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Topic Review
Cooking Mama
Cooking Mama (クッキング ママ, Kukkingu Mama) is a cookery simulation-styled minigame compilation video game for the Nintendo Wii, Nintendo DS, and iOS platforms, developed by Office Create and published by Taito, Majesco Entertainment, and 505 Games. It was awarded IGN's "Best Of E3" award for 2006. It was followed by a sequel for the DS, Cooking Mama 2: Dinner with Friends. Two games have been made for the Wii: Cooking Mama and Cooking Mama.
  • 2.5K
  • 19 Oct 2022
Topic Review
Deathtrap (Plot Device)
A deathtrap is a literary and dramatic plot device in which a villain who has captured the hero or another sympathetic character attempts to use an elaborate, improbable, and usually sadistic method of murdering them. It is often used as a means to create dramatic tension in the story and to have the villain reveal important information to the hero, confident that the hero will shortly not be able to use it. It may also be a means to show the hero's resourcefulness in escaping, or the writer's ingenuity at devising a last-minute rescue or deus ex machina.
  • 2.5K
  • 04 Nov 2022
Topic Review
Anthracnose Caused by Colletotrichum gloeosporioides
Fruits and vegetables are constantly affected by postharvest diseases, of which anthracnose is one of the most severe and is caused by diverse Colletotrichum species, mainly C. gloeosporioides. Colletotrichum gloeosporioides is a cosmopolitan pathogen widely disseminated as a common plant pathogen.
  • 2.5K
  • 26 Jul 2023
Topic Review
Variant Chinese Character
Variant Chinese characters (simplified Chinese: 异体字; traditional Chinese: 異體字; pinyin: yìtǐzì; Kanji: 異体字; Hepburn: itaiji; Korean: 이체자; Hanja: 異體字; Revised Romanization: icheja) are Chinese characters that are homophones and synonyms. Most variants are allographs in most circumstances, such as casual handwriting. Some contexts require the usage of certain variants, such as in textbook editing.
  • 2.5K
  • 29 Nov 2022
Topic Review
Multistakeholder Participation in Disaster Management
The coronavirus disease 2019 (COVID-19) pandemic is affecting society’s health, economy, environment and development. COVID-19 has claimed many lives across the globe and severely impacted the livelihood of a considerable section of the world’s population. We are still in the process of finding optimal and effective solutions to control the pandemic and minimise its negative impacts. In the process of developing effective strategies to combat COVID-19, different countries have adapted diverse policies, strategies and activities and yet there are no universal or comprehensive solutions to the problem. In this context, this paper brings out a conceptual model of multistakeholder participation governance as an effective model to fight against COVID-19. Accordingly, the current study conducted a scientific review by examining multi-stakeholder disaster response strategies, particularly in relation to COVID-19. The study then presents a conceptual framework for multistakeholder participation governance as one of the effective models to fight against COVID-19. 
  • 2.5K
  • 22 Apr 2021
Topic Review
Pet Ownership and Quality of Life
Pet ownership is the most common form of human–animal interaction, and anecdotally, pet ownership can lead to improved physical and mental health for owners. The entry summarizes the literature to determine the evidence for the role pets play in quality of life for their owners. 
  • 2.5K
  • 21 Jan 2022
Topic Review
Protection of Iron by Corrosion Inhibitors
Iron is a widely used metal due to its low cost and availability, but it is susceptible to corrosion in many circumstances. This corrosion can result in economic and environmental losses, and negatively affect the physical and chemical properties of the metal.
  • 2.5K
  • 24 Mar 2023
Topic Review
Laccase
Enzymes play an important role in numerous natural processes and are increasingly being utilized as environmentally friendly substitutes and alternatives to many common catalysts. Both horseradish peroxidase (HRP) and laccase are most often utilized for the formation of enzyme aggregates due to their ability to rapidly oxidize phenols, generating phenoxy radicals which undergo radical coupling to form biphenyl or phenyl ether linkages. 
  • 2.5K
  • 07 Mar 2024
Topic Review
Process Analytical Technology
Various frameworks and methods, such as quality by design (QbD), real time release test (RTRT), and continuous process verification (CPV), have been introduced to improve drug product quality in the pharmaceutical industry. The methods recognize that an appropriate combination of process controls and predefined material attributes and intermediate quality attributes (IQAs) during processing may provide greater assurance of product quality than end-product testing. The efficient analysis method to monitor the relationship between process and quality should be used. Process analytical technology (PAT) was introduced to analyze IQAs during the process of establishing regulatory specifications and facilitating continuous manufacturing improvement. Although PAT was introduced in the pharmaceutical industry in the early 21st century, new PAT tools have been introduced during the last 20 years.
  • 2.5K
  • 22 Jul 2021
Topic Review
LED Lighting Systems for Horticulture
       In recent years, research on light emitting diodes (LEDs) has highlighted their great potential as a lighting system for plant growth, development and metabolism control. The suitability of LED devices for plant cultivation has turned the technology into a main component in controlled or closed plant-growing environments, experiencing an extremely fast development of horticulture LED metrics. In this context, the hereby study aims to provide an insight into the current global horticulture LED industry and the present features and potentialities for LEDs’ applications. An updated review of this industry has been integrated through a database compilation of 301 manufacturers and 1473 LED lighting systems for plant growth. The research identifies Europe (40%) and North America (29%) as the main regions for production. Additionally, the current LED luminaires’ lifespans show 10 and 30% losses of light output after 45,000 and 60,000 working hours on average, respectively, while the vast majority of worldwide LED lighting systems present efficacy values ranging from 2 to 3 μmol J−1 (70%). Thus, an update on the status of the horticultural LED sector, applications and metrics, and the intense innovation are described and discussed.
  • 2.5K
  • 30 Oct 2020
Topic Review
Cavity Disinfectants
Cavity disinfection becomes an important step before a dental restorative procedure. The disinfection can be obtained cleaning the dental cavity with antimicrobial agents before the use of adhesive systems. 
  • 2.5K
  • 27 Jan 2021
Topic Review
Lanthanide-Doped Nanoparticles
Lanthanide-doped nanoparticles exhibit unique luminescent properties, including tunable luminescence emission, narrow emission width, excellent optical stability, and long lifetimes from microseconds to milliseconds. Lanthanide-doped nanomaterials with long lifetimes are independent with background fluorescence interference and biological tissue depth.
  • 2.5K
  • 22 Feb 2022
Topic Review
Hydrogen Peroxide Formation and Elimination in Mammalian Cells
Hydrogen peroxide (H2O2) is a compound involved in some mammalian reactions and processes. It modulates and signals the redox metabolism of cells by acting as a messenger together with hydrogen sulfide (H2S) and the nitric oxide radical (•NO), activating specific oxidations that determine the metabolic response. 
  • 2.5K
  • 29 Sep 2022
Topic Review
Dhyāna Sutras
The Dhyāna sutras (Chinese: 禪経) or "meditation summaries" (Chinese: 禪要) are a group of early Buddhist meditation texts which are mostly based on the Yogacara[note 1] meditation teachings of the Sarvāstivāda school of Kashmir circa 1st-4th centuries CE. Most of the texts only survive in Chinese and were key works in the development of the Buddhist meditation practices of Chinese Buddhism.
  • 2.5K
  • 09 Oct 2022
Topic Review
Maximum Genetic Diversity
Maximum Genetic Diversity (MGD) is a scientific hypothesis relating to molecular evolution, which is the study of how and why populations of organisms experience genetic changes over time. MGD starts with the observation that some regions of the genome are more likely to preserve mutations into the next generation than others. This difference in the observed rate of mutation means some regions of the genome appear to mutate faster than others, and is theorized to relate to balancing the preservation of vital information relating to a species' function against its ability to mutate and adapt to new environmental niches. According to MGD, these regions of the genome eventually drift into two rough categories: faster-mutating sections tuned to respond quickly to environmental pressures and allow adaptive radiation, as well as slower-mutating sections involved in an organism's most fundamental instructions. Because MGD asserts that only slow-mutating genes accurately reflect shared evolutionary history, relationships between species can alternatively be calculated by their "maximum genetic diversity," which is determined by measuring the frequency of mutations in specific corresponding regions of orthologous genes instead of using raw overall genetic similarity. Using calculations based on mutations in these slow-mutating genes provides a chart of genetic ancestry that lines up with the fossil record – measurements based on raw genetic similarity yield results that clash with the fossil record. Also due to this grouping into fast and slow, MGD hypothesizes that over time complex organisms become genetically fragile and less tolerant to mutation as their MGD decreases, since an increasing proportion of their genome will have become slow-mutating over time. MGD asserts that this is because increased organismal and social complexity means more of the genome is needed to preserve the expanding instructional manual necessary for complex behavior and function, and so more of an organism's genome must become slow-mutating as the organism increases in complexity, since being slow-mutating preserves and protects those vital instructions. MGD seeks to reconcile the inconsistencies observed around the neutral theory of molecular evolution, whose "original lines of evidence... are now falsified" according to a paper published in Oxford's Molecular Biology and Evolution in 2018. One example of this is that supposedly consistent and neutral mutation rates from proteins across a wide range of species were demonstrably not neutral nor consistent. Another study published in Nature in December 2019 noted that "defining the evolutionary time scales according to the molecular clock is intrinsically biased, especially for proteins of complex organisms." Although a number of other arguments have been proposed against the neutral theory in recent years, there is not a yet a consensus that the neutral theory is entirely falsified and counter-arguments against the role of selection do exist. Furthermore, beyond the fact that MGD is still relatively unknown, it also contradicts the current paradigm in molecular evolution, since the neutral theory's fundamental premises are still nearly ubiquitously utilized in genetic analysis and admixture studies. Additionally, some of the phenomena explained by MGD could theoretically be accounted for by other processes such as gene conversion or concerted evolution. Lastly, even if the neutral theory is disproved, it does not necessarily validate MGD, as alternative theories have been proposed that also incorporate the effects of selection on the genome. And so MGD will have to be more rigorously tested against any alternative theories before becoming widely adopted. However, to date MGD has not been contradicted in peer-reviewed literature, and its assumptions and framework have been confirmed when it comes to examining the ratio of brain-specific proteins in a range of mammals, for classifying and timing the evolutionary genetic structure of a wide range of organisms ranging from yeast to primates, by evaluating the genetic fitness of yeast which become more genetically fragile as they become more fit, by a genetic model that seeks to more accurately model not only the location of mutations but the rate at which they occur, and by the observation that vital slow-mutating genes are more protected by "transcriptional scanning" in mammalian testes than fast-evolving genes involved with responding quickly to environmental challenges.
  • 2.5K
  • 25 Nov 2022
Topic Review
Zebrafish Heart Development
Proper development and function of the vertebrate heart is vital for embryonic and postnatal life. Many congenital heart defects in humans are associated with disruption of genes that direct the formation or maintenance of atrial and pacemaker cardiomyocytes at the venous pole of the heart. Zebrafish are an outstanding model for studying vertebrate cardiogenesis, due to the conservation of molecular mechanisms underlying early heart development, external development, and ease of genetic manipulation.
  • 2.5K
  • 23 Feb 2021
Topic Review
Human Emotion Recognition
Automated emotion recognition (AEE) is important issue in the various field of activities, which uses human emotional reaction as a signal for marketing, technical equipment or human-robot interaction. Paper analyzes vast layer of scientific research and technical papers for sensor use analysis, where various methods implemented or researched. Paper cover few classes of sensors, using contactless methods, contact and skin-penetrating electrodes with for human emotion detection and measurement of their intensity. Result of performed analysis in this paper presented applicable methods for each type of emotions or their intensity and proposed their classification. Provided classification of emotion sensors revealed area of application and expected outcome from each method as well as noticed limitation of them. This paper should be interested for researchers, needed to use of human emotion evaluation and analysis, when there is a need to choose proper method for their purposes or find alternative decision.
  • 2.5K
  • 27 Jan 2021
Topic Review
Drug Delivery Systems Polymeric Nanocarriers in Cancer Therapy
Conventional chemotherapy is the most common therapeutic method for treating cancer by the application of small toxic molecules that interact with DNA and cause cell death. Unfortunately, these chemotherapeutic agents are non-selective and can damage both cancer and healthy tissues, producing diverse side effects, and they can have a short circulation half-life and limited targeting. Many synthetic polymers have found application as nanocarriers of intelligent drug delivery systems (DDSs). Their unique physicochemical properties allow them to carry drugs with high efficiency, specifically target cancer tissue and control drug release. In recent years, considerable efforts have been made to design smart nanoplatforms, including amphiphilic block copolymers, polymer-drug conjugates and in particular pH- and redox-stimuli-responsive nanoparticles (NPs).
  • 2.5K
  • 25 Mar 2022
Topic Review
Benchmarking the Performance of a Quantum Computer
The quantum computer has been claimed to show more quantum advantage than the classical computer in solving some specific problems. Many companies and research institutes try to develop quantum computers with different physical implementations. Currently, most people only focus on the number of qubits in a quantum computer and consider it as a standard to evaluate the performance of the quantum computer intuitively. However, it is quite misleading in most times, especially for investors or governments. This is because the quantum computer works in a quite different way than classical computers. Thus, quantum benchmarking is of great importance. Currently, many quantum benchmarks are proposed from different aspects.
  • 2.5K
  • 07 Nov 2022
Topic Review
Magnetic Resonance Imaging for Sjögren’s Syndrome
Primary Sjögren’s Syndrome (pSS) is a chronic autoimmune exocrinopathy affecting 0.3–3.0% of the population. Its main clinical hallmarks are the sicca symptoms (mucosal dryness manifesting mainly ocularly and orally) and extra-glandular symptoms, among which joint pain and chronic fatigue are the most important. Besides these symptoms, pSS may also manifest in the central nervous system (CNS), as noted in the original description of the disease by Sjögren himself in 1933. The most common radiological lesions in pSS are white matter hyperintensities (WMH), scattered alterations hyperlucent on T2 and FLAIR sequences, typically located periventricularly and subcortically. Cortical atrophy and ventricular dilatation can also occur in pSS. Whilst these conditions are thought to be more common in pSS than healthy controls, diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (fMRI) alterations demonstrate evident microstructural changes in pSS. As pSS is often accompanied by cognitive symptoms, these magnetic resonance imaging (MRI) alterations are expectedly related to them. 
  • 2.5K
  • 31 Jan 2023
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