas were a series of acts of sexual violence committed by a group of adult men and teenage boys on an underage girl in the town of Cleveland, in Texas , USA.
  • 2.4K
  • 21 Nov 2022
Topic Review
Compound Parabolic Concentrator-Based Hybrid Solar Photovoltaic/Thermal Collectors
The compound parabolic concentrating (CPC) collectors belong to a class of concentrators called non-imaging concentrators. These concentrators allow the design of optical systems that can attain maximum geometric concentrations permitted by laws of physical conservation for a given angular field. As opposed to imaging or focusing concentrators, the concentrators based on non-imaging optics are capable of achieving moderate levels of concentration without tracking the sun.
  • 2.4K
  • 23 May 2022
Topic Review
Empathy Gap
A hot-cold empathy gap is a cognitive bias in which people underestimate the influences of visceral drives on their own attitudes, preferences, and behaviors. The most important aspect of this idea is that human understanding is "state-dependent". For example, when one is angry, it is difficult to understand what it is like for one to be calm, and vice versa; when one is blindly in love with someone, it is difficult to understand what it is like for one not to be, (or to imagine the possibility of not being blindly in love in the future). Importantly, an inability to minimize one's gap in empathy can lead to negative outcomes in medical settings (e.g., when a doctor needs to accurately diagnose the physical pain of a patient), and in workplace settings (e.g., when an employer needs to assess the need for an employee's bereavement leave). Hot-cold empathy gaps can be analyzed according to their direction: They can also be classified in regards to their relation with time (past or future) and whether they occur intra- or inter-personally: The term hot-cold empathy gap was coined by Carnegie Mellon University psychologist George Loewenstein. Hot-cold empathy gaps are one of Loewenstein's major contributions to behavioral economics.
  • 2.4K
  • 04 Nov 2022
Topic Review
Imaging of Cultural Heritage
The imaging of cultural heritage is a necessary part of long term preservation of cultural heritage. While the physical conditions of objects will change over time, imaging serves as a way to document and represent heritage in a moment in time of the life of the item. Different methods of imaging produce results that are applicable in various circumstances. Not every method is appropriate for every object, and not every object needs to be imaged by multiple methods. In addition to preservation and conservation related concerns, imaging can also serve to enhance research and study of cultural heritage.
  • 2.4K
  • 30 Nov 2022
Topic Review
The Foundations of Arithmetic
The Foundations of Arithmetic (German: Die Grundlagen der Arithmetik) is a book by Gottlob Frege, published in 1884, which investigates the philosophical foundations of arithmetic. Frege refutes other theories of number and develops his own theory of numbers. The Grundlagen also helped to motivate Frege's later works in logicism. The book was not well received and was not read widely when it was published. It did, however, draw the attentions of Bertrand Russell and Ludwig Wittgenstein, who were both heavily influenced by Frege's philosophy. An English translation was published (Oxford, 1950) by J. L. Austin, with a second edition in 1960.
  • 2.4K
  • 05 Dec 2022
Topic Review
Vaccinium uliginosum and Vaccinium myrtillus
Vaccinium uliginosum L. (commonly known as bog bilberry) and Vaccinium myrtillus L. (commonly known as bilberry) are species of the genus Vaccinium (family Ericaceae). The red–purple–blue coloration of blueberries is attributed largely to the anthocyanins found in bilberries. Anthocyanins, known for their potent biological activity as antioxidants, have a significant involvement in the prophylaxis of cancer or other diseases, including those of metabolic origin.
  • 2.4K
  • 06 Dec 2023
Topic Review
Transforming Growth Factor-β
Transforming growth factor-β (TGF-β) was originally identified as an anti-tumour cytokine. However, there is increasing evidence that it has important roles in the tumour microenvironment (TME) in facilitating cancer progression. TGF-β actively shapes the TME via modulating the host immunity. These actions are highly cell-type specific and complicated, involving both canonical and non-canonical pathways. In this review, we systemically update how TGF-β signalling acts as a checkpoint regulator for cancer immunomodulation. A better appreciation of the underlying pathogenic mechanisms at the molecular level can lead to the discovery of novel and more effective therapeutic strategies for cancer.
  • 2.4K
  • 16 Nov 2020
Topic Review
Factors Related to Surface Roughness in Machining
Understanding surface roughness generation in machining is critical to estimate the final quality of the part, optimize cutting conditions, reduce costs and improve manufacturing sustainability in industry.
  • 2.4K
  • 25 Mar 2024
Topic Review
Optical Properties of Plasmonic Metal Nanoparticles
Plasmonic phenomena and materials have been extensively investigated for a long time and gained popularity in the last few years, finding in the design of the biosensors platforms promising applications offering devices with excellent performances. Hybrid systems composed of graphene, or other 2D materials, and plasmonic metal nanostructures present extraordinary optical properties originated from the synergic connection between plasmonic optical effects and the unusual physicochemical properties of 2D materials, thus improving their application in a broad range of fields. 
  • 2.4K
  • 08 Jul 2022
Topic Review Peer Reviewed
Periodontal Regeneration
Periodontal regeneration is a technique that aims to regenerate the damaged tissue around periodontally compromised teeth. The regenerative process aims to use scaffolds, cells, and growth factors to enhance biological activity. 
  • 2.4K
  • 13 Apr 2022
Topic Review
Deep Learning-Based Crack Detection Approaches
The application of deep architectures inspired by the fields of artificial intelligence and computer vision has made a significant impact on the task of crack detection. As the number of studies being published in this field is growing fast, it is important to categorize the studies at deeper levels.
  • 2.4K
  • 24 Feb 2022
Topic Review
Pediatric Dosage Forms
The development of pediatric-specific dose forms is particularly difficult due to a variety of factors relating to pediatric population differences from adult populations. The buccal dosage form is considered a good alternative to oral dosage form if the latter cannot be used in pediatric patients. Both oral and buccal dosage formulations uphold great application qualities for pediatric patients.
  • 2.4K
  • 18 Apr 2022
Topic Review
Small-Scale Carbon Capture Systems
Carbon capture is the most costly phase of a carbon capture, utilization, and storage (CCUS) supply chain, due to high capture cost from sources, which are diluted in CO2. This is especially true at a small-scale, as CO2 content in flue gases are significantly lower than those from large scale energy generation. The values of the cost of CO2 captured and the cost of CO2 avoided reported by Rubin et al. would be much lower than those for small-scale generation due to the diluted CO2.
  • 2.4K
  • 28 Apr 2022
Topic Review
Whole Genome Amplification in Preimplantation Genetic Testing
Successful whole genome amplification (WGA) is a cornerstone of contemporary preimplantation genetic testing (PGT). Choosing the most suitable WGA technique for PGT can be particularly challenging.
  • 2.4K
  • 27 Jul 2022
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